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ESAs in Medical News

91 Percent of Oncologists Polled Report Adverse Patient Events as Result of CMS National Coverage Decision on ESAs

HOUSTON, Jan. 30 /PRNewswire/ -- In a national poll of medical oncologists and hematologists, 91 percent reported the occurrence of adverse patient events in the 12-week period following the implementation of the new CMS coverage criteria for Erythropoiesis Stimulating Agents (ESAs). Sponsor...

US Oncology Reports Second Quarter Operating Results

...rowth was partially offset by lower utilization of esas by affiliated physicians. Comparing the same peri...ecrease of $3.5 million, as reduced utilization of esas and the impact of increasing costs for certain pha...ed for qualified physicians to order and prescribe esas for their patients. It is not possible to e...

US Oncology Announces Retirement of R. Dale Ross and Appointment of Bruce Broussard as Chairman of the Board

...cal services by non-governmental payers and cost-containment efforts by such payers, including whether such payers adopt coverage guidelines regarding esas or pharmaceutical reimbursement methodologies that are similar to Medicare coverage, other changes in the manner patient care is reimbursed or adminis...

Nephrologists Indicate High Interest in AMAG Pharmaceuticals' Newly Approved Feraheme According to Latest BioTrends Report

...report published by BioTrends on anticipated impact of the dialysis bundle, Medical Directors foresee the increased use of IV iron to spare the use of esas (such as Amgen's Epogen) as well as IV iron brand selection being heavily influenced by price. Although the bundled payment only impacts the dialysis...

Amgen Highlights Data to Be Presented at ASCO

...to 12 g/dL. Cancer: esas shortened overall survival and/or increased the ri...o avoid red blood cell transfusion. Use esas only for treatment of anemia due to concomitant myelosuppressive chemotherapy. esas are not indicated for patients receiving myelosupp...

Retrospective Analysis Finds Treatment of Cancer Chemotherapy Patients With Epoetin Alfa Associated With Lower Drug Cost Than Darbepoetin Alfa

...o 12 g/dL. Cancer : esas shortened overall survival and/or increased the ri...o avoid red blood cell transfusion. Use esas only for treatment of anemia due to concomitant myelosuppressive chemotherapy. esas are not indicated for patients receiving myelosupp...

Anemia Drugs May Raise Death Risk in Cancer Patients

...n -- but those are very limited circumstances." esas include erythropoietin (Epogen, Procrit) and darbe...tients died overall. The researchers found that esas were associated with a 17 percent increase in deat...udy period. Among patients receiving chemotherapy, esas increased the death risk by 10 percent, they repor...

Product Shifts are Occurring in the Renal Anemia and Bone and Mineral Metabolism Markets According to the Most Recent TreatmentTrends(R): US Nephrology Report from BioTrends Research Group

... over 200 US Nephrologists. In the ESA market, changes that have occurred seem to have taken place at the product level, while the overall use of esas has remained stable compared to the same period last year. Among patients with Chronic Kidney Disease not on dialysis (CKD), market share for Ortho B...

Medicare Change May Impact Black Kidney Patients

...iversity of Minnesota. For example, an analysis of 12,000 dialysis patients revealed that black patients required an 11 percent higher average dose of esas over the first two months on dialysis than white patients do. Since Medicare will no longer reimburse dialysis centers for higher ESA doses, the ne...

US Oncology Reports Fourth Quarter and Yearend 2008 Results

...million as the impact of management fee reductions and lower utilization of esas was partially offset by an increase in affiliated physicians and higher ope...million of the Company's Adjusted EBITDA was attributable to utilization of esas by our network physicians. For the fourth quarter of 2007 and third quarte...
ESAs in Medical Technology

Researchers Urge Caution in Using ESAs for Cancer-Related Anemia

Drugs Might Increase Risk of Tumor Growth, Data Suggest DURHAM, N.C., April 30, 2007 /PRNewswire/ -- Echoing recent FDA warnings, a research group from Northern Ireland cautions against over-aggressive use of a group of drugs called "erythropoiesis-stimulating agents" (ESAs) to treat anemia in som...

