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Dexamethasone in Medical News

Keryx Biopharmaceuticals Announces Agreement with FDA on a Special Protocol Assessment for Phase 3 Trial of KRX-0401 (Perifosine) in the Treatment of Multiple Myeloma

...ifosine Added to the Combination of Bortezomib and dexamethasone in Multiple Myeloma Patients Previously Treated wi...derable activity when combined with bortezomib and dexamethasone in heavily pre-treated patients with relapsed and ...-0401 to placebo when combined with bortezomib and dexamethasone in approximately 400 patients with relapsed or rel...

QLT announces positive results from the evaluation of Visudyne(R) combination therapy

... combination therapy with Lucentis with or without dexamethasone has the potential to significantly decrease patien...travitreal Lucentis (0.5 mg) and then intravitreal dexamethasone (0.5 mg); Half-fluence Visudyne (300mW/cm2 for 83 ...travitreal Lucentis (0.5 mg) and then intravitreal dexamethasone (0.5 mg); Half-fluence Visudyne (300 mW/cm2 for 83...

Combo Treatment Eases Wheezing in Babies

... Epinephrine, dexamethasone reduces hospitalization risk by 35%, study finds ...inephrine and six oral doses of the corticosteroid dexamethasone for five days; the second received nebulized epine...only group had to be admitted, 25.6 percent in the dexamethasone group were hospitalized, and 26.4 percent in the p...

3-Drug Combo Reduces Nausea After Chemo

...ylate (CM) to the conventional two-drug regimen of dexamethasone and ondansetron greatly reduces chemotherapy-induc...ng colorectal and pancreatic cancer. Drugs such as dexamethasone and ondansetron are effective in reducing CINV in ...e 3 study included 810 patients who were receiving dexamethasone and ondansetron after undergoing HEC. They were ra...

Cigarette smoke may alter immune response in COPD exacerbations

...ed if it would have an effect on the efficacy of treatment with the usual corticosteroids. Interestingly, they found that while the corticosteroid dexamethasone was effective in controlling the inflammation following bacterial challenge in both control and cigarette smoke-exposed mice, but it appeared to compr...

Preemies Exposed to Toxins in Liquid Meds

... adults is 20 g/day. When calculated by weight, this level was exceeded in 18 babies for at least one week. The study also found that all babies given dexamethasone exceeded the recommended levels of propylene glycol, which is about two-thirds the strength of ethanol. The seven infants with severe lung disease ...

QLT announces interim results of radical study evaluating Visudyne combination therapy

...2) followed within two hours by intravitreal Lucentis (0.5 mg) and then dexamethasone (0.5 mg) Group 3: Very low-fluence Visudyne (180mW/cm2 for 83 seconds t...2) followed within two hours by intravitreal Lucentis (0.5 mg) and then dexamethasone (0.5 mg) Group 4: Lucentis monotherapy (0.5 mg), mandatory injection fo...

Combo Therapy Helps Multiple Myeloma Patients

...new immunomodulatory drug called pomalidomide with dexamethasone (pom/dex) improved or stabilized disease in 76 per...omide orally a day for a 28-day cycle and 40 mg of dexamethasone orally on days 1, 8, 15 and 22. They also took 325...the U.S. Food and Drug Administration for use with dexamethasone for multiple myeloma patients who've had previous ...

Steroid After Tonsillectomy Raises Bleeding Risk

... But dexamethasone did limit vomiting and results are preliminary, re...thDay News) -- Children who were given the steroid dexamethasone after a tonsillectomy had less nausea and vomiting...dren undergoing [tonsillectomy] should not receive dexamethasone prophylactically unless an adequately designed, va...

New therapy prevents dangerous side effect for lymphoma patients

... new drug combinations against indolent B cell lymphoma that reduce myelosuppression. Two years ago, a combination of fludarabine, mitoxantrone and dexamethasone with rituximab and interferon alpha reduced the incidence of MDS to 4 percent of patients, down from a historical rate of around 10 percent. The ke...
Dexamethasone in Medical Technology

ECOG Phase III Newly Diagnosed Multiple Myeloma Trial (E4A03) Reports Lenalidomide Plus Low-Dose Dexamethasone Suggests Survival Advantage for Patients with Multiple Myeloma

SUMMIT, N.J., April 04, 2007 /PRNewswire-FirstCall/ -- Celgene Corporation announced that the Eastern Cooperative Oncology Group (ECOG) has reported that its Data Monitoring Committee's (DMC) review of preliminary results from a large, randomized clinical trial for patients with newly diagnosed mu...

