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Epidermal in Medical News

Boehringer Ingelheim to Commence Phase III Study Investigating the Role of BIBW 2992 as First-Line Treatment for Non-Small Cell Lung Cancer (NSCLC) Patients with EGFR Mutations

...n Francisco, CA, the initiation of a Phase III clinical study of BIBW 2992 as first-line treatment in non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations. BIBW 2992 is the first orally-administered irreversible dual inhibitor of EGFR and HER2,(1) to reach Phase I...

Fox Chase finds that lung cancer patients respond to erlotinib following cetuximab therapy

...y at the annual meeting of the International Association for the Study of Lung Cancer. Both cetuximab (Erbitux) and erlotinib (Tarceva) inhibit the epidermal growth factor receptor (EGFR) and the assumption has been that once a patient progresses on one EGFR inhibitor they will not respond to another EGFR i...

Advanced targeted therapies effective as first-line treatment for lung cancer

... Media link CLINICAL OUTCOMES OF PATIENTS WITH epidermal GROWTH FACTOR RECEPTOR (EGFR) MUTATIONS IN IPASS (IRESSATM PAN ASIA STUDY) (ABSTRACT # B9.5) An epidermal growth factor receptor (EGFR) is a protein found on the surface of cells to which an epidermal growth factor (EGF) binds. When an EGF attaches to...

Amgen's Second Quarter 2009 Adjusted Earnings Per Share Increased 13 Percent To $1.29

...es in advanced breast cancer patients. Vectibix: The Company discussed the approval of revisions to the U.S. prescribing information for the epidermal growth factor receptor (EGFr) class of antibodies, including Vectibix by the U.S. Food and Drug Administration (FDA). This decision follows the FDA's ...

Small Molecule Might Play Big Part in Lung Cancer

...-21 was found particularly elevated in adenocarcinomas that affect never-smokers, especially in individuals who tested positive for mutations in their epidermal growth factor receptor (EGFR) gene. Annually, more than 10 percent of lung cancers strike people who never touched a cigarette. Japanese and Americ...

Amgen Announces KRAS Safety Update to U.S. Prescribing Information for Vectibix(R) (Panitumumab)

...on (FDA) has approved revisions to the U.S. prescribing information for the epidermal growth factor receptor (EGFr) class of antibodies, including Vectibix((R)) ... Vectibix is indicated as a single agent for the treatment of patients with epidermal growth factor receptor (EGFr)- expressing metastatic colorectal carcinoma a...
Epidermal in Medical Technology

HEALTHPOINT-Sponsored Venous Leg Ulcer Clinical Trial Enrolls First Subject for Second Phase II Study

...ly on the wound bed at the time of treatment: a fibrinogen solution and a cell preparation containing a mixture of growth arrested, living, allogeneic epidermal keratinocytes and dermal fibroblasts. Based on in vitro studies, HP802-247 is expected to release various growth and angiogenic factors into the mic...

Boehringer Ingelheim to Present New Phase II Clinical Data on Two Lead Oncology Compounds at ASCO 2009

...n-small cell lung cancer (NSCLC) patients who have epidermal growth factor receptor (EGFR) mutations.(2) "...y-administered, irreversible dual inhibitor of the epidermal growth factor receptor (EGFR) and human epithelial...Lynch, T. J. et al. "Activating mutations in the epidermal growth factor receptor underlying responsiveness o...

Schering-Plough Highlights Hepatitis C Clinical Data Presentations at the European Association for the Study of the Liver (EASL) Annual Meeting

... in patients with known hypersensitivity reactions such as urticaria, angioedema, bronchoconstriction, anaphylaxis, Stevens Johnson syndrome and toxic epidermal necrolysis to interferon alpha or any other component of the product, autoimmune hepatitis, and hepatic decompensation (Child-Pugh score greater than ...

Final Results of Boceprevir Phase II HCV SPRINT-1 Study Showed Significantly Higher SVR Rates Compared to Standard of Care in Treatment-Naive Genotype 1 Hepatitis C Patients

... in patients with known hypersensitivity reactions such as urticaria, angioedema, bronchoconstriction, anaphylaxis, Stevens Johnson syndrome and toxic epidermal necrolysis to interferon alpha or any other component of the product, autoimmune hepatitis, and hepatic decompensation (Child-Pugh score greater than ...

Healthpoint Initiates Phase II, Dose-Finding Study to Evaluate Effectiveness of a Unique Cell Based Therapy in Venous Leg Ulcers

...ly on the wound bed at the time of treatment: a fibrinogen solution and a cell preparation containing a mixture of growth arrested, living, allogeneic epidermal keratinocytes and dermal fibroblasts. Based on in vitro studies, HP802-247 is expected to release various growth and angiogenic factors into the...

