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Enzymes in Medical News

Low Levels of 2 Enzymes in Ovarian Cancer Cells Shortened Survival

Finding could lead to new treatments for this deadly disease, researchers say WEDNESDAY, Dec. 17 (HealthDay News) -- Women with ovarian cancer who had low levels of either of two enzymes associated with their tumors tended to die much sooner than women who had higher levels of one of t...

Elevated liver enzymes associated with higher future mortality

A new population-based epidemiological study has found that elevated liver enzymes discovered during routine medical care are associated with higher future mortality. The findings are in the March issue of Hepatology, a journal published by John Wiley & Sons on behalf of the American Association f...

Verenium and Add Food Service GmbH Announce Commercial Distribution Partnership for Fuelzyme(R) and Veretase(TM) Enzymes

- Focus on the development and distribution of enzymes for starch processing and starch-based ethanol production in Europe - CAMBRIDGE, Mass. and ASCHEBERG, Germany, June 22 /PRNewswire-FirstCall/ -- Verenium Corporation (Nasdaq: VRNM ), a pioneer in the development of next-generation cell...

Caught in the act: The dynamic dance of enzymes

Waltham, MAIn a new study in Nature, Brandeis University Howard Hughes Medical Investigator Dr. Dorothee Kern and collaborators pull back the curtain on the secret lives of enzymes, the ubiquitous proteins that catalyze chemical reactions in the cell. Harnessing a slew of sophisticated technologie...

Study Attributes Elevated Liver Enzymes in HIV/hepatitis to Coinfection Rather Than Antiretrovirals

Many HIV/hepatitis coinfected individuals on antiretroviral therapy (ART) experience liver enzyme elevation (LEE), and for that reason,// caution is generally advised when prescribing ART in this population. Results from the ICoNA (Italian Cohort of Na?ve for Antiretrovirals) study indicate that co...

New Role of COX Enzymes Discovered

Recent research has revealed that the COX enzymes interact physically in a biochemical partnership as well as function in the development of blood vessels. // The study was conducted by researchers at the University of Pennsylvania School of Medicine and Queen's University, Ontario, Canada and ...
Enzymes in Medical Technology

OPAXIO(TM) Combined with Alimta(R) Well Tolerated in Dose-Ranging Study of Patients with Advanced Non-Small Cell Lung Cancer

... tumor bed allowing significantly more of the dose of chemotherapy to localize in the tumor than with standard paclitaxel. Once inside the tumor cell, enzymes metabolize the protein polymer, releasing the paclitaxel chemotherapy. Preclinical and clinical studies support that OPAXIO metabolism by lung cancer ...

Schering-Plough Expands Vicriviroc Phase II Study in Treatment-Naive Patients With HIV

...pper and lower respiratory tract were the only other infections or adverse events that occurred in 5 percent or more of patients. Elevations of liver enzymes and bilirubin were noted, but were not characteristic of drug-induced liver injury and were judged to be not related to vicriviroc. These infections ...

Acute Lymphoblastic Leukemia, the Most Common Childhood Cancer, Is Curable Without Preventive Cranial Radiation

...lar genetics of ALL, pharmacogenetic traits of patients and pharmacodynamic principles. "We prospectively determined the activity of drug-metabolizing enzymes of each patient and adjusted the dosage of chemotherapy accordingly," said Mary Relling, Pharm.D., chair of the St. Jude Department of Pharmaceutical ...

EUCODIS Bioscience Achieves Development Milestone in Second Collaboration With Lohmann Animal Health

.../ -- EUCODIS Bioscience, a company developing, manufacturing, and marketing enzymes and other proteins for the chemical industry, announced today that it has a...rior properties. EUCODIS Bioscience originally focused on developing enzymes for industrial partners, including GlaxoSmithKline, Henkel, and Lohmann Ani...

Data Demonstrated ACTEMRA(R) (tocilizumab) Significantly Inhibited Progression of Structural Joint Damage in Rheumatoid Arthritis Patients

...nts reported in clinical studies were upper respiratory tract infection, nasopharyngitis, headache, hypertension and increased ALT. Increases in liver enzymes (ALT and AST) were seen in patients; these increases were generally mild and reversible, with no evidence of hepatic injuries. Laboratory changes, inc...

Paclitaxel Poliglumex (OPAXIO(TM)) Added to Cisplatin and Radiation Produces 45% Pathologic Complete Remissions in Patients With Esophageal Cancer

... tumor bed allowing significantly more of the dose of chemotherapy to localize in the tumor than with standard paclitaxel. Once inside the tumor cell, enzymes metabolize the protein polymer, releasing the paclitaxel chemotherapy. Preclinical and clinical studies support that OPAXIO metabolism by lung cancer ...
Enzymes in Medical Products

Permacol surgical implant

Description:...at 3-D architecture is maintained. A precisely controlled degree of cross-linking is introduced into the structure, making it resistant to collagenase enzymes responsible for the breakdown and resorption of implanted collagen. This unique feature enables surgeons to complete operations and procedures involvi...
Company:Tissue Science Laboratories Inc.

