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Depletion in Medical News

Study of anti-CD20 therapy effective B cell depletion

B cells, precursors of autoantibody-secreting cells, have emerged as promising new therapeutic targets in autoimmune diseases, including rheumatoid arthritis (RA). In particular, B cell depletion with the anti-CD20 antibody rituximab seems to work for RA patients resistant to standard disease-mod...

Bionovo Presents Positive Results from Phase 1B Trial of Bezielle for Metastatic Breast Cancer

...reater production of reactive oxygen species in cancer cells. This results in high levels of DNA damage and the hyperactivation of PARP. The resulting depletion of NAD and ATP (PARP substrates), results in the inhibition of glycolysis, energetic collapse, and programmed necrosis. There are currently no ...

Wounded Warrior Project (WWP) Pushes for Senate Bill to Assist Family Caregivers of the Most Severely Injured Veterans

... Many family caregivers are struggling to care for their loved ones who have served our country, often to the detriment of their own health, the depletion of their finances, the loss of jobs and health care, and the endangerment of the family unit due to the emotional and economic toll. The caregiver iss...

Reduced ovarian reserve associated with increased risk of trisomic pregnancy

...ve. However, a woman's ovarian reserve is most likely to be mainly determined by her genes: the number of oocytes a woman is born with and the rate of depletion of her oocyte pool is believed to be heritable. This is reflected in the similar ages at menopause of mothers and daughters. However, exactly which ge...

Protein Branded As Culprit in Mad Cow Disease

...e neurodegenerative disease in which PrP is found in cell cytoplasm -- found that some brain cells lacked Mahogunin in these mice. A similar Mahogunin depletion did not occur if the scientists altered the PrP to avoid contact with the cytoplasm. "PrP probably interferes with other proteins, too. But our fin...

While you were sleeping

... "People look at people snoring and think it's funny. That has to stop." Professor Rae said it was still unclear why the body responded to oxygen depletion in this way. It could be a form of ischemic preconditioning at work, much like in heart attack sufferers whose initial attack makes them more protecte...

HeartMath Launches a Certification Program for Health Professionals that Targets Patients' Stress and Anxiety

...otional patterns that result as stress-producing perceptions, thoughts and feelings. Without these fundamental changes, any relief from stress, system depletion and reduced well-being will likely be short-lived." HeartMath introduced the first affordable consumer emWave® HRV technology in 1999. Th...

Light Sciences Oncology Announces Results of Study on Immunotherapeutic Mechanism of Aptocine(TM), a Novel Light-Activated Drug Therapy for Cancer

...ferred immune protection. The systemic effect is mediated at least in part by CD8+ T-cells; enrichment in T-cell transfer increased effect and depletion eliminated effect. ASCO Poster Details Title: Characterization of an antitumor immune response after light-activated drug thera...

Actuaries: Trustees' Reports Warn of Looming Financial Challenges Facing Retirement Programs

... Trust Funds Closer to depletion According to Latest Projections WASHINGTON , May 12 /PRNewswire-USNewswire/ -- The 2009 Social Security and Medicare trustees' reports issued e...

EaglePicher Medical Power Announces New Li/CFx Battery Technology

...the market. The technology includes a proprietary new Elective Replacement Indicator (ERI) / End of Life (EOL) Indicator to accurately predict battery depletion six months in advance, potentially requiring fewer replacement surgeries over time. "This enhanced chemistry delivers several benefits - to devi...
Depletion in Medical Technology

Trius Announces Positive Results From Phase 2 Clinical Trial of Torezolid in Patients With Complicated Skin and Skin Structure Infections

... key markers of oxazolidinone safety, the 200 mg dose of torezolid was comparable to placebo while the labeled dose of linezolid produced the expected depletion of platelets and other cell lines. It is also encouraging that the efficacy of the 200 mg dose in patients is consistent with the dose predictions bas...

Celladon Corporation Announces Presentation of First-in-Human Gene Transfer to Treat Heart Failure at the 12th Annual Meeting of the American Society of Gene Therapy

...day, May 28 at the 2009 American Society of Gene Therapy Annual Meeting, San Diego Convention Center. "A key underpinning of heart failure is the depletion of SERCA2a enzyme in heart muscle cells, which results in abnormal intracellular calcium cycling and poor contractility," said Zsebo. "Our research sh...

