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degradation in Medical News

Oral osteoporosis meds appear to reduce the risk of jaw degradation

BOSTON, Mass. (Jan. 2, 2008) Athanasios Zavras began receiving messages from distraught patients in 2005 after case reports linked oral osteoporosis meds to bone death in the jaw. A number of doctors and dentists advised women and men taking these drugs to postpone dental work, fearing that proce...

Health Problems Due To Ecosystem's Degradation

The World Health Organization (WHO) in its Health Synthesis Report has declared that 60% of the benefits provided by the global ecosystem is being used unsustainably or degraded, //resulting in negative effects on the health of human beings. The benefits that are thus misused are clean air, fresh w...

Cochlear Americas Announces FDA Clearance of the Cochlear(TM) Baha(R) BP100 Sound Processor, the Industry's First Programmable Bone Conduction Hearing Solution

...ty and listening comfort across different listening environments. Adults are now able to transition easily to different listening environments without degradation in hearing performance. Parents enjoy greater peace of mind knowing that their child can participate all day in various daily activities, without inte...

AMDL Inc. Introduces New Brand Name for Its DR-70 (FDP) In Vitro Diagnostic Cancer Test

...ively monitor and/or detect solid tumor cancers by measuring the accumulation of specific breakdown products in the blood called Fibrin and Fibrinogen degradation Products (FDP). The product is researched, developed and manufactured in AMDL's Tustin, California-based facilities and sold to 3rd party distributor...

Materials and Processes for Medical Devices Event Brings Clinicians, Engineers, Designers Together

..." Gilbert said. Major goals include understanding the interaction of these biomaterials with the clinical environment, and understanding the degradation effects of the human body. Materials processing and fabrication, and materials-based innovation in device design as it relates to clinical performanc...

Stemedica Discovers Significant Breakthrough in the Use of Stem Cells and Stem Cell Factors for the Treatment of Retinal Degeneration

...ium (RPE), neural (NSC) and cilliary body (CB) - all obtained from human donor tissue. Various cells were injected into rats with hereditary pigmented degradation of retina. One eye of each participating rat served the treatment eye and the other eye served as the control eye. Healthy non-dystrophic and non-trea...
degradation in Medical Technology

Proteolix, Inc. Drug Candidate, PR-957, Prevents Disease Progression in Rheumatoid Arthritis Models by Selective Inhibition of the Immunoproteasome

...ar complex present in most cells that mediates the degradation of intracellular proteins, including key component... the inflammatory process. "Targeting protein degradation pathways via the proteasome represents a completel...ercializing novel therapeutics that target protein degradation pathways for cancer and autoimmune diseases. Prot...

Proteolix Presents Positive Clinical Data for Carfilzomib in Multiple Myeloma at the 2009 ASCO Annual Meeting

...hnology company, headquartered in South San Francisco, dedicated to discovering, developing and commercializing novel therapeutics that target protein degradation pathways for cancer and autoimmune diseases. Proteolix's lead product, carfilzomib, is the first in a new class of selective, irreversible proteasome...

Proteolix Presents Phase 1b/2 Clinical Data for Carfilzomib in Advanced Solid Tumor Patients at the 2009 ASCO Annual Meeting

...hnology company, headquartered in South San Francisco, dedicated to discovering, developing and commercializing novel therapeutics that target protein degradation pathways for cancer and autoimmune diseases. Proteolix's lead product, carfilzomib, is the first in a new class of selective, irreversible proteasome...

Autism Genes Discovered; Help Shape Connections Among Brain Cells

...t harbored the common variant reported in Hakonarson's first study. The other gene cluster impacted by copy number variations belongs to the ubiquitin degradation pathway. Ubiquitins are a class of enzymes that eliminate connections among nerve cells, and are involved with processing and degrading neuronal cell-...

AndroScience Corporation Announces Phase 2a Study Results on ASC-J9(TM) for the Treatment of Acne

...efficacy in the treatment of acne." ASC-J9(TM) is a small molecule with a novel mechanism of action, which selectively enhances androgen receptor degradation (ARD) to reduce androgen activity. ARD enhancers act on a key cause of acne, the androgen activation system, through reducing high levels of androgen ...

