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Epigenetic in Medical News

Proteasome inhibition affects epigenetic mechanisms

Alcohol consumption causes alteration in several cellular mechanisms, and leads to inflammation, apoptosis, immunoresponse defect, and fibrosis. These phenomena are associated to significant changes in the epigenetic mechanisms, and, subsequently, to the liver cell memory. Although inhibition of p...

Tackling a hard-to-treat childhood cancer by targeting epigenetic changes

A very difficult-to-treat child leukemia may benefit from the discovery of a small but potent epigenetic change that launches the cancer but could potentially be reversed relatively easily, preventing cancer-promoting genes from being turned on. The study, led by researchers at Children's Hospita...

Tackling Hard-to-treat Childhood Cancer by Targeting Epigenetic Changes

Blocking a histone-modifying enzyme may calm down gene expression driving some leukemias (PRWEB) October 29, 2008 -- A very difficult-to-treat child leukemia may benefit from the discovery of a small but potent epigenetic change that launches the cancer - but could pote...

First evidence that prenatal exposure to famine may lead to persistent epigenetic changes

October 30, 2008 -- A study initiated by researchers at Columbia University Mailman School of Public Health and the Leiden University Medical Center in the Netherlands suggests that prenatal exposure to famine can lead to epigenetic changes that may affect a person's health into midlife. The find...

New revelations in epigenetic control shed light on breast cancer

Epigenetic regulation modifications to the structure of chromatin that influence which genes are expressed in a cell is a key player in embryonic development and cancer formation. Researchers at the European Molecular Biology Laboratory [EMBL] in Heidelberg now gained new insight into one crucia...

Cancer Begins With Epigenetic Changes: Study

In a new study that is to appear in the January issue of Nature Reviews Genetics, a Johns Hopkins researcher suggests that cancers might begin with epigenetic //alterations instead of the traditional view that cancers usually occur in individuals whose genes have been altered by prevailing conditio...

Silenced genes as a warning sign of blood cancer

...ups. This kind of methyl labeling ranges among the epigenetic changes that do not change the sequence of DNA bui...n prevent the attachment of methyl groups or other epigenetic changes and, thus, at least delay the onset of can...he DNA packaging proteins. The most common of such epigenetic mutations is the attachment of methyl groups. The ...

Scientists discover key event in prostate cancer progression

... these genes, and increased expression of that gene correlated with progression to the hormone-independent phase. Furthermore, a chemical change an epigenetic change in a histone protein associated with that gene enabled androgen receptors to bind with and activate the gene in hormone-independent prostate c...

Michael J. Fox Foundation Awards $3.8 Million To Drive Nine Industry Partnerships For Pre-Clinical Parkinson's Drug Development

...atment of Parkinson's disease Gerard Griffioen, PhD, NV reMYND, Leuven, Belgium Exploring curcumin and curcumin derivatives as putative epigenetic targets of histone deacetylase (HDAC) inhibition in Parkinson's disease Lawrence Helson, MD, Sign Path Pharma, Inc., Quakertown, Pennsylvania ...

BioInformatics, LLC New Report - Exploring the Epigenetics Market: Opportunities for Product Placement and Innovations

...fe science suppliers selling products that support epigenetic research involving chromosome immunoprecipitation ... Advances enabling faster and cheaper mapping of epigenetic modifications have accelerated discoveries in the ...oadmap Initiative, which promotes the discovery of epigenetic markers and the development of new epigenetics-bas...
Epigenetic in Medical Technology

Presentation of Data on Progen's Cancer Epigenetic Targets Platform

BRISBANE, Australia, May 30 /PRNewswire-FirstCall/ -- (ASX: PGL; Nasdaq: PGLA) New data on Progen's cancer epigenetic targets program will be presented tomorrow at the American Association for Cancer Research (AACR) Epigenetics Meeting in Boston by Progen's collaborators at the Johns Hopkins U...