Ongoing Landmark ROADMAP Study Demonstrates Significant Improvement in Blood Pressure Control at One Year, According to Blinded Results

...ts are recommended with BENICAR in elderly or in moderate to marked renal impairment*/hepatic dysfunction -- In patients with possible depletion of intravascular volume (eg, patients on diuretics, particularly with impaired renal function), BENICAR should be initiated under close medical superv...

New Data Shows Blood Pressure Reduction Therapy with BENICAR(R) and BENICAR HCT(R) Effectively Reduces Blood Pressure in Elderly Patients to Target Blood Pressure

...are recommended with BENICAR in elderly or in moderate to marked renal impairment*/hepatic dysfunction -- In patients with possible depletion of intravascular volume (eg, patients on diuretics, particularly with impaired renal function), BENICAR should be initiated under close medical superv...

Pharmaxis Announces Positive Results of Phase 3 Cystic Fibrosis Trial

...ria. In CF, an inherited disease, a defective gene disrupts ion transport across the epithelial membrane within cells. In the lungs, this leads to a depletion of the airway surface liquid that normally bathes the cilia, and a resultant reduction in mucociliary clearance. The result is thick, sticky mucus th...

Isis and Collaborators Present New Research at the ATVB Annual Conference

... have elevated levels of triglycerides and apoC-III. Isis scientist, J. Crosby, presented new research titled "Antisense oligonucleotide-mediated depletion of Factor XI results in effective anticoagulation with a favorable risk/benefit profile in mice" demonstrating that antisense drugs that inhibit Facto...

InCode BioPharmaceutics, Inc. Announces Key Data Supporting New Treatment of Paroxysmal Nocturnal Hemoglobinuria (PNH)

...old by Alexion Pharmaceuticals, Inc. rC3-1 promotes the enzymatic partial depletion of C3, the hub of the complement cascade. Complement protein C3 is the mast... Asthma, Rheumatoid Arthritis, and autoimmune and inflammatory diseases. C3 depletion has also been demonstrated as a useful adjuvant to surgery, transplantation...

Medarex Highlights Strength in Antibody Development and Underlying Pipeline Strategy at R&D Day Event in New York City

...ced antibody effector function that selectively binds to CD19, a molecule expressed on a broad range of B-cell malignancies. MDX-1342 also induces the depletion and elimination of B-cells for inflammatory disease indications. Phase 1 trials in chronic lymphocytic leukemia and rheumatoid arthritis are ongoing w...

Trubion Pharmaceuticals Announces Presentation of Positive TRU-015 and SBI-087 Data at the 2008 Annual European Congress of Rheumatology Meeting

...) treatment for RA, resulted in more potent B-cell depletion in peripheral blood and lymphoid tissues than ritu...re-treatment infusions were well-tolerated. B-cell depletion and recovery following re-treatment with TRU-015 w...s. SBI-087 Demonstrates Favorable in Vivo B-Cell depletion and Pharmacokinetic Profiles (THU0171) SBI-087 i...

New Study Shows BENICAR(R) (olmesartan medoxomil) Reverses Blood Vessel Damage Independent of Blood Pressure Lowering

...e adjustments are recommended with BENICAR in elderly or in moderate to marked renal impairment*/hepatic dysfunction -- In patients with possible depletion of intravascular volume (eg, patients on diuretics, particularly with impaired renal function), BENICAR should be initiated under close medica...
Depletion in Medical Dictionary

Lymphocyte

...ytes were admixed with nonstaining cells. ... Dynamics of HIV-specific CD8+ T lymphocytes with changes in viral load. ... CD4+ T lymphocyte depletion from PBMCs was performed using Dynabeads® CD4 coated ... Two of them tested lymphocyte proliferation, analyzing either PBMC (thymidine ... Ronen...

