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Effector in Medical News

Smoking May Trigger Brain Damage

...ional Brain Research Center in India found that NNK increases stress-related proteins such as pro-inflammatory signaling proteins and pro-inflammatory effector proteins, as well as pro-inflammatory cytokines, which act as molecular messengers between cells. This demonstrates that NNK triggers an exaggerate...

New research discovers link between smoking and brain damage

...blot analysis techniques which showed that the introduction of NNK resulted in a clear increase in proinflammatory signaling proteins, proinflammatory effector proteins and other stress related proteins. Increased levels of proinflammatory cytokines, which act as molecular messengers between cells, were also ...

CEL-SCI Expands Testing of Its Vaccine to Determine Efficacy Against More Virulent Strain of H1N1 Swine and Other Influenza Viruses

...P.S. construct and I/TCBL used, CEL-SCI is able to direct the outcome of the immune response towards the development of T-cell function with primarily effector T-cell functions (T Lymphocyte; helper/effector T lymphocyte, type 1 or 2 [Th1 or Th2], cytotoxic [Tc] or suppressor [Ts]). The L.E.A.P.S. vaccine co...

Penn study demonstrates new way to boost immune memory

...al response, meaning they are able to proliferate into an army of so-called effector cells that can clear infection. However, TRAF6-deficient CD8 T cells do no...ty acids when given metformin. T cells proliferating to form an army of effector cells burn glucose for their energy. Non-proliferating T cells, such as mem...

2-drug combination appears safe and active in metastatic kidney cancer

...ation. Therefore, Plimack and colleagues suspect that blocking TORC2 signaling activity could improve patient outcomes. Bryostatin blocks a downstream effector of TORC2, called protein kinase C. Plimack and colleagues designed the phase I trial to test the safety of the bryostatin-temsirolimus combination....

Medarex Announces Clinical Data for MDX-1401 in Hodgkin's Lymphoma at Annual Meeting of the American Association for Cancer Research

...lar cytotoxicity, or ADCC, activity (using the Potelligent(R) Technology of BioWa, Inc.). In preclinical studies, MDX-1401 has shown improved antibody effector function over a first generation anti-CD30 antibody. The ongoing Phase 1 trial of MDX-1401 continues to enroll patients with relapsed or refractory Ho...
Effector in Medical Technology

MacroGenics and Lilly Achieve Targeted Patient Enrollment in PROTEGE, a Global Phase 2/3 Clinical Trial of Teplizumab in Type 1 Diabetes

...), which allows the company to incorporate multiple specificities within a single molecule; and (3) Fc optimization, which enhances antibody-dependent effector functions. These powerful sets of capabilities and technology platforms have enabled MacroGenics to build a proprietary pipeline of innovative produc...

Tolerx Presents Data at 69th Scientific Sessions of the American Diabetes Association

...th type 1 diabetes who have residual beta cells by blocking the function of effector T cells that mistakenly attack and destroy insulin-producing beta cells, while stimulating regulatory T cells that are understood to protect against effector T cell damage, thus preserving the beta cells' ability to make insulin. ...

Medarex Announces Preclinical Data from Multiple Research Programs Demonstrating Anti-Tumor Activity in Cancer

...osylated anti-fucosyl-GM1 antibody, MDX-1110, demonstrated robust cytotoxic effector function (both antibody-dependent cell-mediated cytotoxicity and complement... lead candidate, MDX-1414, was selected for its high affinity, specificity, effector function and internalization properties. MDX-1414 demonstrated anti-tumor...

Trubion Pharmaceuticals, Inc. Announces Upcoming Presentation at the 2009 American Association of Cancer Research Annual Meeting

...ORPION (TM) Therapeutics Like Trubion's SMIP(TM) therapeutics -- single chain polypeptides comprising one binding domain, one hinge domain and one effector domain -- SCORPION therapeutics are also novel, single-chain polypeptides comprised of functional domains from naturally occurring proteins. However, ...

