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Drosophila in Medical News

A New Signaling Mechanism in Drosophila

A new signalling mechanism among cells in the fruit fly, Drosophila melanogaster has been identified by investigators from the Institute of Research in Biomedicine (IRB Barcelona). The researchers found that two independent groups of cells generate the same signal by different pathways an...

Carnegie Mellon algorithm charts evolution of genetic networks during fruit fly life cycle

...URGHA new algorithm developed by Carnegie Mellon University computer scientists has revealed for the first time how genetic networks in the fruit fly, drosophila melanogaster, evolve during the insect's life cycle. Scientists have known that the relationships between fruit fly genes change over time, but exis...

Monell Center receives $100,000 Grand Challenges Explorations grant

...ter in Philadelphia. The Grand Challenges Explorations mosquito project is an extension of his longstanding interests in taste and feeding. Breslin's drosophila Chemosensory Laboratory at Monell uses the fruit fly as a model to understand the relationships between genetics, chemosensation, and feeding. Parall...

Fruit flies soar as lab model, drug screen for the deadliest of human brain cancers

...n of the Public Library of Science Genetics . "We can now use the power of drosophila genetics to uncover genes that drive these tumors and identify novel therap...and first author Renee Read, who spearheaded the project. "We developed the drosophila model to figure out how these genes specifically regulate brain tumor patho...

Blocking molecular pathway with whimsical name possible therapeutic target for pancreatic cancer

...chers at the American Society for Cell Biology (ASCB) 48th Annual Meeting, Dec. 13-17, 2008 in San Francisco. In their studies with the fruit fly, drosophila melanogaster, at the Mayo Clinic College of Medicine in Minnesota, scientists found a link between the "Seven-In-Absentia" or SINA gene and the aggre...

2008 Gruber Genetics Prize awarded to Allan Spradling of Carnegie Institution

... cell niche using ovary tissue from the fruit fly, drosophila melanogaster. Spradling went on to define the mole...tem cell behavior within their niches. His work on drosophila stem cells and niches has helped guide mammalian s...rst successful method for inserting genes into the drosophila genome. Spradling subsequently applied engineered ...

Scientists identify key roadblock to gene expression

...r the first time, a detailed map of how the building blocks of chromosomes, the cellular structures that contain genes, are organized in the fruit fly drosophila melanogaster. The work identifies a critical stop sign for transcription, the first step in gene expression, and has implications for understanding h...

Fruit fly phlebotomy holds neuroscience promise

...he University of Illinois at Chicago managed the feat and say their method could expedite understanding of the physiology of important insects such as drosophila melanogaster, the common laboratory fruit fly that shares almost three-quarters of its genetic code with humans. Scott Shippy, associate professor ...

Tug of war in the cells

...cargo arrives at its destination. Regulatory proteins probably intervene," says Melanie Mueller. Researchers into the transport of fat particles in drosophila embryos examined whether her model applied in reality. It is actually explained by experimental observations that took place previously on the transpo...

Drosophila drug screen for fragile X syndrome finds promising compounds and potential drug targets

... Scientists using a new drug screening method in drosophila (fruit flies), have identified several drugs and s... their current experiment, Emory scientists used a drosophila model lacking the FMR1 gene. These fruit flies ha...py. "Our discovery of glutamate toxicity in the drosophila model of fragile X syndrome allowed us to develop ...
Drosophila in Biological News

Estimation of isolation times in the Drosophila simulans complex

Allentown, PA - The Drosophila simulans species complex continues to serve as an important model system for the study of new species formation. The complex is comprised of the cosmopolitan species, D. simulans, and two island endemics, D. mauritiana and D. sechellia. A substantial amount of effort...

What is wild? Odor attraction among different wildtype Drosophila

Vinegar flies ( Drosophila melanogaster ) show a highly selective behavior towards odor stimuli. A series of behavioral studies showed that a single olfactory stimulus is often not sufficient for immediate attraction to potential food sources or oviposition sites. Interestingly, the behavior diffe...

P(acman) takes a bite out of deciphering Drosophila DNA

P(acman) ?a new method of introducing DNA into the genome of fruit flies or Drosophila ?promises to transform the ability of scientists to study the structure and function of virtually all the fly’s genes, and the method may be applicable to other frequently studied organisms such as mice, said its...