Heat exhaustion

...prone to heat exhaustion are elderly people, people with ... heat exhaustion n. A condition caused by exposure to heat , resulting in the depletion of body fluids and causing weakness, dizziness, nausea, and Heat exhaustion is a milder form of heat -related illness that can develop after ...
Depletion in Biological News

AGU journal highlights -- Aug. 6, 2009

..., Geosystems (G3). In this release: Ozone depletion reduces ocean carbon uptake Study pinpoints sourc...p://www.agu.org/jinstructions.shtml 1. Ozone depletion reduces ocean carbon uptake The Southern Ocean...upled carbon-climate models with and without ozone depletion and find that including ozone...

Symposium to discuss geoengineering to fight climate change at the ESA Annual Meeting

...hat sulfur seeding could destroy atmospheric ozone, leading to increased ultraviolet radiation reaching the Earth's surface. "An increase in ozone depletion over the Arctic could lead to dangerous levels of ultraviolet light hitting the Earth's surface," she says. "In this case, the recovery of the ozone h...

New hope for fisheries

...apse," adds Worm. "But this paper shows that our oceans are not a lost cause. The encouraging result is that exploitation rate the ultimate driver of depletion and collapse is decreasing in half of the ten systems we examined in detail. This means that management in those areas is setting the stage for ecolo...

Global curbs on overfishing are beginning to work

...this paper shows that our oceans are not a lost cause," Dr Worm says. "The encouraging result is that the exploitation rate the ultimate driver of depletion and collapse is decreasing in half of the 10 systems we examined in detail. This means that management in those areas is setting the stage for ecolog...

LincRNAs serve as genetic air-traffic controllers

...o show a significant overlap between the genes which become affected by the depletion of lincRNAs and the depletion of the enzymes. This provided us with the evidence that these proteins work...

Nitrogen research shows how some plants invade, take over others

... "But we found the white pine takes up nitrogen and holds on to it much longer, with leads to an accumulation of much more nitrogen in the plant and a depletion of nitrogen in the soil. We concluded high nitrogen residence time was the key mechanism driving the significantly higher plant nitrogen pool and the ...

Lenfest forage fish task force launched

...enfest Forage Fish Task Force, a team of 13 preeminent scientists from around the world that will develop management plans to tackle the unprecedented depletion of forage fish from our oceans. These small prey fish are a critical food source for marine mammals, seabirds, and many large fish species, and their ...

TGen researchers discover possible way to block the spread of deadly brain tumors

...s cells, when compared to tumor cores, suggesting that this factor plays a significant role in tumor invasion,'' Dr. Eschbacher said. In the study, depletion of NHERF-1 stopped the migration of glioma brain cancer cells, she said. "These results suggest that NHERF-1 plays an important role in tumor biolog...

Research could lead to new non-antibiotic drugs to counter hospital infections

...gery, levels of inorganic phosphate fall. The authors of the PNAS paper, led by scientists at the University of Chicago, hypothesized that phosphate depletion in the stressed intestinal tract signals P. aeruginosa to become lethal. To test this theory, they let worms (Caenorhabditis elegans) feed on "l...

Scripps scientists help decode mysterious green glow of the sea

...he light also may serve as a defensive mechanism, intended to distract predators. Through experiments that included hot and cold testing and oxygen depletion studies, Deheyn and Latz found that the bioluminescence is active in temperatures as low as minus 20 degrees Celsius (minus 4 degrees Fahrenheit). Hig...
Depletion in Biological Technology

Sigma-Aldrich Acquires Seppro(R) Depletion Technology From GenWay Biotech

ST. LOUIS, Mo., Jan. 6 /PRNewswire-FirstCall/ -- Sigma-Aldrich (Nasdaq: SIAL ) has expanded its proteomics offerings with the acquisition of Seppro(R) affinity depletion technology and a library of 700 avian-derived antibodies from GenWay Biotech, Inc. Seppro depletion products enable scien...

Protein Depletion for Plasma and Serum Proteomic Analysis

Human plasma and serum represents an important biological material for disease diagnosis. However, the wide dynamic range in protein concentration remains a major challenge in the development of diagnostic assays for the very low concentration o...