YM BIOSCIENCES ANNOUNCES NIMOTUZUMAB PRESENTATIONS TO BE MADE AT THE 100TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH AND EUROPEAN SOCIETY FOR MEDICAL ONCOLOGY

...reported that its poster entitled, "Binding properties of the anti-EGFR monoclonal antibody, nimotuzumab, limit interaction with the EGFR in renal and epidermal cells", has been accepted for presentation at the American Association for Cancer Research's (AACR) 100th Annual Meeting in Denver, Colorado on April ...
Epidermal in Medical Dictionary

Wart

...locations. ... Explains the causes, transmission, and treatment of common and genital warts . What are warts ... A wart is an intra epidermal or skin tumor caused by a variety of viruses. ... You can see the dark spot on the right of the wart in this picture. ... Warts are actu...

Seborrheic keratoses

...borrheic keratoses are other bumps that appear in groups like the actinic ... keratosis /hyperkeratosis ( Seborrheic keratosis , Callus) · other epidermal ... Seborrheic keratoses (say "seh-buh-REE-ick kair-uh-TOH-sus") are noncancerous ... Seborrheic keratoses may be mistaken for warts, mole...

Scalded skin syndrome

... Scalded skin syndrome symptoms, causes, diagnosis, and treatment information for ... list of 42 symptoms of Scalded skin syndrome (Toxic epidermal necrolysis) ... Scalded skin syndrome - Overview, Scalded skin syndrome is a skin infection in which the skin ... Scalded ski...

Pityriasis

...ea Definition Pityriasis rosea is a mild, pityriasis n. , pl. -ses ( ). Any of various skin diseases of humans and animals, characterized by epidermal shedding of flaky scales The American Academy of Dermatology is committed to advancing the science of medicine and surgery related to promoting ...

Molluscum contagiosum

... ... Molluscum contagiosum (MC) is a skin rash caused by a virus that was first ... Molluscum contagiosum and warts are benign epidermal ... Molluscum contagiosum . ... Resolution of recalcitrant molluscum contagiosum virus lesions in human ... ... molluscum contagiosum ...

Integument

... . TOP Bone Histology. TOP Muscle histology. Smooth muscle. ... Mammal, epidermal layers (EM, Low) Mammal, epidermal layers (EM, Med) ... Bird, beak (Gross, Med) Beak, Horn, Hoof, & Claw R...
Epidermal in Biological News

Newly discovered epidermal growth factor receptor active in human pancreatic cancers

Finally some promising news about pancreatic cancer, one of the most fatal cancers, due to the difficulties of early detection and the lack of effective therapies: Johns Hopkins University pathologist Akhilesh Pandey has identified an epidermal growth factor receptor aberrantly active in approxima...

Protein that promotes cancer cell growth identified

... neuroblastoma cancer cells to proliferate and migrate. For the first time, Caspase-8 was shown to play a key role in relaying the growth signals from epidermal growth factor (EGF) that cause cell division and invasion. The researchers also identified an RXDLL amino acid motif that controls the signaling from ...

$2 million grant aids study of lung cancer in people who never smoked

...ry in this field. They found that lung-cancer patients who have never smoked are much more likely than smokers to harbor one of three mutations in the epidermal growth factor receptor (EGFR) gene. In addition, they found that such mutations are more common in women and among people of Asian ancestry. For th...

Caltech researchers explore how cells reconcile mixed messages in decisions about growth

...t of what Asthagiri calls a "tunable system," one that takes into account, and is influenced by, other signals. Among those are growth signals such as epidermal growth factor (EGF). When Asthagiri and his colleagues studied the interplay between contact inhibition and EGF in groups of epithelial cells, the...

Protein that triggers plant cell division revealed by researchers

... Bergmann, along with Juan Dong, a postdoctoral researcher, and Cora MacAlister, a doctoral candidate, both in the Biology Department, tracked BASL in epidermal cells of Arabidopsis, a small plant used for genetic studies. The epidermis of Arabidopsis contains small pores called stomata that allow the plant to...

Time (and PPAR-beta/delta) heals all wounds

...receptor that regulates gene expression. In mice lacking PPARβ/δ, epidermal cells proliferate excessively after wounding (1). But cultured keratinocyte...at PPARβ/δ might regulate crosstalk between layers of the skinthe epidermal hyperproliferation seen in the knockout mice could be due to faulty signals...
Epidermal in Biological Technology

The Law Offices of Brian D. Witzer Wins 6+ Million Dollar Verdict

...ar-old Chinese female immigrant who suffered Stevens-Johnson Syndrome/Toxic epidermal Necrolysis after taking the drug Allopurinol. She alleged that the Defenda... Stevens-Johnson Syndrome (SJS) and its more severe form called Toxic epidermal Necrolysis (TEN) are serious life-threatening disorders which affect the sk...