Stand Up To Cancer Awards $73.6 Million for Novel, Groundbreaking Cancer Research

...eaders, and they will pursue the following important topics (full list of team members can be found at www.su2c.org ): "Bringing epigenetic Therapy to the Forefront of Cancer Management" / Leader: Stephen B. Baylin, M.D., Deputy Director of the Sidney Kimmel Comprehensive Cancer Center a...

Progen Terminates PATHWAY Trial & Confirms Focus on Potential High Value Molecules and M&A

...le-up manufacture and animal safety studies. -- The Board of Progen has confirmed that it will continue to expand its gene expression modification - epigenetic - compounds platform, added to Progen's technology platform through the CellGate acquisition. In parallel, the Company will be actively pursuing mer...

Orion Genomics Gains Exclusive Worldwide Rights to the IGF2 Gene for Colorectal Cancer Risk Testing Through Licensing Agreement With Johns Hopkins University

...." Loss of imprinting of IGF2 is a non-heritable epigenetic mutation detected in the blood of seven to 10 percent of the general population. Although epigenetic mutations do not affect the DNA sequence of a gene, cancer associated epigenetic changes can either turn off or "silence" genes tha...

Pharmion and MethylGene Announce U.S. Orphan Drug Designation Granted for MGCD0103 for the Treatment of Acute Myelogenous Leukemia

...atients in the U.S., Europe and additional international markets. Pharmion has a number of products on the market including the world's first approved epigenetic drug, Vidaza(R), a DNA demethylating agent. For additional information about Pharmion, please visit the company's website at http://www.pharmion.com ...

Pharmion and MethylGene Announce Orphan Drug Designation Granted by the European Medicines Agency (EMEA) for MGCD0103 for the Treatment of Acute Myelogenous Leukemia

...atients in the U.S., Europe and additional international markets. Pharmion has a number of products on the market including the world's first approved epigenetic drug, Vidaza(R), a DNA demethylating agent. For additional information about Pharmion, please visit the company's website at http://www.pharmion.com ...

Thalidomide Pharmion(R) Receives Positive Opinion for Treatment of First-line Multiple Myeloma from European Medicines Agency

...atients in the U.S., Europe and additional international markets. Pharmion has a number of products on the market including the world's first approved epigenetic drug, Vidaza(R), a DNA demethylating agent. For additional information about Pharmion, please visit the company's website at http://www.pharmion.com ...

Pharmion Submits European Marketing Authorization Application (MAA) for Vidaza(R) in Patients with Higher-Risk Myelodysplastic Syndromes (MDS)

...e deacetylation are two of the more widely studied epigenetic mechanisms. About Vidaza In May 2004, the FDA ... histone deacetylation are two of the more studied epigenetic regulators of gene expression. Epigenetic changes ...r suppressor genes through these two mechanisms of epigenetic regulation has been demonstrated in vitro and in v...

Pharmion and MethylGene Start Phase 2 Combination Clinical Trial With MGCD0103 and Vidaza(R) in Patients With Relapsed or Refractory Hodgkin Lymphoma or Non-Hodgkin Lymphoma

...y. "We are aggressively exploring the utility of epigenetic drug combinations in the treatment of cancer," sai... officer. "The biology of cancer suggests multiple epigenetic mechanisms cooperate to silence tumor suppressor g...ved for IV administration in January 2007. About epigenetic Therapy DNA methylation and histone deacetylatio...

MDS Patients on Five-Day Vidaza(R) Dosing Schedules Achieve Transfusion Independence Consistent with Seven-day Schedule

... histone deacetylation are two of the more studied epigenetic regulators of gene expression. Epigenetics refers to changes in the regulation of gene expression. epigenetic changes can silence gene expression and, unlike DN...istone deacetylation is inhibited by MGCD0103. The epigenetic approach to cancer therapy is that rather than usi...
Epigenetic in Medical Dictionary

Folic Acid

...y, a folic acid deficiency may lead to preeclampsia, premature ... 12 Dietary Fortification of Folic Acid . 13 Confused and need ... 24 epigenetic relation between folic acid supplements and asthma in children. 25 "Folate trap" ... The amount of folic acid in red blood cells measu...
Epigenetic in Biological News

CSHL researchers map changing epigenetic modifications that enable transposons to run amok

Cold Spring Harbor, N.Y. Much like cancer cells, plant cells grown for a long time outside of their normal milieu, in culture dishes, have highly unstable genomes. Changes in gene activity, or how genes are "expressed," help cells cope with challenging culture conditions but inadvertently also le...

