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Defensins in Medical News

Scientists Spot Dog Fur Color Gene

...rom the paper is that in trying to understand what defensins really do, we've been looking under a lamppost bas..."In fact, we really have very little evidence that defensins do much in terms of defending. The genetic approach is more agnostic and suggests that defensins have additional or alternative functions outside t...

Stanford researchers sniff out gene that gives dogs black fur

...rom the paper is that in trying to understand what defensins really do, we've been looking under a lamppost bas..."In fact, we really have very little evidence that defensins do much in terms of defending. The genetic approach is more agnostic, and suggests that defensins have additional or alternative functions outside t...

Genetically Altered Cells Prevent Lethal Infections in Substituted Skin

...adjunct research associate professor at the University of Cincinnati (UC) and researcher at Cincinnati Shriners Hospital for Children. Supp says defensins could become an effective alternative method for burn wound care and infection control. Using them in cultured skin substitutes, she adds, could also ...

A Protein from Primate may Save Humans from HIV !

... no longer made by humans or advanced primates such as chimpanzees. However, theta-defensins are more active against HIV-1 than the other two types of defensins and can be developed in laboratories, two features that suggest retrocyclins still could become an effective way to fight the virus. HIV-1 is the ...

Mushroom found to be a source of a new antibiotic: Plectasin

...s primary, secondary and tertiary structures that closely resemble those of defensins found in spiders, scorpions, dragonflies and mussels. Recombinant plectasin...and show the therapeutic potential of plectasin. They also suggest that the defensins of insects, molluscs and fungi arose from a common ancestral gene. ...

Mushroom found to contain powerful antibiotic

...ia, including streptococcus, enterococcus and staphylococcus. Since about 200,000 other species of fungus exist, it seems likely that many more fungal defensins will be found, possibly allowing for highly targeted antimicrobial drugs that will render today's broad spectrum drugs obsolete. The compound ...

Scientists Discover Ways To Block Virus From Attacking Cells

... First identified more than 20 years ago at UCLA, defensins are peptides naturally produced by the immune syst.../ to ward off viruses. However, it was unclear how defensins worked. Now UCLA and NIH scientists have discovere...V and herpes, as well. Unlike antibodies, however, defensins are not pathogen specific. In addition to blocking...
Defensins in Medical Dictionary

Neutrophil

...l for the resolution of inflammation. ... Neutrophils (x106/g sputum) in P aeruginosa infected patients (Kruskal-Wallis p ... Human neutrophil defensins (alpha-defensins) belong together with the beta ... Activation of neutrophils leads to rapid release of HNP. ... Recirculation-induced neutro...
Defensins in Biological News

NIH funds $9.5 million for research on HIV and the human innate immune system

...berg and his colleagues discovered that human beta defensins (hBDs), frontline innate defense molecules found i... used to study molecular interactions between beta defensins and key receptors on human cells that the research... used to study molecular interactions between beta defensins and key receptors on human cells that the research...

Protein marker for schizophrenia risk

...es not). In these twin sets, both siblings had significantly elevated alpha defensins as compared with a group of control twins. Changes were also found in patie... investigated soon after diagnosis, which means that higher levels of alpha defensins were not caused by medication or progression of the disease. Because bo...

Bypassing the insulin highway

...on in the liver without targeting insulin, researchers have found. Neutrophils, a type of white blood cell, produce special immune proteins called defensins which seem to have a connection with glucose levels. During bacterial infection, defensin production can increase dramatically, a rise that frequently...

UCLA AIDS Institute researchers find a peptide that encourages HIV infection

...IV-1 by about 95 percent, the RC-111 variant enhanced viral infection five-fold. There are three structural varieties of peptides, also known as defensins ?alpha, beta and theta, Lehrer said. Humans have only alpha and beta; monkeys have all three. "Here's a peptide whose normal structure allows it ...

Defense peptide found in primates may block some human HIV transmissions

... no longer made by humans or advanced primates such as chimpanzees. However, theta-defensins are more active against HIV-1 than the other two types of defensins and can be developed in laboratories, two features that suggest retrocyclins still could become an effective way to fight the virus. HIV-1 is the ...

Defensins Ward Off HIV In Two Ways

...attempts to protect itself from HIV infection via the innate immune system. defensins are proteins found in cells, which have been shown to have anti-HIV activity. However, the mechanism by which the defensins control HIV infection has not been known. Appearing online on February 17 i...
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