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Differentially in Medical News

New Analysis: Women of Low Socio-Economic Status Face Unique Challenges Related to Smoking, Smoking Ban Policies

...plement . "Collectively, the papers in this special issue draw attention to the need for lawmakers to consider how the policies they enact may differentially affect less powerful groups in our society. For example, weak provisions for enforcing smoke-free workplaces may result in low SES female bartenders ...

A 'Heart Healthy' Diet and Ongoing, Moderate Physical Activity May Protect Against Cognitive Decline as We Age

... In their analysis, the researchers found that physical activity was associated with enhanced cognitive function, and that this relationship was differentially influenced by the person's APOE genotype: non-E4 carriers and people with one copy of E4 performed better than people with two copies of E4. After adj...

Mayo Clinic study using structural MRI may help accurately diagnose dementia patients

... ROCHESTER, Minn. -- A new Mayo Clinic study may help physicians differentially diagnose three common neurodegenerative disorders in the future. The study ...ith a unique pattern of atrophy specific on MRI, then it may be possible to differentially diagnose new patients. The study looked at 90 patients from the Mayo Clinic...

Mayo Clinic Study Using Structural MRI May Help Accurately Diagnose Dementia Patients

...y 11 /PRNewswire-USNewswire/ -- A new Mayo Clinic study may help physicians differentially diagnose three common neurodegenerative disorders in the future. The study ...ith a unique pattern of atrophy specific on MRI, then it may be possible to differentially diagnose new patients. The study looked at 90 patients from the Mayo Clinic...

Deep Budget Cuts Will Add to Unemployment Rolls at Wrong Time

...rease even less harmful to employment than deep spending cuts. Pennsylvania could target its income tax increase to higher-income earners, through a differentially higher tax on investment income (such as dividends, capital gains, and net profits), Price noted. This can be done in Pennsylvania without a constitut...

VBI researchers develop new method for breast cancer biomarker discovery

... hormone, and tamoxifen, a non-steroidal drug commonly prescribed in hormonal breast cancer therapy. The work resulted in the identification of 16 differentially expressed proteins, which demonstrated the effectiveness of the method for biomarker discovery and also allowed for the establishment of a link betwee...

Research finds photos more useful than words

...ients with AD, allowing them to live more engaged and independent lives," added Ally. "Overall, the current results have shown that pictures and words differentially affect how memorial decisions are made in patients with aMCI. Pictures have a clear memorial advantage over words, but the debate as to why is far fro...

Throwing the micro switch: MicroRNA may link smoking risk gene to neurobiology of addiction

...at mediate the actions of the neurotransmitter dopamine, is associated with tobacco dependence, and that two alleles of a variant within this gene are differentially expressed. "In the current study, we demonstrated that such differential expression of DRD1 is regulated by microRNA miR-504," explains Dr. Li. I...

2009 ESCEO-IOF Alliance for Better Bone Health Young Investigator Award presented to Dr. Nick Harvey

... of Sanofi-Aventis and Stephane Horlait of P&G Pharmaceuticals at an award ceremony on March 21, 2009. Entitled "Indices of intrauterine growth may differentially predict postnatal development of skeletal size and volumetric density", the award-winning abstract describes the results of a study on 380 children fo...

Policy experts urge scrutiny of senior tax breaks

...th a careful review," said PPAR Editor Robert Hudson, PhD. The new PPAR devotes four articles to addressing the twin questions of how tax codes differentially affect older people than others and whether such treatment is consistent with the original intent of these provisions. Among the authors are economist...
Differentially in Medical Technology

Basic Science Discoveries Yield Progress in Hepatology

...ook at different gene expression profiles of patients with the same disease and realize that there are different clusters which may be associated with differentially aggressive disease. For example, in the field of cancer, varying gene expression profiles are linked to better and worse prognoses for hepatocellular ...