Hemaway Tri-Max Detergent

Description:... Hemaway Tri-Max contains the three strongest enzymes available for maximum cleaning and removing stubborn organic materials. Dried blood, tissue, mucous, and other organic matter are no match for Hemawa...
Company:Instrument Specialists, Inc.

Hemaway Enzymatic Foam®

Description:...e. Getting a head start with Hemaway Enzymatic Foam can reduce scrubbing time later and protect your surgical instruments. The foam contains active enzymes that go to work immediately to break down organic material. The bubbly quality of the foam helps prevents spills and splashes while transporting instr...
Company:Instrument Specialists, Inc.

EndoTerg

Description:... EndoTerg is the concentrated enzymatic detergent with three powerful active enzymes used to clean flexible endoscopes. EndoTerg works to break down stubborn organic material on flexible endoscopes without leaving a soapy residue. Dri...
Company:Instrument Specialists, Inc.

NuSieve® 3:1 Agarose

Description:...ng a low melting temperature agarose, we recommend NuSieve GTG® Agarose, which is certified for applications requiring complete compatibility with enzymes used in cloning. Typical Properties Gelling temp : 32.5°-38°C Melting temp : =90°C Moisture content : =10% Sulfate : =0.15...
Company:Cambrex

Growth Hormone Binding Protein ELISA Test

Description:... Growth Hormone receptor cleavage /GHBP shedding is effected by TNF-a converting enzyme, a metalloproteinase of the ADAM family, and possibly related enzymes (1). GHBP circulates in plasma in nanomolar concentrations, sufficient to complex approximately 50% of plasma GH. GHBP modulates GH action via a var...
Company:Diagnostic Systems Laboratories, Inc.

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Enzymes in Medical Definition

Muscle atrophy

...ed ubiquitin onto a substrate protein. When a substrate is thus "poly-ubiquitinated", it is targeted for destruction by the proteasome . Particular enzymes in the ubiquitin/proteasome pathway allow ubiquitination to be directed to some proteins but not others - specificity is gained by coupling targeted p...

Thymocyte

... series of alternative gene fragments. In order to create a functional T cell receptor, the double negative thymocytes use a series of DNA-interacting enzymes to clip the DNA and bring separate gene fragments together. The outcome of this process is that each T cell receptor has a different sequence, due t...
Enzymes in Medical Dictionary

Zinc

...ing, ... Zinc is necessary for the functioning of more than 300 different enzymes and ... Offers information on good sources of zinc , average intake, r...... Zinc is an essential mineral that is a component of more than 300 enzymes needed ... Good sources of zinc include oysters, meat, eggs, seafood, bla...

Xeroderma Pigmentosum

... Xeroderma pigmentosum (XP) is a very rare skin ... xeroderma pigmentosum n. A rare hereditary skin disorder caused by a defect in the enzymes that repair DNA damaged by ultraviolet light Important It is possible that the main title of the report Xeroderma Pigmentosum is not the name ...

Urea Cycle

... urea cycle takes place only in... An urea cycle disorder or urea cycle defect is a genetic disorder caused by a deficiency of one of the enzymes in the urea cycle which is responsible for removing ammonia from the blood stream. The urea cycle involves a... urea cycle n. The sequ...

Tyrosinemia

...ketonuria (PKU) is an autosomal recessive genetic disorder characterized by ... Tyrosinemia is caused by the shortage (deficiency) of one of the enzymes ... Untreated tyrosinemia type I usually presents either in young infants with ... Tyrosinemia type I is inherited in an autosomal recessiv...

Total protein

...gs that can increase total protein measurements include anabolic steroids, ... Proteins are broken down in the stomach during digestion by enzymes known as proteases into smaller polypeptides to provide amino acids for the organism, including ... The total protein test is a rough measur...

Sanfilippo syndrome

...o syndrome , or Mucopolysaccharidosis III (MPS-III) is a rare autosomal recessive lysosomal storage disease caused by a deficiency in one of the enzymes needed to break down the glycosaminoglycan heparan sulfate . Sanfilippo syndrome is an inherited disease of metabolism that makes the body...
Enzymes in Biological News

Powe Award supports research on how enzymes enable the pathogenicity of 2 human disease organisms

Blacksburg, Va. -- Pablo Sobrado, assistant professor of biochemistry ( http://www.biochem.vt.edu/faculty.php?lname=Sobrado&view=yes ) with the infectious disease research group at Virginia Tech, has received a Ralph E. Powe Junior Faculty Enhancement Award for his research on enzymes that are ess...