PacificGMP and USC to Collaborate on Recombinant Protein Development and Manufacturing for Phase 1 Clinical Trial

...tein will be tested in a Phase 1 clinical trial for treatment of dystrophic epidermal bullosa (DEB), a rare disease in children born with defects in the gene tha...Skin in children with DEB lacks anchoring fibrils that normally connect the epidermal layer of the skin to the dermis causing the skin's layers to separate, blis...

Histogen Hair Regrowth Clinical Trial Presented at ISHRS Annual Meeting

...t; said Dr. Gail K. Naughton, CEO of Histogen. "Wnt signaling has been shown by a number of experts in the field to be responsible for initiating epidermal stem cells to form new hair follicles in mice, and to be important in maintaining the hair inducing activity from existing follicles. Histogen's trial...

Video of EpiDerm Skin Irritation Test (SIT) Method Now Available

... was published in the Journal of Visualized Experiments (JoVE). Titled, "An In Vitro Skin Irritation Test (SIT) using the EpiDerm Reconstructed Human epidermal (RHE) Model", this peer-reviewed, PubMed-indexed video article is now available for online viewing on both the MatTek (WWW.MATTEK.COM) and JoVE Web si...

Photos: Amgen and ONSEdge Partner With Cancer Survivor Jan Ping for New Campaign

...ucating oncology nurses about the skin-related side effects associated with epidermal growth factor receptor (EGFR) inhibitors that are used to treat metastatic ... therapy aims to interrupt tumor growth by disrupting signals sent from the epidermal growth factor receptor, which is found on the surface of some cancer cells....

Histogen Aesthetics Launches ReGenica Rejuvenation System

... The resulting product is ReGenica, a complex made up of the naturally produced cell signaling materials and embryonic-like proteins which support the epidermal stem cells that renew skin throughout life. Through Histogen's unique and proprietary technology process, Histogen Aesthetics is able to produce...
Epidermal in Biological Products

Mouse Anti-Desmosomal Protein Monoclonal Antibody, Unconjugated, Clone ZK-31 from ABR-Affinity BioReagents

Description:... Desmosomal Protein Immunogen: Full length, native protein purified from human epidermal keratins. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Company:ABR-Affinity BioReagents

Mouse Anti-Cytokeratin 1 - 8 Monoclonal Antibody, Unconjugated, Clone AE3 from Abcam

Description:... Mouse monoclonal [AE3] to Cytokeratin 1 - 8, prediluted ( Abpromise for all tested applications). Antigen: Tissue / cell preparation - Human epidermal cells. Entrez GeneID: 140807 Swiss Protein ID: P04264...
Company:Abcam

Mouse Anti-Human Cytokeratin Type II Monoclonal Antibody, Unconjugated, Clone AE3 from GeneTex

Description:...th most of the Basic (Type II) keratins. Including epidermal cell keratin of 86 and 58kD and skin at 58kD, 65kD...d 67kD. Broad keratin reactivity is found on human epidermal cell, oesophagus and cornea. Immunogen: Human epidermal cells Specificity: human cytokeratin type II...
Company:GeneTex

REK (R102-05) from European Collection of Cell Cultures (ECACC)

Description:... Rat epidermal Keratinocytes (REK) (>500,000 cells)...
Company:European Collection of Cell Cultures (ECACC)

Neural Stem Cell Expansion Kit - Neurosphere from R&D Systems

Description:...plement, which has been optimized for neural stem cell expansion (Johe, K.K. et al . (1996) Genes & Development 10 :3129). Two growth factors, human epidermal growth factor (EGF) and human fibroblast growth factor basic (FGF basic), are included to promote the in vitro proliferation of neural precursors. Th...
Company:R&D Systems

Neural Stem Cell Expansion Kit - Monolayer Plus from R&D Systems

Description:...velopment 10 :3129). Human fibroblast growth factor basic (FGF basic) is included to promote the in vitro proliferation of neural precursors. Human epidermal growth factor (EGF) is also included and may be used for optimizing human neural precursor growth in culture. However, the use of EGF is optional, and...
Company:R&D Systems
Epidermal in Biological Definition

Leaf

...tissue includes several differentiated cell types: epidermal cells, guard cells, subsidiary cells, and epidermal hairs (trichomes). The epidermal cells are the most numerous, largest, and least sp...

