Ephrin in Biological News
Motor nerve targeting to limb muscles is controlled by ephrin proteins
Montral, December 24, 2008 A study from a team of researchers including Dr. Artur Kania, Director of the Neural Circuit Development Research Unit at the IRCM, and Dr. Dayana Krawchuk, postdoctoral fellow, shows how a family of proteins present in the developing limb control nerve targeting from t...
Chemical signaling helps regulate sensory map formation in the brain
...e 1990s, scientists found the first of those signaling systems, a family of ephrin
proteins that are present in graded fashion in the brain and are involved i...pattern topographic connections in the brain. Disrupting either the Wnt or ephrin
pathway throws the growing axons off their targets, shifting the map from s...
UCLA scientists reveal how Nipah virus infects cells
... is the same doorway that the real Nipah virus enters to infect these cells.
"We now can screen for small molecules that will block viral entry via ephrin
B-2 and develop them as therapeutic drugs," said Lee. "Because pigs are particularly susceptible to Nipah infection, public health officials could use...
Structure-building cell signals also may influence learning and memory
...y even in certain cancers.
By inserting chicken ephrin
genes into rat cells, Fumitoshi Irie, Ph.D., Profe...., Ph.D., and their colleagues found that when the ephrin
subtype EphrinB activated its EphB receptor, a cas...determined, the researchers then looked at whether ephrin
truly increased endocytosis in cells that were not...
Cerebral navigation: How do nerve fibers know what direction to grow in?
... steps of axon guidance are controlled."
The first paper found that when ephrin
binds to Eph receptors on the axon, it activates a protein called Vav2 in t...tically modified to lack ephexin1 had significantly shorter axons. But when ephrin
is present and binds to Eph receptors, ephexin1 is chemically modified, cau...
Ephrin in Biological Technology
Large-scale genetic study sheds new light on lung cancer
... childhood cancer that originates in the eye's retina.
Adenomatosis polyposis coli (APC). Mutations of this gene are common in colon cancer.
receptors A3 and A5 (EPHA3 and EPHA5), neurotrophin receptors (NTRK1 and NTRK3) and other receptor-coupled tyrosine kinases (ERBB4, KDR and FGFR4). Th...
Ephrin in Biological Products