MPM Capital Leads Investment in Proteon Therapeutics
...rapeutics Board of Directors.
Proteon recently initiated a Phase 1/2 clinical trial of its lead product, PRT-201. PRT-201 is a recombinant human elastase
that is being studied for its ability to improve arteriovenous fistula (AVF) surgery outcomes in patients requiring chronic hemodialysis.
Scientists identify new congenital neutropenia syndrome and causative gene mutation
...nown. The most common cause of inherited SCN is a heterozygous mutation (where one copy of the gene is mutated and the other is not) in the neutrophil elastase
(ELA2) gene. In 2007, Klein's lab identified another causative mutation in a subgroup of SCN patients: homozygous mutations (where the defect is prese...
Broccoli compound targets key enzyme in late-stage cancer
...endocrine treatment and reduced survival rates.
is an enzyme that shortens a cellular chemical, cy...ate faster. Firestone showed that I3C prevents the elastase
shortening of cyclin E, thereby arresting developm... The newly reported research pins this activity to elastase
and its effect on cyclin E.
Bjeldanes noted tha...
JCI table of contents: June 20, 2008
...erefore suggest that these data provide rationale for considering inhibitors of NSPs as anti-inflammatory drugs.
TITLE: Proteinase 3 and neutrophil elastase
enhance inflammation in mice by inactivating antiinflammatory progranulin
Max-Planck-Institute of Neurobiology, M...
Enzyme Critical for Early Growth of Abdominal Aortic Aneurysms
In the current study, the researchers used an experimental model in mice that mimics aortic aneurysms in humans. They perfused the enzyme elastase
into the aortas of the mice, causing the aortic wall to dilate. Two weeks later, the aortas of DPPI-deficient mice had not enlarged much, while the ao...
Elastase in Medical Products
Anti-MPO - ELISA (P-ANCA)
Description:...c detection of MPO antibodies using highly purified myeloperoxidase as antigen. No false-positive results caused by contaminations like lactoferrin or elastase
in the antigen preparation. MPO antibodies can not be detected by indirect immunofluorescence; only about 10% of P-ANCA findings with ethanol-fixed gr...
Company:DLD Diagnostika GmbH
Elastase in Medical Dictionary
...ping of Mouse or Rat Leukocytes ... ... Pg was shown previously for many cells, including leukocytes , and was implicated ... Human leukocyte elastase
is an endogenous ligand for the integrin CRR3 (CD11b ... ... were thought to serve only as communication molecules between leukocytes , ... Howev...
...s , pl Cat·-hole n. (k ă t'h ō l`) (Naut. ... harder, less moist feces can sometimes be seen ... Biochemical tests done on feces include fecal elastase
and fecal fat ... provides an easy to understand definition for the medical term, Feces . ... Feces is a fancy way to describe something that...
Elastase in Biological News
Why do aneurysms form? New studies suggest leading role for white blood cells
...he blood artificially low. They applied the enzyme elastase
to the aortas of these mice and normal control mic...n in the aortas of rats that had been injured with elastase
or exposed to control conditions. They also studie...son mice.
In general, the rat aortas exposed to elastase
had far higher levels of L-selectin in the days im...
Elastase in Biological Technology
Elastase in Biological Dictionary
...hour ... Part Two - Total Exposure: Expanded Model for RNase L Fragmentation in CFS Uncovered; The National CFIDS Foundation Announces the Use of elastase
Inhibitors as a ... Since this fragment competes with the native RNase L protein for free 2-5A, it ... Interestingly, for this patient, the RN...