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Enantiomer in Medical News

KAPIDEX(TM) (dexlansoprazole) delayed release capsules Now Available for the Treatment of GERD

...the acid pumps in the stomach, thus helping to protect the esophagus from acidic reflux so that esophageal inflammation can heal. KAPIDEX combines an enantiomer of lansoprazole with a Dual Delayed Release(TM) (DDR) formulation designed to provide two separate releases of medication. KAPIDEX, taken once-daily,...

Cognition Pharmaceuticals Announces Positive Memory Results for Phase II Trial of C105 in Multiple Sclerosis

... developed. About L -amphetamine sulfate The levo enantiomer of amphetamine sulfate ( l -amphetamine) is similar to dextro enantiomer ( d- amphetamine), a widely used central nervous system (CNS) stimulant (kn...

TAK-390MR Phase 3 data presented at Digestive Disease Week

...results are encouraging for the potential of TAK-390MR in treating patients with gastroesophageal reflux disease. About TAK-390MR TAK-390MR, an enantiomer of lansoprazole, employs an innovative dual delayed release technology, which is designed to provide two separate releases of drug for extended durati...

Cheryl Fossum Graham Joins Knopp Neurosciences as Head of Regulatory and Development Strategy

...n orally administered small molecule in clinical development by Knopp for the treatment of amyotrophic lateral sclerosis (ALS). The drug is an optical enantiomer of a selective, high affinity dopamine agonist marketed in other neurological indications. Both KNS-760704 and the marketed agonist demonstrate neurop...

New Chemistry Approach Promises Less Expensive Drugs

... yet our bodies can tell the difference. Where one enantiomer might be the basis for a helpful drug, its mirror ...res that drug companies create only the beneficial enantiomer during the manufacturing process. While this requi...ses where the catalyst can create only the helpful enantiomer -- a process called asymmetric catalysis -- they a...
Enantiomer in Medical Technology

New Report 'Looking at Chiral Technologies' Analyzes the Global Market Growth Forecasts Driven By Two Very Important Components as Single Isomer Drugs and Single Enantiomer Pharmaceuticals

DUBLIN, Ireland--(BUSINESS WIRE)--Jun 21, 2007 - Research and Markets (http://www.researchandmarkets.com/reports/c60415) has announced the addition of Looking at Chiral Technologies to their offering. The advancements in molecular research and continued untiring efforts of the research industry to...

TAP Pharmaceutical Products Inc. Announces Phase 3 TAK-390MR Data Demonstrating Higher Overall Healing Versus Lansoprazole in Patients with Erosive Esophagitis

...g results are encouraging for the potential of TAK-390MR in treating patients with gastroesophageal reflux disease." About TAK-390MR TAK-390MR, an enantiomer of lansoprazole, employs an innovative dual delayed release technology, which is designed to provide two separate releases of drug for extended durati...

DiObex, Inc. Awarded Patent for the Prevention of Insulin-Induced Hypoglycemia

...as a convenient continuous subcutaneous infusion. DIO-901 has received Fast Track status from the FDA. DIO-902 (levdexketoconazole) is an oral, single enantiomer of ketoconazole that is a novel cortisol synthesis inhibitor in development for type 2 diabetes mellitus and diabetic nephropathy. Abnormalities in co...

Knopp Neurosciences Receives Orphan Designation for KNS-760704 for Treatment of ALS

...n orally administered small molecule in clinical development by Knopp for the treatment of amyotrophic lateral sclerosis (ALS). The drug is an optical enantiomer of a selective, high affinity dopamine agonist marketed in other neurological indications. Both KNS-760704 and the marketed agonist demonstrate neurop...

DiObex Begins Dosing Patients in Phase 2b Trial of Type 2 Diabetes Drug

...as also been shown to lower total and LDL-cholesterol by inhibiting 14-alpha-demethylase, a key enzyme in cholesterol synthesis. DIO-902 is the levdex enantiomer of ketoconazole. Pre-clinical and clinical evidence are supportive that DIO-902 may be safer and more effective than racemic ketoconazole. About DiOb...

Knopp Neurosciences Initiates Phase 1 Clinical Trial of KNS-760704 in ALS Development Program

...n orally administered small molecule in clinical development by Knopp for the treatment of amyotrophic lateral sclerosis (ALS). The drug is an optical enantiomer of a selective, high affinity dopamine agonist marketed in other neurological indications. Both KNS-760704 and the marketed agonist demonstrate neurop...

Diobex Announces Successful Completion of Phase 2a Trial Of DIO-902, a Novel Cortisol Synthesis Inhibitor for Type 2 Diabetes

...ucing or preventing of insulin induced hypoglycemia. DIO-901 has received Fast Track status from the Food and Drug Administration. DIO-902 is a single enantiomer of ketoconazole and is a novel cortisol synthesis inhibitor. Abnormalities in cortisol activity may play an important role in the development of metab...

Antares Pharma Announces Positive Results from Application Site Study for Anturol

...the ratio of plasma levels of R- to S- enantiomers of the active metabolite was lower following gel application (in comparison to higher a ratio of R- enantiomer levels known in oral products) indicating lower potential for adverse events from ANTUROL(R). Further, overall plasma levels of combined R- and S- ena...