Late-Breaking Data Highlighting Research Advances in Several Blood Disorders to Be Presented At the American Society of Hematology Annual Meeting

...e is now additional evidence concerning the use of esas in patients with cancer. Last year, ASH collaborat...ment of anemia in patients with cancer showed that esas increased on-study mortality and worsened overall ...nfirming previous studies that have suggested that esas may negatively affect the overall health of these ...

Observational Study Finds Changes in Medicare Reimbursement for Erythropoiesis-Stimulating Agents Associated With Increased Need for Blood Transfusion

...patients who were on chemotherapy and who received esas needed blood transfusions and utilized more units ...blood per patient than those patients who received esas prior to implementation of coverage limitations. ...ional Coverage Determination (NCD), for the use of esas in anemic cancer patients receiving chemotherapy. ...

Data From Investigational Use of PROCRIT(R) (Epoetin alfa) Presented at American Society of Nephrology Annual Meeting

...thin the range of 10 to 12 g/dL. Cancer: -- esas shortened overall survival and/or increased the ri... avoid red blood cell transfusion. -- Use esas only for treatment of anemia due to concomitant myelosuppressive chemotherapy. -- esas are not indicated for patients receiving myelosupp...

Preliminary Data From Experimental Study Demonstrate Increased Mortality in Stroke Patients Treated With Epoetin Alfa

...oved in any country for use in patients with acute ischemic stroke. Epoetin alfa is a member of the class of erythropoiesis-stimulating agents (ESAs). esas should be used strictly in accordance with their approved indications and dosing recommendations. This investigator-initiated experimental study was...

Observational Studies Assess the Potential Impact of Limiting Erythropoiesis-Stimulating Agent Availability on Frequency of Blood Transfusions

..., 2008). A total of 401 Medicare patients received esas for eight weeks (pre-NCD: n=243; post-NCD: n=158)....within the range of 10 to 12 g/dL. Cancer: -- esas shortened overall survival and/or time-to-tumor pr... tumor progression have not been excluded when esas are dosed to target a hemoglobin of -- To minimi...

New Data Highlighting Possible Impact of ESA Reimbursement Policies on Patient Care, Nation's Blood Supply, to be Presented at American Society of Clinical Oncology (ASCO) Annual Meeting

...on transfusion patterns in patients initiated with esas at different baseline Hb levels. Observational dat...hemotherapy-treated oncology patients initiated on esas at baseline Hb of <10 g/dL vs. 10-11 g/dL. Hospita...within the range of 10 to 12 g/dL. Cancer: -- esas shortened overall survival and/or time-to-tumor pr...

Data From Ortho Biotech-Sponsored Studies to be Presented at National Kidney Foundation 2008 Spring Clinical Meetings

...intain hemoglobin levels within the range of 10 to 12 g/dL. Cancer: -- esas shortened overall survival and/or time-to-tumor progression in clinical...of shortened survival and tumor progression have not been excluded when esas are dosed to target a hemoglobin of -- To minimize these risks, as well a...

Ortho Biotech Statement on U.S. Food and Drug Administration Oncologic Drugs Advisory Committee Vote

...vailable data support continuing the option to use esas according to the label in patients with chemothera...ithin the range of 10 to 12 g/dL. Cancer: -- esas shortened overall survival and/or time-to-tumor pr... tumor progression have not been excluded when esas are dosed to target a hemoglobin of -- To minimi...

