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dehydrogenase in Medical News

Alcohol Dehydrogenase Gene may Protect from Developing Alcoholism

Alcohol dehydrogenase (ADH) is one of the major enzymes involved in alcohol metabolism. The genes for ADH are polymorphic at two loci, ADH1B and ADH1C.// The three alleles at the ADH1B locus have previously been linked with protection from alcohol dependence, a new study is the first to exami...

Savient Pharmaceuticals Receives Complete Response Letter from U.S. Food and Drug Administration for KRYSTEXXA(TM)

...vere infusion reactions and possible anaphylaxis, the risk of severe adverse reactions in administering KRYSTEXXA to patients with glucose-6-phopshate dehydrogenase (G6PD) deficiency and major cardiovascular events, and An Assessment Plan to monitor and assess the effectiveness of the Medication Guide and Co...

Raptor Pharmaceuticals Corp. and TorreyPines Therapeutics, Inc. Announce Merger Agreement

...clinical development to treat nephropathic cystinosis , non-alcoholic steatohepatitis ("NASH") , Huntington's Disease ("HD") , and aldehyde dehydrogenase ("ALDH2") deficiency . Raptor's preclinical programs are based upon bioengineered novel drug candidates and drug-targeting platforms derived ...

Raptor Pharmaceuticals Corp. to Present at 2009 Cystinosis Research Network Family Conference

...clinical development to treat nephropathic cystinosis , non-alcoholic steatohepatitis ("NASH") , Huntington's Disease ("HD") , and aldehyde dehydrogenase ("ALDH2") deficiency . Raptor's preclinical programs are based upon bioengineered novel drug candidates and drug-targeting platforms derive...

Key Protein Might Shield Brain Cells

...esearchers found that GOSPEL competes with another protein when it attempts to latch onto a multifunctional molecule called glyceraldehyde-3-phosphate dehydrogenase (GAPDH). By binding to GAPDH itself, GOSPEL prevents the cell death cascade and protects brain cells against toxic compounds, according to the study. ...

Raptor Pharmaceuticals to Collaborate with Roche on Therapeutic Delivery Across Blood-Brain Barrier

...candidates in clinical development to treat nephropathic cystinosis, non-alcoholic steatohepatitis ("NASH"), Huntington's Disease ("HD"), and aldehyde dehydrogenase ("ALDH2") deficiency. Raptor's preclinical programs are based upon bioengineered novel drug candidates and drug-targeting platforms derived from...
dehydrogenase in Medical Technology

Raptor Pharmaceuticals Receives Notices of Allowance for Two NeuroTrans(TM) Patent Applications

... in clinical development to treat nephropathic cystinosis, non-alcoholic steatohepatitis ("NASH"), Huntington's Disease ("Huntington's"), and aldehyde dehydrogenase ("ALDH2") deficiency. Raptor's preclinical programs are based upon bioengineered novel drug candidates and drug-targeting platforms derived from...

Raptor Pharmaceuticals Appoints Dr. Patrice P. Rioux as Chief Medical Officer

...ngton's"), as well as Convivia(TM), for the potential treatment of aldehyde dehydrogenase ("ALDH2") deficiency. Dr. Rioux has extensive experience as a clinicia...eatohepatitis ("NASH"), Huntington's Disease ("Huntington's"), and aldehyde dehydrogenase ("ALDH2") deficiency. Raptor's preclinical programs are based upon bi...

Discovery of Marker for Colon Stem Cells Could Shed Light on What Drives Tumor Growth

... to identify, locate, and isolate normal and malignant colon stem cells, has been elusive. But the discovery by Dr. Boman and colleagues that aldehyde dehydrogenase 1 (ALDH1) is a marker for identifying and isolating colon stem cells is a potential breakthrough in the search for a key to what drives colon cancer g...

Raptor Pharmaceuticals Announces Completion of Patient Enrollment in Phase 2a Clinical Trial in Non-Alcoholic Steatohepatitis (NASH)

...candidates in clinical development to treat nephropathic cystinosis, non-alcoholic steatohepatitis ("NASH"), Huntington's Disease ("HD"), and aldehyde dehydrogenase ("ALDH2") deficiency. Raptor's preclinical programs are based upon bioengineered novel drug candidates and drug-targeting platforms derived from...