Proteolix to Present Clinical and Preclinical Data at the 50th Annual Meeting of the American Society of Hematology

... in the discovery and development of novel therapeutics that target protein degradation pathways in cancer and autoimmune diseases, today announced that data from ...ring, developing and commercializing novel therapeutics that target protein degradation pathways for cancer and autoimmune diseases. Proteolix's lead product, car...
degradation in Medical Products

Fibrin/Fibrinogen Degradation Split Products

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

SDS 200: 200 L Reservoir

Description:...e purified water under pressure to multiple-use locations. Maintain Consistent Purity of Stored Water S.D.S. Systems are designed to prevent the degradation of purified water quality over time and incorporate the following features: Compact design which allows any Elix or RiOs system to be installed di...
Company:Millipore

SDS 350: 350 L Reservoir

Description:...e purified water under pressure to multiple-use locations. Maintain Consistent Purity of Stored Water S.D.S. Systems are designed to prevent the degradation of purified water quality over time and incorporate the following features: Compact design which allows any Elix or RiOs system to be installed di...
Company:Millipore

200 L Storage & Distribution System without pump

Description:...e purified water under pressure to multiple-use locations. Maintain Consistent Purity of Stored Water S.D.S. Systems are designed to prevent the degradation of purified water quality over time and incorporate the following features: Compact design which allows any Elix or RiOs system to be installed di...
Company:Millipore

200 L Storage & Distribution System with pump

Description:...e purified water under pressure to multiple-use locations. Maintain Consistent Purity of Stored Water S.D.S. Systems are designed to prevent the degradation of purified water quality over time and incorporate the following features: Compact design which allows any Elix or RiOs system to be installed di...
Company:Millipore

SDS 350: 350 L Reservoir + Pump

Description:...e purified water under pressure to multiple-use locations. Maintain Consistent Purity of Stored Water S.D.S. Systems are designed to prevent the degradation of purified water quality over time and incorporate the following features: Compact design which allows any Elix or RiOs system to be installed di...
Company:Millipore
degradation in Medical Definition

Muscle atrophy

...ion. During atrophy, there is a down-regulation of protein synthesis pathways, and an activation of protein breakdown pathways. The particular protein degradation pathway which seems to be responsible for much of the muscle loss seen in a muscle undergoing atrophy is the "ATP-dependent, ubiquitin / proteasome ...
degradation in Medical Dictionary

Therapeutic

...pproved therapeutic shoe fitter educational course ... 'One in four' is the pi of the therapeutic society. ... Therapeutic pi confirms human degradation on an unsuspected scale and reveals a ... Therapeutic Associates is a physical therapy company with over 48 locations in ... What is Therapeu...

Osteoarthritis

... Osteoarthritis , is a group of diseases and mechanical abnormalities entailing degradation of joints, including articular cartilage and the subchondral bone next to it. Clinical symptoms of OA may include joint pain,... Features FAQs...

Hormone

...with ... Only a small amount of hormone is required to alter cell metabolism. ... Epinephrine (adrenaline), a catecholamine-type hormone ... degradation of the hormone . ... For women with hormone receptor positive breast cancer, a therapeutic benefit of ... Hormone positive patients recei...

Digestion

...rst phase of swallowing is ... A summary of Stages of Digestion in Digestion . ... Once the appropriate materials for digestion are present, degradation follows. ... The liver, pancreas and biliary system can be affected by many diseases, including hepatitis, cirrhosis, pancreatitis and galls...

Bilirubin

...in and whites of the eyes may appear yellow (jaundice) ... bilirubin n. A reddish-yellow bile pigment, C 33 H 36 N 4 O 6 , derived from the degradation of heme ... The formed bilirubin is transported to the liver, ... bilirubin test (bil′irōō′bin) n Qualitative, presumptive, quantitative, or s...
degradation in Biological News

Wind, salt and water are leading indicators of land degradation in Abu Dhabi

Desert environments are characterized by poor vegetative cover, strong winds, dry, non-cohesive sandy soils, and hyper-arid conditions. In this context, the land resources of Abu Dhabi Emirate in the United Arab Emirates are subjected to various land degradation stresses, including wind erosion, s...

Researchers design first model motor nerve system that's insulated and organized like the human body

... the same defined system. The UCF team plans to use their new model system to explore the origins of diabetic neuropathy. Once the causes of myelin degradation are identified, targets for new drug therapies can be tested with the model. Other planned experiments will focus on how electrical signals travel thr...

US-Mexico border wall could threaten wildlife species

...said Clinton Epps, a wildlife biologist at Oregon State University and co-author on the study. "A major barrier such as this could lead to significant degradation of connectivity for many different species, ultimately threatening their populations." In their study, the authors looked at the potential effects ...

