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Dimer in Medical News

Microscopic 'beads' could help create 'designer' immune cells that ignore transplanted organs

...n those who keep and reject their transplanted kidneys Dr. Horuzsko reported last year in Proceedings of the National Academy of Sciences that the dimer form of HLA-G was the most powerful of the known forms and now he and many others are searching for the most powerful dimer, hoping the most successfu...

New approaches to protecting transplanted organs make first steps toward patients

...milar to the way fetuses and tumors use IDO but Dr. Horuzsko has shown the dimer version comprised of two chemically attracted monomers or molecules is th...nt rejection in a mouse with a skin graft. He already has measured HLA-G dimer levels in the blood of more than 50 kidney transplant patients and found pr...

Immune Molecule Key to Preventing Organ Rejection

... Measuring HLA-G dimer may identify patients who need little, if any, imm...HealthDay News) -- An immune molecule called HLA-G dimer plays a powerful role in preventing the immune sys...nt. He and his colleagues found that when HLA-G dimer binds with its inhibitory receptor ILT4, it trigge...

Immune molecule that plays a powerful role in avoiding organ rejection identified

...ology and Cancer Virology, says of HLA-G dimer. dimer appears to be the most powerful among several know...ight a tumor. Measuring endogenous levels of HLA-G dimer may also help physicians identify which transplant...ional Academy of Sciences details that when HLA-G dimer binds with its inhibitory receptor, ILT4, it trigg...

Scientists Close To Identifying Anti-viral Drug for SARS

...r, for this screening process to work, the SARS proteinase inserted into the wells has to be active to begin with. Knowing the concentration range for dimer formation will therefore help researchers in their search for a compound to stop the virus. “Now that the stage is set, high-throughput screening can ...

DNA-bound p53 Tumor Suppressor Protein Structure Determined

...s, called a dimer, that then binds to a second p53 dimer in a similar way to create the precisely oriented ...imensional structure of the p53 protein bound as a dimer to DNA and used the structure to produce an accura...o core domains of a pair of p53 proteins forming a dimer tracks to a part of the protein often mutated in c...

New Role of COX Enzymes Discovered

...zymes in physiology and disease." "Perhaps this combination of COX enzymes will represent a new drug target," speculates Funk. "Blocking the COX dimer may alter the pattern of usefulness and/or safety that we associate with existing non-steroidal anti-inflammatory drugs." Funk, who has collaborated w...
Dimer in Medical Technology

TriLink Launches CleanAmp(TM) dNTPs for Hot Start PCR

...erase nucleotide incorporation until heat activated. The temperature dependent control of DNA polymerase extension vastly reduces mis-priming, primer dimer formation and other common deleterious effects. "We believe CleanAmp(TM) dNTPs will become the less expensive approach to high stringency PCR," s...

Monogram Announces Posters to be Presented at the 30th San Antonio Breast Cancer Symposium

...ecember 15th, 2007, 5.00 pm - 7.00 pm CST Abstract # 5002: Increased detection of breast cancer markers human epidermal growth factor receptor dimer and downstream signaling proteins utilizing the VeraTag technology with dextran modified antibodies. (Presenter: J. Wallweber) About HERmark...
Dimer in Medical Products

MIS/AMH ELISA Test

Description:... Mullerian Inhibiting Substance (MIS), also known as Anti-Mullerian Inhibiting Substance (AMH), is a glycoprotein dimer composed of two 72 kDa monomers linked by disulfide bridges (1). MIS/AMH belongs to the transforming growth factor-? (TGF-?) superfamily which include...
Company:Diagnostic Systems Laboratories, Inc.

FSH ELISA Test

Description:...mone (FSH) is a glycoprotein hormone secreted by the anterior pituitary gland. Like hCG, LH and TSH, the intact FSH molecule is a noncovalently-linked dimer consisting of alpha- and beta-subunits. Its production and secretion are stimulated by gonadotropin-releasing hormone (GnRH) from the hypothalamus. Gn...
Company:Diagnostic Systems Laboratories, Inc.

FSH IRMA Test

Description:...mone (FSH) is a glycoprotein hormone secreted by the anterior pituitary gland. Like hCG, LH and TSH, the intact FSH molecule is a noncovalently-linked dimer consisting of alpha- and beta-subunits. Its production and secretion are stimulated by gonadotropin-releasing hormone (GnRH) from the hypothalamus. Gn...
Company:Diagnostic Systems Laboratories, Inc.

LH ELISA Test

Description:...g hormone (LH) is a glycoprotein secreted by the anterior pituitary gland. Like the FSH, hCG and TSH, the intact LH molecule is a noncovalently-linked dimer containing alpha- and beta-subunits. These glycoproteins all have homologous alpha-subunits, however each hormone has a unique beta-subunit. Both LH a...
Company:Diagnostic Systems Laboratories, Inc.

