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Disulfide in Medical News

Individuals Who Apply Pesticides Are Found to Have Double the Risk of Blood Disorder

...n. Of the chemicals studied, a significantly increased risk of MGUS was observed among users of dieldrin (an insecticide), carbon-tetrachloride/carbon disulfide (a fumigant mixture), and chlorothalonil (a fungicide). The MGUS risk for these agents increased 5.6-fold, 3.9-fold, and 2.4-fold, respectively. Sever...

Capsules encapsulated

...securely anchored to the cholesterol units and thus attached to the polymer film. Subsequently, more polymer layers are added and then cross-linked by disulfide bridges into a gel by means of a specially developed, very gentle cross-linking reaction. In the final step, the silica core is etched away without da...

Enzyme with a sugar antenna

...the team was finally able to correctly attach the individual fragments, fold the enzyme into its natural form, and correctly couple the cysteines into disulfide bridges to form a functional RNase C. ...

JCI table of contents: Feb. 21, 2008

...nter and Harvard Medical School, Boston, have identified a role for protein disulfide isomerase (PDI) in blood clot formation (also known as thrombus formation) ... outweigh the benefits. TITLE: A critical role for extracellular protein disulfide isomerase during thrombus formation in mice AUTHOR CONTACT: Bruce Furie...

Engineering chimeric polypeptides to illuminate cellular redox states

...hroughout the linker, sense the redox potential of the environment and form disulfide bonds upon oxidation. Under oxidative conditions intramolecular disulfide bonds can form, shifting the free energy minimum from the α-helix, to ...

Study Findings Could Help In Developing A Better Drug Delivery System

... One of the key mechanisms of this breakdown is disulfide reduction, which involves the breaking of chemical bonds. It was thought that disulfide reduction relied on the movement of the material a...alled lysosomes. However, the research showed that disulfide reduction occurred even when such components were ...

Molecular Basis Of ALS Found

... the pathogenesis of ALS by forming intermolecular disulfide bonds," said Siddique. "This phenomenon is in some...in, a copper ion, a zinc ion and an intramolecular disulfide linkage -- a bond within an SOD1 molecule that stabilizes the structure. Intermolecular disulfide bonds, or cross-links, are incorrect bonds that fo...

Garlic a day keeps cancer away

...nd it also has powerful anti-cancer properties. A substance called diallyl disulfide in garlic is known to make the gut produce enzymes that clear out cancer-ca...g particles. Now two New Zealand scientists have fed varying levels of disulfide to rats and found it increased levels of the cancer-protecting gut enzymes ...
Disulfide in Medical Products

Free Activin AB ELISA Test

Description:...stimulate FSH release. Inhibins are heterodimers consisting of a common a-subunit linked to either a A subunit (Inhibin A) or B subunit (Inhibin B) by disulfide bridges, and in contrast to the Activins, inhibit FSH release. Messenger RNA studies demonstrate that both Inhibin and Activin are most abundant in t...
Company:Diagnostic Systems Laboratories, Inc.

Free Activin A ELISA Test

Description:...stimulate FSH release. Inhibins are heterodimers consisting of a common a-subunit linked to either a A subunit (Inhibin A) or B subunit (Inhibin B) by disulfide bridges, and in contrast to the Activins, inhibit FSH release. Messenger RNA studies demonstrate that both Inhibin and Activin are most abundant in t...
Company:Diagnostic Systems Laboratories, Inc.

Free Activin B ELISA Test

Description:...stimulate FSH release. Inhibins are heterodimers consisting of a common a-subunit linked to either a A subunit (Inhibin A) or B subunit (Inhibin B) by disulfide bridges, and in contrast to the Activins, inhibit FSH release. Messenger RNA studies demonstrate that both Inhibin and Activin are most abundant in t...
Company:Diagnostic Systems Laboratories, Inc.