CSHL scientists discover a new way in which epigenetic information is inherited

Hereditary information flows from parents to offspring not just through DNA but also through the millions of proteins and other molecules that cling to it. These modifications of DNA, known as "epigenetic marks," act both as a switch and a dial they can determine which genes should be turned on o...

Scientists clarify a mechanism of epigenetic inheritance

Although letters representing the three billion pairs of molecules that form the rungs of the helical DNA ladder are routinely called the human genetic code, the DNA they comprise transmits traits across generations in a variety of ways, not all of which depend on the sequence of letters in the co...

Einstein researcher receives NIH grant to explore epigenetic regulation of the human genome

(BRONX, NY) A researcher at the Albert Einstein College of Medicine has been awarded a $1.5 million, three-year technology development grant from the National Human Genome Research Institute (NHGRI) of the National Institutes of Health. Dr. John Greally, associate professor of medicine and of mole...

Human embryonic stem cells remain embryonic because of epigenetic factors

A human embryonic stem cell is reined in prevented from giving up its unique characteristics of self-renewal and pluripotency by the presence of a protein modification that stifles any genes that would prematurely instruct the cell to develop into heart or other specialized tissue. But, thanks t...

It's not all genetic: Common epigenetic problem doubles cancer risk in mice

In experiments with mice, a team of scientists from the United States, Sweden and Japan has discovered that having a double dose of one protein is sufficient to change the normal balance of cells within the lining of the colon, thereby doubling the risk that a cancer-causing genetic mutation will t...

Study reveals a reprogrammed role for the androgen receptor

...ndependent cells, they found a group of genes with epigenetic markings tiny attachments to DNA that switchs gen...endent cells. It's not known what causes those epigenetic changes to occur, but "we are profiling the genome-wide epigenetic landscape of androgen-dependent and -independent c...

Cancer's distinctive pattern of gene expression could aid early screening and prevention

...nt adjustments that enable cancer cells to thrive. epigenetic changes actually are more common than the genetic ... even physical activity levels can result in these epigenetic changes that contribute to cancer and other diseas... Coalition Scholar. But why tumors have so many epigenetic changes compared to healthy tissue is one of many ...

Double success for Instituto Gulbenkian de Ciencia scientists working on chromosome segregation

...ear, for a maximum of five years. Lars Jansen moved from California to the Instituto Gulbenkian de Cincia (IGC), in Portugal, last year to head the epigenetic Mechanisms group. The Nature Cell Biology paper, published online this week, in collaboration with a group at Stanford University School of Medicine...

Pushmi-pullyu of B-cell development discovered

...a sort of pushmi-pullyu manner to induce or retard epigenetic changes that allow for the development of a B cell...from being activated. These factors are considered epigenetic states, modifications to existing DNA that control...ch they dubbed a 'pioneer factor.' By altering the epigenetic state of several genes, it is estimated that EBF c...
Epigenetic in Biological Technology

Sigma-Aldrich Introduces Methylated DNA Quantification Technology for Epigenetic Research

Sigma's Imprint(TM) Methylated DNA Quantification Kit significantly simplifies the study of Global Methylation with results in half the time of current methods ST. LOUIS, Oct. 30 /PRNewswire-FirstCall/ -- Sigma-Aldrich (Nasdaq: SIAL) today introduced its Imprint(TM...

Sigma(R) Launches Innovative ChIP Kit Technology For Epigenetic Research

Imprint(TM) ChIP Kit Offers a Complete Solution for the Study of DNA-Protein Interactions ST. LOUIS, April 16 /PRNewswire-FirstCall/ -- Sigma-Aldrich (Nasdaq: SIAL) today announced the launch of its Imprint(TM) Chromatin Immunoprecipitation Kit for epigenetic researc...