LH IRMA Test

Description:...g hormone (LH) is a glycoprotein secreted by the anterior pituitary gland. Like the FSH, hCG and TSH, the intact LH molecule is a noncovalently-linked dimer containing alpha- and beta-subunits. These glycoproteins all have homologous alpha-subunits, however each hormone has a unique beta-subunit. Both LH a...
Company:Diagnostic Systems Laboratories, Inc.
Dimer in Biological News

UCSF researchers identify new drug target for Kaposi's sarcoma

...urface of the dimer, but the herpes virus protease dimer has consistently eluded efforts to disrupt it at i...find ways to instead prevent the two halves of the dimer from connecting at that clamshell joint, to preven...ially unfolded protein to keep it from forming the dimer interface. Herpes viruses make up one of the mo...

New computer simulation helps explain folding in important cellular protein

...arch team developed a two-step Monte Carlo procedure to investigate, for glycophorin A (GpA), an important biochemical process called dimerization. (A dimer in biology or chemistry consists of two structurally similar units that are held together by intra- or intermolecular forces.) "One particularly p...

Researchers observe single protein dimers wavering between two symmetrically opposed structures

...of Ohio State University, has shown that a protein dimer made up of two identical parts can actually twist ... anti by twisting one of the protein copies in the dimer by 180 degrees. Additionally, by using a more comp.... These direct observations show that this protein dimer has two native structures available to it, and tha...

The structure of the Mre11 protein bound to DNA

...ers found is that in both complexes two Mre11 proteins worked together as a dimer, forming a U-shaped structure. In the synaptic complex, the U-shaped dimer binds to two DNA double helices. The branching complex binds to the single helix that is unraveling at the point where forking has been interrupted. ...

New synthetic form of protein holds promise to stop cancer spread

...ould happen if the normal CXCL12 and locked CXCL12 dimer were combined. The combined molecule had the oppo...n says the next step is establishing if the CXCL12 dimer could be effective in inhibiting the spread of can...lp us design experiments to find out if his CXCL12 dimer could interfere with the spread of cancer." Whi...

Media highlights in the November issues of Biophysical Journal

... High-resolution structure of a Na+/H+ antiporter dimer obtained by pulsed EPR distance measurements D...omponents are known beforehand. It is applied to a dimer of the membrane transport protein NhaA, which is r...on of NhaA critically depends on dimerization, the dimer structure provides new insight into the mechanism ...

Structure determined for p53 tumor suppressor protein as bound to DNA for anti-cancer activity

...s, called a dimer, that then binds to a second p53 dimer in a similar way to create the precisely oriented ...imensional structure of the p53 protein bound as a dimer to DNA and used the structure to produce an accura...o core domains of a pair of p53 proteins forming a dimer tracks to a part of the protein often mutated in c...

Scientists get first glimpse at how plants, most animals repair UV-damaged DNA

...t with the right shape and size to accommodate the dimer for the repair. Normally, the enzyme wouldn't be a...yme cause the portion of the DNA that contains the dimer to flip outwards from the coil and into the pocket... DNA bases can recover their original form and the dimer will be gone, as if the UV damage never occurred,"...

Malaria mechanism revealed

...horin A receptor are required for RII binding and for the invasion of red blood cells by the malaria parasite. The new results showed that each RII dimer binds six glycans. Interestingly, these glycans were discovered to be sandwiched between surfaces where the two RII molecules bind to each other when ...
Dimer in Biological Technology

Encouraging high-risk research: DFG approves funding for 2 new Reinhart Koselleck projects

...great importance to basic research. For instance, the two atoms in a helium dimer are very weakly bonded and have an interatomic spacing of about 100 atomic radii making the helium dimer the largest known molecule that exists. It has been proposed that helium tr...

A single VSOP can do a 'proton' magic!

...ne form a multimeric complex to make an assembling hole to carry ions though it. Surprisingly, the research group found that this VSOP protein forms a dimer but each single subunit can carry proton without any assembling hole. They concluded it by using the techniques of FRET (Fluorescence Resonance Energy...

WallSt.net (www.wallst.net) Announces Upcoming Interview With CEO of DNAPrint Genomics

...services are also offered externally to biopharmaceutical companies. The Company's first theranostic product is PT-401, a "Super EPO" (erythropoietin) dimer protein drug for the treatment of anemia in renal dialysis patients (with end stage renal disease). DNAPrint is proud of its continued dedication to d...

Mobile Phase Optimization for the Analysis of an Antibody-Based Fusion Protein and Aggregates using a TSKgel Super SW3000 Size-Exclusion Column

...nt with the use of 0.2M NaCl. Additionally, the expected protein dimer and trimer aggregates are not visible in the chromatogram. By switching ...ffer concentration, less peak tailing and distinct peaks for the dimer and trimer species of MAb1 resulted. Doubling the perchlorate co...