MIS/AMH ELISA Test

Description:...Inhibiting Substance (MIS), also known as Anti-Mullerian Inhibiting Substance (AMH), is a glycoprotein dimer composed of two 72 kDa monomers linked by disulfide bridges (1). MIS/AMH belongs to the transforming growth factor-? (TGF-?) superfamily which includes TGF-? and the various inhibin and activin glycopro...
Company:Diagnostic Systems Laboratories, Inc.
Disulfide in Medical Dictionary

Expectorant

...nding to break down components. The viscosity of mucous secretions in the lungs is dependent upon the concentrations of mucoprotein, the presence of disulfide bonds between... Cough medicine often contains cough suppressants and expectorants . ... phlegm) are treated with expectorants that loosen mu...

Antithrombin III

...inactivates several enzymes of the coagulation system. It is a glycoprotein produced by the liver and consists of 432 amino acids. It contains three disulfide bonds and a... Antithrombin III . Definition. Antithrombin III is a blood test that measures the ... Lower-than-normal AT III may mean ...
Disulfide in Biological News

Sulfurous ping-pong in the urinary tract

...nal PNAS . ETH Zurich researchers crossed the disulfide bridge The discovery of the signal transfer me...bonds between two sulfur atoms in a protein chain, disulfide bridges, play an important role. While examining g... cause urinary tract infections: two genes for the disulfide bond formation machinery were clustered with the g...

Researchers discover cell's 'quality control' mechanism

...as 'manufacturing defects' and degrades it before it can be distributed." The ERdj5 enzyme is the first protein found to be capable of breaking the disulfide bonds that hold the misfolded proteins together in the ER. Once those bonds are broken, the researchers say ERdj5 also helps other enzymes and molecul...

Biophysical Society announces winners of 2008 Student Travel Awards

...cules across Biological Membranes. Ling Wu, University of Illinois at Chicago, Conformational Study of Different Beta-turns Coupled to a Cyclic disulfide Bond to Model the Turn Roles in -hairpin Stability. Qianru Yu, The Pennsylvania State University, Fluorescence-based Biochemistry on Intrinsic ...

Chloroplast f and m Thioredoxins Discovered in Nonphotosynthetic Tissues

...o-called redox-regulated reactions, TRXs can transfer hydrogen to convert a disulfide bridge formed between two cysteine amino acids to their unbridged thiol forms. These TRX-responsive disulfide bridges have regulatory functions in numerous cellular processes, including...

Restoring tamoxifen sensitivity in resistant breast cancer cells

...search at Frederick, Md., found that the effectiveness of tamoxifen in cell cultures and in mice can be fully restored by the use of a compound called disulfide benzamide, or DIBA. The investigators confirmed their study hypothesis about DIBA's effect on tamoxifen resistance by using the compound in mice that ...

Venom doc tracks down snake bioweapons

...xins where those with a very stable molecular structure ?those that are rich in the amino acid cysteine, which enables proteins to form intramolecular disulfide linkages. "These structures provided an excellent framework for the 60-80 million years of 'evolutionary tinkering' that have turned these proteins in...
Disulfide in Biological Technology

Research Published in Nature Medicine Shows Disruption of Chemokine Interactions Inhibits Atherosclerosis in Mice

...prised of sequences from the RANTES protein. CKEY2 was shown to be stable and formed the secondary structural motif found in RANTES when stabilized by disulfide bridged cysteines at both ends of the peptide. The scientists demonstrated that CKEY2 disrupts PF4-RANTES heteromer formation by binding preferentiall...

High Yield Protein Production from Pichia pastoris Yeast: A Protocol for Benchtop Fermentation

...analysis of plasmid instability in recombinant bacterial cultures. Biotechnol. Bioeng., 33, 49-61 Komives, E. A. 1994. Expression of Highly disulfide Bonded Proteins in Pichia pastoris, Structure. 2,1003-1005 Modak, J. M. and H. C. Lim. 1989. Simple nonsingular control approach to fed- ba...

Efficient Primary Structure Elucidation of Disulfide-bridged Peptides

... The primary structure determination of disulfide bridged peptides is greatly facilitated using a co...itive technologies provides information on complex disulfide structures Methods ...were cleaved with immobilised trypsin to eliminate disulfide exchange during digestion, and iodoacetamide was a...

