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Epitope in Medical News

CEL-SCI Expands Testing of Its Vaccine to Determine Efficacy Against More Virulent Strain of H1N1 Swine and Other Influenza Viruses

...of its flu vaccine, utilizing its proprietary L.E.A.P.S. technology (Ligand epitope Antigen Presentation System) to determine its efficacy against the more dan...thetic peptides. The L.E.A.P.S. constructs containing the antigenic disease epitope linked to an Immune/T-cell binding ligand (I/TCBL) can be manufactured by p...

CEL-SCI Corporation Reports 2009 Second Fiscal Quarter Financial Results

... of new biological and stem cell produced products. Promising preclinical studies supporting the Company's proprietary L.E.A.P.S.(TM) (Ligand epitope Antigen Presentation System) vaccine technology. The studies suggest that L.E.A.P.S. could potentially induce protection against illnesses such as swi...

Tracon Pharmaceuticals to Present Clinical Stage Programs at AACR 2009

...er Date and Time: Wednesday, April 22, 2009, 8:00 AM Abstract Number: 5433 TRC093 Abstract Title: Targeting the HU177 cryptic collagen epitope with humanized antibody TRC093 functions cooperatively with anti-VEGF therapy to inhibit tumor growth Presenter: Jennifer M. Roth, PhD, Maine Medic...

GlaxoSmithKline and Genmab Submit Arzerra(TM) (Ofatumumab) Application to FDA for the Treatment of Advanced Stage Blood Cancer

...dy that targets a membrane-proximal (close to the cell surface), small loop epitope (a portion of a molecule to which an antibody binds) on the CD20 molecule on B-cells.(9) This epitope is different from the binding sites targeted by other CD20 antibodies curre...

CEL-SCI Launches Study to Determine Long Lasting Beneficial Effects of its Rheumatoid Arthritis Vaccine

...ongoing research and development activities with its L.E.A.P.S.(TM) (Ligand epitope Antigen Presentation System) technology. L.E.A.P.S. is a novel T-cell modul...thetic peptides. The L.E.A.P.S. constructs containing the antigenic disease epitope linked to a T-cell binding ligand (TCBL) can be manufactured by peptide syn...

EpiVax Receives NIH Grant for $390,000 to Optimize HIV Vaccine Delivery

...i-DEC-205 as a stand-alone HIV antigen delivery system that obviates the dangers associated with non-specific activation of the immune system. epitope modification is an immunomodulatory approach EpiVax previously developed to reduce immunogenicity of protein therapeutics. Here, EpiVax will substitut...

CEL-SCI Presents Favorable Data for Leaps Vaccine Technology at Prestigious Immunology Conference

...armacy and Dr. Dan Zimmerman, CEL-SCI's Senior Vice President of Research and Cellular Immunology, demonstrated that immunization with a LEAPS (Ligand epitope Antigen Presentation System) vaccine altered the immunological hormone (cytokine) balance toward a Th1 environment. It has been shown that a Th1 cellu...

Gene Linked to Inflammatory Arthritis Also Raises Heart Risks

...or of premature death from CVD in patients with inflammatory arthritis. The researchers said that, for RA patients in particular, having the shared epitope (SE) -- a group of HLA-DRB1 alleles with kindred amino acid traits -- plus anti-cyclic citrullinated peptide (anti-CCP) antibodies and being a current...

The HLA-DRB1 gene and premature death in rheumatoid arthritis

...bility and severity, as a predictor of premature death from CVD for inflammatory arthritis patients. For RA patients in particular, having the shared epitope (SE)a group of HLA-DRB1 alleles with kindred amino acid traitsplus anti-cyclic citrullinated peptide (anti-CCP) antibodies and current smoking is an e...

