Bio-imaging mass spectrometry techniques reveal molecular details about complex systems

...mbient conditions. Facundo Fernandez, an assistant professor in the School of Chemistry and Biochemistry, has been using a technique called desorption electrospray ionization (DESI). With DESI, a high-speed, charged spray containing alcohol and water is directed at a sample a few millimeters away. The solvent ...

Faster Test Detects Fake Tamiflu Drugs

...ers trying to make money off the demand for antivirals that fight the deadly disease. Chemists in Georgia are scheduled to describe how Desorption electrospray Ionization Mass Spectrometry (DESI-MS) can determine the authenticity of large batches of Tamiflu up to 20 times faster than conventional methods duri...

Tears Reveal Some of Their Deepest Secrets to Researchers

...nd collected droplets of meibum in tiny glass tubes. The researchers examined the meibum samples in the laboratory. They used a technique called electrospray mass spectrometry to differentiate between the different lipid components. This technique adds an electric charge to microscopic droplets of the oily ...

New Technique to Identify Bacteria for Food Safety

... precisely identify bacteria, including dangerous E. coli, without time-consuming// treatments usually required. The technique, called desorption electrospray ionization, or DESI, could be used to create a new class of fast, accurate detectors for applications ranging from food safety to homeland security, s...

Electrospray in Medical Products

Proteomelab™ PA 800 Protein Characterization System

Features:...abilities. For structural elucidation, the ProteomeLab PA 800's external detector adapter allows for easy interfacing of the separation capillary with electrospray mass spectrometry. Temperature control of the sample compartment ranges from 5 - 60 C, maintaining protein stability while enabling temperature impact...
Company:Beckman Coulter, Inc.

Electrospray in Biological News

Chemists make beds with soft landings

...ar Sciences Laboratory on the PNNL campus, they deposited the peptides on the support layer in one of two ways, starting either from a liquid form for electrospray or from a gaseous mixture for soft-landing. In each case, the chemists began with the peptides (either in liquid or gas), zapped them to give them a s...

NIST trumps the clumps: Making biologic drugs safer

...roblem, NIST researchers hit upon the idea of adapting a technique known as electrospray differential mobility analysis (ES-DMA). Commonly used to size soot and oth...to get right, but the NIST team was able to define the conditions needed to electrospray proteins and protein aggregates reliably and repeatedly. NIST scientists fa...

Powerful yet reliable proteomics techniques are the focus of a new methods book

... gel electrophoresis, chromatography, and mass spectrometry. These are followed by chapters on modern, innovative procedures such as DESI (desorption electrospray ionization) and protein microarrays, as well as clinical applications for proteomic profiling and the analysis of post-translational modifications. T...

Fine print: New technique allows fast printing of microscopic electronics

...s around uncontrollably or breaks up into fine liquid drops. Engineers have used these effects to their advantage in spinning fibers and in industrial electrospray painting, but the reason for the whipping instability, and thus any hope of stopping it, has been a long-standing problem. In the early part of th...

American Chemical Society's Weekly PressPac - Oct. 10, 2007

...hod that combines two state-of-the-art testing techniques called desorption electrospray ionization (DESI) and tandem mass spectrometry. In laboratory studies, the ...ELEASE Rapid Screening of Anabolic Steroids in Urine by Reactive Desorption electrospray Ionization DOWNLOAD PDF http://pubs.acs.org/cgi-bin/sample.cgi/ancham/a...

Tears reveal some of their deepest secrets to researchers

...and collected droplets of meibum in tiny glass tubes. The researchers examined the meibum samples in the laboratory. They used a technique called electrospray mass spectrometry to differentiate between the different lipid components. This technique adds an electric charge to microscopic droplets of the oily ...

Product improves peptide identification for proteomics research

...Booths 181 and 183). Availability The Agilent 1100 Series LC/MSD Trap XCT Ultra ion trap mass spectrometer (G4533AA) includes mass spectrometer, electrospray ionization source, data system and LC/MSD Trap software (6.0). It is expected to ship in July 2005. Further information is available at www.agilent.co...

Current human embryonic stem cell lines contaminated UCSD/Salk team finds

...ryonic stem cells that had been grown in traditional culture conditions. The scientists further confirmed the presence of Neu5Gc with a process called electrospray mass spectrometry. The percentage of total sialic acids present as Neu5Gc in the embryonic stem cells varied from 2.5 to 10.5 percent. In human embryo...

Electrospray in Biological Technology

Fast Analysis of Phenoxyacetic and Phenoxypropionic Herbicides in Vegetable Matrix by Negative Ion Electrospray LC/MS/MS

P.Y. Communal and A. Royer, Girpa, Angers, France C. Schauber and T. Faye, Varian, Inc., France Introduction Phenoxy acids are used as herbicides in agricultural and domestic areas. These compounds have to be detected at trace level to ensure a safe drin...

Analysis of ()-11-Nor-9-Carboxy-Delta-9-THC in Urine by Negative Ion Electrospray LC/MS/MS

J. Beck and C. Schmidt, Varian, Inc. Introduction Marijuana is one of the most commonly used illegal recreational drugs in the United States. The compound that gives the high from smoking marijuana is tetrahydrocannabinol or THC. Toxicology, forensic, and clinical l...

Rapid Screening of Amphetamine Drugs in Urine by Positive Ion Electrospray LC/MS/MS

Z. Yang and S. Sadjadi, Varian, Inc. Introduction Amphetamine drugs are often abused and misused in sports, in the work place, and by recreational users. Forensic, clinical, and doping laboratories are frequently asked to analyze for the presence of amphetamines in ...