Purification and Characterization of beta-Lactoglobulin Genetic Variants A and B Using Preparative Electrophoresis and Isoelectric Focusing

...nd alanine (Ala) in the B variant. All variants contain five cysteine residues, four of which are involved in forming intrachain disulfide bridges. The function of βLG is not yet clear, although binding and transport of retinol, small hydrophobic ligands and fatt...

Decontamination and inhibition of ribonucleases

...ovine pancreatic RNase A. The pancreatic ribonucleases are small enzymes (15 kd) and consist of a single polypeptide chain with four disulfide bridges. RNase A is a single-strand specific endoribonuclease that is active over a wide pH range, is resistant to metal chelating a...
Disulfide in Biological Products

Ph.D.-C7C Disulfide Constrained Peptide Library Kit from New England Biolabs

Description: Applications: Epitope mapping, Mapping protein-protein contacts, Identification of enzyme substrates/inhibitors, Identification of receptor agonists/antagonists...
Company:New England Biolabs

Custom Peptide Synthesis from Raybiotech, Inc.

Description:... Peptide-Protein Conjugation Quantities to Kilograms Multiple disulfide Bridges Complex Peptides/Peptidomimetics Special amino acids and their derivatives Phosphorylated/Biotinylated Structures Peptide labeling AMC...
Company:Raybiotech, Inc.

Origami(DE3) Glycerol Stock from Novagen

Description:...uctase (trxB) and glutathione reductase (gor) genes, which greatly enhances disulfide bond formation in the cytoplasm. Studies have shown that expression in Orig...vectors, since the thioredoxin fusion tag further enhances the formation of disulfide bonds in the cytoplasm. The Origami(DE3)pLacI host is compatible with expre...
Company:Novagen

Origami(DE3)pLysS Glycerol Stock from Novagen

Description:...uctase (trxB) and glutathione reductase (gor) genes, which greatly enhances disulfide bond formation in the cytoplasm. Studies have shown that expression in Orig...vectors, since the thioredoxin fusion tag further enhances the formation of disulfide bonds in the cytoplasm. The Origami(DE3)pLacI host is compatible with expre...
Company:Novagen

ProFound Label Transfer Sulfo SBED Protein:Protein Interaction Reagent from Pierce Biotechnology, Inc.

Description:...ptavidin/NeutrAvidin/monomeric avidin biotin-binding protein support. Amine group-specific reactivity Nonspecific photoreactivity Thiol-cleavable disulfide (S-S) linkage A Biotin handle: This biotin transfers from a labeled purified bait protein to a captured prey protein (Figure 2), which makes it espec...
Company:Pierce Biotechnology, Inc.

Mts-Atf-LC-Biotin Label Transfer Reagent, 5 mg. from Pierce Biotechnology, Inc.

Description:...putative prey protein or prey protein-containing lysate, the Atf moiety is activated with UV light capturing the interacting complex. Reduction of the disulfide bond formed by reaction of -SH with the Mts group of the label-transfer reagent results in the transfer of the biotin label from the bait protein to t...
Company:Pierce Biotechnology, Inc.

Mts-Atf-Biotin Label Transfer Reagent, 5 mg from Pierce Biotechnology, Inc.

Description:...putative prey protein or prey protein-containing lysate, the Atf moiety is activated with UV light capturing the interacting complex. Reduction of the disulfide bond formed by reaction of -SH with the Mts group of the label-transfer reagent results in the transfer of the biotin label from the bait protein to t...
Company:Pierce Biotechnology, Inc.

BL21 Competent Cell Set* from Novagen

Description:...t enable you to maximize the yield and activity of your target proteins, including stringent control over basal expression levels, the ability to form disulfide bonds in the cytoplasm for proper folding and activity, and alleviating codon usage incompatibilities. Every strain of Novagen’s competent cells...
Company:Novagen

Free Activin B ELISA Kit from Diagnostic Systems Laboratories, Inc.