Proteolix Presents Positive Clinical Data for Carfilzomib in Multiple Myeloma at the 2009 ASCO Annual Meeting

...f carfilzomib in combination with lenalidomide and dexamethasone during the "Lymphoma and Plasma Cell Disorders" po...omib in combination with lenalidomide and low-dose dexamethasone in relapsed and refractory patients. The combinat...tudy of carfilzomib plus lenalidomide and low-dose dexamethasone in relapsed and refractory multiple myeloma: Prel...

Neurobiological Technologies' Partner, Celtic Pharma, Announces Results of XERECEPT(R) Phase 3 Clinical Program

...studies are encouraging, both in terms of lowering dexamethasone use over the longer-term and the impact seen in me...acebo patients tolerated a 50 percent reduction in dexamethasone dosing much better than anticipated over this time...ver the twelve weeks of study duration in reducing dexamethasone dose levels. Fifteen percent of patients on XEREC...

Proteolix Presents Phase 1b/2 Clinical Data for Carfilzomib in Advanced Solid Tumor Patients at the 2009 ASCO Annual Meeting

... in collaboration with the Multiple Myeloma Research Consortium (MMRC). A Phase Ib clinical trial of carfilzomib in combination with lenalidomide and dexamethasone in patients with relapsed multiple myeloma is also ongoing. In addition, Proteolix is conducting a single-agent Phase 2 clinical trial of carfilzomib...

Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types

...ent data Abstract #8542: Panobinostat + lenalidomide and dexamethasone Phase I trial in multiple myeloma (MM) In this first Phase I c...ng, Orlando, FL. Spencer A, et al. Panobinostat + lenalidomide and dexamethasone Phase I trial in multiple myeloma (MM). Abstract #8542. American Society of...

Keryx Biopharmaceuticals, Inc. Reports Updated Phase 1/2 Data on KRX-0401 (Perifosine) in Combination with Bortezomib (+/- Dexamethasone) at the 12th International Multiple Myeloma Meeting

...ted "Perifosine in combination with bortezomib and dexamethasone continues to demonstrate an impressive response ra...ne (KRX-0401) in Combination with Lenalidomide and dexamethasone in Patients with Relapsed or Refractory Multiple M... Perifosine in combination with Revlimid(R) + dexamethasone continues to be well tolerated, with a median prog...

Keryx Biopharmaceuticals, Inc. Reports Phase 1/2 Data on KRX-0401 (Perifosine) at 50th Annual Meeting of American Society of Hematology

...ression at some point in their treatment and 20 mg dexamethasone (4 times per week) was added. Best response to ei...urable responses when combined with bortezomib and dexamethasone in a heavily pre-treated patient population. The ...ne (KRX-0401) in Combination with Lenalidomide and dexamethasone in Patients with Relapsed or Refractory Multiple M...

Prolonged Progression-Free Survival Demonstrated by VELCADE(R) (Bortezomib) for Injection Based Induction Regimens in Transplant-Eligible Previously Untreated Multiple Myeloma Patients

...S) was observed in one study comparing VELCADE and dexamethasone (VcD) with vincristine, adriamycin and dexamethasone (VAD), as well as in another study comparing VELCADE, thalidomide and dexamethasone (VcTD) with thalidomide and dexamethasone (TD). Th...

Novel VELCADE(R) (Bortezomib) for Injection Based Four-Drug Combination Was Well Tolerated In Previously Untreated Multiple Myeloma Patients

...yclophosphamide, the highest planned dose, 1.3 mg/m(2) of VELCADE, 40 mg of dexamethasone and 15 mg of lenalidomide. -- The only two dose-limiting toxicities....3 mg/m(2) on days 1, 4, 8 and 11 on a 21-day cycle for up to eight cycles; dexamethasone at 40 mg on days 1, 8 and 15; lenalidomide at 15 mg on days 1 through 14; a...