DiObex Presents Phase 2a Data of DIO-902 Demonstrating Trends of Improved Glycemic Control and Significant Reductions of LDL-Cholesterol and C-Reactive Protein

...y drug being developed for the treatment of type 2 diabetes. It is a single enantiomer of racemic ketoconazole which suppresses cortisol production by inhibiting ...ast Track status from the Food and Drug Administration. DIO-902 is a single enantiomer of ketoconazole and is a novel cortisol synthesis inhibitor. Abnormalities ...
Enantiomer in Medical Dictionary

Phenylalanine

...ical functions, dietary sources, daily dosage, and side ... A brief description of how neurotransmitters actually work in the brain. ... Anhedonia enantiomer Essential Amino Acids Neurotransmitter Opioids Phenylalanine ... Phenylalanine forms part of your daily diet, and plays a certain role in main...
Enantiomer in Biological News

Luminescence shines new light on proteins

...but crucially, in terms of biology, it can be done using microscopes in the laboratory so it's non-invasive." The researchers found that only one enantiomer of certain europium and terbium complexes bound selectively to a drug binding site of the protein serum albumin, and that the luminescence changed dra...

Burnham researchers turn cancer friend into cancer foe

...cting cancer cells from apoptosis (programmed cell death), the process that usually keeps cancer cells in check. This peptide (called NuBCP-9) and its enantiomer (mirror-image molecule) work on Bcl-2 like a molecular switch, converting it into a pro-apoptotic protein, and inducing cell death in cancer cells. ...

BC catalyst discovery promises faster, cheaper drug production

...opposite hand should be around. This way, the unfavorable properties of one enantiomer are eliminated without diluting the desired enantiomer's benefits. What ...emely high selectivity, a silicon atom to an alcohol group so that only one enantiomer is formed. Other molecules are known to promote this important reaction, bu...

Male elephants woo females with precise chemistry

...ling and ratio of enantiomers in signaling." An enantiomer is one of a pair of chemical compounds whose molec...es in two forms, each representing one half of the enantiomer pair and identified as either "plus" or "minus." ..., but by merely changing the ratios of frontalin's enantiomer composition, "you're actually changing the message...
Enantiomer in Biological Technology

FDA Approves KAPIDEX(TM) (Dexlansoprazole) delayed release capsules for the Treatment of GERD

... the acid pumps in the stomach, thus helping to protect the esophagus from acidic reflux so that esophageal inflammation can heal. KAPIDEX combines an enantiomer of lansoprazole with a Dual Delayed Release(TM) (DDR) formulation designed to provide two separate releases of medication. KAPIDEX, taken once-daily, ...

DiObex Announces Presentation of Scientific Poster at Annual Meeting of American Society for Clinical Pharmacology and Therapeutics

...valuating the effects of equal doses of the single enantiomer DIO-902 and racemic ketoconazole, on the pharmacok...s than ketoconazole." DIO-902 is an oral, single enantiomer of ketoconazole, a common anti-fungal drug. DiObex...A. DIO-902 (levdexketoconazole) is an oral, single enantiomer of ketoconazole that is a novel cortisol synthesis...

DiObex and Camurus Sign License Agreement for the Development of DIO-901 in FluidCrystal(R) Extended Release Technology

...nvenient disposable subcutaneous delivery device. DIO-901 has received Fast Track status from the FDA. DIO-902 (levdexketoconazole) is an oral, single enantiomer of ketoconazole that is a novel cortisol synthesis inhibitor in development for type 2 diabetes mellitus and diabetic nephropathy. Abnormalities in co...

DiObex, Inc. to Present at Merrill Lynch Global Healthcare Conference

...as a convenient continuous subcutaneous infusion. DIO-901 has received Fast Track status from the FDA. DIO-902 (levdexketoconazole) is an oral, single enantiomer of ketoconazole that is a novel cortisol synthesis inhibitor in development for type 2 diabetes mellitus and diabetic nephropathy. Abnormalities in co...

Sosei Announces Completion of Phase II Trial of AD 337 in Fibromyalgia Syndrome

...8 /PRNewswire-FirstCall/ -- Sosei Group Corporation ("Sosei"; TSE Mothers Index: 4565), the biopharmaceutical company, today announces that AD 337, an enantiomer of an approved, centrally acting, non-opioid, analgesic, has completed a Phase II proof of principle trial for the treatment of fibromyalgia syndrome ...

Why are new drugs failing?

...irror-image chemical structures (each called enantiomers ). Sepracor splits these chiral drugs into two single enantiomers. The theory is that one enantiomer is usually safer than the other while sharing equal or superior potency. Sepracor then patents the enantioner and theoretically has a better and safer...

Separation and Quantitation of R and S Enantiomers using Normal Phase Chromatography on an API 3000 LC/MS/MS System

...required a significantly longer retention time for enantiomer separation, approximately 65 minutes. The extensiv...methylphenidate with an assay sensitivity for each enantiomer of 0.05 ng/mL. Fluoxetine did not exhibit similar ...imes and high DEA levels to achieve a reproducible enantiomer separation. ...
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