Quantitation of Digoxin in Human Plasma Using Negative Ion Electrospray Ionization LC/MS

D. Garteiz, S. Din, and R. Morrow TexMS Analytical Services, Houston, TX Introduction A Varian 1200L LC/MS/MS system was used for quantitative measurement down to 15 picograms of the cardiac glycoside, Digoxin, in human plasma using Electrospray Ionizati...

Analysis Of Chloramphenicol by Negative Ion Electrospray LC/MS/MS

Z. Yang, Varian, Inc. Introduction Chloramphenicol (CAP) is a potent, broad-spectrum antibiotic and potential carcinogen used in humans only at therapeutic doses for treatment of serious infections. Its use in meatproducing animals, food producing insects, aquacultu...

Analysis of Phenolic Estrogen Mimics in River Water by Negative Ion Electrospray LC/MS/MS

Z. Yang, Varian, Inc. Introduction Bisphenol A (BPA) is a primary raw material used for the production of polyacrylates, epoxy resin, phenolic resin, and polycarbonate plastic. 4-Nonylphenol (4-NP) is a degradation product of alkylphenol ethoxylate detergents used i...

Analysis of Nitrofurans Metabolites by Positive Ion Electrospray LC/MS/MS

Z. Yang, Varian, Inc. Introduction Nitrofuran antibiotics are veterinary drugs. The use of these in food production is already banned in the United States, Australia, Canada, Japan, Singapore, Bangladesh, and the European Union because of a possible increased cancer...

First ASMS Hites Award for Outstanding Research Publication Presented to Prof. Alison Ashcroft for Her Use of Waters Synapt HDMS System to Explore Protein Complexes

...Society of Mass Spectrometry (JASMS). Prof. Ashcroft's paper titled, Monitoring Copopulated Conformational States During Protein Folding Events Using electrospray Ionization-Ion Mobility Spectrometry-Mass Spectrometry appeared in the December 2007 issue of JASMS and was co-authored by Waters scientists Kevin Gi...

Waters Introduces New SYNAPT G2 with Greater Power, Versatility and Speed Than Any Other High-End Mass Spectrometer

...umber of experimental options and research applications. These comprise the nanoACQUITY UPLC(R) and TRIZAIC(TM) UPLC inlets and ion sources including: electrospray (ESI), nanoflow ESI, atmospheric chemical ionization (APCi), combined ESI/APCi (ESCi), atmospheric solids analysis probe (ASAP), and atmospheric press...

HybridSPE(TM)-Precipitation Technology Wins SelectScience.net 2009 Scientists' Choice Award for Best New Separations Product in 2008

... One of the major causes of ion-suppression in bioanalysis is the presence of phospholipids during LC-MS or LC-MS-MS analysis in the positive ion electrospray mode (+ESI). Phospholipids are the second largest lipid component in biological matrices after triglycerides, and are typically present in extremely h...

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Electrospray in Biological Products

MS Grade Protein Standards from Protea Biosciences, Inc.

Description:...iology, and life science laboratories. Proteas Protein Standards are high quality purified proteins for use in the calibration of protein analyses by electrospray ionization mass spectrometry (ESI-MS). For quality control and standardization purposes, each standard protein includes a high resolution mass spectr...
Company:Protea Biosciences, Inc.

Accumix from Protea Biosciences, Inc.

Description:...ing and calibration standard for positive ion mode electrospray ionization mass spectrometry. Accumix is a lyophi...an be used for: Broad mass range tuning of electrospray ionization ion trap mass spectrometers (i.e. Finni... and LTQ-MS) Broad range mass calibration of electrospray ionization Fourier transform mass spectrometers (i...
Company:Protea Biosciences, Inc.

MS Protein Standards from New England Biolabs

Description:... A set of five proteins which can be used to calibrate a Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) or electrospray Ionization (ESI) mass spectrometer....
Company:New England Biolabs

Peptide Standards from New England Biolabs

Description:... A set of five peptides which can be used to calibrate a Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) or electrospray Ionization (ESI) mass spectrometer....
Company:New England Biolabs

LCMS-2010EV from Shimadzu Biotech

Description:...agmentation. The analyzer includes an octopole for high-efficiency ion transmission, and pre-rods and true hyperbolic main rods for mass analysis. The electrospray (ESI) source (probe) features a metal capillary for reliability and to insure consistent electrical contact with the spray. Both the ESI probe and opt...
Company:Shimadzu Biotech

MSQ Plus Mass Spectrometric Detector from Dionex Corporation

Description:...s requirements: A supply of high-purity (>99%) nitrogen capable of supplying 600 L/h at 75 psi (5 bar) Weight: 60 Kg (132 lb) Ionization modes: electrospray (ESI) Atmospheric Pressure Chemical Ionization (APCI) Range: 172000 m/z Features: Compact design frees up bench space and decreases system vo...
Company:Dionex Corporation

microTOF_LC from Bruker Daltonics

Description:... Powerful exact mass measurements in an easy-to-use benchtop package. Our new orthogonal electrospray time-of-flight mass spectrometer (ESI-oa-TOF) concentrates the performance of a big machine in a format, which fits on your bench. The microTOFLC feat...
Company:Bruker Daltonics

NanoMate ™ 100 with ESI Chip Technology from Advion Biosciences, Inc.

Description:... Advion's NanoMate 100 robotic system and disposable ESI Chip allow users to take full advantage of the capabilities of electrospray mass spectrometers for life science applications. Integrating the NanoMate with MS allows users to either speed analysis for increased throughput for ...
Company:Advion Biosciences, Inc.