A paradigm shift in immune response regulation
...he detrimental effect of NEMO mutations in patients suffering from X-linked ectodermal dysplasia and immunodeficiency", Ivan Dikic points out. ectodermal dysplasia is a hereditary disease, which affects 1 to 5 children in 10,000 ...Scientists uncover evolutionary keys to common birth disorders
...ified human sequence variants in Msx likely to underlie disease, and indicated why mutations in the same gene can lead to either orofacial clefting or ectodermal dysplasias. These clinical insights were gleaned from work demonstrating that certain portions of the Msx proteins have remained constant over extr...Caltech researchers get first look at how groups of cells coordinate their movements
...toderm, on the other hand, moves down but converges as it goes. Thus, the mesoderm--which sits atop the ectoderm--passively rides the downward wave of ectodermal movement, but has to actively swim against the tide to spread outward. "It's as if the mesodermal cells are on a moving sidewalk," says Stathopoulo...Researchers document rapid, dramatic 'reverse evolution' in the threespine stickleback fish
...ostdoctoral researcher in the laboratory of David Kingsley, Ph.D., at Stanford University. In humans, mutations in this gene cause a syndrome called ectodermal dysplasia, a group of more than 100 inherited disorders that impact the ectoderm, the outer layer of tissue involved in the formation of many parts of...Octopuses occasionally stroll around on two arms, UC Berkeley biologists report
...order, one of the earliest ones studied, is called ectodermal dysplasia. "It's a famous old syndrome," Kingsl... gene makes a protein, a signaling molecule called ectodermal dysplasin. This molecule is expressed in ectodermal tissue during development and instructs certain ce...Researchers trace evolution to relatively simple genetic changes
...order, one of the earliest ones studied, is called ectodermal dysplasia. "It's a famous old syndrome," Kingsl... gene makes a protein, a signaling molecule called ectodermal dysplasin. This molecule is expressed in ectodermal tissue during development and instructs certain ce...