Karmanos Cancer Institute Research Supports Role of Inflammation to Determine Lung Cancer Risk, Particularly in African-American Women

...African-American women. (Logo: http://www.newscom.com/cgi-bin/prnh/20071106/KARMANOSCANCERINSTITUTELOGO ) The abstract titled, Cytokine SNPs differentially Predict Risk of Non Small Cell Lung Cancer in African American and Caucasian Women, was given at the American Association for Cancer Research (AACR) A...

Preclinical Studies Show Potential Progress Toward Identifying Specific Tumor Types With Higher Likelihood of Demonstrating Response to Anti-Cancer Compounds Early in Clinical Development

..., M.D., Ph.D., Chief of the Laboratory of Molecular Pharmacology at the Center for Cancer Research at the NCI evaluated various cell lines known to be differentially sensitive to ecteinascidin 743 (a minor groove binder). Data showed that brostallicin retained potent cytotoxicity in the submicromolar range in cell ...

Prolexys Pharmaceuticals Initiates Phase 1 Study

...e MIT/ Whitehead Institute in January 2005. Erastin was identified as a potential anti-cancer therapeutic in a screen against cell lines engineered to differentially express several oncogenes (cancer genes), including activated RasV12 (Cancer Cell 3, 285-96, 2003). Extensive medicinal chemistry efforts at Prolexys ...
Differentially in Medical Dictionary

Gene

...s ... We also compared gene expression patterns in astrocytes with those in human HeLa ... To identify functionally related gene sets that are differentially perturbed in ... This procedure generates an enrichment score (ES) for each gene set. ... Information about gene in the free online English di...
Differentially in Biological News

A 'heart healthy' diet and ongoing, moderate physical activity may protect against cognitive decline

...pe. In their analysis, the researchers found that physical activity was associated with enhanced cognitive function, and that this relationship was differentially influenced by the person's APOE genotype: non-E4 carriers and people with one copy of E4 performed better than people with two copies of E4. After adj...

Pitt team first to profile genes in acutely ill idiopathic pulmonary fibrosis patients

... lead author Kazuhisa Konishi, M.D., a visiting postdoctoral fellow in Dr. Kaminski's lab who performed the gene profiling. "But nearly 600 genes were differentially expressed between IPF patients who had accelerated disease and those who were stable." There was no evidence that infection or inflammation was the...

Will IVF work for a particular patient? The answer may be found in her blood

... expression profiles in blood of patients at the time of pituitary down-regulation showed interesting patterns of gene clustering. Over 200 genes were differentially expressed in patients who went on to achieve an IVF pregnancy compared with those who did not," she said. The researchers found that the periphe...

The evolutionary foundation of genomic imprinting in lower vertebrates

...that, as mammalian Igf2 CpG island, goldfish Igf2 CpG island has a parental differentially methylated region (DMR). These results indicate that the evolutionary found...that, as mammalian Igf2 CpG island, goldfish Igf2 CpG island was a parental differentially methylated region that was hypermethylated in sperm but unmethylated in egg...

New findings in taste and smell

...rimination in mouse models of schizophrenia Taste responsive multipolar and elongated neurons in hamster nucleus of the solitary tract (NST) project differentially to targets in the brainstem: an in-vivo intracellular recording, labeling, and tracing study Pregnancy and olfactory sensitivity Expansion, engraf...

The medium is the message: Manipulating salmonella in spaceflight curtails infectiousness

...to microgravity. Interestingly, many of the 167 differentially expressed genes observed in the space-traveling mi...ch." Hfq is known to regulate one third of the 167 differentially expressed genes in the spaceflight LB cultures. I...umber of Hfq-regulated genes were also found to be differentially expressed in the M9 flight samples. In addition to...

Abuse of painkillers can predispose adolescents to lifelong addiction

...12 years old or older have used a prescription opiate illicitly. "Despite the early use of these drugs in young people, little is known about how they differentially affect adolescent brains undergoing developmental change," says Kreek. "These findings gives us a new perspective from which to develop better strateg...

