Demonstrated

New Analyses from 16-Year Follow-up Trial with Betaseron(R) Demonstrated that Early and Sustained Treatment of Multiple Sclerosis Patients Enrolled in the Trial Affected Their Long-term Outcomes

SEATTLE, April 29 /PRNewswire/ -- New analyses of data from the 16-Year Long-term Follow-up study with Betaseron(R) (interferon beta-1b), sponsored by Bayer HealthCare Pharmaceuticals, were presented at the American Academy of Neurology's (AAN) 61st Annual Meeting. The study results showed that e...

Combination of TYKERB(R) (lapatinib) Plus Letrozole Demonstrated Significant Improvement in Delaying Disease Progression for HER2+/ErbB2+ Post-Menopausal Metastatic Breast Cancer

Findings from one of the largest studies in hormone receptor positive women with first-line oral treatment regimen PHILADELPHIA, Dec. 11 /PRNewswire-USNewswire/ -- New results from a study evaluated the combination of TYKERB(R) (lapatinib) plus Femara(R) (letrozole) versus letrozole alon...

Takeda's investigational PPI TAK-390MR demonstrated higher healing rates compared to lansoprazole

Combined results from two Phase 3 studies presented at the American College of Gastroenterology Annual Scientific Meeting (ACG) in Orlando, Fla., demonstrated that TAK-390MR resulted in higher healing rates than lansoprazole among patients with more severe grades of erosive esophagitis (EE). TAK-3...

New AMITIZA 8 mcg phase III studies demonstrated overall symptom improvement in adult women

San Diego, CA May 18, 2008 New study results indicated that treatment with AMITIZA (lubiprostone) 8 mcg lead to significant relief of overall symptoms of Irritable Bowel Syndrome with Constipation (IBS-C). These results were presented at Digestive Disease Week (DDW) 2008, the largest annual i...

ZOLINZA (vorinostat) in combination with bortezomib demonstrated clinical activity

ATLANTA, GA, December 8, 2007 -- Results from two investigational Phase I trials of ZOLINZA (vorinostat) in combination with bortezomib provide preliminary anti-tumor activity in patients with relapsed and/or refractory multiple myeloma. Data from one study showed that 10 of 21 (48 percent) evalu...

Ninety-one Percent of BARACLUDE(R) (entecavir) Treated Patients in a Four-Year Cohort Demonstrated Virologic Suppression to Undetectable Levels

- In this Cohort of Nucleoside-Naive Chronic Hepatitis B e-Antigen (HBeAg) Positive Patients, Resistance Monitoring Identified One Patient with Genotypic Resistance to BARACLUDE - BOSTON, Nov. 2 /PRNewswire-FirstCall/ -- Bristol-Myers Squibb Company (NYSE: BMY ) today announc...

Demonstrated in Medical Technology

5-Year Study Published in Diabetologia Demonstrated Long-Term Safety of Lantus(R) Compared to NPH

BRIDGEWATER, N.J., July 6 /PRNewswire-FirstCall/ -- Sanofi-aventis (EURONEXT: SAN and NYSE: SNY ) announced today that the results of the long-term, 5-year study of Lantus(R) (insulin glargine [rDNA] injection) versus NPH insulin on progression of retinopathy in patients with type 2 diabetes...

Data Demonstrated ACTEMRA(R) (tocilizumab) Significantly Inhibited Progression of Structural Joint Damage in Rheumatoid Arthritis Patients

- Additional data reinforce long-term efficacy of ACTEMRA across a broad range of rheumatoid arthritis patient populations - NUTLEY, N.J., June 9 /PRNewswire/ -- One-year data from the two-year Phase III LITHE (Toci LI zumab Safety and THE Prevention of Structural Joint Damage) study de...

IMPACT Study Showed Longer Valcyte(R) (valganciclovir hydrochloride tablets) Treatment Demonstrated Better Protection Against Cytomegalovirus (CMV) Disease One Year Post-Transplant

CMV is the most serious viral infection affecting transplant patients BOSTON, June 1 /PRNewswire/ -- New Phase III study results presented for the first time today at the ninth annual American Transplant Congress 2009 (ATC) demonstrate that doubling the duration of preventive therapy ('prop...