Novel Therapeutic Approaches May Transform Treatment and Improve Patient Outcomes in Several Platelet Disorders

...ve Randomi z ed Study Comparing Rituximab and dexamethasone Versus dexamethasone Alone in ITP: Results of Final A n alysis and ...ne that adding the immunotherapy drug rituximab to dexamethasone (a steroid that is a standard therapy for ITP) is ...
Dexamethasone in Medical Products

Androstenedione EIA Test

Description:... monitoring therapy of patients with congenital adrenal hyperplasia. J Pediatr 95: 33-37, 1979. Rittmaster RS, Thompson DL: Effects of leuprolide and dexamethasone on hair growth and hormone levels in hirsute women: the relative importance of the ovary and adrenal in the pathogenesis of hirsutism. J Clin Endocrin...
Company:Diagnostic Systems Laboratories, Inc.

Androstenedione RIA Test

Description:... monitoring therapy of patients with congenital adrenal hyperplasia. J Pediatr 95: 33-37, 1979. Rittmaster RS, Thompson DL: Effects of leuprolide and dexamethasone on hair growth and hormone levels in hirsute women: the relative importance of the ovary and adrenal in the pathogenesis of hirsutism. J Clin Endocrin...
Company:Diagnostic Systems Laboratories, Inc.

MAXITROL Ophthalmic Suspension

Description:... Neomycin and Polymyxin B sulfates and dexamethasone ophthalmic suspension is a multiple dose anti-infective steroid combination in sterile suspension form for topical applications....
Company:Falcon Pharmaceuticals, Ltd.

MAXITROL Ophthalmic Oinent

Description:... Neomycin and Polymyxin B sulfates and dexamethasone ophthalmic ointment is a multiple dose anti-infective steroid combination in sterile ointment form for topical applications....
Company:Falcon Pharmaceuticals, Ltd.

Fineline II Sterox Atrial J Model 4480

Features:... Steroid collar containing dexamethasone sodium phosphate. IROX coated electrodes provides low acute and chronic pacing thresholds. Coradial design, 55D polyurethane insulation. Preformed J....
Company:Guidant Corporation

Fineline II Sterox Atrial J Model 4479

Features:... Steroid collar containing dexamethasone sodium phosphate. IROX coated electrodes provides low acute and chronic pacing thresholds. Coradial design, 55D polyurethane insulation. Preformed J....
Company:Guidant Corporation

Fineline II Sterox Model 4459

Features:... Steroid collar containing dexamethasone sodium phosphate. IROX coated electrodes provides low acute and chronic pacing thresholds. Coradial design, 55D polyurethane insulation....
Company:Guidant Corporation

Fineline II Sterox Model 4456

Features:... Steroid collar containing dexamethasone sodium phosphate. IROX coated electrodes provides low acute and chronic pacing thresholds. Coradial design, 55D polyurethane insulation....
Company:Guidant Corporation

Fineline II Sterox Model 4458

Features:... Steroid collar containing dexamethasone sodium phosphate. IROX coated electrodes provides low acute and chronic pacing thresholds. Coradial design, 55D polyurethane insulation....
Company:Guidant Corporation

Fineline II Sterox Model 4457

Features:... Steroid collar containing dexamethasone sodium phosphate. IROX coated electrodes provides low acute and chronic pacing thresholds. Coradial design, 55D polyurethane insulation....
Company:Guidant Corporation
Dexamethasone in Medical Dictionary

Water On The Brain

...our brain is located. ... your doctor told you to take with a small sip of water . ... ... not possible to differentiate between the effects of dexamethasone on edema and ... 1. Bar graph of brain water content (%) ± s from negative controls ... Home " Dogs " The Pet Health Care Library " Hydrocep...
Dexamethasone in Biological News

The IMF says journal editorial documents dramatic increase in survival since the 1980s

...ith improved outcomes. "The benefits and comparisons are particularly interesting looking at the results with lenalidomide (Revlimid) plus low-dose dexamethasone (steroid) compared with prior results with interferon and levamisole. There is essentially a doubling of survival at two years, with preliminary evide...

Scientists tackle mystery mountain illness

...sufferer may need to be carried for miles on a stretcher, only to descend a few hundred feet. Other treatments include breathing oxygen and two drugs, dexamethasone and nifepidine, which may not be available when somebody becomes ill. Blood vessels inside the lungs constrict in response to low oxygen to such an...

