EGF

EGF receptor activation prevents microbes from going more than skin deep

Our skin not only serves as a physical barrier against infection but skin cells themselves can mount an immune response to kill invading microbes by producing antimicrobial polypeptides (AMPs). As overt infection in the skin is a rare event, researchers have theorized that AMPs must not only help fight infection, but play a role in preventing infection from developing in the first place. I...

Novel EGFR ectodomain mutations in glioblastoma

The Epidermal Growth Factor Receptor (EGFR), a so-called kinase protein, is often abnormally active in cancer. A new class of anticancer drugs inhibiting the activated EGFR kinase have shown to be effective against such cancers, especially lung cancer. In a new study in PLoS Medicine, researchers have catalogued and characterized the mutations in the EGFR gene that occur in glioblastoma, a deadly...

EGF at Biology Products

Mouse Anti-VEGF Receptor 1 Monoclonal Antibody, Unconjugated, Clone Flt-1 / EWC from Abcam

Description:Mouse monoclonal [Flt-1/EWC] to VEGF Receptor 1 ( SwissProtID: P17948...
Company:Abcam

Anti-Human VEGFR-2 / KDR Antibody, Unconjugated from Cell Sciences

Description:Anti-human VEGFR-2/KDR (Protein-A Purified) Polyclonal Antibody...
Company:Cell Sciences

Mouse Anti-Human VEGFB Monoclonal Antibody, Unconjugated, Clone 4H5 from Abnova Corporation

Description:Mouse monoclonal antibody raised against a partial recombinant VEGFB. NCBI Entrez Gene ID = VEGFB...
Company:Abnova Corporation

Mouse Anti-Human VEGF R2 (KDR) Monoclonal Antibody, Unconjugated, Clone 89106 from R&D Systems

Description:Human VEGF R2 (KDR) MAb (Clone 89106)...
Company:R&D Systems

Rabbit Anti-Human EGFr, phospho (Tyr992) Concentrate Polyclonal Antibody, Unconjugated from Invitrogen

Description:Rabbit anti-phospho-EGFr (Tyr992) - Concentrate...
Company:Invitrogen

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EGF at Biology Technology

Performance of Ad-A-Gene EGFP-Glucocorticoid Receptor (EGFP-GCCR): an adenoviral vector gene delivery system

adenoviral vector • viral transduction • EGFP • IN Cell Analyzer • gene delivery There is a requirement in the drug discovery process to investigate lead candidate drugs arising from primary screens and to validate those compounds in suitable biological assays. There is also a need in early-stage drug discov...

Performance of Ad-A-Gene EGFP-MAPKAP-k2: an adenoviral vector gene delivery system

adenoviral vector • viral transduction • EGFP • IN Cell Analyzer • gene delivery Biological assays developed in cultured and primary cells can greatly aid secondary screening as well as lead and target validation, but their development presents several challenges. Establishing stable cell systems to express...

EGF at Medicine News

eGFR Diagnostic Test -A reliable and understandable measure of kidney impairment

Kidneys are in charge of maintaining the water level in the body and ensuring the toxins and impurities are excreted out. When the kidneys get affected, it results// in accumulation of toxins in the body, which might lead to health complications and even chronic renal failure. Chronic renal failure can occur due to health conditions such as diabetes, high blood pressure, and heart fai...

New Antibody for EGFR Causes Lung Cancer Regression

Mutant forms of the protein EGFR are important for the development of lung cancer in a substantial proportion of individuals with this disease. However, not all individuals// express the same mutant EGFR, for example, some have a mutation that affects the intracellular part of EGFR and some have a mutation that affects the extracellular part of EGFR (known as the EGFRvIII mutant). Th...

EGF at Medicine Products

EGFR by FISH

Description:ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' clients include more than half of the nation's university teaching hospitals and children's hospitals, maj...
Company:ARUP Laboratories

EGFR pharmDx Tissue Assay, Paraffin

Description:ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' clients include more than half of the nation's university teaching hospitals and children's hospitals, maj...
Company:ARUP Laboratories

EGF at Medicine Technology

YM BioSciences Announces Preclinical Data Confirming Nimotuzumab Binds to the EGF Receptor and Potentiates Radiotherapy

MISSISSAUGA, ON, July 09, 2007 /PRNewswire-FirstCall/ - YMBioSciences Inc. , an oncology company that identifies, developsand commercializes differentiated products for patients worldwide,today announced that a study presented by investigators from KinkiUniversity School of Medicine and Kyoto University at the 11thmeeting of The Japanese Association for Molecular Target Therapy ofCancer...

Genmab's HuMax-EGFr Shows Broad Potential in Cancer Treatment

COPENHAGEN, June 3, 2007 - Genmab A/S (CSE: GEN) announcedtoday pre-clinical data illustrating its fully humanHuMax-EGFr™ (zalutumumab) antibody may have broad potentialto treat cancers that over-express several types of EGFr (epidermalgrowth factor receptor). Recently, mutations which appear to alter the signaling abilityof EGFr have been identified in tumors from lung canc...

VEGF Trap-Eye Phase 2 Wet AMD Results Reported at ARVO Annual Meeting

FORT LAUDERDALE, Fla.--(BUSINESS WIRE)--May 9, 2007 - RegeneronPharmaceuticals, Inc. (Nasdaq: REGN) today announced positiveresults from several studies evaluating the VEGF Trap-Eye in theneovascular form of age-related macular degeneration (wet AMD) anddiabetic macular edema (DME). These findings were presented thisweek at the annual meeting of the Association for Research inVision and Oph...

Positive Results Using Affitech-Identified Human Antibody That Blocks VEGF Binding to VEGF Receptor 2 in Preclinical Cancer Model Reported by Peregrine

OSLO, Norway--(BUSINESS WIRE)--Apr 23, 2007 - Affitech AS, thehuman antibody therapeutics company announced today that PeregrinePharmaceuticals, Inc. reported positive in vivo test results of R3,a fully human monoclonal antibody developed by Affitech, in apancreatic cancer model at the recently concluded Centennial AnnualMeeting of the American Association for Cancer Research (AACR). R3has...

AVEO Presents Preclinical Efficacy Data on AV-412, a Novel Oral Tyrosine Kinase Inhibitor of EGFR/HER2 for EGFR Mutant and Drug-Resistant Lung Cancer

LOS ANGELES & CAMBRIDGE, Mass.--(BUSINESS WIRE)--Apr 17, 2007 -AVEO Pharmaceuticals, Inc., a biopharmaceutical company focused onthe discovery and development of novel, targeted cancer medicines,today announced encouraging preclinical data of AV-412, a novel,next generation oral tyrosine kinase inhibitor of EGFR/HER2 usingAVEO's unique EGFR mutant and drug-resistant lung cancer tumormod...

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