Dynamin drug discovery team win prestigious international epilepsy grant
The two year US$278,800 grant to the dynamin
Drug Discovery Program will support the refinement...ds clinical development and commercialisation. The dynamin
Drug Discovery Program consists of leading expertise in synaptic vesicle endocytosis and dynamin
biology, medicinal chemistry and translational stu...
Study Revises Dynamin's Role in Nerve Cell Function
...cience, suggests that a key cellular enzyme called dynamin
1 is not essential to all synaptic transmission, a...is not always necessary for this process. Instead, dynamin
1 goes into action only when the synapse enters mo... especially high activity.
'In that sense, dynamin
1 remains crucial, allowing the synapse the freedo...
Cells use import machinery to export their goods as well
...ow that some of the key molecules regulating endocytosis, such as clathrin, dynamin
and actin, are also at work in exocytosis.
"In retrospect, it makes pe...molecules known for their membrane-bending role in endocytosis -- clathrin, dynamin
and actin. In the absence of any one of these molecules, the researchers fo...
The downside of microtubule stability
...e of these mutations leads to production of faulty dynamin
2, a protein that is crucial for endocytosis but a...bules. Tanabe and Takei investigated how defective dynamin
2 hampers cells.
Normal microtubules are contin...tubules from cells that made the faulty version of dynamin
were abnormally stable, as measured by how many...
U of M researchers identify gene linked to common ailment in labrador retrievers
... The research team identified a mutant form of the dynamin
1 gene as highly associated with EIC. The dynamin
1 protein normally functions to maintain proper ch...ic transmission. However, the mutated form of the dynamin
protein appears to have diminished function, inter...
Hopkins researchers discover how brain protein might control memory
...n the two cells. New receptors constantly replace the swallowed-up ones.
The two proteins that came out of the Arc fishing expedition - known as dynamin
and endophilin - previously were known to be critical for this swallowing action. And, it turns out that Arc controls these two proteins and therefore...
Common bacteria pirate natural mechanism to get inside cells
...ng with millions of receptors on the cell surface. "Adding nitric oxide to dynamin
changes it from an inactive protein inside the cell to the active protein t...t we could do is limit internalization and ensuing infection by controlling dynamin
activity through the inhibition of nitric oxide synthases, enzymes that pro...