New Study Evaluating the ADHD Medication VYVANSE(R) (lisdexamfetamine dimesylate) CII Demonstrated No Change in the Pharmacokinetic Profile of VYVANSE When Coadministered with Prilosec OTC(R) 40 mg (20 mg X 2), a Commonly Used Proton Pump Inhibitor (PPI)

PHILADELPHIA, May 22 /PRNewswire-FirstCall/ -- Shire plc (LSE: SHP, Nasdaq: SHPGY ), the global specialty biopharmaceutical company, announced results of a study showing that coadministration of the ADHD medication VYVANSE(R) (lisdexamfetamine dimesylate) CII with the proton pump inhibitor (PP...

Prolonged Progression-Free Survival Demonstrated by VELCADE(R) (Bortezomib) for Injection Based Induction Regimens in Transplant-Eligible Previously Untreated Multiple Myeloma Patients

SAN FRANCISCO, Dec. 8 /PRNewswire/ -- Millennium: The Takeda Oncology Company today reported updated results from two large, multi-center, randomized Phase III clinical trials of VELCADE based combinations for the induction treatment of transplant-eligible patients with previously untreated multip...

Recent Study Demonstrated VYVANSE(R) (lisdexamfetamine dimesylate) CII Provided Improvements in Behavior, Inattention, and Math Test Scores from 1.5 Hours up to 13 Hours following Administration in Children with ADHD

VYVANSE is the first oral ADHD stimulant medication with published data demonstrating symptom control at 13 hours post-dose in a pediatric clinical study CHICAGO, Oct. 29 /PRNewswire-FirstCall/ -- Shire plc (LSE: SHP, Nasdaq: SHPGY), the global specialty biopharmaceutical company, today anno...

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Demonstrated in Medical Products

Myobloc®(Botulinum Toxin Type B) Injectable Solution

Description:... Myobloc (Botulinum Toxin Type B) Injectable Solution, the only Botulinum Toxin Type B treatment available, has been demonstrated in numerous published studies to be safe and effective in treating cervical dystonia. Delivered as a purified, ready-to-use solution, in three conven...
Company:Solstice Neurosciences, Inc.

EnteroScreen 4™

Description:...gella from other members of the Enterobacteriaceae family. Hardy Diagnostics EnteroScreen 4™ contains a unique media combination, which has been demonstrated to be less redundant and less labor intensive; yet equivalent in performance to the traditional three tube set....
Company:Hardy Diagnostics

PYY, Total ELISA Test

Description:...eurons that stimulate feeding behavior (2). In a recent study (4), an infusion of PYY3-36 on appetite and food intake in 12 obese and 12 lean subjects demonstrated that, unlike leptin, there was no evidence of resistance to PYY3-36 in obese subjects. Endogenous levels of PYY3-36 were low in the obese subjects, su...
Company:Diagnostic Systems Laboratories, Inc.

Androstenedione EIA Test

Description:...ne occurs [1,2,3]. Measurement of serum androstenedione provides a useful marker of androgen biosynthesis. Elevated androstenedione levels have been demonstrated in virilizing congenital adrenal hyperplasia [4]. Serum androstenedione levels are also increased in polycystic ovary syndrome, ovarian stromal hypert...
Company:Diagnostic Systems Laboratories, Inc.

Androstenedione RIA Test

Description:...ne occurs [1,2,3]. Measurement of serum androstenedione provides a useful marker of androgen biosynthesis. Elevated androstenedione levels have been demonstrated in virilizing congenital adrenal hyperplasia [4]. Serum androstenedione levels are also increased in polycystic ovary syndrome, ovarian stromal hypert...
Company:Diagnostic Systems Laboratories, Inc.

Erythropoietin RIA Test

Description:...[1, 2, 3]. Postnatal production occurs primarily in the renal tubular epithelium, although significant continued postnatal hepatic production has been demonstrated [4]. EPO is secreted into the circulation from where it is taken up by target tissues. EPO binds to specific cell membrane receptors on erythroid prog...
Company:Diagnostic Systems Laboratories, Inc.

Demonstrated in Medical Definition

Artificial induction of immunity

... patient to another, thus infecting the second patient with cowpox. He then demonstrated that the latter was immune by exposing him to smallpox. The principle had been demonstrated some years earlier by Benjamin Jesty , who had not publicized his discover...

Autoimmune regulator

...e homolog Aire has created a transgenic mouse model to study the mechanism of disease in human patients. [2] Research on the knockout mouse has demonstrated that Aire functions through initiating the transcription of a diverse set of self-antigens, such as insulin , in the thymus . [3] This expressi...