Genmab Initiates Ofatumumab Phase II Study in Diffuse Large B-Cell Lymphoma

...nal, fully human, next generation monoclonal antibody that targets a unique epitope of the CD20 receptor on the surface of B-cells. Other anti-CD20 antibodies currently available or in development bind to a different epitope on the CD20 receptor. Ofatumumab is being developed under a co-development ...
Epitope in Medical Technology

MacroGenics and Lilly Achieve Targeted Patient Enrollment in PROTEGE, a Global Phase 2/3 Clinical Trial of Teplizumab in Type 1 Diabetes

... function of the T lymphocytes that mediate the destruction of the insulin-producing beta cells of the islets of the pancreas. Teplizumab binds to an epitope of the CD3-epsilon chain expressed on mature T cells and by doing so, may modulate the immunologic response that is a key component of the disease. If...

CEL SCI Collaborators Demonstrate Novel L.E.A.P.S. Vaccines Immunize Mice Against Tuberculosis Antigens and Suggest Potential to Treat Swine and Other Influenzas

...n data at the annual American Society for Microbiology in Philadelphia, PA. This data demonstrates that vaccines utilizing its L.E.A.P.S.(TM) (Ligand epitope Antigen Presentation System) vaccine technology with specificity for particular Mycobacterium tuberculosis (TB) antigens can elicit immune responses...

FDA Advisory Panel Makes Favorable Recommendation for GlaxoSmithKline and Genmab's ARZERRA(TM) (ofatumumab)

... About Ofatumumab Ofatumumab is an investigational monoclonal antibody that targets a membrane-proximal (close to the cell surface), small loop epitope (a portion of a molecule to which an antibody binds) on the CD20 molecule on B-cells. Ofatumumab also binds to the large loop of the CD20 molecule. Th...

Circassia Begins Phase II Clinical Trial With Ragweed Allergy Therapy

... is a specialty biopharmaceutical company focused on the field of allergy. The company's range of allergy therapeutics utilizes its proprietary T-cell epitope desensitization technology, ToleroMune. Circassia's products offer potential major clinical benefits compared with existing therapies, and consequentl...

Circassia's Allergy Therapy Begins Phase II Clinical Trial in Asthma Patients

... is a specialty biopharmaceutical company focused on the field of allergy. The company's range of allergy therapeutics utilizes its proprietary T-cell epitope desensitization technology, ToleroMune. Circassia's anti-allergy products offer potential major clinical benefits compared with existing therapies, an...

Circassia Completes Patient Recruitment for Phase II Clinical Trial of Toleromune(R) Allergy Treatment

...and nearly 10% of Europeans suffering from the condition. Circassia's lead products target allergies utilizing the company's proprietary T-cell epitope desensitization technology, ToleroMune. In addition to ToleroMune's potential therapeutic benefits, its state-of-the-art manufacturing processes fit w...

Arzerra(TM) (ofatumumab) Demonstrates High Response Rates in Patients With Fludarabine Refractory Chronic Lymphocytic Leukemia (CLL)

...dy that targets a membrane-proximal (close to the cell surface), small loop epitope (a portion of a molecule to which an antibody binds) on the CD20 molecule on B cells.(4) This epitope is different from the binding sites targeted by other CD20 antibodies curre...

Circassia Initiates Further Phase II Clinical Study of Toleromune(R) Anti-Allergy Technology

...ions, Lansdowne Partners, Goldman Sachs and Invesco Perpetual. Circassia's lead products target allergies utilizing the company's proprietary T-cell epitope desensitization technology, ToleroMune. The company is also developing its ToleroTrans organ anti-rejection technology, which uses a similar approach ...

Circassia Achieves Successful Phase II Clinical Results With Toleromune(R) Anti-Allergy Technology

...ions, Lansdowne Partners, Goldman Sachs and Invesco Perpetual. Circassia's lead products target allergies utilizing the company's proprietary T-cell epitope desensitization technology, ToleroMune. The company is also developing its ToleroTrans organ anti-rejection technology, which uses a similar approach ...

