Damon Runyon Cancer Research Foundation awards prestigious fellowships to 14 top young investigators

... San Francisco, California, is exploring the cell engulfment process called endocytosis using quantitative RNAi-based genetic interaction maps. Understanding endocytosis is directly relevant to cancers involving viral entry and indirectly involv...

Dynamin drug discovery team win prestigious international epilepsy grant

...in Drug Discovery Program consists of leading expertise in synaptic vesicle endocytosis and dynamin biology, medicinal chemistry and translational studies in acqui...n, while limiting potential side effects. Dynamin mediates synaptic vesicle endocytosis (SVE), a process which replenishes synaptic vesicles prior to reloading and...

Insights into cell movement likely to aid immune study, cancer research

...proteins that activate or deactivate Arp2/3. These proteins are regularly found in actin patches on the surfaces of yeast cells, which are areas where endocytosis is about to take place. "We wanted to know why there needed to be six of these proteins, if any one could either turn Arp2/3 on or off," says Galle...

Study Revises Dynamin's Role in Nerve Cell Function

... Dynamin 1 is one of a family of enzymes involved in synaptic vesicle endocytosis a reverse of the process of transmission of cellular signaling chemicals, ...se findings really change our outlook on dynamin 1, and on synaptic vesicle endocytosis in general,' Dr. Ryan says. 'It's an exciting new discovery, one that we di...

Scientists Identify Cancer Pathway

...ay vary. In the model system, the researchers discovered critical differences between cancer cells and normal cells regarding a mechanism called endocytosis -- which cells employ to let materials enter through the cell membrane, the report said. They used a protein called v-Src derived from an oncogenic ...

Endocytosis in Medical Technology

Researchers Identify Intracellular Pathway of Alfacell's Onconase

...P-2/clathrin-mediated endocytosis, enabling its subsequent delivery to the cytosol. The published data indicate that unlike other RNases, the ONCONASE endocytosis pathway is not targeted to lysosomes. "ONCONASE has a very specific property in that it is selectively toxic to malignant cells," said Kuslima Shoge...

Endocytosis in Medical Dictionary

Membrane

...g regions, structures, or organs of an animal or cell membrane n. The semipermeable membrane that encloses the cytoplasm of a cell. ... During endocytosis the membrane maintains its orientation, with its cytoplasmic ... The increased knowledge of the molecular basis of neurobiology will ultimately ...

Endocytosis in Biological News

Cells use import machinery to export their goods as well

...essively inhibited three molecules known for their membrane-bending role in endocytosis -- clathrin, dynamin and actin. In the absence of any one of these molecule...se the same machinery for both," Jaiswal says. "This blurs the line between endocytosis and exocytosis. Perhaps we should just call it membrane trafficking." Th...

The downside of microtubule stability

...ase slow nerve impulses, reduce their strength, or both. One of these mutations leads to production of faulty dynamin 2, a protein that is crucial for endocytosis but also latches onto microtubules. Tanabe and Takei investigated how defective dynamin 2 hampers cells. Normal microtubules are continually extend...

The challenges of avian influenza virus: Mechanism, epidemiology and control

...research field with seven reviews and one manuscript of original studies on endocytosis and H5N1 influenza virus. The Website for Avian Flu Information consisting ...in human infection and presents their recent work on the clathrin-dependent endocytosis of H5N1 influenza virus. H5N1 virus research is a scientifically fascina...

Tips from the American Journal of Pathology

...nostic marker for breast cancer progression. These articles are highlighted by an accompanying Commentary. Caveolin-1, a protein that functions in endocytosis and signal transduction, plays a major role in breast cancer tumorigenesis. However, although calveolin-1 expression has been extensively studied in ...

Scientists unveil mechanism for 'up and down' in plants

...oteins only showed up at the bottom of a cell. endocytosis An international group of scientists from labs i...ry.) Subsequently they produced cells in which the endocytosis was disrupted in two different ways. The PIN prote...yo was distorted. When these plants with disrupted endocytosis grew further, roots developed where the first leaf...

Researchers close in on origins of main ingredient of Alzheimer's plaques

...munication called synaptic activity. "Blocking endocytosis isn't a viable option for treatment because cells throughout the body, including brain cells, need endocytosis for healthy function," says first author John Cirr... new treatments for Alzheimer's disease." While endocytosis is necessary for normal function of brain cells, C...

First study hints at insights to come from genes unique to humans

...endocytosis, a process cells use to take in material from their surface. endocytosis plays an important role in the Stahl laboratory. His group studies how grow...tein. To turn them off, cells take in the combined receptor-protein through endocytosis and put it through a number of different processes before finally breaking ...

A key enzyme helps keep the synapse on track

...y at Weill Cornell Medical College. Here's how endocytosis works: Within brain cells, information is stored a... "We found that it does," Dr. Ryan says. In fact, endocytosis slows down once synj1 is disabled in any key way, ...ocytic machinery," Dr. Ryan says. In each case, endocytosis slowed to a crawl, due in part, at least, to a bui...

Breakthrough technology observes synapse in real time, supporting theory of vesicular recycling

... laid to rest a competing theory as to how key cellular processes -- called endocytosis and exocytosis -- work. The scientists published their findings in this...l membrane, where they deliver their information-rich cargo to the synapse. endocytosis involves a similar function in the reverse direction, with incoming vesicle...

