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Elucidation in Medical News

Bionovo to Present at Wall Street Analyst Forum's 20th Annual Institutional Investor Conference

...can Society of Pharmacognosy 4th Interim Meeting, describing the structural elucidation of active estrogen receptor beta selective compounds from VG101, Bionovo's drug candidate for vaginal atrophy. This structural elucidation is key to the development of the drug candidate's mechanism of action and i...

Jan Ake Gustafsson, M.D., Ph.D., Joins Bionovo's Scientific Advisory Board

... in the regulation of all aspects of health and disease. He has since published more than 1,300 peer-reviewed articles, with findings ranging from the elucidation of the receptors' DNA-binding mechanism to the more recent discovery of a second estrogen receptor, estrogen receptor beta, resulting in a paradigm sh...

Clarus Ventures Hires Former Merck President Ed Scolnick and Broad Institute Scientist Finny Kuruvilla

...used globally to study billions of genotypes in academic and industrial settings. Prior to joining the Broad, Dr. Kuruvilla's research focused on the elucidation of the mechanism of action of rapamycin. In addition to his scientific achievements, Dr. Kuruvilla has been a practicing physician and cared for adul...

Activation of LYN kinase is associated with imatinib-resistance in CML patients

...rimary patient samples in the current study is particularly important and provides clues as to how consistent LYN activation may occur in CML. Further elucidation of this pathway will be essential, as will surveying a larger patient sample to determine how frequently this type of resistance develops in CML patie...

Scientists solve structure of gene regulator that plays key role in cancer

...activities, Marmorstein says. In a report published in the Feb. 14 issue of the journal Nature, Marmorstein, Cole and their colleagues detail their elucidation of the three-dimensional structure of a p300/CBP HAT domain, or segment, bound to a small molecule that inhibits its activity. The study also reveals ...

7th Annual Wiley Prize in Biomedical Sciences Awarded to Dr. Richard P. Lifton

... Professor of Cellular and Molecular Physiology at the Yale University School of Medicine, and Investigator, Howard Hughes Medical Institute for their elucidation of the molecular machinery that guides proteins into their proper functional shape, thereby preventing the accumulation of protein aggregates that und...

Indian medicinal plant Acanthus ilicifolius may combat liver cancer

...seem interesting and encouraging. Lack of toxicity favors further preclinical evaluation of A. ilicifolius in a defined chemical carcinogenesis model. elucidation of its anticarcinogenic mechanisms of action at the intricate molecular circuits, and isolation and characterization of its active principles, will pr...

Medivir Reshapes Drug Discovery

...s that help us meet our scientific requirements," added Benkestock. Benkestock's plans for the Synapt HDMS System are far-ranging including structure elucidation of metabolites and impurities, ligand screening during early drug discovery, protein and peptide work, protein identification and studying post-transl...

Understanding HIV Interference With Infected Cell Division

...ubiquitin ligase complex, is essential for the defect in cell division induced by Vpr. Further characterization of this protein complex as well as the elucidation of the mechanism by which it affects cell division may open new avenues for therapeutic intervention against HIV. ...

New Treatment For Psoriasis Is Highly Effective

...that refinement of disease association patterns to specific genetic variants within IL-12/23 and the IL-23 receptor will play an important role in the elucidation of the causes of psoriasis, and IBD. Krueger says that, 'Further studies should help determine whether any of the identified differential risk p...
Elucidation in Medical Technology

Oncology Drug Development Update - Molecular Profiling Redefines the Nature of Malignancy and Increases the Adoption of Targeted Therapeutics

...velopment for each of these tumor types. Similarly, most other malignancies are also undergoing reclassification based on specific molecular profiles. elucidation of the role of Kras in the success or failure of EGFr inhibition in the treatment of colorectal cancer exemplifies the recent remarkable achievements ...

DNA Therapeutics Reports a Novel Mechanism of Action and a Biomarker of its Lead Molecule Dbait That Open an Innovative Pathway-Targeting in Molecular Cancer Therapy

...utical company specialized in innovative cancer therapy announces today the elucidation of a new mechanism of action and the identification of a biomarker of its f...olecular cancer therapy". J.S. Sun, CEO of DNA Therapeutics comments "The elucidation of Dbait's mechanisms of action and the identification of gamma-H2AX as a s...

ImClone Systems Showcases Extensive Research and Development Program at the AACR Annual Meeting

...uman tumor xenografts and enhances antitumor activity of an anti-VEGFR2 antibody.) -- IMC-EB10, NC7, and D4-3 (Anti-FLT3 MAb) (#4110 Williams et al. elucidation of the antagonistic mechanisms of various anti-FLT3 antibodies via binding epitope dissection.) -- IMC-D11 (anti-FGFR3 MAb) (#2080 DiRenzo et al. Ne...

Othera Pharmaceuticals Announces Upcoming Presentation Based Upon Expanded Understanding of Lead Compound Mechanism of Action

... host of inflammation-related ocular and non-ocular diseases. In combination with OT-551's previously known antioxidant and antiangiogenic activities, elucidation of this new mechanism provides strong support for the ophthalmic indications that Othera is currently pursuing with OT-551, as well as new non-ophthal...