Data Suggest CEL-SCI's CEL-2000 Vaccine Prevents or Retards Permanent Damage of Rheumatoid Arthritis

...ongoing research and development activities with its L.E.A.P.S.(TM) (Ligand epitope Antigen Presentation System) technology. L.E.A.P.S.(TM) is a novel T-cell m...ic peptides. The L.E.A.P.S.(TM) constructs containing the antigenic disease epitope linked to a T-cell binding ligand (TCBL) can be manufactured by peptide syn...
Epitope in Medical Products

Shandon TissueWave

Description:...for tissue fixation and processing, decalcification of hard material, routine special stains where heat would accelerate the staining process, and for epitope enhancement during immunohistochemistry staining. Product Detail It is designed for greater flexibility to meet the growing workload demands....
Company:ThermoFisher Scientific
Epitope in Biological News

NIH selects LIAI for major study on allergy molecular causes and possible treatments

...able to scientists worldwide via the NIAIDs Immune epitope Database (IEDB), the worlds largest research datab...h bioinformatics along with the use of the allergy epitope information already in the IEDB. Bioinformatics u...ake advantage of that huge resource to improve our epitope identification algorithms based on that data, said...

New details on how the immune system recognizes influenza

...tention." The analysis drew upon a much larger effort called the Immune epitope Database and Analysis Resources Program, which began in 2004 after NIAID aw...eys, and very little comes from humans or birds. In fact, only one antibody epitope came from a human. The LIAI researchers say more studies should be focused ...

LIAI completes world's most comprehensive analysis on influenza virus data

...to date worldwide, drawing from the NIAID's Immune epitope Database, a new worldwide scientific resource that... the first time that all known antibody and T cell epitope information has been compiled in one place," said ..., but would have no way of knowing if a particular epitope had been used one time, for example by a single in...

Fragment of yellow fever virus may hold key to safer vaccine

...y all homed in on one particular part of the protein coating the virus. The epitope is called E-71, signifying its address on the envelope protein. Several oth...bodies against yellow fever likely span the pairs by grabbing the essential epitope on one and the supporting amino acids on the other, ter Meulen speculates. ...

Touching Molecules With Your Bare Hands

...in. One region strongly associated with inhibiting epitope presentation to killer T cells corresponded to red...latent virus. These results indicate that avoiding epitope presentation during episome maintenance is key to ...dies will have to determine the responsible MHV-68 epitope and the mechanisms that engineer immune avoidance....

How A Latent Virus Eludes Immune Defenses

...in. One region strongly associated with inhibiting epitope presentation to killer T cells corresponded to red...latent virus. These results indicate that avoiding epitope presentation during episome maintenance is key to ...dies will have to determine the responsible MHV-68 epitope and the mechanisms that engineer immune avoidance....
Epitope in Biological Technology

Enhanced Protein Tomography(TM) Method for Rapid Epitope Determination

STOCKHOLM, Sweden, June 5 /PRNewswire/ -- Sidec has of today introduced a new version of its Protein Tomography(TM) technology. The new developments drastically improve the analysis of therapeutic antibodies and drug targets in biological systems. (Logo: http://www.newscom.com/cgi-bin/prnh/...

An Epitope Tagging Vector for Gene Expression in Mammalian Cells

An Epitope Tagging Vector for Gene Expression in Mammalian Cells Use tag-specific antibodies to study expressed genes Tanya Hosfield Quinn Lu Stratagene The pCMV-Tag1 vector is an epitope tagging vector designed for gene expression in mammalian cells. A target gene insert...

CEL-SCI Files Patent Application to Support Company's Treatment for More Virulent Strain of H1N1 Swine and Other Influenza Viruses

...y mimic cell/cell interactions on the dendritic and T-cell surface with synthetic peptides. The L.E.A.P.S. constructs containing the antigenic disease epitope linked to an Immune/T-cell binding ligand (I/TCBL) can be manufactured by peptide synthesis or by covalently linking the two peptides. Depending upon...

CEL-SCI Developing Immune-Based Treatment Against Swine and Other H1N1 Flu Viruses Using Proprietary L.E.A.P.S. Technology

...related H1N1" flu viruses, utilizing its proprietary L.E.A.P.S.(TM) (Ligand epitope Antigen Presentation System) vaccine technology. The Company plans to util...thetic peptides. The L.E.A.P.S. constructs containing the antigenic disease epitope linked to an Immune/T-cell binding ligand (I/TCBL) can be manufactured by p...