Totality of Available Data Reaffirms PROCRIT(R) (Epoetin alfa) Is Safe and Effective When Used Appropriately as Labeled to Treat Chemotherapy-Induced Anemia

...label to treat chemotherapy- induced anemia (CIA). esas are an important treatment option for CIA patients...sible explanation for increased mortality with esas in cancer patients seen in some studies with h...ata from relevant, randomized controlled trials of esas to treat CIA. "The known risks of ESA use are prom...
ESAs in Biological News

Successful cooperation extends Dragon Program

... Opening the Dragon 1 final symposium and Dragon 2 Kick-Off symposium, esas Director for Legal Affairs and External Relations Mr Rene Oosterlinck said:...ge for a wide range of domains in Earth sciences and in applications," said esas Stefano Bruzzi, Head of EO Programme Planning & Coordination Service. "...

Venus Express reboots the search for active volcanoes on Venus

... esas Venus Express has measured a highly variable quantity of the volcanic gas sulphur dioxide in the atmosphere of Venus. Scientists must now decide wheth...

Satellites take sustainability to new heights

... in this project was to help quantify habitat change in various ways and to understand how a habitat may be influenced by the oil sand operations. esas Envisat satellite acquired eight Full Resolution images with its optical instrument, Medium Resolution Imaging Spectrometer (MERIS), covering the enti...

Predicting the radiation risk to ESA's astronauts

...al effects of the radiation on the astronauts" This project, funded by esas General Studies Programme and the Swedish National Space Board, mostly conc...rately predicting radiation doses onboard Columbus," says Petteri Nieminen, esas Technical Officer on the study. The first step was to build a programme...

New radar satellite technique sheds light on ocean current dynamics

...for Earth Observation in Frascati, Italy, demonstrated how this new method on data from the Advanced Synthetic Aperture Radar (ASAR) instrument aboard esas Envisat, enabled measurements of the speed of the moving ocean surface. Synthetic Aperture Radar (SAR) instruments, such as ASAR, record microwave...

Final preparations for first human-rated spacecraft to be lauched from Europe's Spaceport

...ules Verne respects all the human spacecraft safety requirements. This also applies to the 7 tonnes of cargo carried into orbit, said Patrice Amadieu, esas ATV Deputy Project Manager. Over five days, the interior of the cabin has been first disinfected, filled with approximately 1300 kg of dry cargo s...

UN climate conference hears how EO can help

...orious for persistent cloud cover, which prevents traditional satellite sensors from making regular acquisitions. Satellite radar sensors flown aboard esas Envisat and ERS satellites are able to produce reliable high-quality images of these areas because they are able to peer through clouds, haze and smok...

Mars Express -- 5000 orbits and counting

...vide the best possible scientific return. In an effort to meet the needs of the various science teams with instruments on Mars Express, controllers at esas Space Operations Centre in Darmstadt, Germany, are currently fine-tuning the spacecrafts orbit. Between 18 November and 16 December, the thrusters...

ESA honored at White House ceremony

...s a $10,000 grant for continued mentoring work. esas program, Strategies for Ecology Education, Develop...epresented undergraduate students. Managed by esas Office of Education and Diversity Programs, these ...ith a field trip. Another facet to the program is esas web series, Focus on Ecologists: What do Ecologist...

Entomological Society announces 2007 award winners

...hat promotes cross-cultural understandings. She was the recipient of two of esas Presidents Prizes, the Sigma Xi Grants-In-Aid Research Award, and numerous ...ssertation research has earned him several awards and honors, including the esas Presidents Prize, the Manis award, the Barr endowment award, and Phi Sigma ...
ESAs in Biological Technology

Ortho Biotech Supports FDA Advisory Committees' Recommendations on Use of ESAs in Chronic Renal Failure Patients

GAITHERSBURG, Md., Sept. 11 /PRNewswire/ -- Ortho Biotech is pleased with recommendations of the Food and Drug Administration (FDA) Cardiovascular and Renal Drugs Advisory Committee (CRDAC) and Drug Safety and Risk Management Advisory Committee (DSRMAC) resulting from the Committees' evaluatio...

