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Endotoxin in Medical News

Associates of Cape Cod (ACC) and MDS Analytical Technologies Collaborate to Offer a More Robust LAL Endotoxin Assay Platform

EAST FALMOUTH, Mass. and SUNNYVALE, Calif., July 8 /PRNewswire/ -- Associates of Cape Cod, Inc. (ACC) and MDS Analytical Technologies are pleased to announce the launch of ACC's Chromogenic LAL Endotoxin assay kits utilizing MDS Analytical Technologies' SpectraMax(R) instrument platform and So...

Nephros Receives 510k Approval for Dual Stage Ultrafilters

...and represents an important milestone for the company," said Ernest Elgin, President and CEO of Nephros, Inc., "within dialysis clinics, microbial and endotoxin contamination of the water and dialysate concentrate used to prepare dialysate is an ongoing concern. Nephros's DSU filters are designed to eliminate ...

Elusys Therapeutics and Lonza Enter Into Manufacturing Agreement

...iche bioproducts which play an important role in the development of novel medicines and healthcare products. Lonza is a leader in cell-based research, endotoxin detection, and cell therapy manufacturing. Lonza is also a leading provider of value chemical and biotech ingredients to the nutrition, hygiene, prese...

Nephros, Inc. Receives the 2009 Frost & Sullivan Medical Device Patient Care Company of the Year Award

...t & Sullivan. Nephros has filed a 510k application for approval to market its DSU to dialysis clinics. Within these clinics, microbial and endotoxin contamination of the water treatment system used to prepare dialysate is an ongoing concern. Several studies have shown a reduction in many inflammati...

How did glycine significantly decrease liver injury?

...t dietary glycine protected both the lung and liver against lethal doses of endotoxin in rat or other animals and improved graft survival after liver transplanta...t macrophages of the liver, are involved in several disease states, such as endotoxin shock, alcoholic liver diseases, and other toxicant-induced liver injury by...

Who is the arch-criminal in the development of hepatopulmonary syndrome?

...substantial basis for the development of HPS in cirrhotic rats. On the other hand , they also observed and found that dynamic alterations of plasma endotoxin were closely associated with increased expression of eNOS, iNOS, HO-1 and increased number of capillaries, which demonstrated that eNOS, iNOS and HO-1...

JCI online early table of contents: Dec. 6, 2007

...the whole body in response to severe infection. For Gram-negative bacteria septic shock is mainly caused by the inflammatory response to the bacterial endotoxin LPS. Left untreated, septic shock can lead to organ failure and death. Previous attempts to identify the mechanisms responsible for LPS removal during...

Liver fibrosis will be treated by a potential target

...-6 cells. An additional result was that the expression level of ARIP2 mRNA in the Hapel-6 cells was elevated 12 h after treatment with activin A and endotoxin LPS. Thus, it was concluded that ARIP2 participates in the negative feedback regulation of signal transduction in the late stage by affecting the expr...

Poor indoor air quality means poorer health for patients with COPD

...of particulate matter up to 2.5g (PM2.5) every five minutes, sampled indoor endotoxin concentrations and measured indoor NO2 with passive samplers. Recorded data...d greater adverse effects that nonsmokers. No significant effects of NO2 or endotoxin levels were found. While these findings may be an artifact of the higher...

Toxic Substance in House Dust may Reduce Eczema Risks in Early Life

...to it up to age of 3. The toxic substance, endotoxin is an element of the cell wall of gram-negative ba...a type of bacteria that repeatedly causes disease. endotoxin is released when the bacteria dies or is damaged. ... The new study found that the lower amount of endotoxin in young childrens homes is associated with more w...
Endotoxin in Biological News

Researchers create new class of fluorescent dyes to detect reactive oxygen species in vivo

...ch exhibit a physiological environment that closely resembles in vivo conditions. Explants were incubated with hydro-Cy3 and either lipopolysaccharide endotoxin (LPS), an inflammatory molecule that binds to aortic cells and causes reactive oxygen species to be produced, or the control saline solution. Samp...

