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Dyspnea in Medical News

Centocor Ortho Biotech Statement on the FDA ODAC Opinion Regarding DOXIL(R) for Treatment of Advanced Breast Cancer

... stomatitis (41 percent vs 15 percent), vomiting (33 percent vs 44 percent), diarrhea (21 percent vs 35 percent), anorexia (20 percent vs 22 percent), dyspnea (15 percent vs 23 percent), HFS (51 percent vs 1 percent), and rash (29 percent vs 12 percent) In addition, 19 percent vs 52.3 percent repo...

New Shape-HF™ Cardiopulmonary Testing System to be on Display at 2009 American Association of Heart Failure Nurses Annual Meeting

...sing patient functional capacity, monitoring their response to therapy and predicting outcome. Shape-HF™ is designed to quantify the severity of dyspnea on exertion and fatigue and evaluate the interaction between the heart, lungs, and other organ systems. This makes it possible to evaluate therapy opt...

Recognizing signs and symptoms of acute HF

...ailure patients peripheral oedema (in 35%) cough (in 33%) breathing difficulty when lying flat (orthopnea, in 30%) chest pain (in 29%) nocturnal dyspnea (in 28%) fatigue (in 17%) palpitations (in 7%) Shortness of breath, said Professor Follath, is by far the most common presenting symptom, and f...

Healthier Lifestyle Can Cut COPD Symptoms

...distance, exercise capacity, dyspnea, handgrip force and fat free mass index. After 24 months, significant improvements remained in exercise capacity, dyspnea and disease-specific quality of life. During the two-year study, the overall cost per patient was about $3,686 more for the intervention group. But...

Lifestyle program for patients with COPD is health and cost effective

...force and fat free mass index. After two years improvements in exercise capacity remained significant, as were improvements over the entire period in dyspnea (MRC) and disease-specific quality of life. Furthermore, perceived effectivenessthe patients' subjective evaluation of the benefits of the program h...

Perforomist Inhalation Solution data to be presented today at American Thoracic Society conference

...otropium, resulted in improved pulmonary function, dyspnea (shortness of breath) and rescue medication use ve...s, significant improvements in pulmonary function, dyspnea and rescue medication use were seen over tiotropiu...cy was measured by serial spirometry, transitional dyspnea index (TDI), rescue albuterol use and the St. Geor...

Perforomist(R) Inhalation Solution Data in Patients With Moderate to Severe COPD to Be Presented at the International Conference of the American Thoracic Society

...otropium, resulted in improved pulmonary function, dyspnea (shortness of breath) and rescue medication use ve...s, significant improvements in pulmonary function, dyspnea and rescue medication use were seen over tiotropiu...cy was measured by serial spirometry, transitional dyspnea index (TDI), rescue albuterol use and the St. Geor...

Important Data Presented on Independent Predictors of Mortality in Patients With Idiopathic Pulmonary Fibrosis

...ictors of one-year mortality included age, baseline percent predicted diffusing capacity (DLCO), baseline FVC, history of respiratory hospitalization, dyspnea score (as measured by the University of California at San Diego Shortness of Breath Questionnaire) and 24-week change in patient-reported respirator...

BioCryst Pharmaceuticals Announces Presentation of Forodesine Data at the 45th Annual Meeting of the American Society of Clinical Oncology

...esine treatment for 12 or more months, the most frequent adverse events were nausea (44 percent), fatigue (22 percent), peripheral edema (22 percent), dyspnea (22 percent) and urinary casts (22 percent). Grade 3 or higher adverse events were diffuse large B-cell lymphoma and peripheral edema. There were no...