Can-Fite Proceeds with Development of Third Drug; Progress in Development of CF502 Will Be Presented at the Annual European Congress of Rheumatology

...progress in the CF502 development program and with the in-vitro and in vivo trial results showing impressive anti-inflammatory activity for this drug. elucidation of CF502 mechanism of action and the ability to examine this activity in human cells improve the chances that this drug can offer effective treatment ...
Elucidation in Medical Products

Ghrelin, Total ELISA Test

Description:...anagement of obesity. Finally, recent evidence suggests that Ghrelin may play a role in reproductive function, a scenario that is analogous to the elucidation of a role of leptin in the control of reproductive function (4). Kojima M, et al. Nature 402: 656-660, 1999. Nakazato M, et al. Nature. 409: 194-...
Company:Diagnostic Systems Laboratories, Inc.
Elucidation in Medical Definition

Pathology

...ogy is the way in which the body's responses to injury, while evolved to protect health, can also contribute in some ways to disease processes. [8] elucidation of general principles underlying pathologic processes, such as cellular adaptation to injury, cell death, inflammation, tissue repair, and neoplasia, ...
Elucidation in Medical Dictionary

Tetanus

...begins with mild spasms in the jaw muscles (lockjaw) ... Tetanus results from an intoxication. with tetanospasmin, the neurotoxin that ... The elucidation of tetanus was one of. the triumphs of the "golden age" of ... Contains links to information about Tetanus and the Tetanus Vaccine. Tet...

Creutzfeldt

...kob Disease Definition In-depth discussion and explanation of these diseases along with several related prion-driven disorders are covered for the elucidation and education of the embalmer. Learn about Creutzfeldt -Jakob disease (CJD) symptoms such as progressive dementia, insomnia, dperssion, and unu...
Elucidation in Biological News

Growing fuel and medicine: Advancing biofuels and plant-produced therapeutics

...l physiological processes such as photosynthesis, cell division, and stress tolerance. Although ascorbate as a chemical entity is an old molecule, the elucidation of how plants make this vitamin is a recent discovery. Four different pathways are known to be functional in plants, one of them proposed by our group...

The Rett Syndrome Research Trust launches operations

...ug discovery platform. Our first five projects represent diverse yet complimentary approaches to treatment and reversal, encompassing drug screening, elucidation of target areas, and control of MECP2. The projects include an international collaboration sponsored jointly with Autism Speaks and the Medical Res...

Imiquimod, an immune response modifier, is dependent on the OGF-OGFr signaling pathway

...athway - native to body chemistry - has been discovered to regulate cell proliferation by imidazoquinolines." Co-author, Moshe Rogosnitzky adds: "The elucidation of imiquimod's immune-independent mechanism of action in cancer also creates exciting new therapeutic possibilities for a number of non-cancer conditi...

New edition of a classic molecular biology textbook from CSHL Press and Benjamin Cummings

...ems biology (Chapter 20). These chapters focus on RNAi and microRNAs, the opportunities offered by the new generation of genome technologies, and the elucidation of gene regulatory networks. The twenty-two chapters offer balanced coverage of prokaryotic and eukaryotic systems, and are divided into five maj...

HU scientist finds way to catch terrorists red-handed

...hed in the Journal of Forensic Sciences. The second part of the work, carried out by research student Nitay Lemberger, involved unequivocal structure elucidation of the red dye. Although instruments do already exist to detect urea nitrate, they are much more sophisticated and quite expensive. According to P...

A search for biomarkers for early detection of colorectal cancer

...issue of Experimental Biology and Medicine. Adenoma is the major precursor lesion of colorectal cancer, one of the most common cancers worldwide. The elucidation of the molecular mechanism underlying adenoma is essential for early detection, prevention and intervention of colorectal cancer. The research team, ...

All eukaryotic kinases share 1 common set of substrates

...l death. Dysregulation of protein phosphorylation plays a major role in many diseases such as cancer and neurodegenerative disorders. In addition, the elucidation of many kinase cascades has proved pivotal for understanding and manipulating cellular behaviour in a variety of divergent eukaryotes. Within these...

Beyond the DNA: Chemical signatures reveal genetic switches in the genome

... on the DNA sequence alone, but these are inadequate because we have an incomplete understanding of the sequence features that identify enhancers. The elucidation of a common histone modification signature will enable scientists to quickly identify enhancers and promoters for a gene, which will lead in turn to r...

ATR checkpoint-activating DNA structure

...nse. While many proteins involved in the DNA damage response have been uncovered, this type of structural information is quite novel and valuable. The elucidation of the first defined DNA structure capable of eliciting the ATR checkpoint will aid researchers to further identify additional checkpoint proteins, as...