Purification and Characterization of beta-Lactoglobulin Genetic Variants A and B Using Preparative Electrophoresis and Isoelectric Focusing

... However, βLG is not found in human milk. 5, 6, 7, 8 βLG is a glycoprotein which exists at the normal pH of bovine milk as a dimer with a molecular weight of 36,000, and consists of two monomeric subunits with molecular weight of 18,000 (162 residues). Severa...

A Multiple Mutation Model System as a Test Development and Training Tool for Denaturing Gradient Gel Electrophoresis

...s the general principles of PCR primer design with respect to sequence specificity, lack of internal homology and minimal primer dimer formation. In addition, a GC-rich sequence or clamp is often appended to one of the primers. Such a clamp can be of various leng...

Mutation detection for the K- rasand P16 genes

...is of the exon 3 region of the P16 gene was researched. At first, the discovery of multiple bands on the chip image was thought to be primer dimer or an annealing stringency problem. After comparing normal and mutated samples from DNA sequencing data to the Agilent data, the correspondence ...

General Notes on Primer Design in PCR*

... the middle regions of two primers can interfere with hybridization. If the homology should occur at the 3' end of either primer, Primer dimer formation will occur which, more often than not, will prevent the formation of the desired product via competition. ...
Dimer in Biological Products

Mouse Anti-PRKAR2 Monoclonal Antibody, Unconjugated, Clone RS17 from GeneTex

Description:...holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits o...
Company:GeneTex

Mouse Anti-Lambda Free Light Chain Monoclonal Antibody, Unconjugated, Clone 3D12 from GeneTex

Description:...f light chains of human immunoglobulin. Specificity: Specific for independent constantly expressed epitope of lambda chain. Reacts with monomer and dimer forms of free lambda chains but not with lambda chain-bearing immunoglobulins....
Company:GeneTex
Dimer in Biological Definition

Dimer

Sucrose , or common table sugar, is composed of glucose and fructose. A dimer is a molecule composed of two subunits linked together. It is a special case of a polymer . Among the most common dimers are certain types of sugar ; sucrose , for example, is a dimer of a glucose ...

Amino acid

...e very uncommon amino acids, which can be found in peptidic antibiotics (e.g. nisin or alamethicin ). Lanthionine is a sulfide-bridged alanine dimer which is found together with unsaturated amino acids in lantibiotics (antibiotic peptides of microbial origin). 1-Aminocyclopropane-1-carboxylic a...

Lambda phage

...2 OR1 cro gene The lambda repressor is a dimer also known as the cI protein. It regulates the tra...lytic cycle if cro proteins predominate. The cI dimer may bind to any of three operators, OR1, OR2, and ...3, in the order OR1 > OR2 > OR3. Binding of a cI dimer to OR1 enhances binding of a second cI...
Dimer in Biological Dictionary

Dimer

A dimer is a chemical or biological entity consisting of two structurally similar subunits called monomers, which are held together by either intramolecular forces or weaker intermolecular forces. D- dimer is a fibrin degradation product, a small protein fragment present in the blood after ...

UvrA

... Two UvrA proteins form a dimer and they both have ATPase/GTPase activity. The UvrA dimer binds with UvrB and forms a trimer which is able ...tor in bacterial ... We also show that the UvrA dimer has a high preference of binding the end of a ......

Tubulin

...stitute ... For maximal rate and extent of polymerisation into microtubules, tubulin requires GTP. ... Microtubules are polymers of tubulin , a dimer of two 55-kDa subunits, designated ... rate and extent of polymerisation into microtubules, tubulin requires GTP. ... Confocal immunofluorescent...

Thymine

...d by methylation of uracil at the 5th carbon. In RNA,... A thymine dimer is the covalent bonding of two adjacent thymine residues within a DNA mol...e thymine in mRNA (messenger ribonucleic acid) ... ( synthetic thymine dimer DNA fragments, blended into suntan lotion, ... Pyrimidine bases are C...

MutS

... MutS forms a dimer (MutS2) that recognises the mismatched base on the daughter ... The crystal structure of MutS reveals that it is exceptionally asymmetric, and ...

MSH2

...oteins (clear filter) ... ... analysis of HeLa cells using MSH2 (D24B5) XP™ Rabbit mAb (green) ... MSH2 (MutS homologue 2) forms the hMutS-α dimer with MSH6 and is an essential ... Feedback / suggest a new topic for MSH2 . Search: Summary Information ... Medline Search: hereditary nonpolyp...

Heteroduplex Dna

...chnique to screen for sequence variants in diploid DNA . ... DNA mixtures are amplified by PCR for heteroduplex detection, ... ... a MutS dimer and a DNA heteroduplex are converted ... unmodified strand of hemimethylated heteroduplex DNA is subject to correction, ... Heteroduplex ...

Disulfide bridge

...,biology terms,biology abbreviations ... disulfide bridge A covalent cross link between two ... Interestingly, the disulfide bridge -linked dimer was completely absent in the ... This inhibited completely the disulfide bridge -linked dimerization of the ... What is disulfide ? Meaning of...
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