New Overall Survival Study Results Confirm Oral Xeloda(R) plus Oxaliplatin (XELOX) is Comparable to FOLFOX-4 for the First-Line Treatment of Advanced Colorectal Cancer

...opathy. Xeloda is contraindicated in patients who have a known hypersensitivity to 5-fluorouracil, and in patients with known dihydropyrimidine dehydrogenase (DPD) deficiency. Xeloda is contraindicated in patients with severe renal impairment. For patients with moderate renal impairment, dose reduction is...

Alexion Reports Positive Results from AEGIS Registration Study of Soliris in Japanese Patients With PNH

...ysis, the primary trial endpoint, was rapidly and significantly reduced with Soliris treatment. A standard measure of hemolysis, lactate dehydrogenase (LDH), decreased 86 percent from a median of 1,814 U/L at baseline to a median of 244 U/L following 12 weeks of treatment (P<0.001; n...
dehydrogenase in Medical Products

Glucose-6-Phosphate Dehydrogenase

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

LDH

Description:... The LDH method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of lactate dehydrogenase activity in serum or plasma...
Company:Randox Laboratories Ltd.

LD Lactate –> Pyruvate

Description:... For the quantitative in vitro determination of Lactate dehydrogenase (LD) in serum and plasma....
Company:Randox Laboratories Ltd.

Androstenedione EIA Test

Description:...drenal hyperplasia [4]. Serum androstenedione levels are also increased in polycystic ovary syndrome, ovarian stromal hyperthecosis, 3b-hydroxysteroid dehydrogenase deficiency, and other causes of hirsutism in women [3,5]. Elevated serum androstenedione levels may also occur in adrenal and ovarian virilizing tumor...
Company:Diagnostic Systems Laboratories, Inc.

Androstenedione RIA Test

Description:...drenal hyperplasia [4]. Serum androstenedione levels are also increased in polycystic ovary syndrome, ovarian stromal hyperthecosis, 3b-hydroxysteroid dehydrogenase deficiency, and other causes of hirsutism in women [3,5]. Elevated serum androstenedione levels may also occur in adrenal and ovarian virilizing tumor...
Company:Diagnostic Systems Laboratories, Inc.

DHEA RIA Test

Description:...oadrenalism, while elevated levels occur in several conditions including virilizing adrenal adenoma and carcinoma, 21-hydroxylase and 3-hydroxysteroid dehydrogenase deficiencies and in some cases of female hirsutism [3]. Because very little DHEA is produced by the gonads, measurement of DHEA levels may aid in the ...
Company:Diagnostic Systems Laboratories, Inc.
dehydrogenase in Biological News

Scientists discover gene mutation responsible for hereditary neuroendocrine tumor

...aragangliomas are hereditary. Of the four familial PGL syndromes, three forms have previously been associated with mutations in genes of the succinate dehydrogenase (SDH) complex, an enzyme complex involved in the ability of cells to extract energy from nutrients. Studies in Yeast "Defects in mitochondria,...

Scientists sequence genome of the N2-fixing, soil-living bacterium Azotobacter vinelandii

...l location of the three known oxygen-sensitive nitrogenases, as well as the genes that code for other oxygen-sensitive enzymes such as carbon-monoxide dehydrogenase and a formate dehydrogenase. The sequence also provided important information on the genes that code for alginate, a polymer that further protects the...

American Chemical Society's Weekly PressPac -- May 13, 2009

...radio-contaminated environment. Interestingly, plants from contaminated fields produced one-third more of a protective protein called betaine aldehyde dehydrogenase the same protein known to protect human blood from radiation damage. ARTICLE #3 FOR IMMEDIATE RELEASE "Proteomic Analysis of Mature Soybean Seed...

New hope for advances in treating malaria

...-causing parasite, Plasmodium falciparum including those resistant to existing drugs. The compounds work by preventing the enzyme dihydroorotate dehydrogenase (DHODH) - essential to the growth of the parasite - from working, which results in its death. Says lead researcher Dr Glenn McConkey, from Leeds' Fa...