New book, 'Untangling the Double Helix,' explores enzymes responsible for maintaining genome integrity

COLD SPRING HARBOR, N.Y. If it were not for a group of enzymes called topoisomerases, DNA would become a knotted, coiled, dysfunctional mess inside of a cell as it gets twisted, rolled, unzipped, and pulled by the cellular machinery that reads and copies its sequence. Topoisomerases, which are r...

New drug agent knocks out multiple enzymes in cancer pathway

A team of 24 researchers from the U.S., Europe, Taiwan and Japan and led by University of Illinois scientists has engineered a new anti-cancer agent that is about 200 times more active in killing tumor cells than similar drugs used in recent clinical trials. The study appears this week in the ...

Newly found enzymes may play early role in cancer

SALT LAKE CITYResearchers have discovered two enzymes that, when combined, could be involved in the earliest stages of cancer. Manipulating these enzymes genetically might lead to targeted therapies aimed at slowing or preventing the onset of tumors. "We could conceivably reactivate a complet...

Iowa State researcher studies how enzymes break down cellulose

AMES, Iowa Peter Reilly pointed to the framed journal covers decorating his office. Each of the six showed the swirling, twisting, complicated structure of an enzyme. Those bright and colorful illustrations are the work of his lab. And theyre part of Reillys work to understand how the structur...

Biochemists manipulate fruit flavor enzymes

Would you like a lemony watermelon? How about a strawberry-flavored banana? Biochemists at The University of Texas Medical School at Houston say the day may be coming when scientists will be able to fine tune enzymes responsible for flavors in fruits and vegetables. In addition, it could lead to e...
Enzymes in Biological Technology

DOE JGI plumbs termite guts to yield novel enzymes for better biofuel production

WALNUT CREEK, CA --- Termites -- notorious for their voracious appetite for wood, rendering houses to dust and causing billions of dollars in damage per year -- may provide the biochemical means to a greener biofuel future. The bellies of these tiny beasts actually harbor a gold mine of microbes ...

Genencor Appoints New Executive Vice President - Technical Enzymes

Glenn E. Nedwin, Ph.D., MBA to Join Genencor's Senior Management Team ROCHESTER, N.Y., Oct. 1 /PRNewswire/ -- Genencor, a division of Danisco A/S, today announced that Dr. Glenn E. Nedwin will join the Division as Executive Vice President - Technical Enzymes, effective Oct. 1, 2007. As a memb...

Properties of PCR Enzymes

The primary requirements for a DNA polymerase used in PCR are optimal activity at temperatures around 75C and the ability to retain that activity after prolonged incubation at even higher temperatures (95C). Initially, single DN...

Choice of RT-PCR Enzymes

Obviously, in RT-PCR a major factor to consider is the choice of reverse transcriptase used to synthesize cDNA. Since each of the available enzymes has different enzymatic properties, one may be more suitable for a specific expe...

Comparing Fidelity and Performance of Proofreading PCR Enzymes

PfuTurbo DNA polymerase is superior to Platinum Pfx DNA polymerase Michael Borns Janice Cline Holly Hogrefe Stratagene We recently evaluated the properties of Platinum Pfx DNA polymerase, a competitors new PCR enzyme formulation ...

Transposagen Creates a Rat Model of the Human Immune System

...g the pharmacodynamics and toxicity of potential therapeutic compounds. This is partially because the number and type of many of the rat's detoxifying enzymes are very similar to those in humans. Rats are also better models than mice for specific disease categories including human cardiovascular disease, dia...
Enzymes in Biological Products

EDTA, 0.5 M solution from GE Healthcare, formerly Amersham Biosciences

Description:... EDTA, 0.5 M solution, 100 ml. Ethylene diaminetetraacetic acid.Sterile, nuclease-free. Category: Nucleotides & enzymes & Biochemicals, Ultrapure Biochemicals ....
Company:GE Healthcare, formerly Amersham Biosciences

X-Gal from GE Healthcare, formerly Amersham Biosciences

Description:...d-galactoside.Histochemical substrate for b-galactosidase, used in blue/white screening.Store at -20 C. Protect from moisture. Category: Nucleotides & enzymes & Biochemicals, Ultrapure Biochemicals ....
Company:GE Healthcare, formerly Amersham Biosciences

3-O-Methylguanosine 5-Triphosphate, Sodium from GE Healthcare, formerly Amersham Biosciences

Description:... 3'-O-Methylguanosine 5'-Triphosphate, Sodium, 1 umol. Category: Nucleotides & enzymes & Biochemicals, Nucleotides, Additional Nucleotide Products....
Company:GE Healthcare, formerly Amersham Biosciences