A resetting signal keeps circadian rhythm on track in Drosophila fruit flies

A Brandeis University study published this week in Nature shows for the first time that a molecular signal maintains coherence among brain clock cells that regulate daily activity of Drosophila melanogaster (fruit flies). The two key groups of neurons control morning and evening activity and are ma...

Carbon nanoparticles toxic to adult fruit flies but benign to young

...ung to adults. The scientists found that larval drosophila melanogaster showed no physical or reproductive ef...ming carbon nanoparticles in their food. Yet adult drosophila experienced a different fate. Tests showed adults ...ins in the dust." The scientists immersed adult drosophila in a control test tube and test tubes containing f...

Protecting cells from their neighbors

...ism fails, the embryo dies. Made in the fruit fly drosophila melanogaster , this finding could be universal. Th...r mechanisms. "Most of the processes described in drosophila can be extrapolated to other organisms. Given tha...o universal", explains Casanova. In the 1960s, drosophila was the model in which researchers described a ph...

Parasites ready to jump

...versitt (LMU) in Munich and a team of researchers working with the fruitfly drosophila melanogaster have now uncovered a new type of cellular defence that acts ag...shable chemically. "We will now test whether the mechanism we have found in drosophila also exists in mammalian cells. We would also like to know how the mechanis...

Rampant helper syndrome

...e now shown that, in many organisms, this cofactor is F0/F420," Carell reports. "This molecule has been conclusively detected in DNA repair enzymes of drosophila melanogaster, the fruit fly. Not long ago, another research group even postulated that F0/F420 is co-responsible for DNA repair in plants. Our view of...

Scripps Research scientists observe human neurodegenerative disorder in fruit flies

... by a defect in the synthetase's activity for protein synthesis, the researchers created the same mutations to the equivalent protein in the fruit fly drosophila melanogaster, which caused the insect to develop a condition with several of the hallmarks of the human disease. This suggests that Charcot-Marie-Toot...

P[acman]-generated fruit fly gene 'library': A new research tool

...alled P[acman], a collaboration of researchers led by Baylor College of Medicine has established a library of clones that cover most of the genome of drosophila melanogaster (fruit fly) and should speed the pace of genetic research. In a report in the current online issue of the journal Nature Methods , D...
Drosophila in Biological Technology

New technique allows simultaneous tracking of gene expression and movement

...ern California, Los Angeles, who carried out the fluorescent experiments in drosophila flies. When the flies are illuminated with blue light, the authors' video t...o-fluorescent protein is used as a reporter for specific gene expression in drosophila and other organisms. -Our methods should be readily adaptable to such reage...

Stem cells stand up for themselves

...e shapes stem cells, not vice versa. O'Reilly et al. found evidence for more active stem cells while studying how the cells anchor themselves in the drosophila ovary. Previous work indicated that ovary stem cells attach to the niche through the protein E-cadherin. O'Reilly et al. tested whether the stem ce...

J. Craig Venter Institute Names Robert Friedman, Ph.D., Deputy Director of West Coast Facility

...JCVI in 2002, Dr Levy worked at Celera Genomics and was involved in developing computational tools for gene discovery and functional annotation in the drosophila and the first human genome sequences. Dr. Levy received a B.Sc. in Molecular Biophysics at the University of Leeds, UK, and his Ph.D. in cell and comp...

Microsurgery on the brain of the fruit fly leads to new insights into irreparable nerve injuries

...or patients with nerve injuries that have been irreversible up to now. drosophila as model organism The drosophila melanogaster fruit fly is an important, low-cost model organism with a 60% ...

Rice Centromere, Supposedly Quiet Genetic Domain, Surprises

...sible, in theory, to construct an artificial chromosome. In most organisms, including the critical model organisms such as the mouse, the fruit fly drosophila melanogaster and the plant Arabidopsis thaliana, centromeres have proved to be nearly intractable for sequencing. The rice centromere is accessible...

Using the DCode System to Identify DNA Sequence Variation for Studies of Population Structure in Marine Organisms

...tretch immediately downstream from the forward (GC-clamped) primer. For this region, we substituted the homologous sequence from drosophila yakuba inferred from a manual alignment of oyster and fly 16S sequences, in order to construct a theoretical melting profile of ...