Systems Biology poised to revolutionize the understanding of cell function and disease

...anating from European-wide programmes on mammalian cell cycle, tissue development and degeneration, stem cell differentiation, organelle function, and endocytosis are paving the way in this rapidly moving field. The EU has emerged as a major world player in Systems Biology, says Alfred Game from the BBSRC in Swi...

Endocytosis in Biological Technology

The Genesis of Gendicine: The Story Behind the First Gene Therapy

... the coxsakie adenovirus receptor (CAR) on tumor cells. Subsequently, Gendicine enters tumor cells via receptor-mediated endocytosis and begins to over-express the encoded exogenous p53 gene. The overexpressed p53 protein triggers multiple tumor fightin...

High-content screening of GPCR activation with MetaXpress, AcuityXpress and the Transfluor assay system

... Holt, J.A., Barak, L.S., Caron, M.G. Association of beta-arrestin with G-protein-coupled receptors during clathrin-mediated endocytosis dictates the profile of receptor resensitization. J Biol Chem 1999;274:3224832257. 3. Zhang, J.H...

Endocytosis in Biological Products

MHC Volume 1 from Promega

Description:... MHC. Sections include: the isolation and functional properties of antigen-presenting cells analysis of MHC class II endocytosis and peptide turnover analysis of signalling via MHC class II molecules peptide translocation into the ER ...
Company:Promega

Endocytosis in Biological Definition

Antigen

...ntigens Exogenous antigens are antigens that have entered the body, e.g., by inhalation, ingestion, or injection. These antigens are taken up by endocytosis or phagocytosis into the antigen presenting cells (APCs), and degraded into fragments. The fragments are then presented on the surface of APCs by ...

Biological membrane

...le to cross the membrane by itself, but is still needed by a cell, it could either go through one of the protein channels, or be taken in by means of endocytosis . More general information on this topic may be found in the article at cell membrane . See also membrane protein ...

Cell growth

...solic components from adjacent cells through cytoplasmic bridges ( Drosophila ) or by internalization of nutrient storage granules (yolk granules) by endocytosis ( frogs ). Increases in the size of plant cells is complicated by the fact that almost all plant cells are inside of a solid cell wall . Under t...

Eukaryote

...tments, called vesicles or vacuoles , can form by budding off of other membranes. Many cells ingest food and other materials through a process of endocytosis , where the outer membrane invaginates and then pinches off to form a vesicle. It is probable that most other membrane-bound organelles are ultimately...

Cell membrane

.... This can be either symport (in the same direction) or antiport (in the opposite direction). See also: active transport . Examples include: endocytosis exocytosis , in which molecules packaged in membrane vesicles are either imported or exported, respectively. Molecular exchangers , transporters...

Cell membrane

.... This can be either symport (in the same direction) or antiport (in the opposite direction). See also: active transport . Examples include: endocytosis exocytosis , in which molecules packaged in membrane vesicles are either imported or exported, respectively. Molecular exchangers , transporters...

Virus

...e attached, enzymes make a small hole in the cell wall, and the virus injects its DNA into the cell. Other viruses (such as HIV ) enter the host via endocytosis , the process whereby cells take in material from the external environment. After entering the cell, the virus's genetic material begins the destruct...

Endocytosis in Biological Dictionary

Endocytosis

Endocytosis is the process by which cells absorb molecules from outside the cell by engulfing it with their cell membrane. It is used by all cells of the body because most substances important to them are large polar molecules that cannot pass through the hydrophobic... endocytosis n...

Transferrin receptor

...tric binding of transferrin receptor to parvovirus capsids" ... ... endocytosis of ligand occupied transferrin receptor into specialized endosomes. .....ablished as a gatekeeper for ... The first involves receptor -mediated endocytosis of transferrin . ... Efforts to crystallize transferrin receptor pro...

Receptor

...of receptor from the Merriam-Webster Online Dictionary with audio pronunciations, thesaurus, Word of the Day, and word games. Receptor -Mediated endocytosis ... up cholesterol by receptor -mediated endocytosis. ... The pneumococcus exploits this receptor for a return trip into the cell. ... Targeting...

Pinocytosis

... In cellular biology, pinocytosis is a form of endocytosis in which small particles are brought into the ce...docytosis. The LDL Receptor. Games Parasites Play. endocytosis ... But pinocytosis also provides a much more el...cesses collectively known as endocytosis, and ... endocytosis is pinocytosis , which is ... What is pinocy...

Phagocytosis

... of phagocytes and protists of engulfing solid particles by the cell membrane to form an internal phagosome. Phagocytosis is a specific form of endocytosis involving the vesicular... process by which certain living cells called phagocytes ingest or engulf other cells or particles. The phagocyte...

Passive transport

... transport . ... BACK to main. to passive versus active transport page ... Passive Transport (Facilitated Diffusion) Active Transport . endocytosis and Exocytosis ... Passive Transport (or Facilitated Diffusion). Passive transport is ... Passive transport is dependent on the permeab...

Facilitated diffusion

...n are not actively pumping the ... Lipid Diffusion . Osmosis and Water Potential. Passive Transport ( Facilitated Diffusion ) Active Transport. endocytosis and Exocytosis ... Encyclopedia article about Facilitated diffusion . Information about Facilitated diffusion in the Columbia Encyclopedia, ...