Oncogene

...tein kinases and related proteins that can become an oncogene: Receptor tyrosine kinases that become constitutive (permanently) active like the epidermal growth factor receptor (EGFR), platelet-derived growth factor receptor (PDGFR), vascular endothelial growth factor receptor (VEGFR), etc. Cytoplas...

Plasmolysis

...nduced in the laboratory by immersing a plant cell in a strongly saline (salty) or sugary solution , so that water is lost by osmosis . If onion epidermal (outer) tissue is immersed in a solution of calcium nitrate , cells rapidly lose water by osmosis and the protoplasm of the cells shrinks. This oc...
Epidermal in Biological Dictionary

Subsidiary cells

.... subsidiary cell . subsidiary coin. subsidiary compan... Epidermis (botany) Cross-section of a flax plant stem: 1. Pith , 2. ... Adjacent epidermal cells will also divide asymmetrically to form the subsidiary cells . ... New German company expects to be one of the largest producers of si...

Rhizoid

...id medical term. What does rhizoid mean? ... rhizoid /rhi·zoid/ (ri'zoid) 1. resembling a root. ... A root hair is a tubular outgrowth of root epidermal cells of vascular plants. ... Root hairs are a specialized form of rhizoid . ... The rhizoid pole is marked by a cortical patch of dynamic ac...

Pericycle

...le ring of ... A. It is found of the pericycle ... E. Pericycle . Monocots lack a vascular cambium, so they do not produce ... 31. A root has an epidermal layer, cortex, endodermis, pericycle , xylem and phloem. ... ...

Parenchyma cells

... bulk of a substance. It is used in different ways in animals and in plants. The form of parenchyma cells varies with their function. The epidermal parenchyma cells of a leaf are barrel shaped in cross section, but ... Aspects of the topic parenchyma -cell are discussed in the follow...

Meristematic tissue

...ocations: near tips of ... The Meristematic region consists of meristematic tissue and is protected by the root cap. ... hairs arise from the epidermal tissue of the root and are called ... Meristematic tissues are responsible for the division of new cells... We will go into more detail on ...

Guard cell

...af or stem through ... " Guard Cell Photosynthesis" ... The Guard Cell Chloroplast: A Perspective ... guard cell n. One of the paired epidermal cells that control the opening and closing of a stoma in plant ... between a human nerve cell and plant guard cell ? ... Guard ce...
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(Date:8/1/2014)... at the University of California, San Diego School of ... in chili peppers produces chronic activation of a ... a reaction that ultimately reduces the risk of colorectal ... 1, 2014 issue of The Journal of Clinical ... TRPV1, was originally discovered in sensory neurons, where it ...
(Date:8/1/2014)... brain plays a central role in regulating appetite and ... in the brain,s control of food intake and body ... process has been unclear. A new study ... that PPARγ activity in a type of neuron known ... response to high-fat diet. Sabrina Diano and colleagues ...
(Date:8/1/2014)... HealthDay Reporter FRIDAY, Aug. 1, 2014 (HealthDay News) ... have significantly less endurance than those who weigh less, a new ... were obese, half were of normal weight -- people who were ... Obesity also was associated with less strength, increased discomfort and ... to 65 years of age -- neither improved nor reduced a ...
(Date:8/1/2014)... -- The U.S. Food and Drug Administration announced on ... help fight type 2 diabetes. Jardiance (empagliflozin) ... regimens to control blood sugar levels in the overall ... Office of Drug Evaluation II in the FDA,s Center ... statement. The FDA also recommended that Jardiance be ...
(Date:8/1/2014)... study, researchers at University Hospitals Rainbow Babies & Children,s ... at greater risk for death on a commercial airline ... worldwide between January 2010 and June 2013 and found ... age of 2. , The study was conducted ... of an in-flight pediatric fatality onboard commercial airline flights ...
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(Date:7/31/2014)... Bureau, Latinos are the largest minority group in the ... one-third of Latinos are obese and are 1.2 times ... , NYU College of Nursing student researcher Lauren ... the factors that contribute to this problem by compiling ... food patterns in Latina women recently published in ...
(Date:7/31/2014)... (HPV-023; NCT00518336) shows the sustained efficacy, immunogenicity ... (HPV) vaccine Cervarix. Women vaccinated with the ... than nine years, and vaccine efficacy (VE) ... the longest follow-up report for a licensed ... the full paper. , HPV and ...
(Date:7/31/2014)... An international team of scientists from Spain, France, ... rove beetle that is the oldest definitive member ... found in amber. The discovery and description were ... phase-contrast X-ray synchrotron imaging technique, which allows the ... amber. The new species is described in the ...
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