Perforomist Inhalation Solution data to be presented at American Thoracic Society conference

...an Diego. In one analysis, use of Perforomist Inhalation Solution, when added to maintenance tiotropium, resulted in improved pulmonary function, dyspnea (shortness of breath) and rescue medication use versus treatment with tiotropium alone. In a second study, patient satisfaction increased in those tr...
Dyspnea in Medical Technology

Results and Additional Analyses From Study Show That Corthera's Relaxin for Acute Heart Failure is the Strongest Predictor of Improved Longer-Term Outcomes Following Hospital Discharge When Compared to Other Variables

...line patient characteristics, early improvement in dyspnea (breathlessness) to day five, physician-determined...aused rapid, substantial and sustained relief from dyspnea (breathlessness). Relaxin also demonstrated consi...ected for the study presented to the hospital with dyspnea due to AHF and with normal or elevated blood press...

Bayer Announces Leukine(R) Data Presentations at 45th American Society of Clinical Oncology (ASCO) Annual Meeting

...llary leak syndrome, pleural and or/pericardial effusion, supraventricular tachycardia, sequestration of granulocytes in the pulmonary circulation and dyspnea have been reported in patients after Leukine administration. Leukine has induced the elevation of serum creatinine or bilirubin and hepatic enzymes i...

Results From Study Show Promising Efficacy and Safety Results for Corthera's Relaxin in Acute Heart Failure

...aused rapid, substantial and sustained relief from dyspnea (breathlessness). Relaxin also demonstrated consi... use of relaxin led to considerable improvement in dyspnea when compared to placebo and lasted up to 14 days,...ected for the study presented to the hospital with dyspnea due to AHF and with normal or elevated blood press...

Video: Zometa(R) Reduces Risk of Breast Cancer Recurrence in Premenopausal Women, Study in The New England Journal of Medicine Reports

...h Zometa 4 mg (n=1031) were as follows: bone pain (55%), nausea (46%), fatigue (39%), anemia (33%), pyrexia (32%), vomiting (32%), constipation (31%), dyspnea (27%), diarrhea (24%), weakness (24%), myalgia (23%), anorexia (22%), cough (22%), arthralgia (21%), lower-limb edema (21%), malignant neoplasm aggrav...

Study Finds DOXIL(R) Combination Therapy Delays Disease Progression for Patients With Metastatic Breast Cancer

..., fever (21% vs 31%), nausea (46% vs 63%), stomatitis (41% vs 15%), vomiting (33% vs 44%), diarrhea (21% vs 35%), anorexia (20% vs 22%), dyspnea (15% vs 23%), HFS (51% vs 1%), and rash (29% vs 12%) - In addition, 19% vs 52.3% reported alopecia (all grades) - Grade 3/4 h...

Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma

...resthesia and dysesthesia and headache (each 22%), dyspnea (21%), cough and insomnia (each 20%), rash (18%), ...rhea (5%), vomiting (4%), and nausea, dehydration, dyspnea and thrombocytopenia (each 3%). In the Ph...), pneumonia (16% vs 11%), dizziness (16% vs 11%), dyspnea (15% vs 13%), headache (14% vs 10%), pain in extre...

Prolonged Progression-Free Survival Demonstrated by VELCADE(R) (Bortezomib) for Injection Based Induction Regimens in Transplant-Eligible Previously Untreated Multiple Myeloma Patients

...resthesia and dysesthesia and headache (each 22%), dyspnea (21%), cough and insomnia (each 20%), rash (18%), ...rhea (5%), vomiting (4%), and nausea, dehydration, dyspnea and thrombocytopenia (each 3%). In the Pha...), pneumonia (16% vs 11%), dizziness (16% vs 11%), dyspnea (15% vs 13%), headache (14% vs 10%), pain in extre...

Dacogen(R) (decitabine for injection) Data Presented on a Phase II Clinical Trial in Elderly Patients with Acute Myeloid Leukemia (AML)

...n, the most commonly reported adverse events considered possibly related to decitabine treatment were febrile neutropenia, fatigue, pneumonia, sepsis, dyspnea and bacteraemia. The five-day dosing regimen of Dacogen(R) is currently being further evaluated in a global, Phase III survival study in elde...

