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Dicer in Medical News

Low Levels of 2 Enzymes in Ovarian Cancer Cells Shortened Survival

...tment. The two enzymes examined in this study, dicer (so named because it dices up RNA) and Drosha, are...esearchers measured messenger RNA (mRNA) levels of dicer and Drosha in tissue samples from 111 patients wit...t 60 percent of cancer cells had low levels of the dicer gene, about half had low levels of Drosha, and abo...

MicroRNAs appear essential for retinal health

...f the forms or alleles of the gene that produces dicer in the retina, scientists were able to observe retinal development when dicer levels were half of normal or completely eliminated. Electrical activity in retinas devoid of dicer was abnormally low at the time of eye opening and ...

JCI online early table of contents: April 8, 2008

.... The generation of miRNAs is a complex process that involves a protein known as Dicer. In the study, mice expressing substantially lower levels of dicer than normal mice (Dicerd/d mice) were found to have only one defect the female mice were infertile. Infertility was a result of impaired functioning ...
Dicer in Biological News

October 2008 Biology of Reproduction highlights

..., an RNaseIII enzyme, plays a role in the biogenesis of microRNAs; recently there has been a flurry of activity to determine the developmental role of dicer by whole-organism and conditional gene disruptions. In a paper on p. 696 of this issue, Maatouk et al. add important new information to the emerging s...

Advanced genomics and proteomics improve the diagnosis and treatment of a deadly lung disease

...nal picture of an enzyme known as Dicer. In cells, dicer jumpstarts RNA interference, a process that causes...key developmental events. With the structure of dicer solved, Doudna's group showed that the enzyme is m...snips strands of RNA into precise increments. When dicer cleaves large strands of RNA into smaller fragment...

Molecule does more than slice and dice RNA

...nal picture of an enzyme known as Dicer. In cells, dicer jumpstarts RNA interference, a process that causes...key developmental events. With the structure of dicer solved, Doudna's group showed that the enzyme is m...snips strands of RNA into precise increments. When dicer cleaves large strands of RNA into smaller fragment...

Twin molecular scissors link creation of microRNAs with gene-silencing

...ger RNAs. In RISC, two of the three components, dicer and Argonaute 2, are enzymes bound together by the third member, TRBP. dicer cuts double-stranded precursor molecules shaped li...o a particular length of its target messenger RNA, dicer and TRBP then hand over the messenger RNA for cutt...

Micro-molecule plays big role in birth defects

...do their jobs, scientists believe an enzyme called dicer must be present. Harfe, who worked in collaboratio...y modified mice so that scientists could eliminate dicer in specific tissues at any stage in the developmen...f microRNAs in limb development. In cases where dicer is not present in developing limb tissue, Harfe sh...

Ancient immune defense mechanism is no match for HIV-1

... also can function as a suppressor of RNA silencing (SRS). Tat helps HIV-1 to elude the cell's natural RNAi defense by interfering with the ability of dicer to process dsRNAs. "Our results suggest that the dynamic interplay between RNAi and SRS remains physiologically conserved from plants and invertebr...
Dicer in Biological Technology

Nastech Assigns Intellectual Property Related to the Development of RNA-Based Therapeutics to its Subsidiary, MDRNA, Inc.

...onic lipids, and formulations; -- the RNA drug cargo, i.e., RISC and dicer substrate constructs; -- delivery chemistry, both covalent conjugates and...tech has exclusive and non-exclusive rights under a license in the field of dicer substrates for patent applications owned by City of Hope. -- 200502448...

RNA Interference and Gene Silencing: History and Overview

...an RNase that appears to be distinct from dicer (27 ). ... the target mRNA, generating a dsRNA substrate for dicer and thus more siRNAs (
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