Quantitative Analysis of Protein-DNA Associations in Vivo Using Real-Time PCR, Rev A

...t years to identify the association of histone complexes and transcription factors with specific genomic DNA targets in cells of drosophila or yeast. As shown in Figure 1, the technique first involves the treatment of cells with formaldehyde or ultraviolet light to co...

SUPERIOR RNA FOR DEMANDING APPLICATIONS

...human, mouse and rat tissues, human brain regions, human and drosophila cell lines and E.coli* Human Tissues & Cell Line- 100 g Brain...RNA from specific human, mouse and rat tissues and human and drosophila cell lines* 5 g Quality and stability checked u...

A Better Way to Isolate RNA AND Protein From the Same Sample

...rose gel electrophoresis, Northern blot, or Western blot. SCR represents a scrambled siRNA sequence. (B) 5 x 10 5 Schneider's drosophila cells were treated for 48 hours in a 6 well plate with 10 nM of the indicated dsRNA prepared with Ambion's MEGAscript ...

Silencer Validated siRNAs

...nix was founded in 1999 and pioneered the use of genome-wide dsRNA libraries by targeting all of the genes in the C. elegans and drosophila genomes (1). Cenix was the first company to espouse the goal of developing siRNAs for the entire human genome. To achieve this g...
Drosophila in Biological Products

Schneider's Drosophila Medium (1X) liquid from Invitrogen

Description: Modified and insect cell culture tested....
Company:Invitrogen

GIBCO Schneider's Drosophila Medium (1X) liquid from Invitrogen

Description: Schneider's Drosophila Medium is formulated for the expression of heterologous proteins in Drosophila S2 cells....
Company:Invitrogen

Mouse Anti-Drosophila Yan Drosophila protein Antibody, Unconjugated from Developmental Studies Hybridoma Bank

Description: anti-Yan 8B12H9...
Company:Developmental Studies Hybridoma Bank

Drosophila S2 Cells (Schneider's Drosophila Medium) from Invitrogen

Description: Drosophila S2 cells are used for heterologous protein expression in the Drosophila Expression System (DES). The S2 cell line was derived from a primary culture of late stage (20-24 hours old) Drosophila melanogaster embryos (1). This versatile cell line grows rapidly at room temperature wit...
Company:Invitrogen

Schneider's Drosophila - Insect medium from AppliChem GmbH

Description: Schneider's Drosophila - Insect medium...
Company:AppliChem GmbH

COPAS 500 from Union Biometrica

Description:...This is one of our most versatile systems, ideal for use by multiple labs with different applications. Applications include all stages of C. elegans, drosophila embryos to first instar larvae, other like-sized model organisms, cells, pollen, seeds and beads even delicate cell clusters such as pancreatic islet...
Company:Union Biometrica

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Drosophila in Biological Definition

Drosophila

Drosophila melanogaster Drosophila subobscura Drosophila is a genus of small flies whose members are often called small fruit flies , or more appropriately vinegar flies, wine flies, pomace flies, grape flies, and picked fruit-flies. The genus contains about 1000 species...

Alternative splicing

... has been transcribed from the DNA , it includes several introns and exons . In nematodes , the mean is 4-5 exons and introns; in the fruit fly drosophila there are more than 100 introns and exons in one transcribed pre-mRNA. But what is an intron and what is an exon is not decided yet. This decision i...

Arabidopsis

...liana ), are one of the model organisms for studying plant sciences, including genetics and plant development. Similarly as mouse and fruit fly ( drosophila ) are used as model organisms to understand human biology, Arabidopsis thaliana is used to study agronomic crops. The genome of Arabidopsis , ...

Biology

...to tissues , organs and anatomy . Model organisms for developmental biology include the round worm Caenorhabditis elegans , the fruit fly drosophila melanogaster , the zebrafish Brachydanio rerio , the mouse Mus musculus , and the weed Arabidopsis thaliana . Physiology of organisms ...

Cell growth

...ed by fusion of thousands of myocytes . Genetic studies of the fruit fly drosophila have revealed several genes that are required for the formation of multin...g in cytosolic components from adjacent cells through cytoplasmic bridges ( drosophila ) or by internalization of nutrient storage granules (yolk granules) by en...