Frogs reveal clues about the effects of alcohol during development

...operly. The researchers, at the Hebrew University in Israel, found that shutting down a molecule needed to produce retinoic acid, called retinaldehyde dehydrogenase or RALDH2, increased sensitivity of developing embryos to low doses of alcohol. Conversely, more of the molecule RALDH2 protected embryos from the ne...

HWI scientist first in world to unravel structure of key breast cancer target enzyme

...art of this project were estrone sulfatase (2003) and 17beta-hydroxysteroid dehydrogenase type 1 (1996). All three enzymes control the levels of estradiol in differe...atase. A number of collaborators played a role in the 17beta-hydroxysteroid dehydrogenase project's early work including scientists in Canada, Finland and HWI Hauptm...
dehydrogenase in Biological Technology

Preparative Nondenaturing Gel Electrophoresis to Purify NADP-Specific Glutamate Dehydrogenase From Chlorella, Rev B

Contributed by Philip W Miller, Waltraud I Dunn, and Robert R Schmidt, University of Florida, Dept. Microbiology and Cell Science, Gainesville, FL 32611 USA Florida Agricultural Experiment Station Serial Number T-00256 Introd...

Raptor Pharmaceuticals Doses First Patient in Phase 2b Clinical Trial of DR Cysteamine for Cystinosis

...candidates in clinical development to treat nephropathic cystinosis, non-alcoholic steatohepatitis ("NASH"), Huntington's Disease ("HD"), and aldehyde dehydrogenase ("ALDH2") deficiency. Raptor's preclinical programs are based upon bioengineered novel drug candidates and drug-targeting platforms derived from...

Medarex Announces Presentations at Annual Meeting of the American Society of Clinical Oncology

... "Effect of ipilimumab at 10 mg/kg on disease control in patients (pts) with M1c-stage melanoma in relation to baseline lactate dehydrogenase (LDH) levels" (Abstract #9041, Melanoma Session) M. Smylie - General poster from 8:00 a.m. to 12:00 p.m. local time on Monday, June 1, 2009. ...

Paper in Cell Cycle Reports Alfacell's ONCONASE(R) Targets siRNA

...h Institute and Department of Pathology at New York Medical College and Alfacell. The study demonstrated that silencing the glyceraldehyde 3-phosphate dehydrogenase (GAPDH) gene (an abundant and ubiquitously expressed housekeeping gene) in human lung adenocarcinoma A549 cells by siRNA was effectively prevented by ...

Vista Partners Updates Coverage on Raptor Pharmaceuticals Corp. (OTC Bulletin Board: RPTP)

...nical-stage product candidates towards marketing approval and commercialization and is currently involved in clinical trials in patients with aldehyde dehydrogenase ("ALDH2") deficiency as part of Raptor's Convivia(TM) program and nephropathic cystinosis as part of Raptor's DR Cysteamine program. Raptor's preclini...

Raptor Pharmaceuticals Expands Board of Directors and Scientific Advisory Board

... clinical-stage product candidates towards marketing approval and commercialization and is currently running clinical trials in patients with aldehyde dehydrogenase ("ALDH2") deficiency and nephropathic cystinosis. Raptor's preclinical division bioengineers novel drug candidates and drug-targeting platforms derive...
dehydrogenase in Biological Products

Goat Anti-Bacillus species Glucose Dehydrogenase Polyclonal Antibody, Unconjugated from Abcam

Description: Goat polyclonal to Glucose Dehydrogenase ( Abpromise for all tested applications). Antigen: Glucose Dehydrogenase (Bacillus species)...
Company:Abcam

Chicken Anti-Lactate Dehydrogenase Antibody, Unconjugated from Immunology Consultants Laboratory, Inc.

Description: anti-Lactate Dehydrogenase...
Company:Immunology Consultants Laboratory, Inc.