Biotextile

...round these devices so it’s not relying solely on synthetic foreign implanted material. One of Dr. Martin King's graduate students, Jessica Gluck, has demonstrated that viable and functioning liver cells can be grown on textile scaffolds. External links website NC State’s College of Textiles on bio...

Depolarization-induced suppression of inhibition

...diated neurotransmission is reduced. This has been demonstrated to be caused by the release of endogenous cannabin...DSI is a pretty ubiquitous phenomenon and has been demonstrated in other areas of the brain such as the basal gan...ue of another reputable journal, Neuron. All three demonstrated heavy involvement of the CB1 cannabinoid receptor...

Episodic memory

...he first to provide evidence that animals may possess episodic memory. They demonstrated that Florida scrub-jays ( Aphelocoma coerulescens ) remember where they c...e brains more similar to humans. For example, Kart-Teke and colleagues have demonstrated rats' preference for items it sees which is dependent on what it saw, where...

Demonstrated in Medical Dictionary

Violence

... Violence and Disasters ... Violence is a learned behavior, and it is often learned in the home or the ... Psychological research has not only demonstrated that violence is learned. ... Actively supervise your child's exposure to all forms of media violence . ... Children who experience or witness ...

Toxin

...expression, the ... toxin genes in plants has presented a technical challenge ... toxin gene expression. Two previous ... Researchers have demonstrated that a bacterial toxin from the common bacterium Staphylococcus aureus shuts down the control mechanism of the tunnel, called an ion ... Physi...

Scotoma

...coma) ... Every normal mammalian eye has a scotoma in its field of vision, usually termed its blind spot. ... presence of the scotoma can be demonstrated subjectively ... Home > Metal > Charts > SCOTOMA . Site-wide search (default search) Band/Artist Song Member name ... Scotoma has been...

Prevalence

...valence rate of any other group in San Francisco, according to a report presented at a Jan. 10 meeting of the ... However, other studies have not demonstrated any difference in prevalence among men and women. ... The white-coat hypertension response: prevalence and predictors. ... The prevalence ...

Phlegm

...more irritating to ... Information about phlegm in the free online English dictionary and encyclopedia. yellow phlegm , ... phlegm - apathy demonstrated by an absence of emotional reactions ... Discussion of Excessive Phlegm in Adults and how to eliminate Phlegm ... The excess phlegm got a bi...

Percutaneous

...s : Through the skin, as in a percutaneous biopsy. ... ... in evaluating the use of percutaneous atherectomy in 579 lesions with ... Our study demonstrated that percutaneous excisional atherectomy is beneficial in ... Definition of percutaneous from the Merriam-Webster Online Dictionary with audio...

Demonstrated in Biological News

Eribulin mesylate demonstrated anti-tumor activity in patients with advanced breast cancer

Woodcliff Lake, N.J., May 15, 2008The investigational chemotherapeutic agent eribulin mesylate (E7389) demonstrated activity in a heavily pretreated population of women with locally advanced or metastatic breast cancer, according to results of a multi-center Phase II clinical trial. The study als...

To Stop Evolution: New Way Of Fighting Antibiotic Resistance Demonstrated By Scripps Scientists

A team of scientists at The Scripps Research Institute and the University of Wisconsin have demonstrated a new way of fighting antibiotic resistance: by stopping evolution. In the June issue of the open-access journal PloS Biology, the team describes how a protein called LexA in the bacterium Es...

Navigating in the ocean of molecules

...ly to display similar activity to related natural molecules, as the program also creates and visualizes virtual scaffolds. The researchers immediately demonstrated how efficiently the program works by discovering new inhibitors of pyruvate kinase. The inhibition of this enzyme is seen as a promising approach to t...

Beautiful plumage: Feather color and sex start the species revolution

...species. Birds use plumage colour to recognize and select potential mates. A mutation of a single DNA base can lead to a striking colour change, as demonstrated by two closely related flycatcher populations in the Solomon Islands. According to a report in the American Naturalist -- selected and reviewed by F...

Leicester research paves way for first use in Europe of an insect to fight invasive plant

... molecular tools to discover the origin of Japanese Knotweed were in place and the trip to Japan already arranged. That Japanese Knotweed had been demonstrated to be a single clone and was thus lacking any population resistance was a bonus for a Biological Control Program. Like Britain Japan is not particular...

Jet-propelled imaging for an ultrafast light source

...s weren't individual protein specimens, and while the 9.0.1's x-ray beams aren't as bright or as rapidly pulsed as SLAC's LCLS will be, the experiment demonstrated the jet technique's high potential for speeds and exposures that won't subject the samples to radiation damage. Some of the patterns the researchers o...