Developmental biology

...tes Sea urchin Round worm Caenorhabditis elegans Fruit fly drosophila melanogaster ( drosophila embryogenesis ) Plants ( Plant embryogenesis ) Arabidopsis thali...

Morphogenesis

...e") 1 Anterior-posterior axis patterning in drosophila 1.1 Maternal effect genes 1.2 Gap genes ...o Anterior-posterior axis patterning in drosophila Morphogenesis of the fruit fly drosophila melanogaster starts with the construction of asy...

Gene

...hat genes occupy specific locations on the chromosome. With this knowledge, Morgan and his students began the first chromosomal map of the fruit fly drosophila . In 1928 , Frederick Griffith showed that genes could be transferred. In what is now known as Griffith's experiment , injections into a mouse ...

Genome project

...s) Rhesus Macaque Rhesus monkey Gallus gallus Chicken Macropus eugenii Kangaroo Felis domesticus Cat Canis lupis Dog drosophila melanogaster Fruit fly Saccharomyces cerevisiae Yeast Neurospora crassa A type of mold Arabidopsis thaliana Mustard weed Ory...

Homeobox

...us abortion in vertebrates . Pit-1 homeobox-containing protein bound to DNA The homeobox genes were first found in the fruit fly drosophila melanogaster and have subsequently been identified in many other species, from insects to reptiles and mammals . The diagram to the right is a ...
Drosophila in Biological Dictionary

Drosophila

Drosophila is a genus of small flies, belonging to the family Drosophilidae, whose members are often called "fruit flies" or more appropriately pomace flies, vinegar flies, or wine flies, a reference to the characteristic of... Drosophila melanogaster is a two-winged insect tha...

Vitelline membrane

... jelly coat/ vitelline layer. ... Thus, any additional sperm are released from the vitelline membrane and no more bind. ... The European ... drosophila vitelline membrane genes contain a 114 base pair ... melanogaster genes encoding vitelline membrane proteins. ... The European Bioinforma...

Vessel cell

...ell eNOS but not iNOS contributes to angiogenesis and vessel morphogenesis ... The Hox gene abdominal-A specifies heart cell fate in the drosophila dorsal vessel ... non-Tin expressing cell (those cells of the dorsal vessel lacking black nuclei) ... An apparatus including a single e...

Tubulin

... Tubulin was long thought to be specific to eukaryote. Eukaryote ... drosophila has four ß- tubulin genes: each encodes a distinct isoform. ... Maternally...porated into zygotic mitotic spindles. ... The four ß- tubulin genes of drosophila each encode a distinct isoform. ... The ß3- tubulin gene encodes a diver...

Transposon

...tulated in the late 1940s by Barbara ... [4] The transposon codes for antibiotic resistance to kanamycin and other ... FlyBase: a database for drosophila genetics and molecular biology ... The date that the natural transposon was entered into the chado database ... Here we report that transpo...

Transposable element

... Genetic transformation of drosophila with transposable element vectors" ... A wiki specially dedica...osable element clusters in the set of ... Genetic transformation of drosophila with transposable element vectors" ... A wiki specially dedicated to t...

Transmembrane proteins

...mp, ... we have constructed a TransMembrane Protein DataBase, TMPDB (Shimizu and Nakai, ... Secreted and Transmembrane Proteins Involved in drosophila Embryogenesis ... Secreted and transmembrane proteins play an essential role in intercellular ... The Effects of Alternative Splicing on Trans...

Tandem repeat sequences

...minology,biology terms,biology abbreviations ... Tandem repeat sequences Multiple copies of the ... Genomic Tandem Repeats Play a Role in drosophila Gene Regulation. ... Benson, G. (1999) Tandem repeats finder: a program to analyze DNA sequences . Nucleic Acids Res. ... Use of Short Tandem...

Splicing

...f web pages to find the most relevant information on splicing , and allows you to compare prices on... Analysis of splicing -regulator targets in drosophila ... These signals are recognized by splicing regulators, the most common of which ... Group 1 introns are self- splicing : they pinch themselve...

Spiracles

...y half the ... The posterior spiracles are composed of two structures: the filzkörper, an ... The development of the posterior spiracles of drosophila may serve as a model to ... spiracles . b. molting. c. mandibles. d. parthenogenesis. Hint. 2. ... the spiracles . b. the tympanum. c. the legs. ...
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