Fate Therapeutics and Stemgent Launch Catalyst: A Unique Industry Program for First Access to the Most Advanced Induced Pluripotent Stem Cell Technology

... discovery and development. "Catalyst's technology - creating and differentiating iPS cells into distinct cell types - will uncover the essential epigenetic and gene expression profiles associated with the derivation of specific cell lineages," said Mr. Grayson. "These same technologies will prove critical...

Keynote Panel at Bio-IT World Expo to Feature Five Leaders in the Field of "Personal Genomics"

...esent recent work on computational epigenetics (performed in conjunction with The Broad Institute) that highlight a systematic workflow for optimizing epigenetic biomarker candidates for clinical applications. Mark Boguski, M.D., Ph.D., Founder, Resounding Health Incorporated will present "Online Healt...

Bert W. O'Malley, M.D., Recipient of the 2008 National Medal for Science, Joins Bionovo's Scientific Advisory Board

...family of mediators for their actions -- namely, the nuclear receptor coregulators. These discoveries provided a coherent foundation for understanding epigenetic promotion of reproductive tissue growth and development by steroid hormones, and provided the foundation for all future regulatory studies of the impa...

Applied Biosystems SOLiD System Named Life Science Innovation of the Year : The Scientist Magazine Cites the Technology's High Throughput, Lower Sequencing Cost, and Rapid Technology Innovation for Unlocking New Approaches to Clinical Research

...st improvement in data output per run is expected to further decrease the cost of genomic sequencing for multiple applications, including DNA, RNA and epigenetic analysis. By providing the life science community with access to high quality genomic data at a lower cost per sample, researchers will be able to acc...

Frost & Sullivan Awards Genpathway 2008 Healthcare Innovation Award

... pathways by studying transcription factor binding, gene transcription, and epigenetic events such as DNA methylation and histone modifications." Frost & Sulliv... pathways by studying transcription factor binding, gene transcription, and epigenetic events such as DNA methylation and histone modifications. Based on the info...

New insights into cellular reprogramming revealed by genomic analysis

...ncing technologies to generate genome-wide maps of epigenetic modifications which control how DNA is packaged a...lls, or iPS cells, demonstrate gene expression and epigenetic modifications that are strikingly similar, althoug... By identifying characteristic differences in the epigenetic maps and expression profiles of these partially re...

Genetic Breakthroughs Honored With New Scientific Award

...t features therapies that show promise in changing epigenetic signals by reversing the effects of trauma. The aw...We wanted to draw attention to the fact that while epigenetic influences affect particular genes, they can also ...vironment for the body. In subsequent years, the epigenetic Medicine Award will be awarded annually by a commi...

Biotage Launches New 24 Well Pyrosequencing(R) System

... Next Generation Pyrosequencing(R) System; PyroMark(TM)Q24 Pyrosequencing Technology in a 24 Well Format for Low Throughput epigenetic Studies UPPSALA, Sweden, March 31 /PRNewswire/ -- Pyrosequencing AB, a subsidiary of Biotage AB today announced the launch of PyroMark(TM)Q24 the la...
Epigenetic in Biological Definition

Centromere

...re, and there are functioning centromeres with no α-satellite DNA. epigenetic inheritance plays a major role in specifying the centromere in most organi...he assembly of the kinetochore on the centromere and may play a role in the epigenetic inheritance of the centromere site. In the yeast Schizosaccharomyces po...

Epigenetics

...n addition'), but also because various theories of epigenetic development, inheritance, and evolution have been ...rs, there has been rapid progress in understanding epigenetic mechanisms, which include differences in DNA me... ). Other mechanisms have also been proposed. See epigenetic inheritance for a more detailed discussion. The...

Evolution

... heritable variation exist. The processes that produce these variations leave the genetic information intact and are often reversible. This is called epigenetic inheritance and may include phenomena such as DNA methylation, prions , and structural inheritance . Investigations continue into whether these mec...