Coral face 'a stormy future'

...s well as eroding the rocky platforms they need to grow on, or burying them in sand. "Maintaining coral reef populations in the face of large-scale degradation depends critically on recruitment the ability of the corals to breed successfully and settle on the reef to form new colonies. Our research suggests ...

Phthalic symbol

...ter which fell to less than 1.0 milligram per liter within two days of treatment with the microbial honeycomb. The team points out that the rate of degradation was two and a half times faster with immobilized microbes than with microbes floating free in the sample. ...

World Day to Combat Desertification focuses on human security

...ecurity is under threat from desertification, land degradation and drought. Combating this threat requires an int...uring our common future'. Desertification, land degradation and drought (DLDD) deprive people of food, water a...serts, but to the creation of new ones through the degradation of drylands, which cover 40% of the world's land s...
degradation in Biological Technology

Novel Mass Spectrometry-based Assay Reveals Degradation and Low Levels of Bioactive B-type Natriuretic Peptide (BNP) in Patients with Heart Failure

TEMPE, Ariz., Oct. 16 /PRNewswire/ -- A team of researchers from Intrinsic Bioprobes Inc. has reported on a novel quantitative mass spectrometry immunoassay for the detection of bioactive B-type natriuretic peptide (BNP), in an article published online on Oct. 14 in the journal of Circulation:...

Nanoengineered barrier invented to protect plastic electronics from water degradation

A breakthrough barrier technology from Singapore A*STARs Institute of Materials Research and Engineering (IMRE) protects sensitive devices like organic light emitting diodes (OLEDs) and solar cells from moisture 1000 times more effectively than any other technology available in the market, opening...

Polymer Degradation Mechanisms Encountered in Pyrolysis-GC/MS

Author: Thomas Wampler CDS Analytical, Inc. 465 Limestone Road Oxford, PA 19363-0277 Introduction The use of analytical pyrolysis 1 with gas chromatography/ mass spectrometry (GC/MS) to study the structure of polymeric ...

Protector RNase Inhibitor Enhance the Protection of RNA against Degradation

Protector RNase Inhibitor Is a new type of RNase inhibitor and inhibits a wide known spectrum of RNases. Does not interfere with the performance of enzymes in an assay - even when high amounts (e.g., up to 1...

Nanopillars promise cheap, efficient, flexible solar cells

...e solar cell in clear plastic (polydimethylsiloxane) to make a bendable device, which could be flexed with only marginal effect on performance and no degradation of performance after repeated bending. "There are lots of ways to improve 3-D nanopillar photovoltaics for higher performance, and ways to simplif...

Sorenson Molecular Genealogy Foundation to Protect Archived DNA Using Biomatrica's Room Temperature Storage

...olecular mechanisms used by these organisms. The technology works by forming a thermo-stable barrier during the drying process to protect samples from degradation during storage at room temperature. About Biomatrica (R) , Inc. Biomatrica ( www.biomatrica.com ) is a biostability company that provides i...
degradation in Biological Products

Anti-UbcH7 Antibody, Unconjugated from CHEMICON

Description:...e c-Cbl RING domain. Evidence suggests that this E2 is involved in both the degradation of non-""N-end rule"" protein substrates and of certain N-a -acetylated proteins as well as the degradation of tumor suppressor protein p53....
Company:CHEMICON

N-terminal Sequencing from Primm Biotech, Inc.

Description:...ified by HPLC or mono-and bidimensional SDS-PAGE, followed by electroblotting on PVDF (Polyvinylidene difluoride) membranes using the well known EDMAN degradation method. Pre-treatment of the sample, i.e. reduction and alkylation of the cysteine residues, is also performed. Set-up for protein sequencing + $96....
Company:Primm Biotech, Inc.