A step forward in the fight against bacterial infections

...ity Institute for Biotechnology (VIB) connected to Ghent University shows that certain mice, by nature, can withstand particular bacterial infections. elucidation of the biological process that underlies this natural ability offers perspectives for the development of new therapeutics. A cascade of reactions ...
Elucidation in Biological Technology

Efficient Primary Structure Elucidation of Disulfide-bridged Peptides

The combination of Edman sequence analysis and electrospray tandem mass spectrometry provides accurate and detailed structural data of highlyknotted spider toxins Purpose The primary structure determination of disulfide bridged peptides...

Professor Wing Wong Elected to the National Academy of Sciences

...algorithms for the analysis of gene expression data from microarray chips, identification of gene regulatory elements in developmental genomics, and elucidation of genetic networks. According to Professor Paul Schimmel, co-founder of aTyr Pharma and fellow NAS member: "We are pleased to see this well d...

Bionovo Announces 2008 Highlights and Year-End Financial Results

...can Society of Pharmacognosy 4th Interim Meeting, describing the structural elucidation of active estrogen receptor beta selective compounds from VG101, Bionovo's drug candidate for vaginal atrophy. This structural elucidation is key to the development of the drug candidate's mechanism of action and i...

Ethan Weiss, M.D., Joins Bionovo's Scientific Advisory Board

...man and CEO. He added, "Dr. Weiss's research focuses on the mechanism of clotting activation by estrogens. His work is critical to the clotting safety elucidation of Bionovo's estrogen receptor beta selective drugs." Dr. Weiss added, "Our results, so far, are very comforting. In early experiments we can see th...

Microsurgery on the brain of the fruit fly leads to new insights into irreparable nerve injuries

...ogaster fruit fly is an important, low-cost model organism with a 60% genetic similarity to humans. The fruit fly is playing a significant role in the elucidation of various neurological processes (such as the functioning of our memory and our sense of smell) as well as in the study of certain neurodegenerative ...

Michael D. Taylor, Ph.D., Joins Cequent Pharmaceuticals' Board of Directors

... chemistry from the State University of New York at Buffalo and was awarded an NIH postdoctoral fellowship in natural products synthesis and structure elucidation at the University of Pennsylvania. About Cequent Pharmaceuticals, Inc. An early-stage biopharmaceutical company, Cequent is pioneering the develop...

Bionovo Identifies and Describes ER-beta Selective Compounds for the Treatment of Vaginal Dryness

...t, Ph.D., a member of Bionovo's chemistry team, will present the structural elucidation of active estrogen receptor beta selective compounds from VG101, Bionovo's drug candidate for vaginal atrophy. This structural elucidation is key to the development of the drug candidate's mechanism of action and i...

HU scientist finds way to catch terrorists red-handed

...hed in the Journal of Forensic Sciences. The second part of the work, carried out by research student Nitay Lemberger, involved unequivocal structure elucidation of the red dye. Although instruments do already exist to detect urea nitrate, they are much more sophisticated and quite expensive. According to P...

Sigma Launches The New Ion Channel Solutions Brochure and Web Site

...ons ). In addition to the most comprehensive product line in this area, the new tools will provide a wealth of scientific information to assist in the elucidation of ion channel function. The Sigma Ion Channel Solutions Brochure provides a scientific overview of both voltage-gated and ligand-gated channels. Ove...

Analysis of a Verapamil Microsomal Incubation using Metabolite ID and Mass FrontierTM

... Chromatography and Mass Spectrometry Application Note Key Words Metabolism Study Structure elucidation Metabolite ID Mass Frontier Mark R. Kagan, Thermo Electron Corporation Introduction The characterization of a dr...
Elucidation in Biological Products

ProtoArray Yeast PPI Kit from Invitrogen

Description:... The Yeast ProtoArray high-density functional protein microarray is the first microarray product that enables rapid elucidation of proteinprotein interactions on a proteome scale. The Yeast ProtoArray contains 4,088 S. cerevisiae open reading frames (ORFs) expressed as 5'-GST f...
Company:Invitrogen

LTQ XL Linear Ion Trap from Thermo Scientific

Description:...ftware packages, the LTQ XL delivers complete solutions for your structural elucidation questions MetWorksTM - Automated Metabolite Identification Mass FrontierTM 5 - Structure elucidation BioWorksTM 3.3 - Protein Identification SIEVETM - Automated Label-F...
Company:Thermo Scientific
Elucidation in Biological Definition

Diabetes mellitus

...rce computer program. History Although diabetes has been recognized since antiquity, and treatments were known since the Middle Ages, the elucidation of the pathogenesis of diabetes occurred mainly in the 20th century 7 . Until 1922 , when insulin was first discovered and made clinically avai...
Elucidation in Biological Dictionary

G-banding

...Stem Cell Information. The National Institutes of Health ... Page citation: G-Banding Images . In Stem Cell Information [World Wide Web site] ... elucidation of a C-Rich Signature Motif in Target mRNAs of RNA ... High resolution G-banding patterns of Syrian hamster chromosomes. Li S, Pathak S, Hsu TC .....
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