JCI online early table of contents: Aug. 1, 2008
...PICK: A mechanism for the development of obesity-associated conditions
are substances produced by several cells in the body that are very similar ...ce, and dyslipidemia. It is important to determine whether these effects of endocannabinoids
occur via activation of the protein CB1 in the brain, liver, or other tissu...
...ave shown this to be a region thats rich in a receptor called CB1, part of the brains cannabinoid system.
The human brain produces compounds called endocannabinoids
that act on these receptors, and are involved in anxiety and fear-learning, or the learning of which threats to be afraid of. But little has been know...
Leicester medical team announces 'predictor' for pregnant women who may have miscarriages
...r a number of years. Previously, his team reported than the levels of these endocannabinoids
fall during the early period of pregnancy and rise towards term. Measuring ...livering preterm, Professor Konje and his team discovered that the level of endocannabinoids
was four times higher in those who went on to deliver compared to those who...
Curing addiction with cannabis medicines
...nces like nicotine.
Scientists have known about endocannabinoids
since the mid-1990s. This led to an explosion in t...et researchers like Professor Kendall believe the endocannabinoids
could be a crucial link to addictive behaviour: We... tends to indicate that that if the link involving endocannabinoids
and the reward pathway, using inhibitors, can be i...
Cannabinoids Regulate Inflammation Process
produced in human body have anti-inflammatory effe...
However, according to these most recent results, endocannabinoids
also seem to play an important part in regulating ...
Step on the brakes
When inflammation occurs the endocannabinoids
act like someone stepping on the brakes. They prev...
Cannabis can Help to Treat Allergies, Autoimmune Disorders
...ich are marijuana like substances. They are produced in the body naturally.
The researchers created a group of mice that lack the receptor for endocannabinoids
and noticed that the mice soon developed a severe skin allergy to the nickel in the metal tags the researchers had fastened to their ears.
Marijuana Helps to Combat Lung Cancer
...nnabinoids, the natural cannabinoids stimulate appetite and control pain and inflammation.
THC seeks out, attaches to and activates two specific endocannabinoids
that are present in high amounts on lung cancer cells, Preet said. This revs up their natural anti-inflammatory properties. Inflammation can promote t...
Natural Brain Substance Linked to Parkinson's Symptoms
... the researchers found, brain cells stop-producing endocannabinoids
in the proper amount needed to control movement. ...in the striatum - a region deep in the brain where endocannabinoids
and dopamine operate - could be identified and rec...c. - blocked the action of an enzyme that degrades endocannabinoids
in the brain.
The result of this one-two punch...
Drug Combination Improves Parkinson’s Symptoms In Mic
... develop even if dopamine is present in smaller levels.
The scientists tried a combination of an experimental drug which reduced the break down of endocannabinoids
along with an existing drug that increased the dopamine level. This led to a remarkable movement from the mice. Though this result appears to be hopef...
Non-addictive antidepressant drug
...nd that the new drug URB597 increases the level of endocannabinoids
by blocking the degradation in the brain and relax... in brain which is responsible for relaxing brain, endocannabinoids
are released when specific brain receptors are tri...ises and other well-being activities. The level of endocannabinoids
is measured by measuring the levels of serotonin a...
Endocannabinoids in Medical Definition
Depolarization-induced suppression of inhibition
2 DSI mediation by endocannabinoids
3 A note on DSE
...5, Matyas et al. 2006)
DSI mediation by endocannabinoids
DSI was thought to be due to a reduction in pre...cannabinoid receptor in DSI, suggesting that the endocannabinoids
were the brain's mediators of DSI. They showed th...
Endocannabinoids in Biological News
22nd Congress of the European College of Neuropsychopharmacology, Sept. 12-16, 2009, Turkey
...he brain has led to the identification of endogenous chemicals playing a crucial role in various physiological systems. For instance, the discovery of endocannabinoids
has been of central importance in establishing the existence of a new biochemical system involved in the protective reaction to a long list of neurolo...
February 2009 highlights from Biology of Reproduction
... Bliss* blocks sperm. Evidence suggests that human male fertility is impacted by long-term exposure to marijuana. Indeed, endocannabinoids
and their receptors are present in the male reproductive tract, further suggesting a functional role in fertility, but there has been no genetic test ...
Scripps research team defines new painkilling chemical pathway
...ing a set of proteins known as cannabinoid receptors, which can also regulate appetite, inflammation, and memory. The body also has chemicals known as endocannabinoids
that naturally activate these same receptors, namely N-arachidonoyl ethanolamine (AEA) and 2-arachidonoylglycerol (2-AG). These natural components of ...
The body's own 'cannabis (marijuana)' is good for the skin
...ame to this conclusion by treating cell cultures from human sebaceous glands (the glands that make the oil on our skin) with various concentrations of endocannabinoids
(substances produced by the body that are similar to the active ingredient in marijuana). Then they measured the production of lipids (fat cells, such...
The endocannabinoids: Functional roles and therapeutic opportunities
...em, to mention a few.
One of the main roles of endocannabinoids
is neuroprotection, but over the last decade they ... 2001; Pachter et al., 2006).
Cannabinoids and endocannabinoids
are supposed to represent a medicinal treasure tro...elps repair the blood brain barrier after TBI. The endocannabinoids
act via specific cannabinoid receptors, of which t...
Enhancing activity of marijuana-like chemicals in brain helps treat
...experimental compound that can boost the level of endocannabinoids
in the brain. When they used the combination in mi...of endocannabinoids." Based on prior knowledge of endocannabinoids
and dopamine, they speculated that the two chemic...dded a drug that slows the enzymatic breakdown of endocannabinoids
in the brain - URB597, being developed by Kadmus ...
New weapon in battle against osteoporosis
... the osteoblasts, which are responsible for building bone, carry CB2 receptors on their surface. In this way it appears that signal molecules like the endocannabinoids
being formed by the body are able to regulate bone growth.
This thesis has been supported by experiments on mice whose ovaries were removed. The re...
Brain's own cannabis compound protects against inflammation
...w such substances act within the brain's own immune system.
Now, experiments by Oliver Ullrich and colleagues have pinpointed how one of the brain's endocannabinoids
protects neurons from inflammation after such damage. They say their studies could lead to new drugs to treat the inflammation and brain degeneration ...
Endocannabinoids ?the brain's cannabis ?demonstrate novel modes of action to stress
...endent research results pointing to involvement of endocannabinoids
as a novel neural messenger in various stress-rela...ch as feeding.
Di says that the "actions of the endocannabinoids
on the synaptic circuits that control the activity...
She said they are particularly interested in how endocannabinoids
influence oxytocin cells in the brain, because bec...