Mung Bean Nuclease from Promega

Description:... Mung Bean Nuclease catalyzes the degradation of single-stranded DNA and RNA endonucleolytically to yield 5-phosphoryl terminated products. While the nuclease prefers ssDNA over dsDNA by 30,000-fo...
Company:Promega

Flow Cytometry Kit for Apoptosis from Sigma-Aldrich

Description:...uridine triphosphate labeled with larger dyes such as FITC, biotin or digoxigenin. One of the biological characteristics that defines apoptosis is the degradation of genomic DNA into fragments of 180-200 bp, commonly called "DNA laddering". The fragmentation creates a large number of 3'-hydroxyl sites at the DN...
Company:Sigma-Aldrich

Mouse Anti-p14 ARF / p16Beta Ab-2 Mouse Monoclonal Antibody, Unconjugated, Clone 14P02 from Lab Vision

Description:... both of which function in tumor suppression. p14^ARF^ arrests the cell cycle in a p53-dependent manner. p14^ARF^ binds to mdm2 and promotes the rapid degradation of mdm2 proteinrequired for mdm2 modification and concurrent p53 stabilization and accumulation. This interaction is mediated by the exon 1Beta-encod...
Company:Lab Vision

Endoplasmic Reticulum Isolation Kit from Sigma-Aldrich

Description:...efficient enrichment of functional endoplasmic reticulum (ER) from mammalian tissue or cell culture. The isolated ER are useful for protein synthesis, degradation and metabolic pathway analysis. Metabolic abnornalities of ER include carnitine acetyltransferase deficiency in children, cystic fibrosis and many mor...
Company:Sigma-Aldrich
degradation in Biological Definition

Apoptosis

...roteins ) in the cell nucleus ) undergoes initial degradation and condensation (see the article by Madeleine Kih... specialized caspases have already advanced in the degradation of nuclear pore proteins and have begun to degrade...romatin bodies or nucleosomal units due to the degradation of DNA [4] . Plasma membrane blebbings. ...

Biodiversity

...l ecosystem is destined for collapse if it further reduced in complexity. Some justify this situation not so much by a species overuse or ecosystem degradation than by their conversion in very standardized ecosystems (e.g., monoculture following deforestation ). Before 1992, others pointed out that n...

Biopolymer

...of the biopolymer. There are a number of biophysical techniques for determining sequence information. Protein sequence can be determined by Edman degradation , in which the N-terminal residues are hydrolyzed from the chain one at a time, derivatized, and then identified. Mass spectrometer techniques can a...

Blood

... 2 Anatomy of blood 3 Physiology of blood 3.1 Production and degradation 3.2 Transport of oxygen 3.3 Transport of carbon dioxide 3.4 Transp...hitecture of the blood vessels. Physiology of blood Production and degradation Blood cells are produced in the bone marrow ; the process is termed hem...

Collagen

...e tissue . It has great tensile strength , and is the main component of ligaments and tendons . It is responsible for skin elasticity, and its degradation leads to wrinkles that accompany aging. Collagen also fills out the cornea where it is present in crystalline form. Collagen is the most abund...

Evolution

...e mutation effect is the proposition that a gene that is not under selection will be destroyed by accumulated mutations. This is an aspect of genome degradation . Selection of organisms for desirable characteristics, when done by humans, e.g. for agriculture or as pets, is called artificial selection ....
degradation in Biological Dictionary

Ubiquitin

...l protein modifier ubiquitin as a way to regulate cellular functions degradation by covalent ligation to ubiquitin , a highly conserved small protein. Ubiquitin -mediated degradation of regulatory proteins plays important roles in ... Pfam is a large co...

Transfer RNA

...... Total Aminoacyl- Transfer RNA Pool Is Greater ... Messenger RNA . RNA Interference. Protein Destruction. Inhibit Protein Expression. MRNA degradation ... Rna . Search multiple engines for messenger rna . www. ... Transfer RNA and its Interactions with Seryl-tRNA Synthetase. Michael W. Hapia...

S phase

...which DNA ... S phase . ( 2009) ... Cell cycle articles relating to ' S phase inhibitors' ... Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase . ... ... activity is restricted to the G1- S phase of the cell cycle. ... During S phase , cyclin A forms a compl...

RNA interference

...he expression of target genes. ... referred to as the RNA interference (RNAi) pathway. ... RNA interference (RNAi) is the process of mRNA degradation that is induced by ... Introduction of synthetic siRNAs can induce RNA interference in mammalian cells. ... An up-to-the-minute listing of publ...

Ribonuclease

... Ribonuclease is a type of nuclease that catalyzes the degradation of RNA into smaller components. Ribonucleases can be divided into endoribonucleases and exoribonucleases, and comprise several sub-classes within the ...

Proteolysis

... Proteolysis is the directed degradation (digestion) of proteins by cellular enzymes called proteases or by intramolecular digestion. A protease is any enzyme that conducts proteoly...
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