Data Suggest CEL-SCI's CEL-2000 Vaccine Prevents or Retards Permanent Damage of Rheumatoid Arthritis

...S.(TM) construct and TCBL used, CEL-SCI is able to direct the outcome of the immune response towards the development of T-cell function with primarily effector T-cell functions (T Lymphocyte; helper/effector T lymphocyte, type 1 or 2 [Th1 or Th2], cytotoxic [Tc] or suppressor [Ts]). Therefore, it would appear...

Tolerx Initiates Dosing of Otelixizumab, a Novel Type 1 Diabetes Agent, in DEFEND, a Phase 3 Clinical Trial

...cell signaling. Otelixizumab is thought to work by blocking the function of effector T cells that attack the body's tissues and cause autoimmune disease while i...tory T cells. It is thought that the regulatory T cells may protect against effector T cell damage well after the antibody has been eliminated from the body. In...
Effector in Medical Dictionary

Neuron

...Pennsylvania School of Medicine, have published a group of papers ... Efferent neurons transmit signals from the central nervous system to the effector cells. ... da: Neuron de:Nervenzelle eo:Neŭrono es:Neurona fi:Neuroni fr: ... Εταιρία δημιουργίας ιστοσελίδων με τη χρήση πολυμέσων. ... In Febru...

Granulocyte

...elty's syndrome (rheumatoid arthritis, an enlarged spleen, an abnormally low white ... (cells called granulocyte s or neutrophils) ... ... the effector cells were stimulated with granulocyte colony-stimulating factor. ... cell killing in patients treated with granulocyte colony-stimulating facto...

Complement

...S ... Deficiencies of complement proteins are frequently associated with an ... of definite complement deficiency states during ... Summary: effector Functions of Complement . The Alternative Pathway ... the complement system provides the actual protection from the response while ... during ...
Effector in Biological News

Reviews of microbial gene language published in special issue of Trends in Microbiology

...to disease. They include descriptions of bacterial effector proteins, virulence factors, effector protein delivery systems, and infection by filamen...obes have developed many ingenious ways to deliver effector molecules into their hosts to facilitate colonizat...

Understanding plants' overactive immune system will help MU researchers build better crops

...more damage than good." One way that plants fight pathogens is through effector-triggered immunity (ETI), which relies on the detection of pathogen effector proteins (proteins that are deployed by pathogens to interfere with the plant immune system). After the detection of a pathogen, specific proteins in ...

TB -- hiding in plain sight

...erculosis can evade the immune response. The related report by Rahman et al, "Compartmentalization of immune responses in human tuberculosis: few CD8+ effector T cells but elevated levels of FoxP3+ regulatory T cells in the granulomatous lesions," appears in the June 2009 issue of The American Journal of Pat...

Identification of a key molecular pathway required for brain neural circuit formation

...hrough a group of molecules called Src family kinases (SFKs) that, until now, were not known to be linked to Shh function. Remarkably, these novel Shh effector molecules are absolutely required for the ability of Shh to guide axons. Connecting axons with an appropriate set of targets is very complex. Inapprop...

Cutting-edge amfAR grants fight HIV/AIDS in the lab and on the phone

...dly in the body. Dr. Groot will examine the role played by cell-to-cell spread of HIV in the establishment of latent viral reservoirs, the identity of effector and target cells, and how the response of the immune system may affect the extent to which the reservoir can be established. Navid Madani, Ph.D./...

Special issue of BMC Microbiology spotlights standardized language for describing microbes

...ommunity-driven effort to develop this resource. Another paper looks at how effector molecules from diverse microbes get into cells, where they reside, what the...ntology terms to reveal similarities and differences for a specific type of effector protein in very different bacterial organisms is shown by taking a close-up...
Effector in Biological Technology

DOR BioPharma Receives FDA Orphan Drug Designation for orBec(R) for the Treatment of Chronic Gastrointestinal GVHD

...sease initiated by T cells in the donor graft that recognize histocompatibility and other tissue antigens of the host, and is mediated by a variety of effector cells and inflammatory cytokines. GVHD presents in both acute and chronic forms. The symptoms of cGVHD typically present at between 100 days and three...

