EMBL

EMBL GeneCore purchases Genomatix's next generation sequencing data analysis solution

...ay, Chief Business Officer at Genomatix says: "We are very pleased that the embl has chosen our GMS and GGA. With our combined hardware/software approach, ...enomics Core Facility (GeneCore) is the in-house genomics service centre at embl equipped with state-of-the-art technologies required for functional genomic...

New research sheds light on the molecular basis of crib death

...ims of SIDS show alterations in those brainstem neurons that communicate using the signalling molecule serotonin. Cornelius Gross and his group at the embl Mouse Biology Unit modified the serotonin system of mice to understand the role of this signalling molecule in the brainstem. They overexpressed an im...

New revelations in epigenetic control shed light on breast cancer

...ion a mechanism of long-term regulation of a gene's activity, because the methylation marks are stable and maintained through cellular replication. embl researchers of the group of Frank Gannon, current director of the Science Foundation Ireland, now found out that methylation marks occur rapidly in br...

Life savers in the gut

...ns throughout the body. Since too little or too much iron is dangerous for our health a range of regulatory proteins tightly controls iron metabolism. embl scientists now assessed the role of two of these proteins, iron regulatory proteins 1 and 2 (IRPs), for the first time in living mice and found that t...

EMBL reaches north

...ersity, Sweden, officially launch their new Nordic embl Partnership for Molecular Medicine. The agreement ...ombining complementary strengths in the new Nordic embl Partnership equips us to tackle some of the most c...The partnership will result in the adoption of the embl model for international recruitment, staff turnove...

Boffins Identify Gene That can Protect Humans from Nephronopthisis

...m has discovered that mutations in the gene GLIS2 can lead to nephronopthisis (NPHP) in both humans and mice. Mathias Treier and his group at embl have paved way to develop innovative treatment for the disease by working on a mouse model. "Our mice show striking similarities with NPHP pat...

New Therapies for Kidney Diseases

...kidney transplantation in early age has been the only way to save patients suffering from NPHP. With a new mouse model Mathias Treier and his group at embl have shed new light on the molecular mechanisms underlying NPHP opening up novel ways to treat the disease. Our mice show striking similari...

Neural Basis of Anxiety: Newer Insights

...ormal mice show less fear towards such ambiguous cues than to clearly threatening stimuli. A team of researchers led by Cornelius Gross at the embl Mouse Biology Unit now discovered that this response to ambiguous stimuli requires a specific receptor molecule for serotonin, a signal many brain cel...

Molecular Basis of Obesity-Revealing the Unknown Facts

...linked. When we are hungry, our spontaneous activity increases and provides us with the drive to go out and find food. Mathias Treier and his group at embl have now discovered the molecule that brings about this link between locomotor activity and food intake in mice. "The molecule is called Bsx a...

Now Fight Iron Disorders With a Drug Against Hypertension

...ollaborators from the University of Heidelberg and embl now found out that nifedipine, a substance commonl...nces its excretion into the urine," says Weiss, an embl alumnus who now heads a lab at the Department for ...e used on patients," says Martina Muckenthaler, an embl alumna who is now at the University of Heidelberg....

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EMBL in Biological News

Luxembourg joins EMBL

Today, the European Molecular Biology Laboratory [EMBL] announces Luxembourg as the new member of its international community. Accepted by EMBL's council and ratified by the parliament of Luxembourg, the Grand-Duchy has officially joined the institute as the 20th member state. "EMBL is a key pl...

Scientists open doors to diagnosis of emphysema

...ntions in patients with inflammatory lung diseases," says Marcus Mall, group leader at the Children's Hospital at the University of Heidelberg. The embl and University researchers hope that the new testing strategy can be extended to other enzymes involved in lung inflammation and that, with a better p...

New e-science service could accelerate cancer research

...d by Prof Carole Goble at The University of Manchester and Rodrigo Lopez at embl EBI. Other contributors include Khalid Belhajjame, Franck Tanoh, Jiten ...f Manchester and Eric Nzuobontane, Hamish McWilliam and Thomas Laurent from embl EBI. The project is been funded by the Biotechnology and Biological Scie...

Sugarcoating fruit fly development

... is called Ogt but since its discovery it has remained elusive why attaching GlcNAc to proteins is important. Researchers in the group of Jrg Mller at embl have now discovered that flies lacking Ogt show dramatic developmental defects. In the absence of Ogt cells do not develop into the appropriate cell t...

EMBL scientists develop first fully automated pipeline for multiprotein complex production

..., now makes the biologist's life easier. In a paper published in the current issue of Nature Methods researchers of the groups of Imre Berger at embl and Michel Steinmetz at the PSI describe ACEMBL, the first fully automated pipeline for the production of multiprotein complexes. Requiring much less ...

New study reveals the protein that makes phosphate chains in yeast

..., but how the same process works in eukaryotes has so far remained elusive. embl scientists now show that in yeast a protein called Vtc4p is responsible for...e a factory," says Klaus Scheffzek, whose group carried out the research at embl in collaboration with the Dpartement de Biochimie at the Universit de Lausa...

Winners announced in the Elsevier Grand Challenge

...nference. First prize winner: Sean I. O'Donoghue, Lars Jensen, Heiki Horn, Evangelos Pafilis, Michael Kuhn, Nigel P. Brown and Reinhard Schneider, embl Germany, for their project "Reflect: Automated Annotation of Scientific Terms" Second prize winner: Vit Novacek, Tudor Groza and Siegfried Handschu...

Digital zebrafish embryo provides the first complete developmental blueprint of a vertebrate

...pens in the first 24 hours and allows you to zoom in on all cellular and even subcellular details," says Jochen Wittbrodt, who has recently moved from embl to the University of Heidelberg and the Karlsruhe Institute of Technology. New insights provided by the digital embryo include: fundamental cell mo...

Pregnant mice block out unwelcome admirers to protect their pups

...bryos have already been implanted into the uterus and loosing them would bear a high cost for the female. Liliana Minichiello and her team at the embl Mouse Biology Unit now discovered the molecular mechanism that underpins this change in sensitivity to male odours. "At day 3 of the pregnancy a ...

Zooming in on genetic shuffling

...ombination can also act to separate the transmission of neighbouring genes, which are normally inherited together. The groups of Lars Steinmetz at embl and Wolfgang Huber at EMBL-EBI have produced the most detailed map to date of recombination events in the yeast genome. "Our map has the highest r...

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EMBL in Biological Dictionary

Sequence similarity

...ilies shared significant sequence similarity . ... Sequence similarity search page at EBI. NCBI: BLAST notebook. BLITZ ULTRA Fast Search at embl ... PimaII find sequence similarity using dynamic programming ... Sequence Similarity - Conclusions. • Always compare Protein Sequences ......

Nucleotide

...r Glycoside, Nucleotide , and ... Site for the embl database including documentation and how to submit data to embl ... NCBI - The Nucleotide Sequence Database is p...lign, EMBL-Bank, EMBL-CDS, Ensembl, Genome ... The embl Nucleotide Sequence Database is the European mem...