Centocor Ortho Biotech Data to be Presented at American Society of Clinical Oncology (ASCO) Annual Meeting

...o 12 g/dL. Cancer: esas shortened overall survival and/or increased the ri...o avoid red blood cell transfusion. Use esas only for treatment of anemia due to concomitant myelosuppressive chemotherapy. esas are not indicated for patients receiving myelosupp...

BioTrends Releases TreatmentTrends(TM): US Nephrology, an Ongoing Syndicated Publication Providing Insight into Physician Perceptions and Management of Renal Anemia, Hyperphosphatemia, and Secondary Hyperparathyroidism

...th Chronic Kidney Disease not on dialysis (CKD) on esas declined significantly compared to the same period...tients' iron status. The commercialization of new esas could also alter market dynamics in which Amgen's ...ived need for new ESA therapies is relatively low, esas with extended dosing intervals are desired in CKD ...

European Nephrologists Share Insights on the Management of Renal Anemia and Hyperphosphatemia in Latest BioTrends Report

...mpared to other ESAs. While the use of biosimilar esas did increase in the past six months, this was prim...cate a high concern with the quality of biosimilar esas and there appears to be ambivalence about this cla...nderstanding of the differences between biosimilar esas and their reference brands. Projected ESA share g...

BioTrends Releases TreatmentTrends(TM): Nephrology and Renal Dietitians, Two Syndicated Reports Providing Continuing Insight into the Management of Renal Anemia, Hyperphosphatemia, and Secondary Hyperparathyroidism

... two-thirds do not anticipate making any additional changes to their use of esas in CKD or dialysis. While Amgen's Epogen continues to dominate the dialysis...bcutaneous dosing and less aggressive treatment of EPO hypo-responders. New esas in development could also shift market dynamics particularly if these produ...

New Study by BioTrends Highlights Anemia Practice Patterns According to Anemia Managers in Both Dialysis Units and CKD Clinics/Offices

...e management of renal anemia, including the use of esas and IV iron. Comparisons to Nephrologist responses...nd adjusting treatment based on protocols for both esas and IV iron. In CKD, however, Anemia Managers tend...ed focus by managed care on iron status to approve esas and restrictions on starting...

BioTrends Releases Quarterly TreatmentTrends(TM): Nephrology Report Highlighting Market Trends for Renal Anemia, Hyperphosphatemia, and Secondary Hyperparathyroidism

...08. In the renal anemia market, while the use of esas remains consistent in hemodialysis patients compar...t of Stage 3 and Stage 4 CKD patients treated with esas compared to the previous year. And, approximately ...d care reimbursement. Despite the decreased use of esas in CKD, Nephrologists do not expect any significan...

Positive clinical data for PBI-1402 presented at the Annual Congress of the European Hematology Association

... need for RBC transfusions. Approximately 50% of anemic patients receiving chemotherapy require RBC transfusions, and 20%-25% of patients treated with esas still require RBC transfusions. About ProMetic Life Sciences Inc. ProMetic Life Sciences Inc. ("ProMetic") (http://www.prometic.com ) is a biopha...

New Study by BioTrends Highlights Practice Management Shifts Among European Nephrologists

...istration and extended dosing intervals, while performing on par with other esas for efficacy, safety, and tolerability. Roche launched Mircera in the EU du...sed over the past six months. Worth noting is the slow uptake of biosimilar esas such as Binocrit. While overall share for biosimilars is less than 1% and o...

BioTrends Releases Two Publications - TreatmentTrends(TM): Nephrologists and TreatmentTrends(TM): Renal Dietitians - Highlighting Market Trends for Renal Anemia, Hyperphosphatemia, and Secondary Hyperparathyroidism

... In the renal anemia market, safety concerns with esas seem to have had more of an impact on use in CKD than in dialysis with use of esas in CKD Stage 4 decreasing significantly from 54% i... Q107 to 42% in Q108. Despite the decrease in use, esas still tend to be the first renal related product i...
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