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Endosome in Medical News

Gene silencer and quantum dots reduce protein production to a whisper

...re weakly charged siRNA complex crosses the cellular wall, escapes from the endosome (a fatty bubble that surrounds incoming material) and accumulates in the ce...s, however, still a mystery. "We believe the improvement is caused by the endosome escape, and the ability of the quantum dots to separate from the siRNA," Ga...

Genetic Pills A Future Thought

...ken up by a cell, it's moved to an acid-filled compartment called the endosome. A key step here, is to engineer lipids that can get the DNA out of the endosome and into the cell nucleus where most of the genetic material resides. Thus researchers conclude saying "What we're doing is reinventing a virus thro...
Endosome in Biological News

Tick-borne encephalitis virus reveals its access code

... the endosome's acidic environment. Low pH prompts the aptly named fusion protein, on the virus's outer membrane, to change shape and grab hold of the endosome membrane, bringing the two membranes together. In their search for possible pH sensors, researchers have focused on five highly conserved histidine re...

Scientists uncover Ebola cell-invasion strategy

...e compartment known as an endosome, which is pulled, together with the virus, into the cell. Then at a critical point the virus bursts free from the endosome and begins to reproduce itself. However, if the PI3 kinase pathway is shut down as the UTMB team did with a drug designed for that purpose Ebola ...

New, more direct pathways from outside the cell-to-cell nuclei discovered

...he resulting membrane-bound intracellular compartment, which is known as an endosome or phagosome. It was also already known that material can migrate out of an endosome or phagosome and eventually enter the cell nucleus. But the Brooklyn Colleg...

Shutting down the HIV assembly line

...s way from this site to the cell membrane before assembling into particles. Although many studies have demonstrated that Gag is present in the late endosome and have focused on particle assembly at that point, none have tackled how the Gag protein gets there in the first place. The current work fills this ...
Endosome in Biological Technology

The use of CypHer5E and the IN Cell Analyzer 1000 for live-cell receptor internalization studies

.... A fused image showing the nucleus (blue) and CypHer5E (red) signal demonstrates the juxtanuclear localization of CypHer5E, indicative of a recycling endosome compartment (Fig 1c).

Agonist-induced internalization of CypHer5E-labeled antibodies is concentration dependent. The interna...

Endosome in Biological Definition

Amino acid

... It is used by many proteins as a regulatory mechanism, changing the conformation and behavior of the polypeptide in acidic regions such as the late endosome or lysosome . I Ile Isoleucine hydrophobic 131.17 6.05 2.32 9.76 K Lys Lysine basic 146....
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