American Chemical Society's Weekly PressPac -- Aug. 27, 2008

...ctions. These proteins could be used as the basis for new medications to prevent infection, the scientists suggest. ARTICLE # 4 "Identification of differentially Expressed Proteins in the Cervical Mucosa of HIV-1-Resistant Sex Workers" DOWNLOAD FULL TEXT ARTICLE http://dx.doi.org/10.1021/pr800406r CON...

September 2008 Biology of Reproduction highlights

...in animals. Jiajun Feng, Mark A. Lawson, and Philippa Melamed. A Proteomic Comparison of Immature and Mature Gonadotrophs in Mice Reveals Novel differentially Expressed Nuclear Proteins That Regulate Gonadotropin Gene Transcription and RNA Splicing. Biol Reprod 2008; 79:546-561. Published online in BOR-...

Little teeth suggest big jump in primate timeline

...ne lower molar. "From the tooth size and structure we can say something about the animals' body weight and diet, because teeth have crests that are differentially developed depending on whether they ate primarily insects, leaves or fruit," he said. But without more body parts, Kay and Williams declined to deduce...
Differentially in Biological Technology

Identification of Differentially Expressed Gene Products with the CastAway System*

CastAway precast gels for fast analysis of RAP-PCR and differential display Douglas McKenzie and Douglas Drake Stratagene Cloning Systems, Inc. Stratagenes new CastAway precast sequencing gels were used to detect and isolate differentially expressed gene products amplified by...

Lumbar Matrix(TM) Scan From SpineMatrix(R) Revolutionizes the Diagnosis of Low Back Pain

... Matrix Scan collects thousands of bioelectrical signals from the back and reconstructs them into easily interpreted images, which helps physicians to differentially diagnose lower back pain by identifying disc, facet and muscle pathology. The FDA-approved procedure monitors and displays the bioelectric sign...

Axial Biotech Appoints Dr. Roberto Macina to Vice President of Research and Development

... Axial Biotech, Dr. Macina worked with the molecular diagnostics department at SmithKline Beecham in the discovery and characterization of novel genes differentially expressed in different cancers. "Dr. Macina's decision to join Axial strengthens our company's position as a major player in the molecular diag...

Many paths, few destinations: How stem cells decide what they'll be

...to look at the cells entire genome. Again, they found tremendous variability within the apparently uniform cell population: more than 3,900 genes were differentially expressed (turned on or off) between the low- and high-Sca-1 cells. And again, this variability was dynamic: the differences diminished over time, wit...

March of Dimes Awards $250,000 Prize to Leaders in Understanding Embryonic Development

...t of an organism, and how errors in this process lead to birth defects. His work with the Sonic hedgehog gene led to the first identification of genes differentially expressed on the left and right sides of the early embryo, a major breakthrough in understanding left-right asymmetry; as well as to an understanding ...

ARIUS presents new findings for anti-cancer antibody programs at AACR

...mors, as well as blood cancers. Our cancer stem cell antibody targeting CD9 differentially recognizes AML cancer stem cells compared to normal stem cells. Furthermore...n phosphorylation of several receptor tyrosine kinases. CD9 is highly and differentially expressed in AML versus normal CD34+CD38- stem cells. Experiments strongly ...

Human Genome Sciences Initiates Second Randomized Phase 2 Trial of HGS-ETR1 in Combination With Chemotherapy

...out Previous Results in Non-Small Cell Lung Cancer The results of in vitro and in vivo preclinical studies demonstrate that: (1) TRAIL receptor 1 is differentially expressed on non-small cell lung cancer (NSCLC) cells compared with normal cells; (2) HGS-ETR1 specifically binds TRAIL receptor 1 and triggers NSCLC ...

GeneNews initiates patient sample accrual for validation studies of colon cancer blood test

...e genes in patients with colorectal cancer could be differentiated from controls. Blood RNA samples from an Asian population were profiled to identify differentially expressed genes. This analysis yielded a combination of five genes that achieved sensitivity of 90% and specificity of 79% in the training set. Sinc...

