Epirubicin

Sagent Pharmaceuticals Announces Launch of First Two Oncolytic Products: Fludarabine Phosphate for Injection, USP and Epirubicin Hydrochloride Injection

SCHAUMBURG, Ill., Aug. 5 /PRNewswire/ -- Sagent Pharmaceuticals, Inc., a privately-held specialty pharmaceutical company, today announced that it has launched fludarabine phosphate for injection, USP and epirubicin hydrochloride injection. IMS data indicates the combined U.S. market...

High-Dosage of Epirubicin and Cyclophosphamide may cause AML

Adjuvant chemotherapy with epirubicin and cyclophosphamide for early breast cancer// patients increased the risk of Acute myeloid leukemia or Myelodysplastic syndrome. Recent study published in Journal of clinical oncology reports that early breast cancer patients undergoing chemotherapy with ...

Gene alterations associated with response to anthracycline therapy for breast cancer

... 2 gene. Several studies have shown that women whose tumors have amplified HER2 derive benefit from regimens that include anthracyclines, such as epirubicin and doxorubicin, while patients whose tumors lack such alteration do not. Scientists have hypothesized that this difference could be due to alteration...

How chemotherapy drugs block blood vessel growth, slow cancer spread

...reduced HIF-1's gene-activating ability by more than 99 percent. They tested other members of the anthracycline drug class and found that doxorubicin, epirubicin and idarubicin also blocked HIF-1 activity. But further examination showed that both drug-treated and untreated cells contained similar amounts of HIF...

Biomarkers: What can they tell us

...ycline chemotherapy. Researchers analyzed 1,625 samples from NEAT (National epirubicin Adjuvant Trial) and found that those patients with C17 polysomic tumors had significantly greater benefit from epirubicin than those without, even when taking HER2 status into consideration. Resear...

India's Breast Cancer Drug Market Will Almost Double by 2012

...revalence, increasing wealth and growing disease awareness. The report finds that docetaxel (Sanofi-Aventis's Taxotere, Indian products) and epirubicin (Pfizer's Farmorubicin, Indian products) will continue to be the market leaders, but sales of trastuzumab and bevacizumab (Roche's Herceptin and Avast...

Also in the July 29 JNCI

...icin. New models can help physicians calculate the epirubicin dose associated with a 5 percent risk of cardiotox...cologists frequently use anthracyclines, including epirubicin and doxorubicin, to treat breast cancer patients. ...ggest that patients receive no more than 900 mg/m2 epirubicin over the course of their cancer care. In the c...

NovoCure presents results from breast cancer pilot study

...aboratory work with a single-arm human pilot trial to determine the safety and efficacy of the Novo-TTF with neo-adjuvant chemotherapy (doxorubicin or epirubicin together with docetaxel) in locally advanced breast cancer patients. This study is under way. Neo-adjuvant refers to chemotherapy delivered in advanc...

New Taxotere(R) (docetaxel) Injection Concentrate Data to be Presented at the 30th Annual San Antonio Breast Cancer Symposium (SABCS)

...ght cycles. *FEC : Fluorouracil 600mg/m squared, epirubicin 60 mg/m2 , and Cyclophosphamide 600 mg/m2 q 3wk x 8 E-CMF: epirubicin 100 mg/m2 q3wk x 4 followed by Cyclophosphamide100...igned to evaluate concomitant Taxotere(R) and epirubicin versus a standard French chemotherapy regimen (FEC...

Intra-arterial combination chemotherapy induces long-term survival for hepatocellular carcinoma

...udied prospectively to examine the efficacy of treatment by intra-arterial infusion of a chemotherapeutic agents consisting of etoposide, carboplatin, epirubicin and pharmacokinetic modulating chemotherapy by 5-FU and enteric-coated tegafur/uracil by Ishikawa, et al. The median survival time after the thera...

Epirubicin in Medical Technology

New Data Show That Herceptin, Xeloda and Avastin Help Patients With Early and Advanced Breast Cancer Live Longer or Remain Disease Free for Longer

...when capecitabine (X) is 11:45 hrs Cancer Group integrated into docetaxel (T) General 5-FU + epirubicin + cyclophosphamide Session 7 (CEF) adjuvant therapy for high-risk early breast cancer (BC): interim ...

US Oncology Research Network Presents Clinical Studies at San Antonio Breast Cancer Symposium

... M.D. Anderson Cancer Center. Tissue from 34 patients was sent for chemoresponse testing with ChemoFx(R). After FNA, FEC100 given as 5-FU 500 mg/m2, epirubicin 100 mg/m2 (75 mg/m2 if HER2+: "FEC75 +H"), and cyclophosphamide 500 mg/m2 all IV every 21 D x 4 cycles. Post ASCO '05, HER2+ pts received H (4 mg/kg o...

Making Science Personal: Lilly Oncology to Unveil 76 Studies at ASCO 2007

... -- Abstract # 595: June 2, 2007; 2:00 p.m. -- Neoadjuvant chemotherapy with a dose-dense sequential combination of epirubicin and cyclophosphamide followed by paclitaxel and gemcitabine +/- trastuzumab in stage II and III breast cancer --...

Epirubicin in Biological News

New chemotherapy combo produces side effects, but no extra efficacy, in early breast cancer patients

...he said. Each received the normal preoperative treatment of four cycles of epirubicin and cyclophosphamide. We then randomised them to either four cycles of doc... these factors we would recommend staying with current standard treatments epirubicin and cyclophosphamide followed by a taxane, or TAC, another commonly used th...