First-degree fetal heart block may be reversible

...kers. Joshua Copel, M.D., professor in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale helped conduct the PR Interval and dexamethasone Evaluation (PRIDE) study with a team of other researchers to evaluate an early marker of cardiac injury before there is permanent scarring. The P...
Dexamethasone in Biological Technology

AEterna Zentaris Partner, Keryx, Announces Agreement with FDA on a Special Protocol Assessment for Phase 3 Trial with Perifosine (KRX-0401) for the Treatment of Multiple Myeloma

...ifosine Added to the Combination of Bortezomib and dexamethasone in Multiple Myeloma Patients Previously Treated wi...osine to placebo when combined with bortezomib and dexamethasone in approximately 400 patients with relapsed or rel... for perifosine in combination with bortezomib +/- dexamethasone in relapsed and refractory myeloma. About Spe...

AEterna Zentaris Discloses Preliminary Phase 2 Trial Results for Perifosine in Combination with Radiotherapy for Non-Small Cell Lung Cancer

... combination with capecitabine for advanced metastatic colon cancer (placebo-controlled), as well as for perifosine in combination with bortezomib +/- dexamethasone in relapsed and refractory myeloma. About AEterna Zentaris Inc. AEterna Zentaris Inc. is a global biopharmaceutical company focused on endoc...

Proteolix Presents Clinical Data from Two Clinical Studies of Carfilzomib in Multiple Myeloma at the 14th Congress of the European Hematology Association

...omib in combination with lenalidomide and low-dose dexamethasone in relapsed and refractory patients was presented ...f carfilzomib in combination with lenalidomide and dexamethasone administered on a 28-day treatment cycle. Lenalidomide in combination with dexamethasone is currently indicated for use in patients with mu...

Proteolix to Present Carfilzomib Clinical Data During the 2009 ASCO Annual Meeting

... carfilzomib (CFZ) plus lenalidomide (LEN) and low-dose dexamethasone (loDex) in relapsed and refractory multiple myeloma (MM): Prel...Phase Ib clinical trial of carfilzomib in combination with lenalidomide and dexamethasone in patients with relapsed multiple myeloma is also ongoing. In addition, P...

Palonosetron Warrants Adequate Caloric Intake in Oncology Patients Receiving High Emetogenic Chemotherapy

...a single dose of palonosetron, the second generation 5-HT3 antagonist, plus dexamethasone not only prevents chemotherapy-induced nausea and vomiting (CINV), but also...o. The findings confirmed the efficacy of a single dose of palonosetron and dexamethasone to control chemotherapy-induced nausea and vomiting (CINV) episodes in pati...

Proteolix Announces Positive Data From Two Ongoing Phase 2 Clinical Trials of Carfilzomib in Multiple Myeloma at the 50th Annual Meeting of the American Society of Hematology

...ond in relapsed patients stratified by prior treatment with bortezomib. A Phase Ib clinical trial of carfilzomib in combination with lenalidomide and dexamethasone in patients with relapsed multiple myeloma is also ongoing. In addition, based on promising Phase 1 results, Proteolix is conducting a single-agent P...

Visualizing asthma-causing immune cells at work

... produced by eosinophils known as MMPs. Using a combination of the sensitive optical sensor and fluorescence-mediated tomography, it was observed that dexamethasone (a drug used to treat severe asthma) decreased the number of eosinophils in the lungs of mice with allergic airway inflammation. As some of the imagin...

Millennium Over-Delivers on 2007 Goals and Financial Guidance

... 482 patients, the combination of VELCADE and dexamethasone (VcD) demonstrated a significantly higher... percent with vincristine, adriamycin and dexamethasone (VAD), a commonly used induction therapy ... combination of VELCADE, thalidomide, and dexamethasone (VcTD), as induction therapy prior to SCT...

Screening of Corticosteroids in Urine by Negative Atmospheric Pressure Chemical Ionization LC/MS/MS

...ide and fluorometholone-desoximethasone pairs also share their transitions, but are separated by their retention times. The epimeres betamethasone and dexamethasone have similar retention times and mass spectra, and they could not be separated in the LC/MS conditions described. Figure 1 (page 3) shows th...

Performance of Ad-A-Gene EGFP-Glucocorticoid Receptor (EGFP-GCCR): an adenoviral vector gene delivery system

...n was shown to alter in response to drugs, such as dexamethasone and prednisolone.

Quantitation of the EG...ma)

Test compounds dexamethasone (Sigma). 50-mM stock in ethanol; β-estradiol,...inetic live cell) Test compounds (e.g., 200-nM dexamethasone containing 2.5-μM Hoechst nuclear dye) were add...

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