Description:...stimulate FSH release. Inhibins are heterodimers consisting of a common a-subunit linked to either a A subunit (Inhibin A) or B subunit (Inhibin B) by disulfide bridges, and in contrast to the Activins, inhibit FSH release. Messenger RNA studies demonstrate that both Inhibin and Activin are most abundant in t...
Company:Diagnostic Systems Laboratories, Inc.

Free Activin AB ELISA Kit from Diagnostic Systems Laboratories, Inc.

Description:...stimulate FSH release. Inhibins are heterodimers consisting of a common a-subunit linked to either a A subunit (Inhibin A) or B subunit (Inhibin B) by disulfide bridges, and in contrast to the Activins, inhibit FSH release. Messenger RNA studies demonstrate that both Inhibin and Activin are most abundant in t...
Company:Diagnostic Systems Laboratories, Inc.
Disulfide in Biological Definition

Amino acid

...ysteine hydrophobic (Nagano, 1999) 121.16 5.05 1.92 10.70 8.37 Under oxidizing conditions, two cysteines can join together by a disulfide bond to form the amino acid cystine . When cysteines are part of a protein, insulin for example, this enforces tertiary structure. D Asp...

Antibody

...hains and two identical light chains connected by disulfide bonds . There are five types of heavy chain: &g...gA2 the heavy and light chains are not linked with disulfide but with noncovalent bonds. The IgA found in se...mmunoglobulins are covalently linked together with disulfide bonds, usually as a pentamer or a hexamer. It has ...

Disulfide bond

... A disulfide bond ( SS-bond ), also called a disulfide bridge , is a strong covalent bond between two ...h their side chains, they normally do so through a disulfide bond. The particular side chain involved is the su...

Endoplasmic reticulum

...ylation. Glycosylation involves the attachment of oligosaccharides . disulfide bond formation and rearrangement. disulfide bonds stabilize the tertiary and quaternary structure of many proteins. ...

Keratin

... strands called intermediate filaments. These proteins contain a high percentage of sulfur -containing amino acids , largely cysteine , which form disulfide bridges between the individual molecules, resulting in a fairly rigid structure. Human hair is approximately 14% cysteine. There are two main for...

Protein biosynthesis

...o post-translational modification . This is may include the formation of disulfide bridges or attachment of any of a number of biochemical functional groups... chain, leaving a protein consisting of two polypeptide chains connected by disulfide bonds. External links Protein Synthesis DNA Workshop ...

Protein

...er by hydrogen bonds . The tertiary structure is held together primarily by hydrophobic interactions but hydrogen bonds , ionic interactions, and disulfide bonds are usually involved too. The process by which the higher structures form is called protein folding and is a consequence of the primary st...

Endoplasmic reticulum

...ylation. Glycosylation involves the attachment of oligosaccharides . disulfide bond formation and rearrangement. disulfide bonds stabilize the tertiary and quaternary structure of many proteins. ...

Endoplasmic reticulum

...ylation. Glycosylation involves the attachment of oligosaccharides . disulfide bond formation and rearrangement. disulfide bonds stabilize the tertiary and quaternary structure of many proteins. ...

Endoplasmic reticulum

...ylation. Glycosylation involves the attachment of oligosaccharides . disulfide bond formation and rearrangement. disulfide bonds stabilize the tertiary and quaternary structure of many proteins. ...
Disulfide in Biological Dictionary

Intermembrane space

... ... GO:0005758 : mitochondrial intermembrane space [161 gene products] ... Mitochondria articles relating to ' intermembrane space ' ... A disulfide relay system in the intermembrane space of mitochondria that mediates protein ... Intermembrane space - Wikipedia, the free encyclopedi...

Disulfide bridge

... In chemistry, a disulfide bond is a covalent bond, usually derived by the ...roups. The linkage is also called an SS-bond or disulfide bridge . The overall connectivity is therefore C-S-S-C. The terminology... In chemistry, a disulfide usually refers to the structural unit composed of...

Denaturation

...Protein Denaturation . l. Any modification in conformation not ... Water content affects heat denaturation . l. Other consequences. Splitting of disulfide bonds ... Zoology information, history, articles and research from Academic Journals, Newspapers, and magazines at HighBeam.com. Free Trial, Credit...
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