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EGF in Medical News

Advanced targeted therapies effective as first-line treatment for lung cancer

...e surface of cells to which an epidermal growth factor (EGF) binds. When an egf attaches to an EGFR, it activates the enzyme tyrosine kinase, triggering re...b is intended to attach to the EGFR and, thereby, inhibit the attachment of egf and stop cancer cell division. IPASS is a randomized phase III study tha...

'Happy hour' gene discovery suggests cancer drugs might treat alcoholism

... work by blocking the so-called Epidermal Growth Factor (EGF) pathway. That egf pathway is best known for its role in cancer, and drugs designed to inhibit the egf receptor, including erlotinib (trade name Tarceva) and gefitinib (trade nam...

Transition Therapeutics Announces Second Quarter Fiscal 2009 Financial Results

... epidermal growth factor analogues. In humans, Transition's Phase IIa clinical trial data showed that a 4-week therapy with TT-223 in combination with egf (combination of gastrin analogue and epidermal growth factor analogue) in type 2 diabetes patients resulted in sustained reductions in blood glucose c...

Researchers Zero In on GI Cancers

...isk factor for esophageal cancer, which is on the rise. A variant of the egf gene known as G/G was associated with nearly twice the risk of developing e...dicated to us that there was indeed an interaction of some sort between the egf gene and GERD in the esophagus," said study author Dr. Winson Y. Cheung, a ...

Researchers identify new protein that triggers breast cancer

...th factor, called epidermal growth factor or EGF, which has previously been shown to stimulate tumour growth and invasion. Their findings suggest that egf works through ARF1 in these cells. In addition, when ARF1 activity was chemically blocked, breast cancer cell migration and growth was reduced. Conver...

Einstein researchers discover protein that contributes to cancer spread

...udy investigators propose that drugs which inhibit egf may lack effectiveness on tumor cells that express...v. That's because Menainvcells are so sensitive to egf that even the small amount of egf signal that the drugs fail to block may be enough ...

Scientists ID Protein Aiding Breast Cancer Spread

...r cell's invasive potential. Drugs that inhibit egf may not be effective against cancer cells that exp...cause tumor cells with Menainv are so sensitive to egf that even a small amount of egf signal not blocked by the drugs may be enough to s...

Transition Therapeutics Announces First Quarter Fiscal 2009 Financial Results

... epidermal growth factor analogues. In humans, Transition's Phase IIa clinical trial data showed that a 4-week therapy with TT-223 in combination with egf (combination of gastrin analogue and epidermal growth factor analogue) in type 2 diabetes patients resulted in sustained reductions in blood glucose c...

Fruit fly protein acts as decoy to capture tumor growth factors, find Penn researchers

...gnaling cancer cell growth. The investigators previously found that Argos works this way in the fruit fly, binding and neutralizing the fly version of egf called Spitz. Inhibition of Spitz in this way is crucial for proper development of the fly eye. "There are several designer' cancer drugs that figh...

AACR's Seventh Annual Landon Awards

...d interest in this area of clinical cancer research. Continued research on egf receptors, carried out by Mendelsohn and numerous collaborators for almost ...lsohn had a hunch that paid off. When he identified an antibody against the egf receptor in the early 1980s, he immediately forged ahead on the path to eva...
EGF in Medical Technology

YM BioSciences Announces Preclinical Data Confirming Nimotuzumab Binds to the EGF Receptor and Potentiates Radiotherapy

MISSISSAUGA, ON, July 09, 2007 /PRNewswire-FirstCall/ - YM BioSciences Inc. , an oncology company that identifies, develops and commercializes differentiated products for patients worldwide, today announced that a study presented by investigators from Kinki University School of Medicine and Kyoto ...

YM BIOSCIENCES ANNOUNCES NIMOTUZUMAB PRESENTATIONS TO BE MADE AT THE 100TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH AND EUROPEAN SOCIETY FOR MEDICAL ONCOLOGY

... YM at the AACR Translational Medicine conference held in June 2008, which demonstrated that, in tumor cells expressing moderate-to-high levels of the egf receptor, nimotuzumab has binding equivalent to the currently marketed EGFR-targeting antibodies. The AACR 2009 presentation includes data demonstrati...

YM BioSciences Announces Milestone Payment For Approval Of Nimotuzumab In The Philippines And Indonesia

...rade III/IV acneiform rash, also a severe and dose-limiting side-effect observed in all of the other antibodies and with small molecules targeting the egf tyrosine kinase signaling pathway. Unrelated to the rash, Grade III/IV radiation dermatitis is a severe toxicity reported in almost half the patients ...

Genmab A/S - Company Announcement: Novel Insights into HuMax-EGFr Mechanisms of Action Published in PNAS

... to inhibition of cancer cell growth. HuMax-EGFr is able to induce potent immune system defense activity known as ADCC, block growth factor binding to egf receptors, and we now established that HuMax-EGFr inhibits EGFR activation by limiting receptor flexibility. This new data further underlines the pote...