CEL-SCI's L.E.A.P.S. Technology Shows Potential to Treat Swine Influenza in Preclinical Studies

...demonstrated that vaccines utilizing its proprietary L.E.A.P.S.(TM) (Ligand epitope Antigen Presentation System) vaccine technology could potentially induce pr...thetic peptides. The L.E.A.P.S. constructs containing the antigenic disease epitope linked to an Immune / T-cell binding ligand (I/TCBL) can be manufactured by...

CEL-SCI Presents Data at Prestigious Medical Conference Demonstrating That Its L.E.A.P.S. Technology Stimulates Maturation of Human Blood Cells Into Dendritic Cells Suggesting Potential for Prevention and Treatment of Infectious Disease

...timore which demonstrates how vaccines utilizing its L.E.A.P.S.(TM) (Ligand epitope Antigen Presentation System) vaccine technology can induce protection again...thetic peptides. The L.E.A.P.S. constructs containing the antigenic disease epitope linked to an Immune / T-cell binding ligand (I/TCBL) can be manufactured by...

ExonHit Therapeutics Invested Strongly in 2008 for Pivotal 2009 Results

... - Expanding EHT 202 program to other CNS indications - Initiation of epitope discovery programs for ocular disorders with Allergan - Preparing...igate a variety of ocular disease related models in order to discover novel epitope targets for the development of therapeutic antibodies. EHT/AGN 0001,...

PharmAthene Presents Data for SparVax(TM) and Valortim(R), a Novel Vaccine and Anti-Toxin for the Prevention and Treatment of Anthrax Infection at the 7th Annual ASM Biodefense Meeting

...s monkeys (cynos) is believed to follow a similar disease course as in humans. Valortim(R), a fully human monoclonal antibody that binds to a distinct epitope on protective antigen, has demonstrated preliminary efficacy in the post-exposure prophylaxis and therapeutic settings in these animal models. PharmAt...

Epitomics Appoints Dr. Zhiqiang An as Chief Scientific Officer

... "RabMAb(R) is a novel class of monoclonal antibodies which possess unique biological properties, including ultra-high affinity, diversity in epitope recognition, and high target specificity. Epitomics provides me with the opportunity to expand the healthcare promises of biologics by developing RabM...

Publication on 'Tregitopes' in Blood Journal of October 2008

...to generate new therapeutics for cancer and autoimmune diseases as well as new vaccines for infectious diseases such as HIV, TB, and hepatitis. T cell epitope mapping, the selection of target peptides from any protein sequence, is a powerful resource for the development of novel protein therapeutics. EpiVax ...
Epitope in Biological Products

IHC Select TE Buffer pH 9.0 [Antigen/ Epitope Retrieval Reagent], 10x from CHEMICON

Description: Request Info...
Company:CHEMICON

PT ModuleTM Deparaffinization and Heat-Induced Epitope Retrieval Solution (10X) from Lab Vision

Description: This product is designed to deparaffinize and perform Heat Induced Antigen Retrieval (HIER) on formalin fixed paraffin-embedded tissue sections mounted on glass microscope slides. Deparffinization is accomplished by melting the paraffin at the high temperature used in HIER (over 90degrees C) along ...
Company:Lab Vision

PT ModuleTM Deparaffinization and Heat-Induced Epitope Retrieval Solution (100X) from Lab Vision

Description: This product is designed to deparaffinize and perform Heat Induced Antigen Retrieval (HIER) on formalin fixed paraffin-embedded tissue sections mounted on glass microscope slides. Deparffinization is accomplished by melting the paraffin at the high temperature used in HIER (over 90degrees C) along ...
Company:Lab Vision

Sheep Anti-Human FLAG EPITOPE (CLONING VECTOR PVP-FLAG) Polyclonal Antibody, Unconjugated from AbD Serotec