MacroGenics Announces the Initiation of a Phase 2 Clinical Trial to Evaluate the Safety and Efficacy of Monoclonal Antibody MGAWN1 in Subjects with Suspected Central Nervous System Infection Due to West Nile Virus

...), which allows the company to incorporate multiple specificities within a single molecule; and (3) Fc optimization, which enhances antibody-dependent effector functions. These powerful sets of capabilities and technology platforms have enabled MacroGenics to build a proprietary pipeline of innovative produc...

CEL-SCI Files Patent Application to Support Company's Treatment for More Virulent Strain of H1N1 Swine and Other Influenza Viruses

...P.S. construct and I/TCBL used, CEL-SCI is able to direct the outcome of the immune response towards the development of T-cell function with primarily effector T-cell functions (T Lymphocyte; helper/effector T lymphocyte, type 1 or 2 [Th1 or Th2], cytotoxic [Tc] or suppressor [Ts]). The L.E.A.P.S. vaccine co...

Paulo F. Costa Joins MacroGenics Board of Directors

...), which allows the company to incorporate multiple specificities within a single molecule; and (3) Fc optimization, which enhances antibody-dependent effector functions. These powerful sets of capabilities and technology platforms have enabled MacroGenics to build a proprietary pipeline of innovative produc...

CEL-SCI Developing Immune-Based Treatment Against Swine and Other H1N1 Flu Viruses Using Proprietary L.E.A.P.S. Technology

...P.S. construct and I/TCBL used, CEL-SCI is able to direct the outcome of the immune response towards the development of T-cell function with primarily effector T-cell functions (T Lymphocyte; helper/effector T lymphocyte, type 1 or 2 [Th1 or Th2], cytotoxic [Tc] or suppressor [Ts]). The L.E.A.P.S. vaccine co...

CEL-SCI's L.E.A.P.S. Technology Shows Potential to Treat Swine Influenza in Preclinical Studies

...P.S. construct and I/TCBL used, CEL-SCI is able to direct the outcome of the immune response towards the development of T-cell function with primarily effector T-cell functions (T Lymphocyte; helper/effector T lymphocyte, type 1 or 2 [Th1 or Th2], cytotoxic [Tc] or suppressor [Ts]). The L.E.A.P.S. vaccine con...
Effector in Biological Definition

Allostery

... In biochemistry , an enzyme or other protein is allosteric if its activity or efficiency changes in response to the binding of an effector molecule at a so-called allosteric site . Changes that enhance activity are referred to as allosteric activation , while the opposite is called ...

Allostery

... In biochemistry , an enzyme or other protein is allosteric if its activity or efficiency changes in response to the binding of an effector molecule at a so-called allosteric site . Changes that enhance activity are referred to as allosteric activation , while the opposite is called ...

Antibody

...have two primary functions: they bind antigens -- see below they combine with different immunoglobulin receptors specific for them and exert effector functions. These receptors are isotype specific, which gives a great flexibility to the immune system, because this enables that in different situatio...

Apoptosis

...rotein, VDAC2, interacts with BAK to keep this potentially lethal apoptotic effector under control. When the death signal is received, products of the activatio...pro-caspase rendering the active form of caspase-9, which in turn activates effector caspase-3. ( See also the articles on caspases and the Bcl-2 protein fam...

Insulin

...d in the Islets of Langerhans in the pancreas ) is a polypeptide hormone that regulates carbohydrate metabolism . Apart from being the primary effector in carbohydrate homeostasis, it also takes part in the metabolism of fat ( triglycerides ) and proteins – it has anabolic properties. It a...

Monoclonal antibody

...tive conjugate; it is also possible to design bispecific antibodies that can bind with their Fab regions both to target antigen and to a conjugate or effector cell. In fact every intact antibody can bind to cell receptors or other proteins, however with their Fc region. The picture below shows all these poss...
Effector in Biological Dictionary

Thermoregulation

...romised in any way, by drugs or other ... Thermoregulation refers to the mechanisms and control systems used by the body ... There are three main effector mechanisms involved in thermoregulation . ... thermoregulation n. Maintenance of a constant internal body temperature independent from the envir...