Novel VELCADE(R) (Bortezomib) for Injection Based Four-Drug Combination Was Well Tolerated In Previously Untreated Multiple Myeloma Patients

...resthesia and dysesthesia and headache (each 22%), dyspnea (21%), cough and insomnia (each 20%), rash (18%), ...rhea (5%), vomiting (4%), and nausea, dehydration, dyspnea and thrombocytopenia (each 3%). In the Pha...), pneumonia (16% vs 11%), dizziness (16% vs 11%), dyspnea (15% vs 13%), headache (14% vs 10%), pain in extre...

More Than 200 Abstracts at ASH and SABCS Reveal Potential Compelling Patient Benefits From Novartis Oncology Current and Pipeline Therapies

...h Zometa 4 mg (n=1031) were as follows: bone pain (55%), nausea (46%), fatigue (39%), anemia (33%), pyrexia (32%), vomiting (32%), constipation (31%), dyspnea (27%), diarrhea (24%), weakness (24%), myalgia (23%), anorexia (22%), cough (22%), arthralgia (21%), lower-limb edema (21%), malignant neoplasm aggrav...
Dyspnea in Medical Dictionary

Dyspnea

Dyspnea or dyspnoea, from Latin dyspnoea, from Greek dyspnoia from dyspnoos, shortness of breath) or shortness of breath (SOB) is a debilitating symptom that is the experience of unpleasant or uncomfortable respiratory sensations. It is a common symptom of numerous... Dyspnea is a common ...

Silicosis

...newsletter will soon make relevant medical and ... is Silicosis " Dangerous ... Chronic silicosis initially causes no symptoms or only mild dyspnea but over ... Silicosis , the oldest known occupational pulmonary disease, is caused by ... Silicosis is the oldest known environmental lung ...

Orthopnea

... Greek from ortho , straight + pnoia , breath) is dyspnea which occurs Breathing difficulty - lying dow...he insidious onset of fatigue, orthopnea , and dyspnea due to progressive right ... Chief Complain...ical ... Cardiovascular: Chest pain, orthopnea , dyspnea on exertion, claudication, extremity edema. ... ...

Cardiac Failure

.... This issue ... Heart failure Heart failure Classification and external resources The major ... of heart failure is paroxysmal nocturnal dyspnea also known as " cardiac asthma" ... The online version of Journal of Cardiac Failure on ScienceDirect, the world's leading platform for high...
Dyspnea in Biological News

Franklin Square to study airway bypass procedure for severe emphysema

... are supported and kept open by Exhale Drug-Eluting Stents manufactured by Broncus Technologies, Inc. Patients could see an immediate improvement in dyspnea (shortness of breath). "We are excited to be part of this study because currently there are limited treatment options for emphysema. Patients are ...

Researchers at Sarasota Memorial Health Care System to study airway bypass treatment for emphysema

...ing Stent manufactured by Broncus Technologies, Inc. - to allow the trapped air in the lung to escape. Patients could see an immediate improvement in dyspnea (shortness of breath). The airway bypass procedure could be an excellent option for those who may be considering lung transplant or who may not be ...

Positive results for airway bypass

...vement in RV over baseline at 6 months (p=0.04). Patients also showed a statistically significant improvement in the modified Medical Research Council dyspnea Scale (mMRC), a breathlessness test, of -0.5 points (p= 0.025). Retrospective analysis revealed that patients with the most severe hyperinflation of t...

Extra-aggressive form of idiopathic pulmonary fibrosis identified

...onic and progressive lung disorder from which most patients die within 5 years after diagnosis. The disease is characterized by the insidious onset of dyspnea or cough and usually evolves slowly. Now, Selman and coworkers present in an article published in the online, open-access journal PLoS ONE on We...

Eisai announces Phase II data on E7389, a potential new therapy for the treatment of breast cancer

...eutropenia (low white blood cell counts). Other side effects were considered mild to moderate and included nausea, fatigue, dehydration, arthralgias, dyspnea and neuropathy. None of the patients discontinued the study due to hematological toxicity. "The results from this study with E7389 appear promisin...
Dyspnea in Biological Technology

Ascenta Therapeutics Announces Presentation of Promising Results From Clinical Trials of AT-101 in Prostate, Brain, and Lung Cancers at 2009 ASCO Annual Meeting

... increase in 6-month survival compared to the docetaxel plus placebo arm. Common adverse events included fatigue (18 percent), anemia (18 percent) and dyspnea (18 percent). Using NSCLC cell lines, a genomic profile predicting response to AT-101 was developed in collaboration with Duke University . Opportu...