Researches discover gene critical for protection against septic-shock-induced death

...'s team found that the deletion of the Nrf2 gene increased the inflammatory response and caused early death in mice subjected to septic peritonitis or endotoxin shock or both. Mice deficient in Nrf2 gene expressed dramatically increased levels of effector molecules (cytokines) that mediate innate immune respon...

Study Unlocks Insects?Secret for Love in the Dark

...tion similar to sepsis, with one important difference--it is well-defined and lasts only 24 hours. By comparing the changes in gene activity caused by endotoxin exposure with those caused by trauma, the researchers hope to identify the molecular markers that spell sepsis. The research team zeroed in on whi...

Study reveals genomics of inflammation from severe injury

...tion similar to sepsis, with one important difference--it is well-defined and lasts only 24 hours. By comparing the changes in gene activity caused by endotoxin exposure with those caused by trauma, the researchers hope to identify the molecular markers that spell sepsis. The research team zeroed in on whi...

Bacteria in Household Dust May Trigger Asthma Symptoms

...versity of Iowa found a strong association between endotoxin levels and the prevalence of diagnosed asthma, ast...oom floor and bedding dust. Households with higher endotoxin concentrations experienced higher prevalence of re...se association analysis was performed to correlate endotoxin concentrations to specific health outcomes. “Wh...

Device traps, disables harmful bacteria

...compared concentrations of total bacteria, culturable bacteria and airborne endotoxin -- a poison present in gram-negative bacterial cell walls that can cause se..., respectively, over the same span. But the filters did not affect airborne endotoxin concentrations. "This specific filter has a blower that takes a high vol...

Researchers report new pro-inflammatory role for anti-inflammatory enzyme

... When immune cells are exposed to pro-inflammatory cytokines or bacterial endotoxin (part of the bacterial cell wall) they start to produce inducible nitric ox...d NO3- and less mortality than normal mice. The scientists also showed that endotoxin activates eNOS in macrophages and that this effect is an essential trigger ...
Endotoxin in Biological Technology

Spectral announces presentations at the 29TH International Symposium on Intensive Care and Emergency Medicine focusing on the role of endotoxin

TORONTO, March 25 /PRNewswire-FirstCall/ - Spectral Diagnostics Inc. (TSX:SDI), a company developing products for the treatment of sepsis, today announced that the 29th International Symposium on Intensive Care and Emergency Medicine in Brussels, Belgium from March 24-27, 2009 will feature a key s...

Spectral announces publication demonstrating Toraymyxin(TM) significantly reduces mortality from sepsis in prospective controlled trial

...artridge, a blood purification device that absorbs endotoxin from the bloodstream, when added to conventional t...r, President and CEO of Spectral Diagnostics. "Our endotoxin Activity Assay (EAA(TM)) has the ability to identi...tle against sepsis. Spectral's lead product is its endotoxin Activity Assay (EAA(TM)), the only FDA cleared ass...

Morphotek(R), Inc and Lonza Group Ltd Enter Into Manufacturing Services Agreement

...iche bioproducts which play an important role in the development of novel medicines and healthcare products. Lonza is a leader in cell-based research, endotoxin detection and cell therapy manufacturing. Lonza is also a leading provider of value chemical and biotech ingredients to the nutrition, hygiene, preser...

Spectral announces first quarter 2009 results

... standard of care. We believe that, when used together with our proprietary endotoxin Activity Assay (EAA(TM)), Toraymyxin(TM) represents a significant medical a...al is a leader in the battle against sepsis. Spectral's lead product is its endotoxin Activity Assay (EAA(TM)), the only FDA cleared assay for the measurement of...

ImClone Systems and Lonza Walkersville to Discuss Paperless QC Micro at PDA Annual Meeting

...iche bioproducts which play an important role in the development of novel medicines and healthcare products. Lonza is a leader in cell-based research, endotoxin detection and cell therapy manufacturing. Lonza is also a leading provider of value chemical and biotech ingredients to the nutrition, hygiene, preser...