Affinity Depletion Cartridges for Removal of Human Serum Albumin and Immunoglobulins from Human Serum

Overview: One of the major difficulties in analyzing the proteome of human serum is the dynamic range of the concentrations of the proteins present in the sample. Human serum albumin (HSA) constitutes 57-71% of total serum protein and gammaimmunoglobulin (IgG) ran...

Trubion Presents Preclinical Data on Its SCORPION(TM) Multispecific Therapeutics at the 2009 American Association of Cancer Research Annual Meeting

...itro activity against B-cell lymphoma B-cell depletion with agents such as Rituxan(R) has proven successf...enhanced potency was shown to be restricted to the depletion of B-cells when in the presence of T cells, as 48 ...eripheral blood mononuclear cells showed selective depletion of B (CD19+) but not T (CD3+) cells. A copy o...

Kiadis Pharma Reports ATIR(TM) Clinical Data, Further Supporting its Potential in Mismatched Bone Marrow Transplantations

...nts in the higher dose cohorts show high survival rates (75%) with no transplant related mortality (TRM). These results show that the selective depletion of allo-reactive T-cells in the ATIR(TM) cell based product by the proprietary photo-sensitizing agent TH9402 is highly effective and can result in fa...

Viroblock SA Reports Positive Results of Preclinical Studies in Antiviral Nasal Spray

... active against human influenza. Viroblock's patented Cholesterol Catalytic depletion Technology (VCCD Tech) inactivates enveloped viruses during the extra-cellu...r inactivating a number of enveloped viruses and their strains. "Our depletion technology shows no toxicity at the dosage we tested thus far and allegedly...

Trubion Pharmaceuticals, Inc. Announces Initiation of Phase 1 Study of SBI-087 for the Treatment of Systemic Lupus Erythematosus (SLE)

...a demonstrated that a single dose of SBI-087 resulted in more potent B-cell depletion in peripheral blood and lymphoid tissues than rituximab. The objective of t...ous dose. Administration of SBI-087 resulted in dose-dependent B-lymphocyte depletion in peripheral blood and lymphoid tissues that was more profound and sustain...

Bionovo to Present Recent Findings of BN107, its Anticancer Agent, at the 31st Annual San Antonio Breast Cancer Symposium

...tosis through the mitochondrial pathway. BN107 induces death only in estrogen receptor negative breast cancer cells. Our studies show that cholesterol depletion and disruption of lipid raft-mediated signaling is most likely responsible for the pro-apoptotic effect of BN107. "BN107 mechanism of action a...

Soliris(R) Reduced Measures of Thrombosis and Inflammation, and Decreased Indicators of Pulmonary Hypertension, in Studies of Patients with PNH

...liris in the regulation of cell-free plasma hemoglobin levels, nitric oxide depletion and subsequent cardiovascular morbidities in patients with PNH. This analys...be monitored to determine if iron supplementation should be altered or iron depletion therapy should be considered. For details, visit: http://ash.confex.com/as...

MedImmune Advances Asthma Program With Start of Phase 2 Clinical Trial for Antibody Targeting IL-5 Receptor

...ma. Data from the completed Phase 1 study demonstrated that the antibody was well-tolerated with biologic activity producing substantial and prolonged depletion of blood eosinophils, thus supporting its continued development. Published literature suggests that reduction of eosinophils in sputum was associated ...
Depletion in Biological Products

Dynabeads Mouse Pan B (B220) from Dynal Biotech

Description:... 5 ml Dynabeads Mouse pan B (B220), 4.5 m, coated with anti-B220 monoclonal antibody. For the efficient positive isolation or depletion of mouse B cells directly from spleen or lymph node cell suspensions. B220 antigen is expressed on mouse B cells and lytically active subsets of lymph...
Company:Dynal Biotech

ProteoPrep 20 Plasma Immunodepletion Kit from Sigma-Aldrich

Description:...unodepletion Kit specifically removes 20 of the most abundant proteins from human plasma or serum in preparation for further proteomics analysis. This depletion enables deeper penetration into the plasma proteome whether you use one- or two-dimensional electrophoresis, single or multidimensional chromatography...
Company:Sigma-Aldrich

StemSep Rat T Cells, 2 mL from StemCell Technologies, Inc.