Second messenger

...ger system is a method of cellular signaling whereby a diffusable signaling molecule is rapidly produced/secreted, which can then go on to activate effector proteins within the cell to... The Boeing Delta II rocket carrying MESSENGER lifted off from Cape Canaveral Air ... On December 12, 2005, a...

Plasma cells

... Plasma cells , also called plasma B cells , plasmocytes, and effector B cells , are white blood cells that produce large volumes of antibodies. They are transported by the blood plasma and the lymphatic system. Like...

Humoral immunity

... proteins in blood Humoral immunity refers to antibody production, and all the accessory processes ... Each antibody isotype has specific effector functions in humoral immunity . ... Chapter title: Humoral Immunity ... Humoral immunity is that mediated by antibodies. ... For humora...

Effector cell

... (Redirected from effector cell ) Jump to: navigation, search ... effector B cells , are white blood cells that produce ...mes of antibodies. ... 2 Determination of the effector T cell response. 2.1 Th1/Th2 Model for helpe...

Cytotoxic T cell

... cytotoxic T cells detect fragments of the virus on ... Microscopic movie of cytotoxic . T cells killing a tumor cell (1257 kb) ... effector PROTEINS OF CD8+ T CYTOTOXIC CELL (Tc) ... Cytotoxic T cell granules contain Perforin & Granzyme, in addition to other factors. ... ...
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(Date:8/27/2014)... August 27, 2014 Scientists at The Scripps ... a specific signaling pathway can be associated with alcohol ... a gene, called neurofibromatosis type 1 (Nf1), which TSRI ... The new research shows Nf1 regulates gamma-aminobutyric acid (GABA), ... relaxation. , "This novel and seminal study provides ...
(Date:8/27/2014)... Georgia State University’s Center for ... $600,000 grant from the Maternal and Child Health ... to support implementation of the Autism Plan for ... youth with autism spectrum disorder. , In preparing ... Advisory Council composed of key stakeholders from across ...
(Date:8/27/2014)... Foundation scientists examined the implications for cultural diversity ... rehabilitation. The article by Anthony Lequerica, PhD, and ... acquired brain injury (ABI) rehabilitation (doi:10.3233/NRE-141079) was ... and Krch are research scientists in Traumatic Brain ... for the Northern New Jersey TBI Model System. ...
(Date:8/27/2014)... significantly improve musculoskeletal and overall health, and minimize or ... of the latest research on senior athletes (ages 65 ... Journal of the American Academy of Orthopaedic Surgeons ... aging causes an inevitable deterioration of the body and ... of related injuries such as sprains, strains and fractures; ...
(Date:8/27/2014)... Will Holbrook, CP LP, has joined ... over 15 years of experience in the prosthetics field. ... with a Bachelor of Science degree with a major ... received his graduate degree in prosthetics at Northwestern University ... Will join us at Fourroux,” says Keith Watson, owner ...
Breaking Medicine News(10 mins):Health News:Scripps Research Institute scientists link alcohol-dependence gene to neurotransmitter 2Health News:Center for Leadership in Disability Awarded $600,000 Grant to Improve Services for Georgia’s Children and Youth with Autism 2Health News:Lifetime of fitness: A fountain of youth for bone and joint health? 2
(Date:8/27/2014)... LAKE CITY, Aug. 27, 2014 University of Utah ... his native Turkey, has won that nation,s highest science ... of Science. , Sekercioglu is among five researchers picked ... and Technical Research Council of Turkey. Three researchers won ... won the Special Award, which is equivalent to the ...
(Date:8/27/2014)... what is described by the Volunteer Wildfire Services of ... Cape provincial government warned residents in certain parts of ... veld fires. A high veld fire danger rating ... coast in the Great Kei and Mnquma area. ... thunderstorms. The thunderstorms bring lightning strikes and subsequent ...
(Date:8/27/2014)... release is available in German . ... is the most common inherited disease affecting the peripheral ... the Max Planck Institute of Experimental Medicine and University ... Schwann cells is impaired in rats with the disease. ... layer known as myelin, which facilitates the rapid transfer ...
Breaking Biology News(10 mins):University of Utah biologist wins Turkey's top science prize 2Potential therapy for incurable Charcot-Marie-Tooth disease 2
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