Description: ANTI FLAG EP CL VEC...
Company:AbD Serotec

Rabbit Anti-RFP Epitope Tag Antibody, Unconjugated from ABR-Affinity BioReagents

Description: Immunogen: Synthetic Peptide: V(22) N G H E F E I E G E G E G R(36) Storage: -20 C, Avoid Freeze/Thaw Cycles...
Company:ABR-Affinity BioReagents

Concentrated Epitope Retrieval Buffer-Reduced pH from Bethyl Laboratories

Description: Bethyl Laboratories Epitope Retrieval Buffer-Reduced pH will unmask antigenic sites from formaldehyde fixation and allow for subsequent immunostaining. Shelf-Life: 1 year from date of receipt...
Company:Bethyl Laboratories

Custom Epitope Peptide Microarray from LC Sciences

Description: Microarrays designed for immunological studies, vaccine development, and biosensor development built on the flexible and powerful Paraflo microfluidic on-chip synthesis platform. These microarrays are available as part of our comprehensive Epitope Peptide Microarray Service. Custom Probe Content ...
Company:LC Sciences

Rabbit Anti-Human PITPNB Polyclonal Antibody, Unconjugated from Atlas Antibodies

Description:...er protein beta isoform (PtdIns transfer protein beta) (PtdInsTP) (PI-TP-beta). [Source:Uniprot/SWISSPROT;Acc:P48739] Antigen: Recombinant Protein epitope Signature Tag (PrEST)....
Company:Atlas Antibodies

Rabbit Anti-Human SP2 Polyclonal Antibody, Unconjugated from Atlas Antibodies

Description:... Transcription factor Sp2. [Source:Uniprot/SWISSPROT;Acc:Q02086] Antigen: Recombinant Protein epitope Signature Tag (PrEST)....
Company:Atlas Antibodies

Rabbit Anti-Human C1QC Polyclonal Antibody, Unconjugated from Atlas Antibodies

Description:... Complement C1q subcomponent subunit C precursor. [Source:Uniprot/SWISSPROT;Acc:P02747] Antigen: Recombinant Protein epitope Signature Tag (PrEST)....
Company:Atlas Antibodies

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Epitope in Biological Definition

Immune system

...h edition is ISBN 0815341016 . NCBI makes the 5th edition availiable electronically at [2] . See also antigen /antigenic determinant / epitope / hapten / memory cell autoimmune disorders CD4 receptor /CD8 receptor / perforin / apoptosis /clonal selection immunosuppression i...

Monoclonal antibody

...phocyte produces antibodies that are specific not to an antigen, but to an epitope of that antigen. An epitope is a small piece of the antigen to which the antibody binds. Polyclonal an...
Epitope in Biological Dictionary

Epitope

An epitope , also known as antigenic determinant, is the part of a macromolecule that is recognized by the immune system, specifically by antibodies, B cells, or T cells. The part of an antibody that recognizes the epitope is called a paratope. Although epitopes are usually thought to be deriv...

Sequential Epitope

A linear or a sequential epitope is an epitope that is recognized by antibodies by its linear sequence of amino acids, or primary structure. In contrast, most antibodies recognize a conformational epitope that has a specific three-dimensional shape and its protein... Linear epitop...

Conformational epitope

A conformational epitope is a sequence of subunits composing an antigen that come in direct contact with a receptor of the immune system. A linear or a sequential epitope is an epitope that is recognized by antibodies by its linear sequence of amino acids, or primary structure....

Lampbrush

...ampbrush form are useful model for ... ... on the basis of its immunofluorescent staining of lampbrush chromosome loops. ... a phosphorylated epitope stains lampbrush chromosome loops and small granules ... ... end of the short arms of lampbrush bivalent 2 in the chicken (Gallus ... Sing...

Antigenic determinant

...ls. The part of an antibody that recognizes the epitope is called a paratope. Although epitopes are usual... Visual Thesaurus. Pronunciation Symbols ... D. epitope or Antigenic Determinant ... In an antigen, th...inant is an alternative term for an epitope: See epitope ... www.PharmCast.com is the premier Web site...
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