Novel Photoconductive Cellular Depolarization Technology Reveals Insight Into Neuronal Growth, Guidance, and Regeneration

BOSTON, Jan. 30 /PRNewswire/ -- Neurosilicon's novel Photoconductive Stimulation Device (PSD) was highlighted in the recent scientific publication by Hung and Colicos titled, Astrocytic Ca2+ Waves Guide CNS Growth Cones to Remote Regions of Neuronal Activity. The article appearing in the November ...

Clues Found to Brain Mechanism Behind Migraines

...familial hemiplegic migraine (FHM), a subtype of severe migraine accompanied by the aura. Brain imaging has previously shown that strong neuronal depolarization creeps across the cerebral cortex during CSD, initially increasing electrical signals in the brain, then suppressing neural activity for an extended p...

Slices of living brain tissue are helping scientists identify new stroke therapies

...at engulf and engorge brain cells following a stroke. It's called anoxic depolarization and it primarily results from the brain getting insufficient blood and oxyg...Kirov is testing to see whether these sigma receptor ligands inhibit anoxic depolarization in humans to forecast translational success. ...

Tsunami in the brain

...e, even unaffected areas of the brain are at risk depolarization waves arise at the edges of the dead tissue and sp...rizations first proven in stroke patients The depolarization waves in the brain known as cortical spreading de...features are thus known from animals the waves of depolarization that can spread out at a speed of two to five mill...

Depolarization in Medical Technology

Novel Photoconductive Life Science Research Innovation Enables Rapid, Reproducible, and Non-Invasive Cellular Excitation

...s generated. This LFP can be harnessed to initiate depolarization in excitable cells without causing any damage to the cell. Further, the PSD induced depolarization can be applied at user-definable frequency, intens... while optical targeting enables highly controlled depolarization of only target cells. The PSD can also be used in ...

Depolarization in Medical Definition

Depolarization-induced suppression of inhibition

...of inhibitory currents could be invoked simply by depolarization of the target cell, this phenomenon was termed de...r whose synthesis or release was stimulated by the depolarization of the target cell. This messenger then diffused "... cerebellum, Kreitzer's group also discovered that depolarization of Purkinje cells could also cause a temporary red...

Depolarization in Medical Dictionary

EKG

...tery disease). Learn about causes like ... An EKG is taken of the person before, during, and after the stress tests. ... Visual of EKG with depolarization and Repolarizaton ... 12-Lead EKG Interpretation Tips ... Atrial Enlargement and Ventricular Hypertrophy EKG Characteristics ... An electrocar...

Depolarization in Biological News

Researchers uncover mechanisms of estrogen in promoting cell death in breast cancer

...e membrane of cell organelles called mitochondria. Estradiol increased the expression of several proteins on the membrane of cell mitochondria, led to depolarization of the mitochondrial membrane, and stimulated the release of a molecule called cytochrome c into the cell's interior, where it could activate several ...

Depolarization in Biological Technology

Receptor Binding Assays using Fluorescence Polarization Detection: the [FP]2TM Characterized Tracers

...ation that occurs over this time. The greater the rotation, the greater the depolarization of the excitation light leading to a smaller polarization signal. ...n occur over the fluorescence lifetime, which translates into a significant depolarization (small signal). In the intermediate cases of partially bound derivatized pe...

Depolarization in Biological Definition

Depolarization

In biology, depolarization refers to the event a cell undergoes when its membrane potential grows more positive with respect to the extracellular solution. Depolarization typically results from the influx of positively charged ions (such as sodium or calcium ) into the cell. Alternative...

Ion channel

...a favorite target. Diversity and activation Voltage-gated channels sense the transmembrane potential and open or close in response to depolarization or hyperpolarization , respectively. Examples include the sodium and potassium voltage-gated channels of nerve and muscle, and the voltage-gated ...

Neurotransmitter

...Within the cells , small-molecule neurotransmitter molecules are packaged in vesicles . When an action potential travels to the synapse, the rapid depolarization causes calcium ion channels to open. Calcium then stimulates the transport of vesicles to the synaptic membrane: the vesicle and cell membrane fus...

Depolarization in Biological Dictionary

Depolarization

In biology, depolarization is a change in a cell's membrane potential, making it more positive, or less negative. In neurons and some other cells, a large enough depolarization may result in an action potential. Hyperpolarization is the opposite of depolarization , and... Depolariz...

Sarcolemma

...a deep invagination of the sarcolemma , which is the plasma membrane, only found in skeletal and cardiac muscle cells. These invaginations allow depolarization of the membrane to quickly penetrate to the interior of the cell. ... a role in remodelling of sarcolemma , sarcoplasmic reticulum, and myofibril...

Hyperpolarization

... voltage changes across ... For example, hyperpolarization , in which the difference between the interior and ... Hyperpolarization reduced and depolarization increased the 5-HTH; the mean ... Hyperpolarization of the membrane decreased or caused no apparent change in 5-HTD. ... The hyperpolarization ...

Action potential

...diately after an action potential , in which it is difficult or ... The action potential is the all-or-nothing electrical ... This spike of depolarization represents the action potential . ... There is thus no loss of signal as an action potential travels along an axon. ... Textbook Reference ...