Exelixis Reports XL647 Clinical Data at AACR-NCI-EORTC Conference

...stered orally at a dose of 350 mg on Days 1-5 of repeated 14-day cycles. The trial is designed to enrich for patients with activating mutations in the egf receptor (EGFR) which have been associated with improved sensitivity to other EGFR inhibitors. Based on the selection criteria, Exelixis anticipates t...

Data Show SuperGen's Multi-Targeted Tyrosine Kinase Inhibitor Suppresses Critical Double-Stranded DNA Repair Protein, Rad51

...itor, in combination with Tarceva was more effective than either treatment alone in the inhibition of cell proliferation and phosphorylation of Akt in egf and PDGF pathways. Moreover, in combination with Tarceva, MP470 inhibited Akt phosphorylation in LNCaP prostate cells. Finally, the MP470/Tarceva trea...

Final Vectibix Positive Pivotal Phase 3 Trial Results In Metastatic Colorectal Cancer Patients Published

...cer every 9.3 minutes. About Vectibix Although egf receptors normally help regulate the growth of man... cancer cells actually require signals mediated by egf receptors for their survival. Residing on the surfaces of these tumor cells, egf receptors are activated when naturally occurring p...

Genmab's HuMax-EGFr Shows Broad Potential in Cancer Treatment

...lung cancer. In a novel cancer cell laboratory model, HuMax-EGFr effectively inhibited the growth of tumor cells that express both mutated or normal egf receptors. This inhibition occurred through different mechanisms of action including direct inhibition of cancer cell growth and an immune cell-mediat...

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EGF in Biological News

Protein that promotes cancer cell growth identified

...no acid motif that controls the signaling from the egf receptor through the protein kinase Src to the mas...ing immuno-blot assays, the scientists showed that egf signaling was absent in a cancer cell line that is deficient in Caspase-8 and that egf signaling can be restored by reconstituting the ce...

Grant supports LSUHSC research on how like cell receptor systems determine very different functions

...el mechanism might be important in treating conditions that are dependent upon specific growth factor receptors, like some breast cancers in which the egf receptor family drives growth and survival. "Our studies might provide insight into how specific functions of a pathway might be targeted therapeut...

Caltech researchers explore how cells reconcile mixed messages in decisions about growth

...udied the interplay between contact inhibition and egf in groups of epithelial cells, they found that the cells have a threshold of sensitivity to EGF. If egf levels dip below the threshold, contact inhibition... hold and puts the brakes on cell division. But if egf levels rise above the threshold, it overrides the ...

Newly discovered epidermal growth factor receptor active in human pancreatic cancers

...laboratories and clinical trials already had tried egf inhibitors as a treatment for pancreatic cancer an...he only case in 12 cases that had responded to the egf inhibitor was the only case with an activated egf receptor. Dr. Pandey would like to see other resea...

Tuning in on cellular communication in the fruit fly

...lated protein, Kek1, regulates the Epidermal Growth Factor (EGF) pathway, which is another important developmental pathway. Problems with the BMP and egf pathways are implicated in cancer, bone disorders, heart disease, and neurodegenerative diseases. Developing compounds that can regulate or repair the...

Newly discovered molecular switch helps decide cell type in early embryo development

...ve regulation of a secreted protein called EGF, or epidermal growth factor. egf is a cell messenger protein that affects cell differentiation, growth and e... development. The research team noticed that Hox's permissive regulation of egf led to cell specification when it interacted with the influence of Sens in ...

Gene variation may elevate risk of liver tumor in patients with cirrhosis

...ing HCC. If these results are confirmed, this egf variation could be used to determine which cirrhot... In addition, the molecular pathway controlled by egf and its receptor EGFR which is known to be import...o determine whether cirrhotic patients with higher egf levels are at greater risk for liver cancer and to...

Genes and biomarkers that allow doctors to choose the right therapy for the right patient

...mutations in the KRAS gene could allow the enzyme to function whether or not it receives the commanding signal from EGFR. Therefore, the inhibition of egf receptor by cetuximab will not block the molecular signals that are activated farther down the cascade. The researchers also determined that KRAS...

MIT bioengineer advances survival, promise of adult stem cells

...the implant site was previously unknown. When egf attaches to receptors on the stem cell surface, it...ifferentiation. However, the cell normally absorbs egf and degrades it, and the growth factor loses its power to influence cell behavior. This has made egf notoriously difficult to develop as a clinical pro...