Sheep Anti-Pig Malate Dehydrogenase Polyclonal Antibody, Unconjugated from Abcam

Description: Sheep polyclonal to Malate Dehydrogenase ( Abpromise for all tested applications). Antigen: Full length protein - Pig heart malate dehydrogenase. Entrez Gene ID: 4190 Swiss Protein ID: P14152...
Company:Abcam

Rabbit Anti-Porcine LACTATE DEHYDROGENASE H4 Polyclonal Antibody, Unconjugated from AbD Serotec

Description: ANTI PIG LDH H4...
Company:AbD Serotec

Rabbit Anti-ISOCITRATE DEHYDROGENASE Polyclonal Antibody, Unconjugated from AbD Serotec

Description: RABBIT ANTI ISOCITRATE DEHYDROGENASE...
Company:AbD Serotec

Mouse Anti-Porcine Pyruvate Dehydrogenase (PDH), complex Immunocapture Kit Monoclonal Antibody, Protein G-Agarose Conjugated, Clone 15D3G9C11 from MitoScience LLC

Description: 250 g monoclonal antibody irreversibly crosslinked to protein G-agarose beads which can immunocapture ~13 g of PDH complex from heart mitochondria. Also included are 2 mg of bovine heart mitochondria for control immunocapture. The pyruvate dehydrogenase complex (PDH) immunocapture kit allows isol...
Company:MitoScience LLC

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dehydrogenase in Biological Definition

Coenzyme A

...te into Acetyl-CoA is referred to as the Pyruvate dehydrogenase Reaction. It is catalyzed by an enzyme-complex called pyruvate dehydrogenase . The enzyme consists of 60 subunits : 24 pyruvat...ihydrolipoyl transacetylase , and 12 dihydrolipoyl dehydrogenase (commonly denoted E1, E2, and E3). 24 pyruvate...

Alcohol

... to be metabolized, and often their metabolism produces even more toxic substances. Methanol, or wood alcohol , for instance, is oxidized by alcohol dehydrogenase enzymes in the liver to the poisonous formaldehyde , which can cause blindness or death. Interestingly, an effective treatment to prevent formalde...

Citric acid cycle

...H 2 O III. Isocitrate 3. Isocitrate dehydrogenase Oxidation NAD + NADH + H + IV. Oxalosuccinate 4. Isocitrate dehydrogenase Decarboxylation V. α- Ketoglutarate 5. α-Ketoglutarate dehydrogenase Oxidative decarboxylation NAD + + CoA-SH ...

Electron transfer chain

...he ultimately reduce oxygen . There are five complexes normally associated with the mitochondrial electron transfer chain . Complex I - NADH dehydrogenase , also called NADH coenzyme Q reductase. Complex II - Succinate - coenzyme Q reductase . Complex III - Coenzyme Q - cytochrome c reductase . ...

Enzyme

...h the word ending in "-ase". Examples are alcohol dehydrogenase and DNA polymerase . Kinases are enzymes that ... by converting ATP into cyclic AMP Alcohol dehydrogenase : breaks down alcohols to aldehydes in human l...ansmitters and biologically active amines NADH dehydrogenase : the first complex in the electron transfer chai...

Flavin

... phosphorylation, one molecule of FADH 2 yields approximately 1.5 ATP FMN Flavin mononucleotide is a prosthetic group found in NADH dehydrogenase . ...
dehydrogenase in Biological Dictionary

Oxidation

...traightforward Guide: What is Oxidation ? ... Oxidation is defined as the interaction between oxygen molecules and all the ... Hydroxyacyl-CoA dehydrogenase catalyzes oxidation of the hydroxyl in the b ... NADH produced during fatty acid oxidation is reoxidized by transfer of 2e- to ... Oxidation ...

Isoenzyme

... usage examples and isoenzyme quotes. ... isoenzyme definition. iso·enzyme (ī′sō en′zīm) noun ... Manufacturer of Highest Quality Human LACTATE dehydrogenase ISOENZYME from LEE BIOSOLUTIONS specializing in developing high purity, stable enzymes, antigens and ... (Redirected from Isoenzyme ) ... Isoz...

Deficiency

...ency can range from mild to ... Learn about G6PD deficiency , a disorder caused by an abnormal X-chromosome gene, ... What is glucose-6-phosphate dehydrogenase deficiency ? ... Iodine deficiency is caused by a lack of iodine, a chemical element essential to ... The incidence of iodine deficiency occur...
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