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Elastase in Medical News

MPM Capital Leads Investment in Proteon Therapeutics

...rapeutics Board of Directors. Proteon recently initiated a Phase 1/2 clinical trial of its lead product, PRT-201. PRT-201 is a recombinant human elastase that is being studied for its ability to improve arteriovenous fistula (AVF) surgery outcomes in patients requiring chronic hemodialysis. "MPM co...

Scientists identify new congenital neutropenia syndrome and causative gene mutation

...nown. The most common cause of inherited SCN is a heterozygous mutation (where one copy of the gene is mutated and the other is not) in the neutrophil elastase (ELA2) gene. In 2007, Klein's lab identified another causative mutation in a subgroup of SCN patients: homozygous mutations (where the defect is prese...

Broccoli compound targets key enzyme in late-stage cancer

...endocrine treatment and reduced survival rates. elastase is an enzyme that shortens a cellular chemical, cy...ate faster. Firestone showed that I3C prevents the elastase shortening of cyclin E, thereby arresting developm... The newly reported research pins this activity to elastase and its effect on cyclin E. Bjeldanes noted tha...

JCI table of contents: June 20, 2008

...erefore suggest that these data provide rationale for considering inhibitors of NSPs as anti-inflammatory drugs. TITLE: Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin AUTHOR CONTACT: Kai Kessenbrock Max-Planck-Institute of Neurobiology, M...

Enzyme Critical for Early Growth of Abdominal Aortic Aneurysms

... says. In the current study, the researchers used an experimental model in mice that mimics aortic aneurysms in humans. They perfused the enzyme elastase into the aortas of the mice, causing the aortic wall to dilate. Two weeks later, the aortas of DPPI-deficient mice had not enlarged much, while the ao...
Elastase in Medical Products

Anti-MPO - ELISA (P-ANCA)

Description:...c detection of MPO antibodies using highly purified myeloperoxidase as antigen. No false-positive results caused by contaminations like lactoferrin or elastase in the antigen preparation. MPO antibodies can not be detected by indirect immunofluorescence; only about 10% of P-ANCA findings with ethanol-fixed gr...
Company:DLD Diagnostika GmbH
Elastase in Medical Dictionary

Leukocytes

...ping of Mouse or Rat Leukocytes ... ... Pg was shown previously for many cells, including leukocytes , and was implicated ... Human leukocyte elastase is an endogenous ligand for the integrin CRR3 (CD11b ... ... were thought to serve only as communication molecules between leukocytes , ... Howev...

Feces

...s , pl Cat·-hole n. (k ă t'h ō l`) (Naut. ... harder, less moist feces can sometimes be seen ... Biochemical tests done on feces include fecal elastase and fecal fat ... provides an easy to understand definition for the medical term, Feces . ... Feces is a fancy way to describe something that...
Elastase in Biological News

Why do aneurysms form? New studies suggest leading role for white blood cells

...he blood artificially low. They applied the enzyme elastase to the aortas of these mice and normal control mic...n in the aortas of rats that had been injured with elastase or exposed to control conditions. They also studie...son mice. In general, the rat aortas exposed to elastase had far higher levels of L-selectin in the days im...
Elastase in Biological Technology

Proteon Therapeutics Completes Second Closing of Equity Financing; Raises Total Series B to $50 million

...ncing will allow Proteon to develop PRT-201 beyond completion of an AVF Phase 2 clinical study. About PRT-201 PRT-201 is a recombinant human elastase that is being studied for its ability to improve arteriovenous fistula (AVF) surgery outcomes in patients requiring chronic hemodialysis. PRT-201 has ...

Proteon Therapeutics Completes $38M Equity Financing; Initiates Phase 1/2 Clinical Study of PRT-201 in Hemodialysis Patients and Signs Option Agreement With Major Pharmaceutical Company

...rt of this successful financing structure, and I look forward to working closely with Proteon." About PRT-201 PRT-201 is a recombinant human elastase that is being studied for its ability to improve arteriovenous fistula (AVF) surgery outcomes in patients requiring chronic hemodialysis. PRT-201 has ...

Proteon Therapeutics to Present New Data on PRT-201 at Transcatheter Cardiovascular Therapeutics (TCT) Annual Symposium in Washington, D.C., October 13, 2008

...-201 to enhance outcomes in patients suffering from lower limb peripheral arterial disease (PAD). The presentation, entitled, "Local Catheter-Directed elastase Therapy: A Novel Approach to Vessel Dilation and Restenosis," is being made at the 20th annual Transcatheter Cardiovascular Therapeutics (TCT) scienti...

Proteon Therapeutics to Present at Annual Meeting of American Society of Nephrology in San Francisco on November 2, 2007

...dney and vascular diseases, is presenting tomorrow at the Annual Meeting of the American Society of Nephrology an abstract entitled "Recombinant Human elastase (PRT-201) Dilates Outflow Veins in a Preclinical Model of Arteriovenous Fistula." Findings to be presented represent an important preclinical demonstr...
Elastase in Biological Dictionary

RNase

...hour ... Part Two - Total Exposure: Expanded Model for RNase L Fragmentation in CFS Uncovered; The National CFIDS Foundation Announces the Use of elastase Inhibitors as a ... Since this fragment competes with the native RNase L protein for free 2-5A, it ... Interestingly, for this patient, the RN...
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