One signal elicits thousands of answers

...he first time all phosphorylations of all proteins in living cells - and in their temporal dynamic. For this approach cell cultures were stimulated by egf for different lengths of time. The "Epidermal Growth Factor" is known for causing the phosphorylation of a multitude of enzymes and proteins along a s...
EGF in Biological Technology

YM BIOSCIENCES RECEIVES CLEARANCE TO INITIATE RANDOMIZED DOUBLE-BLIND CLINICAL TRIALS OF NIMOTUZUMAB IN LUNG CANCER AND BRAIN METASTASES FROM LUNG CANCER

...rade III/IV acneiform rash, also a severe and dose-limiting side-effect observed in all of the other antibodies and with small molecules targeting the egf tyrosine kinase signaling pathway. Unrelated to the rash, Grade III/IV radiation dermatitis is a severe toxicity reported in almost half the patients ...

/R E P E A T -- Oncolytics Biotech Inc. Announces U.S. Phase 2 Combination Clinical Trial for Non-Small Cell Lung Cancer Patients with K-RAS or EGFR-Activated Tumours/

...R) is in the treatment of patients with metastatic cancers including NSCLC who have a mutated K-RAS gene and are unlikely to respond to treatment with egf receptor inhibitors." About Lung Cancer Lung cancer is the second most common cancer in men and women and is the leading cause of cancer death. Mo...

Oncolytics Biotech Inc. Announces U.S. Phase 2 Combination Clinical Trial for Non-Small Cell Lung Cancer Patients with K-RAS or EGFR-Activated Tumours

...R) is in the treatment of patients with metastatic cancers including NSCLC who have a mutated K-RAS gene and are unlikely to respond to treatment with egf receptor inhibitors." About Lung Cancer Lung cancer is the second most common cancer in men and women and is the leading cause of cancer death. Mo...

AstraZeneca Completes Enrollment in Two Pivotal Phase III Studies of the Investigational Drug Vandetanib (ZACTIMA(R)) in Non-Small Cell Lung Cancer (NSCLC)

...cer Res 2002; 62(16):4645-55. (4) Holden SN, Eckhardt SG, Basser R et al. Clinical evaluation of ZD6474, an orally active inhibitor of VEGF and egf receptor signaling, in patients with solid, malignant tumors. Ann Oncol 2005; 16(8): 1391-1397. (5) Tada, H, Vasselli, J, Langmuir, P. Cli...

Agendia Acquires Rights to the Discovery of a Major Drug Resistance Mechanism in Breast Cancer Potentially Leading to a Herceptin(R) Sensitivity Test

... Agendia's CEO, Dr. Bernhard Sixt. "It is likely that a similar mechanism contributes to unresponsiveness to other cancer therapeutics that target the egf receptor in colon and lung cancer". Agendia will develop a microarray-based diagnostic to identify this drug resistance mechanism. About Agendia Age...

YM BIOSCIENCES REPORTS 2007 YEAR END OPERATIONAL AND FINANCIAL RESULTS

...ul regulatory review of the manufacturing of nimotuzumab. - YM reported preclinical data separately confirming that nimotuzumab binds to the egf receptor and that it also potentiates radiotherapy in non-small-cell lung cancer cells. Subsequent to the end of the fiscal year: - YM USA wa...

ONCOSCIENCE AG, THE EUROPEAN PARTNER OF YM BIOSCIENCES, ANNOUNCES COMPLETION OF PATIENT ENROLLMENT IN PHASE III BRAIN CANCER TRIAL OF NIMOTUZUMAB

...s to demonstrate a significantly more benign side-effect profile compared to all the other EGFR-targeting antibodies and small molecules targeting the egf tyrosine kinase signalling pathway. The absence of any cases of severe rash to date and the very rare instances of any of the other debilitating side ...

TKXtra DataFile: Homogenous tyrosine kinase detection using High Efficiency Fluorescence Polarization

... Screening of agonists or antagonists of tyrosine kinases The TKXtra assay is capable of detecting a number of kinases. For example v-abl , egf receptor, insulin receptor, and c-src have all been detected with good sensitivity. Assay Performance TK...

The use of CypHer5E and the IN Cell Analyzer 1000 for live-cell receptor internalization studies

...using the β-2 adrenergic, δ-opioid, and egf receptors in live-cell model assays to demonstrate...ceptor HEK293 cell line expressing egf receptor HEK Culture medium: MEM (...oterenol, DADLE ([D-Ala 2 , D-Leu 5 ]-Enkephalin), egf (epidermal growth factor, murine submaxillary glan...

The use of CypHer5 for receptor internalization studies in both a range of GPCRs and a non-GPCR

...

HEK293 cell line expressing egf receptor

HEK Culture medium: ...pin releasing hormone), angiotensin II, egf (epidermal growth factor, murine submaxillary glan...t from light.

Assay for egf receptor internalization 1. ...

EGF in Biological Dictionary

Phenotype

...nd discuss your questions with phenotype experts. BioInfoBank Library :: Phenotype :: [A variant of DDRT-PCR using anchored mini ... of mouse egf receptor: effect of genetic background on mutant phenotype . ... Brief and Straightforward Guide: What is a Phenotype ? ... For example, blue eye...
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