EGTA from GE Healthcare, formerly Amersham Biosciences

Description:... EGTA, 10 g. Ethylene glycol-O,O-bis-[2-amino-ethyl]-N,N,N,N,-tetraacetic acid.Assay: > 99.0%. Category: Nucleotides & enzymes & Biochemicals, Ultrapure Biochemicals ....
Company:GE Healthcare, formerly Amersham Biosciences

EGTA from GE Healthcare, formerly Amersham Biosciences

Description:... EGTA, 50 g. Ethylene glycol-O,O-bis-[2-amino-ethyl]-N,N,N,N,-tetraacetic acid.Assay: > 99.0%. Category: Nucleotides & enzymes & Biochemicals, Ultrapure Biochemicals ....
Company:GE Healthcare, formerly Amersham Biosciences

Polyethylene Glycol 8000 from GE Healthcare, formerly Amersham Biosciences

Description:... Polyethylene Glycol 8000, 1 kg. PEG 8000.Used in differential DNA precipitation. Category: Nucleotides & enzymes & Biochemicals, Ultrapure Biochemicals ....
Company:GE Healthcare, formerly Amersham Biosciences
Enzymes in Biological Definition

Acrosome

...s completed during testicular maturation. The acrosome contains digestive enzymes (including hyaluronidase and acrosin ) needed to penetrate the zona pe...mal vesicle fuses with the plasma membrane of the egg cell, and digestive enzymes are released from the sperm to digest the zona pellucida and give access to...

Acrosome

...s completed during testicular maturation. The acrosome contains digestive enzymes (including hyaluronidase and acrosin ) needed to penetrate the zona pe...mal vesicle fuses with the plasma membrane of the egg cell, and digestive enzymes are released from the sperm to digest the zona pellucida and give access to...

Active site

...ding of the substrate . The active site in many enzymes can be inhibited or suppressed by the presence of ...yme. Models There are several models of how enzymes work. The lock and key model and the induced fit m...e binds and encloses the substrate molecule. Often enzymes bond to their substrate by Van der Waals forces ...

Active transport

...o drive the transport of another. Primary Primary active transport directly uses energy to transport molecules across a membrane. Most of the enzymes that perform this type of transport are transmembrane ATPases . A primary ATPase universal to all cellular life is the sodium-potassium pump , which...

Adenosine triphosphate

...ide diphosphokinase : Energy is released when hydrolysis of the phosphate-phosphate bonds is carried out. This energy can be used by a variety of enzymes , motor proteins , and transport proteins to carry out the work of the cell. Also, the hydrolysis yields free inorganic phosphate and adenosine d...

Alcohol

...ed, and often their metabolism produces even more toxic substances. Methanol, or wood alcohol , for instance, is oxidized by alcohol dehydrogenase enzymes in the liver to the poisonous formaldehyde , which can cause blindness or death. Interestingly, an effective treatment to prevent formaldehyde toxic...
Enzymes in Biological Dictionary

Enzymes

Enzymes are biomolecules that catalyze chemical reactions. Nearly all known enzymes are proteins. However, certain RNA molecules can be effective biocatalysts too. These RNA molecules have come to be known as ribozymes. In... Provides a basic introduction to enzymes , their catalytic activi...

Restriction enzymes

A restriction enzyme is an enzyme that cuts double-stranded or single stranded DNA at specific recognition nucleotide sequences known as restriction sites. Such enzymes , found in bacteria and archaea, are thought to have... restriction enzyme n. Any of a group of enzymes that c...

Zinc finger

...veral different structural families and typically function as interaction modules... Zinc - finger nucleases (ZFNs) are artificial restriction enzymes generated by fusing a zinc finger DNA-binding domain to a DNA-cleavage domain. Zinc finger domains can be engineered to target desired DNA sequ...

Xanthophyll

...ophyll . ... "http://en.wikipedia.org /wiki/Talk: Xanthophyll " ... The enzymes in the xanthophyll ... energetically expensive xanthophyll cycle is a ... xanthophyll cycle, anthocyanins require no enzymes to function and are ... XANTHOPHYLL CAROTENOIDS AND AGE-RELATED MACUL...

Urea cycle

...e urea cycle takes place only in... An urea cycle disorder or urea cycle defect is a genetic disorder caused by a deficiency of one of the enzymes in the urea cycle which is responsible for removing ammonia from the blood stream. The urea cycle involves a... urea cycle n. The sequenc...

Ubiquitin

...Rabbit polyclonal ... Ubiquitin -conjugating enzymes, also known as E2 enzymes and more rarely as ... The activated ubiquitin is then transferred to an... Proteins and Derivatives. Ubiquitin and Ubiquitin -like Protein Cascade enzymes and Substrates ... ...
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