Demonstrated in Biological Technology

Study Published in Child and Adolescent Psychiatry and Mental Health Demonstrated Once-Daily Vyvanse(R) (lisdexamfetamine dimesylate) CII Provided Significant Improvement of ADHD Symptoms for Children at 13 Hours After Administration

PHILADELPHIA, July 22 /PRNewswire-FirstCall/ -- Shire plc (LSE: SHP, Nasdaq: SHPGY ), the global specialty biopharmaceutical company, today announced that a study published online in the peer-reviewed journal Child and Adolescent Psychiatry and Mental Health found once-dai...

Clinical Pharmacology Study With AZILECT(R) (Rasagiline Tablets) Demonstrated It Does Not Increase Tyramine Sensitivity

Study Indicated Rasagiline Selectivity for Inhibiting MAO-B at Maximum Approved Dose KANSAS CITY, Mo., June 9 /PRNewswire/ -- Teva Neuroscience, Inc. today presented results from a clinical pharmacology study in which AZILECT(R) (rasagiline tablets) did not increase the risk of tyramine sensi...

WaferGen's SmartChip(TM) System Performance Successfully Demonstrated in Initial Phase of Alpha Testing Program

FREMONT, Calif., Jan. 12 /PRNewswire-FirstCall/ -- WaferGen Biosystems, Inc. (OTC Bulletin Board: WGBS), a leading developer of state-of-the-art gene expression, genotyping, cell biology and stem cell research systems, today announced that academic researchers have successfully demonstrated th...

Antiangiogenic Role of 2ME2 Demonstrated in Rheumatoid Arthritis Models

ROCKVILLE, Md., Nov. 3 /PRNewswire-FirstCall/ -- EntreMed, Inc. (Nasdaq: ENMD ), a clinical-stage pharmaceutical company developing therapeutics for the treatment of cancer and inflammatory diseases, today announced the publication of preclinical results for 2ME2 (Panzem(R) or 2- methoxyestra...

Volcano Announces Activities at TCT 2007: Expanded Role of IVUS in PCI to be Demonstrated

Live Cases, Studies and Testimony by Stent Manufacturers Expected to Highlight and Explain Increasing Use of IVUS - Witness Live Case Examples of Advanced Practices by Leading Interventionalists, Broadcast from Around the World. - Hear About Current and New Studies Designed...

Arizona Pain Specialists Contend Recent Vertebroplasty Studies are Misleading

... group condition, where patients would receive no treatment. The 'control' patients actually received a different effective treatment and both groups demonstrated highly clinically significant reductions in pain. This demonstrates that vertebroplasty is an effective procedure, although facet injections are also...

Demonstrated in Biological Products

Flp-In pcDNA5/FRT Complete Kit from Invitrogen

Description:... Flp-In System creates isogenic cell lines all transfected clones produce equivalent levels of the protein of interest. This homogeneous expression is demonstrated in Figure 3. In this experiment the coding sequence for chloramphenicol-acetyl transferase (CAT) was subcloned into pcDNA5/FRT and transfected into Fl...
Company:Invitrogen

Flp-In pcDNA5/FRT Core Kit from Invitrogen

Description:... Flp-In System creates isogenic cell lines all transfected clones produce equivalent levels of the protein of interest. This homogeneous expression is demonstrated in Figure 3 (click link below). In this experiment the coding sequence for chloramphenicol-acetyl transferase (CAT) was subcloned into pcDNA5/FRT and ...
Company:Invitrogen

Anti-P-selectin Glycoprotein Ligand-1 (PSGL-1) Monoclonal Antibody, Unconjugated, Clone KPL-1 from CHEMICON

Description:...GL-1 by either P-selectin or by L-selectin, but does not affect leukocyte recognition of E-selectin. Two color flow cytometry of normal leukocytes has demonstrated that PSGL-1 is expressed on essentially all blood neutrophils, NK cells, blood cells, T cells, and monocytes, but PSGL-1 stains B cells at significant...
Company:CHEMICON

Rabbit Anti-Human XAB2 (N-terminus) Polyclonal Antibody, Unconjugated from GeneTex

Description:...n XAB2 (amino terminus) XAB2 (XPA-binding protein 2) was first identified through its interaction with XPA. Immunoprecipitation experiments have also demonstrated that a fraction of XAB2 interacts with the transcription-coupled repair-specific proteins CSA and CSB as well as with RNA polymerase II. Microinjectio...
Company:GeneTex

TargeTron Gene Knockout System from Sigma-Aldrich

Description:... utilizes a simple PCR step to re-target the TargeTron group II intron for specific insertion into the host genome. Utility of the technology has been demonstrated for prokaryotic genetic engineering, systems biology and functional genomics approaches. Compared to existing knockout methodologies, the TargeTron s...
Company:Sigma-Aldrich

Mutation Surveyor from SoftGenetics, LLC.