Centocor Ortho Biotech Data to be Presented at American Society of Clinical Oncology (ASCO) Annual Meeting

...a (40% vs 51%), fever (21% vs 31%), nausea (46% vs 63%), stomatitis (41% vs 15%), vomiting (33% vs 44%), diarrhea (21% vs 35%), anorexia (20% vs 22%), dyspnea (15% vs 23%), HFS (51% vs 1%), and rash (29% vs 12%) In addition, 19% vs 52.3% reported alopecia (all grades) Grade 3/4 hema...

Nile Therapeutics CD-NP Clinical Program for Acute Heart Failure Released From Clinical Hold by FDA

...-NP is a novel chimeric natriuretic peptide in clinical development for the treatment of acute heart failure. CD-NP was designed to reduce symptoms of dyspnea in heart failure patients through both a reduction in intracardiac pressure and an improvement in renal function. The Company believes that the curren...

University of Illinois Medical Center in Chicago First Hospital to Install Innovative Shape-HF™ Cardiopulmonary Testing System

...sing patient functional capacity, monitoring their response to therapy and predicting outcome. Shape-HF™ is designed to quantify the severity of dyspnea on exertion and fatigue and evaluate the interaction between the heart, lungs, and other organ systems. This makes it possible for the physician to ev...

InterMune Reports Results of Two Phase 3 CAPACITY Studies of Pirfenidone in IPF

...Categorical assessment of absolute change from Baseline to Week 72 in percent predicted FVC 4. Change from Baseline to Week 72 in dyspnea measured by the University of California at San Diego Shortness-of-Breath Questionnaire (UCSD SOBQ) 5. Change from Ba...

Synvista Therapeutics Announces Progress in Phase 2 Clinical Trial Program for Alagebrium

... or functional cardiac disorder that impairs the ability of the ventricle to fill with or eject blood. The primary manifestations of heart failure are dyspnea and fatigue, which may limit exercise tolerance, result in fluid retention, and lead to pulmonary congestion and peripheral edema. These abnormalities...

Lilly to Acquire ImClone Systems in $6.5 Billion Transaction

...l pain (59%), and pain-other (51%). The most common grade 3/4 adverse events (greater than or equal to 10%) included: fatigue (33%), pain-other (16%), dyspnea (16%), abdominal pain (14%), infection without neutropenia (13%), rash/desquamation (12%), and other-gastrointestinal (10%) -- The most frequent adv...

AMITIZA(R) (lubiprostone) 8 mcg Now Available to Treat Irritable Bowel Syndrome with Constipation in Adult Women

...an if the diarrhea becomes severe. Patients taking AMITIZA may experience dyspnea within an hour of first dose. This symptom generally resolves within three hours, but may recur with repeat dosing. Patients who experience dyspnea should inform their physician. In clinical trials of AMITIZA (24 mcg) in ...

Synvista Therapeutics Announces Initiation of the BREAK Study of Alagebrium for Diastolic Heart Failure

... or functional cardiac disorder that impairs the ability of the ventricle to fill with or eject blood. The primary manifestations of heart failure are dyspnea and fatigue, which may limit exercise tolerance, result in fluid retention, and lead to pulmonary congestion and peripheral edema. These abnormalities...

Millennium Announces VELCADE(R) (Bortezomib) for Injection First-Quarter 2008 U.S. Net Sales

...AEs) during the studies. The most commonly reported SAEs included pneumonia (7%), pyrexia (6%), diarrhea (5%), vomiting (4%), and nausea, dehydration, dyspnea and thrombocytopenia (each 3%). Adverse events thought by the investigator to be drug-related and leading to discontinuation occurred in 22% of patien...
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