ORNL super water repellent could cause big wave in market

...n said. The process for making superhydrophobic glass powder is based on differentially etching of two glass phases from phase-separated glass. Simpson starts with... heats to separate further. He then crushes this material into a powder and differentially etches the powder to completely remove the interconnected borate glass phas...

Kodak in vivo imaging system: precise coregistration of molecular imaging with anatomical X-ray imaging in animals

...d the microfocus X-ray generator emits a maximum energy of 35 Kvp for the desired imaging time (typically <30 s). The X-rays are differentially absorbed by bone and soft tissue, creating a projection of the animals anatomical structure on the phosphor screen. The bright-f...
Differentially in Biological Products

1-D PAGE Cleavable ICAT Reagent Applications Development Kit for Targeted Protein ID and Quantitation (monoplex Version) from Applied Biosystems

Description:...l Electrophoresis (PAGE), isotope-coded affinity tag chemistry, and cleavable-linker technology to facilitate the identification and quantification of differentially expressed proteins....
Company:Applied Biosystems

ImmEdge Hydrophobic Barrier Pen from Vector Laboratories

Description:...ge Pen provides a heat-stable, water-repellent barrier that keeps staining reagents localized on the tissue sections, prevents mixing of reagents when differentially staining two sections on the same slide, and allows use of less reagents per section....
Company:Vector Laboratories

Pyronin Y from Sigma-Aldrich

Description:... Application: Pyronin Y is most widely used in combination with methyl green to selectively and differentially stain nucleic acids following polyacrylamide gel electrophoresis. In a dichromatic dye solution, Pyronin Y stains RNA red, while methyl green stains D...
Company:Sigma-Aldrich

CompenFlow Flow Cytometry Compensation Kit 6 m from Molecular Probes (Invitrogen)

Description:... Using multicolor analysis in a modern flow cytometer, a scientist can resolve subsets of cells that are differentially labeled with fluorescent probes. However, the emission spectra of the dyes typically used for cell labeling are broader than the light collection wind...
Company:Molecular Probes (Invitrogen)
Differentially in Biological Definition

Chromatography

...in the solvent composition passing through the column is used to separate analyte mixtures, as a function of how well the changing solvent composition differentially mobilizes the analyte. For instance, using a water/methanol gradient, the more hydrophobic components will elute under conditions of relatively high ...

Developmental biology

... cell nucleus. Signal transduction pathways often involve receptors , receptor ligands and enzymes such as tampons. One key class of genes that are differentially regulated by transcription factors in different cell types are genes for cell adhesion proteins. Cell adhesion proteins are among the key regulators...

Morphogenesis

...erior-posterior axis of the fly is established by mRNA molecules that are differentially localized within the oocyte. The genes that code for these differentially localized oocyte mRNAs are called maternal effect genes . They have profou...

Morphogenesis

...erior-posterior axis of the fly is established by mRNA molecules that are differentially localized within the oocyte. The genes that code for these differentially localized oocyte mRNAs are called maternal effect genes . They have profou...
Differentially in Biological Dictionary

Neo-darwinism

...al selection acts on the heritable (genetic) ... mony of Neo - Darwinism . Each has significance for a revised view ... Neo - Darwinism . 57. by differentially preserving those random variants yielding smaller ... Darwinism , as developed by Weismann and other " Neo -Darwinists," came to the ... Neo - Da...

Expressed gene

...ssed Genes , IEEE/ACM Transactions on Computational Biology and ... PaGE, differentially expressed genes , microarray, pattern generation, q-values ... Extrac...e brain specific, the false positives are going to be ... the signal (truly differentially expressed genes ) to noise (spurious, non ... ...

Chaperone Proteins

...cle seems to rely on a precise concentration of a " chaperone " protein known as UNC-45, according to ... Individual chaperone proteins were differentially effective in their abilities ... Purification of Tumor-derived Chaperone Proteins . ... Chaperone Proteins Hsp70 and BiP Fold and Traffic Is...
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