Description:...uracy of the software in the bi-directional analysis mode is over 99%, with sensitivity to greater than 5% of the primary peak. Our collaborators have demonstrated an accuracy of 95% when processing single direction sequence traces. Mutation Surveyors detection sensitivity has been enhanced to report similar pea...
Company:SoftGenetics, LLC.

Demonstrated in Biological Definition

Antibiotic

...biotic resistance 6 Beyond antibiotics 7 External links 7.1 Resources History Following earlier experiments that had demonstrated interesting anti-bacterial effects from various bacterial secretions, the German scientist E. de Freudenreich in 1888 isolated a bacterial secretion a...

Antibiotic resistance

...vive will live on to reproduce. They will then pass this trait to their offspring, which will be a fully resistant generation. Several studies have demonstrated that patterns of antibiotic usage greatly affect the number of resistant organisms which develop. Overuse of broad-spectrum antibiotics , such as sec...

Cancer

...ancer in comparison to men taking placebo pills. Daily use of tamoxifen , a selective estrogen receptor modulator, for up to 5 years, has been demonstrated to reduce the risk of developing breast cancer in high-risk women by about 50%. Cis-retinoic acid also has been shown to reduce risk of second prim...

Charles Darwin

... New fossil evidence proved the antiquity of man, but other writers failed to fully tackle human evolution. Opponents claimed that the beauty of birds demonstrated divine guidance. These two subjects were tackled in The Descent of Man and Selection in Relation to Sex and followed up by The Expression of Emo...

Chromatography

...n print in 1906 in his two papers about chlorophyll in the German botanical journal, Berichte der Deutschen botanischen Geselschaft . In 1907 he demonstrated his chromatogaph for the German Botanical Society. The phenomenon of precipitational separation was observed before Tsvet as well. His contribution wa...

Cryptozoology

...yptozoologists have collected statistical data and studied witness accounts that challenge the validity of many Bigfoot sightings. Scientists have demonstrated that some creatures of mythology , legend or local folklore were rooted in real animals or phenomena. Thus, cryptozoologists hold that people should...

Demonstrated in Biological Dictionary

Vestigial organ

...s anatomical structures, behaviors... Charles Darwin argued that vestigial organs are evidence of evolution and ... Vestigial organs have demonstrated remarkably how ... The term ? vestigial organ ? ... The standard definition of vestigial ' is an organ that once was useful in an ... The list...

Triplet repeat expansion

... of a CTG triplet repeat sequence in the 3' ... GAA Triplet – Repeat Expansion as an Impediment to Transcription ... Several groups have demonstrated that the GAA- repeat expansion interferes with transcription. ... ... dominant, was found to result from expansion of a triplet repeat (CA...

Transcapsidation

...sidation approach consisted of the transfection of pairwise ... virus groups determines vector specificity, transcapsidation ... (1994) have demonstrated partial transcapsidation of potyvi ... between transcapsidation and ... ... dressing the virion: the transcapsidation of adeno-associated vi...

Thymus gland

...e Thymus gland so it grows back to full size ... IAS Anti-Aging Bulletin Article. ... The thymus gland is small in size, ... Later research demonstrated that the thymus gland produced a family of specific ... Curiously, when the thymus is removed from adult mammals, ... thymus develops ......

T lymphocytes

...ls are being activated in order to fight ... ... wherein freshly isolated human T lymphocytes were added at 6 hours during ... We recently demonstrated that T lymphocytes are rapidly activated by H2O2 ... We describe the CMRF-35pos and CMRF-35– fractions of CD4+ T lymphocytes . ... T lymp...

Synergid

...e identified one mutant, gfa2, with a defect in synergid cell death. ... We analysed feronia with synergid -specific GUS marker lines, which demonstrated ... ( C) PT entering the FG through the receptive synergid . ... Synergid Cell Death in Arabidopsis Is Triggered following Direct Interaction .....