Histone

...ones act in gene regulation . Histones can undergo posttranslational modifications . These modifications can play a role in gene regulation in an epigenetic manner. Regulation occurs at the TATA box . Structure Histones are rich in lysine and arginine and are water-soluble. Histones are subje...

Jean-Baptiste Lamarck

...his view was, until very recently, thought to be completely inconsistent with modern genetics, but recent discoveries, as discussed in the article on epigenetic inheritance , show that this is not quite the case. So there may be room for some sort of Lamarckian evolution after all. Another contemporary view i...

Molecular evolution

...ated fields 4 See also 5 References 6 External links Exceptions to the general description Genomic imprinting (which is " epigenetic ") constitutes heritability that is not coded in DNA. Evolution is prevalent also in viruses , although these are not considered to be organisms. T...

Population genetics

... (adapted from Lewontin 1974, p. 12). T 1 represents the genetic and epigenetic laws, the aspects of functional biology, or development , that transform ...pe map ". T 2 is the transformation due to natural selection, T 3 are epigenetic relations that predict genotypes based on the selected phenotypes and final...
Epigenetic in Biological Dictionary

Epigenetic

In biology, the term epigenetics refers to changes in phenotype (appearance) or gene expression caused by mechanisms other than changes in the underlying DNA sequence, hence the name epi- -genetics. These changes may remain... Epigenetics: The Science Of Change, Location: Main Section of...

Self-incompatibility

... incompatibility (SI) in flowering plants is a biochemical recognition and ... The most common type is sporophytic self - incompatibility , ... epigenetic Mechanisms for Breakdown of Self - Incompatibility in Interspecific Hybrids. ... Many flowering plants prevent inbreeding and increase genetic...

Pineal gland

...Effects of Quran. 16 Paired ... The pineal gland (epiphysis cerebri) has an important role in the sleep/wake ... Pineal Gland and Cancer-An epigenetic Approach to the Control of Malignancy: ... We believe that the pineal gland and retina both evolved from the same primitive ... Characterizat...

Methylation

...original DNA sequence. As such, it is part of the epigenetic code and is also the best characterized epigenetic mechanism. Because methylation ... What is DN...mal methylation . ... DNA methylation is an epigenetic modification known to have widespread effects ....

Intergenic region

...ition from Wiktionary, a free dictionary. Jump to: navigation, search ... intergenic region . Plural. uncountable. intergenic region ... An epigenetic aberration increased in intergenic regions of cloned mice ... variation of H3K9Ac enrichment in intergenic regions is the most prominent in...

Imprinting

...g ... Defining the Extent of Imprinting . Trends and Mechanisms. Microimprinted Domains ... A number of genes undergo imprinting as a result of epigenetic modifications ... The Wellcome Trust provides a brief overview of imprinting . Additional information about genomic imprinting is available fro...

Histone

...n of histone H3 lysine 9 creates a binding site for HP1 proteins" ... Elucidating the histone code -- The Judd Rice laboratory studies the epigenetic regulation of gene expression by histone modification Histone proteins are essential for the packaging of DNA into chromosomes within ...

Genetic assimilation

... assimilation as a means of facilitating ... epigenetic inheritance, genetic assimilation and speciation. ... Keywords: epigenetic inheritance • genetic assimilation • speciation. Interact with us! ... epigenetic landscape, canalisation, homeorhesis, genetic a...

Gene silencing

... Gene silencing is a general term describing epigenetic processes of gene regulation. The term gene silencing is generally use...ne silencing (PTGS) ... ... silencing is a general term describing epigenetic processes of gene regulation. ... Transcriptional gene silencing is ...

Epigenetics

...genetics , hear an audio slide show describing an epigenetic study carried out on agouti mice, and ... ... ...expression in many biological processes involves epigenetic mechanisms. ... are consequences of epigenetics ...ular mechanisms and biological processes in which epigenetic modifications play a primordial role are describe...
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