Dihydrotestosterone

Research Findings on Nine GlaxoSmithKline Cancer Compounds to be Presented at ASCO 2009

... (R) (dutasteride) Dutasteride inhibits both type 1 and type 2 5-alpha reductase isoenzymes, which are responsible for converting testosterone to dihydrotestosterone (DHT), the most potent male hormone in the prostate. Basic science studies indicate that both types of the enzyme - type 1 and type 2 - are present in...

New ASCO/AUA guideline recommends men and their doctors discuss using 5-ARIs to reduce prostate cancer risk

...e disease should talk to their doctors about using a 5-alpha reductase inhibitor (5-ARI) to prevent the disease. 5-ARIs lower the level of the hormone dihydrotestosterone (DHT), which can contribute to the growth of prostate cancer. This guideline aims to provide a useful tool for clinicians and their patients in mak...

Drugs May Help Healthy Men Lower Prostate Cancer Risk

...5-alpha reductase inhibitors (5-ARI). These drugs -- which include finasteride (Propecia), used to treat male pattern baldness -- can reduce levels of dihydrotestosterone (DHT), a hormone that spurs prostate cancer development. Previous studies have been shown that 5-ARIs reduce risk of contracting the illness by 25 ...

Relationship between prostate information and lower urinary-tract symptoms evident

... the risk of biopsy-detectable prostate cancer. Dutasteride is a 5-alpha-reductase inhibitor, a drug that inhibits the conversion of testosterone into dihydrotestosterone (DHT), a hormone that may cause benign prostatic obstruction. The trial involves men with a negative prostate biopsy. The men were given either dutast...

How DDT metabolite disrupts breast cancer cells

...ect on the proliferation of MCF7-AR1 cells, an estrogen responsive cell line genetically engineered to over express the AR. Adding the potent androgen dihydrotestosterone together with estradiol to the cell culture medium decreased the recruitment of CAMA-1 cells in the S phase and the expression of ESR1 and CCND1, by ...

Enlarged Prostate Treatment Study Shows Combination of AVODART(R) and Tamsulosin Provides Greater Benefit Than Either Medication Alone

... dual 5ARI for the treatment of enlarged prostate, inhibits both the type I and type II isoenzymes responsible for the conversion of testosterone into dihydrotestosterone (DHT). DHT is the primary male hormone responsible for the enlargement of the prostate. AVODART suppresses DHT by 93 percent at 2 years. AVODART is ...

Coffee Could Help Cure Baldness

...ew at a much slower rate. The scientists believe caffeine affects hair cells in such a way that they are able to resist the damaging effects of dihydrotestosterone (DHT), a chemical that contributes to baldness. Most baldness is caused when hair follicles are exposed to too much DHT, the researchers said. ...

Hair-Growth Drug Artificially Lowers Psa Levels in Prostate Cancer Screening

...drogenic alopecia), Dr. Roehrborn said. Both BPH and male-pattern hair loss have to do with the male hormone testosterone, which is being converted to dihydrotestosterone (DHT) by an enzyme named 5-alpha reductase. DHT activates the genes responsible for the development of male-pattern hair loss. Finasteride interferes ...

Dihydrotestosterone in Medical Technology

Dendreon Presents Preclinical Data Demonstrating Activity of TRPM8 Agonist, D-3263, in Benign Prostatic Hyperplasia

...ride resulted in lower prostate weights than either agent given alone, suggesting a potential additive effect. BPH-induced animals showed increases in dihydrotestosterone (DHT) concentrations in the plasma, levels of which were reduced in animals treated with D-3263, finasteride or a combination of the two. While finas...

Study Shows Combination Therapy Incorporating AVODART(R) and Tamsulosin Provides Continuous Symptom Improvement Over 2 Years

... dual 5ARI for the treatment of enlarged prostate, inhibits both the type I and type II isoenzymes responsible for the conversion of testosterone into dihydrotestosterone (DHT). DHT is the primary male hormone responsible for the enlargement of the prostate. AVODART provides the power to suppress DHT by 93 percent at 2 ...

Dihydrotestosterone in Medical Products

SHBG IRMA Test

Description:...globulin (SHBG) is a serum glycoprotein which binds several sex steroids with relatively high specificity and low capacity, including testosterone and dihydrotestosterone (combined 95% bound to SHBG) and, to a much lesser extent, estradiol [1]. SHBG specifically binds C18 and C19 steroid structures and regulates the bio...
Company:Diagnostic Systems Laboratories, Inc.

Androstanediol Glucuronide RIA Test

Description:... Androstanediol glucuronide (3alpha-diol G) is the glucuronide conjugate of 3alpha-androstanediol, a major metabolite of dihydrotestosterone (DHT) [1,2]. 3alpha-diol G has strong androgenic activity estimated at 75% of the bioactivity of testosterone [2]. Serum 3alpha-diol G is the product ...
Company:Diagnostic Systems Laboratories, Inc.

Androstanediol Glucuronide EIA Test

Description:... Androstanediol glucuronide (3alpha-diol G) is the glucuronide conjugate of 3alpha-androstanediol, a major metabolite of dihydrotestosterone (DHT) [1,2]. 3alpha-diol G has strong androgenic activity estimated at 75% of the bioactivity of testosterone [2]. Serum 3alpha-diol G is the product ...
Company:Diagnostic Systems Laboratories, Inc.

Dihydrotestosterone in Biological News

New medications show promise in treating drug-resistant prostate cancer

...shington and Medivation. About 186,000 new cases of prostate cancer are diagnosed each year in the United States. The male hormones testosterone and dihydrotestosterone -- also known as androgens -- spur the growth of prostate cells, and drugs that block the receptors for these hormones are the most common treatment f...

Hair-growth drug artificially lowers PSA levels in prostate cancer screening, study finds

...drogenic alopecia), Dr. Roehrborn said. Both BPH and male-pattern hair loss have to do with the male hormone testosterone, which is being converted to dihydrotestosterone (DHT) by an enzyme named 5-alpha reductase. DHT activates the genes responsible for the development of male-pattern hair loss. Finasteride interferes ...

Dihydrotestosterone in Biological Technology

FDA Approves GlaxoSmithKline's AVODART(R) in Combination with Tamsulosin for the Treatment of Symptomatic Enlarged Prostate

... dual 5ARI for the treatment of enlarged prostate, inhibits both the type I and type II isoenzymes responsible for the conversion of testosterone into dihydrotestosterone (DHT). DHT is the primary male hormone responsible for the enlargement of the prostate. AVODART suppresses DHT by 93 percent at 2 years. AVODART is in...

Sex Steroid Regulation of Vasopressin Levels Secreted by hNT Neurons*

...ical and supraphysiological levels of estrogen, testosterone and dihydrotestosterone ( table 1 ). Cell culture media was collected at 6, 24 and 48 ho... steroids to monitor sex steroid alterations in protein synthesis. dihydrotestosterone appeared to be the most potent initiator of protein synthesis in...

Dihydrotestosterone in Biological Definition

Hormone

... Sex steroids Androgens testosterone dehydroepiandrosterone (DHEA) dehydroepiandrosterone sulfate (DHEAS) androstenedione dihydrotestosterone (DHT) Estrogens estradiol Progestagens progesterone Progestins Sterol hormones Vitamin D derivatives calci...