Description:... This depletion cocktail is tailored to highly enrich T cells from suspensions of rat spleen cells. Cells are separated using the StemSep (or compatible 0.5 Tesla) im...
Company:StemCell Technologies, Inc.

StemSep Rhesus T Cell Purging, 2 mL Kit from StemCell Technologies, Inc.

Description:... This depletion cocktail is tailored to efficiently deplete T (CD3+CD4+CD8+) cells from sus...le 0.5 Tesla) immunomagnetic negative selection system, achieving a 2.6 Log depletion of T cells....
Company:StemCell Technologies, Inc.

StemSep Rhesus CD4+ T Cells, 2 mL Kit from StemCell Technologies, Inc.

Description:... This depletion cocktail is tailored to highly enrich CD4+ T cells from suspensions of non-human primate (Rhesus monkey) cells. Cells are separated using the StemSep ...
Company:StemCell Technologies, Inc.

StemSep Rat CD4+ T Cells, 10 mL from StemCell Technologies, Inc.

Description:... This depletion cocktail is tailored to highly enrich CD4+ T cells from suspensions of rat spleen cells. Cells are separated using the StemSep (or compatible 0.5 Tesl...
Company:StemCell Technologies, Inc.

RosetteSep Anti-Human IgE, 200 ul from StemCell Technologies, Inc.

Description:... This depletion cocktail is tailored to deplete IgE-bearing (I.e. basophils and mast cells) from whole blood...
Company:StemCell Technologies, Inc.

Anti-human CD41 Tetramer, 200 uL from StemCell Technologies, Inc.

Description:... This bispecific antibody complex has been tested for efficient depletion of CD41+ cells using the StemSep ; negative immunomagnetic cell separation system....
Company:StemCell Technologies, Inc.
Depletion in Biological Definition

Anaerobic

...ge . See also: Anaerobic exercise Anaerobic glycolysis Anaerobic metabolism Anaerobic organism Anaerobic respiration oxygen depletion ...

Growth curve

...curves for certain biological systems display periods of exponential growth . Typically, periods of exponential growth are of limited duration due to depletion of some rate-limiting resource. ...
Depletion in Biological Dictionary

Sarcoplasmic reticulum

...ulum ... ( A) Fractions of rat heart sarcoplasmic reticulum (SR) were subjected to a solid ... Assessment of sarcoplasmic reticulum Ca2+ depletion during spontaneous Ca2 ... posted to sr sarcoplasmic ryanodine reticulum release receptor protein channel ... Zoology information, history,...

Oviduct

...ithin the oviduct , adenosine regulates rhythmic contractions and the ciliary ... BSO-treated oviduct epithelial cells displayed a continued depletion of GSH over ... The oviduct provides the proper environment for the final preparations gametes ... Basic Histology -- Ciliated Epithelium of ...

Neurotransmitter

...Food, and the Good Things in Life. General review with an emphasis on dopamine's relationship to addiction. The first is that neurotransmitter depletion is nutritionally based. ... If you have neurotransmitter deficiency, most likely you have been given a ... Chemistry and physiology of neurotra...

Kinetochore

...e assembly. 8. Assembly of the mitotic spindle. 9. Chromosome segregation ... A number of other kinetochore proteins have been identified whose depletion ... Cell cycle articles relating to ' kinetochore ' ... The kinetochore , the protein complex assembled at each centromere, serves as the ... ...

Elongation factor

...RNA polymerase II elongation factor . Synonyms ... with its role as an accessory factor for transcription elongation (Adelman, 2005) ... depletion of one Negative elongation factor E (NELF) subunit in salivary glands ... found in a complex with another positive elongation factor called ...

Antibodies

...nes. Collaborators ... Antibodies . ELISAs. ELISpot Kits. Multiplex Assays/Arrays ... and polyclonal antibodies are available, ... Mouse Lineage depletion Monoclonal Antibodies ... Antibodies are proteins that comprise a memory system which detects and links antigens to an effector system th...
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