Spectral announces 2008 financial results

...erapeutic for the treatment of sepsis that removes endotoxin from the bloodstream, and which has been used on m...in Europe and Japan. Together with our proprietary endotoxin Activity Assay (EAA(TM)), used for measuring endotoxin levels in the blood, the combination has demonstra...

Spectral signs exclusive license agreement to bring sepsis therapeutic to the U.S. market

...ic device for the treatment of sepsis that removes endotoxin from the bloodstream. Under the terms of the agree...nds to commercialize the product together with its endotoxin Activity Assay (EAA(TM)), the only FDA cleared dia...management. Spectral's lead product is its EAA(TM) endotoxin Activity Assay, the only FDA approved diagnostic f...

Spectral announces third quarter 2008 results

... President and CEO of Spectral. "Combined with our endotoxin Activity Assay, EAA(TM), the only FDA cleared diag...r the approximately 100,000 patients with elevated endotoxin levels that develop severe sepsis or septic shock ...tle against sepsis. Spectral's lead product is its endotoxin Activity Assay (EAA(TM)), the only FDA cleared ass...

Morria Biopharmaceuticals Plc Announces Results From its Pre-Clinical Screening of Novel Anti-Inflammatory Compounds

... Morria's proprietary multi-functional anti-inflammatory compounds. The Immunoprofiler(TM) Screen uses rat macrophage cells which are stimulated using endotoxin (LPS), a potent inflammation-inducing agent. The assay measures key inflammatory mediators, which are released by the stimulated cells. A steroid comp...

Spectral to bring anti-sepsis therapy to the U.S. market

...erapeutic for the treatment of sepsis that removes endotoxin from the bloodstream. Under the terms of the agree...is that will include Toraymyxin(TM) and Spectral's endotoxin Activity Assay (EAA(TM)), the only FDA cleared dia...tle against sepsis. Spectral's lead product is its endotoxin Activity Assay (EAA(TM)), the only FDA cleared ass...
Endotoxin in Biological Products

bacterial endotoxin Chromogenic Assay Kit from Cell Sciences

Description: LAL Chromogenic Endpoint assay...
Company:Cell Sciences

Silencer In Vivo Ready siRNAs from Ambion

Description:...ulation or direct injection into animals Provided in convenient 100, 250, 1000 and 10,000 nmol sizes HPLC purified, salt free, sterile filtered, and endotoxin tested ...
Company:Ambion

GIBCO Donor Calf Serum from Invitrogen

Description:... Performance, mycoplasma, virus, and endotoxin tested...
Company:Invitrogen

GIBCO Water distilled from Invitrogen

Description:... Water Distilled (Gibco™) is membrane filtered and endotoxin screened....
Company:Invitrogen

GIBCO Newborn Calf Serum from Invitrogen

Description:... Performance, mycoplasma, virus, and endotoxin tested. Collected from calves 14 days old or less...
Company:Invitrogen

Plasmid DNA Preparation (Large Scale) from Nature Technology Corporation

Description:... to two years) Endotoxin-free reagents and procedures Lot sample archiving Custom formulation Large scale certificate of analysis Final endotoxin (LAL) assay *Prices apply to high copy plasmids only (pUC). Additional charges apply to medium and low copy plasmids. 1gram @ 1-2mg/ml in ...
Company:Nature Technology Corporation

Mouse Anti-Salmonella typhimurium Monoclonal Antibody, Unconjugated, Clone 6331 from GeneTex

Description:... antigen (part of the LPS moiety) and the "Vi" or capsular antigen (referred to as "K" in other Enterobacteriaceae). Salmonellae also possess the LPS endotoxin characteristic of Gram-negative bacteria. This LPS is composed of an "O" polysaccharide ("O" antigen) an "R" core and the endotoxic inner "Lipid A". E...
Company:GeneTex

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Endotoxin in Biological Dictionary

Transferrin receptor

... ... Leinco Technologies is the premier supplier of custom development and preclinical ... Anti-Human CD71 ( Transferrin Receptor ) Purified Low endotoxin Functional ... Transferrin receptor was identified in serum (6) after investigators recognized ... Circulating transferrin receptor is a ...
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