Defective in Medical Technology
Study Shows How Defective DNA Repair Triggers Two Neurological Diseases
St. Jude scientists' findings in ataxia telangiectasia-like disease and Nijmegen breakage syndrome offer insight into the links between brain disease and cancer vulnerability in people carrying the diseases
MEMPHIS, Tenn., Jan. 14 /PRNewswire-USNewswire/ -- Scientists at St. Jude Children's...
Synvista Collaboration Demonstrates in Preclinical Studies the Mechanism for Defective Cholesterol Transport in Patients with Diabetes
MONTVALE, N.J., Nov. 5 /PRNewswire-FirstCall/ -- Synvista Therapeutics,
Inc. (Amex: SYI ) announced results of a series of preclinical studies
designed to explain the mechanism underlying dysfunctional high density
lipoprotein (HDL), that creates a defect in reverse cholesterol transport
Pharmaxis Announces Positive Results of Phase 3 Cystic Fibrosis Trial
...n, there is a constant flow of mucus over the surfaces
of the air passages in the lungs, removing debris and bacteria. In CF, an
inherited disease, a defective
gene disrupts ion transport across the
epithelial membrane within cells. In the lungs, this leads to a depletion of
the airway surface liquid that no...
Torax Medical Launches Pivotal Clinical Study of New Acid Reflux Treatment
...ients suffering from GERD despite medical therapy.
GERD is caused by a defective
lower esophageal sphincter, a ring-like muscular valve that surrounds the e...s), may improve heartburn symptoms but it does not address the mechanically defective
sphincter, allowing gastric reflux to continue. Chronic gastric reflux may ...
AMT: Glybera(R) Lowers Pancreatitis Incidence Significantly
... is well-tolerated and safe.
AMT has developed Glybera as an effective treatment for patients with the
rare genetic disorder LPLD. Because of a defective
gene, LPLD patients do not
produce an enzyme that normally breaks down a certain type of fat carrying
particles in the blood. Glybera is a gene therap...
First Clinical Experience With Soliris(R) in Treating Patients With Two Rare Complement-Mediated Diseases Presented at ASH Annual Meeting
...remic Syndrome (aHUS) and Cold Agglutinin
Disease (CAD), two rare and serious diseases. Like patients with PNH, patients
with aHUS are missing or have defective
complement inhibitors that help to
regulate the body's immune system. These patients suffer from hemolysis, blood
clotting which can be measured in pa...
Defective in Medical Products
Contigen Bard Collagen Implant
Description:...ption for the treatment of Stress Urinary Incontinence (SUI). Natural collagen protein adds bulk to surrounding urethral tissue to aid coaptation in a defective
internal sphincter. Compatible with the body's own structure, Contigen Bard Collagen Implant forms a soft network of fibers, inducing new tissue growt...
Company:Bard Urological Division
Integra SP II Anesthesia Machine
Specifically designed for low flow
Left or right handed layout
Writing table and footrest
Contemporary ergonomic design
Larger work area
Recessing absorber and ventilator
Only two preventive maintenances are required each year
Defective in Medical Dictionary
...cocele treatment has ... Varicocele is a dilation (enlargement) of the internal spermatic veins that ... A varicocele develops because of defective
valves that normally allow for blood ... vasectomy reversal, vasectomy reversals, male infertility, vasectomy, vasovasostomy, no-scalpel vasec...
...ve mild thalassemia , you may not need ... thalassemia ( ′thalə′sēmēə ) ( medicine ) A hereditary form of hemolytic anemia resulting from a defective
synthesis of hemoglobin: thalassemia major Thalassemia describes a group of inherited disorders characterized by reduced or ... Beta thalasse...
...nzyme called ... Tay - Sachs disease occurs when the body lacks hexosaminidase A, a protein that ... Tay - Sachs disease is caused by a defective
gene on chromosome 15. When both ... Tay - Sachs disease is a fatal genetic disorder, inherited in an autosommal ... Based in part on th...
...nosing celiac sprue disease. ... sprue n. A chronic, chiefly tropical disease characterized by diarrhea, emaciation, and anemia, caused by defective
absorption of nutrients from the More about Celiac Disease: Causes and symptoms Diagnosis Treatment Prognosis ... Also known as gluten-induced e...
...ness and contractility in ... Airway smooth muscle tissues are subjected to large changes in shape and volume ... A research team identifies a defective
gene that affects vascular smooth - muscle cells in people who suffer from hereditary thoracic aortic disease. ... Analysis of CCN5 in Ani...
... Sickle cell disease is an inherited blood disorder characterized by defective
hemoglobin. ... is similar to sickle cell -C disease except that an el... Sickle cell disease is an inherited blood disorder characterized by defective
hemoglobin (a protein in red blood cells that carries oxygen to the...
Defective in Biological News
La Jolla Institute discovers novel tumor suppressor
...s. He and his team set out to investigate further, choosing to focus specifically on myeloproliferative disease because almost all of the mice with a defective
PLC-beta 3 gene eventually developed severe myeloproliferative disease.
The team determined that tumor production hinged on the PLC-beta 3's abili...
Little-known protein found to be key player
...ted membrane tubes and chambers that's critical for normal cell function. The tests also showed too little atlastin led to a fragmented ER. Flies with defective
atlastin were sterile and short-lived.
"The endoplasmic reticulum is an ever-changing environment," McNew said. "It grows. It retracts. It expands....
Bad mitochondria may actually be good for you
... Mice with a defective
mitochondrial protein called MCLK1 produce elevated amounts of reactive oxygen when young; that should spell disaster, yet according to a study in thi...
Preimplantation genetic diagnosis may pose neurological risks
...sure couples that may be carriers of genetic disease (e.g. Ashkenazi Jews who have a high incidence of Tay-Sachs among their population) don't pass on defective
genes to their children. While PGD is not believed to pose any serious health risks, the procedure does involve manipulating the developing embryo and...
Munich researchers discover new target for tailored antibiotics
...led examination of the reaction mechanism using computer simulation and mutagen experiments, in which E. coli bacteria are coerced into synthesizing defective
IspH enzymes. Thus, the X-ray structure, kinetic measurements, and mutagenic analyses ultimately confirmed the unusual arrangement of three iron and f...
The downside of microtubule stability
...ads to production of faulty dynamin 2, a protein that is crucial for endocytosis but also latches onto microtubules. Tanabe and Takei investigated how defective
dynamin 2 hampers cells.
Normal microtubules are continually extending and shrinking. But microtubules from cells that made the faulty version of d...
Defective in Biological Technology
Evidence for a New Genetic Link to Therapeutic Efficacy for Alzheimer's Disease
...ease. In clinical trials, Axona has been shown to safely improve cognitive function and memory in AD patients. Axona addresses the hypometabolism or defective
metabolism of glucose that occurs in those areas of the brain that are involved in Alzheimer's disease. Accera engages in research, development and c...
Sorenson Molecular Genealogy Foundation to Protect Archived DNA Using Biomatrica's Room Temperature Storage
"I am all too familiar with losing precious biological materials since my wife has lost an enormous number of samples in defective
freezers, and I have seen decreased sample quality through repeated freeze/thaw cycles, even when stored at minus 80 degrees," said Rolf Muller, Ph.D....
Telik Reports Preclinical Results at AACR Annual Meeting
...and apoptosis in human cancer cell lines, such as HCT116 (colon), HL60 (promyelocytic leukemia) and A549 (lung) - reflecting cell lines with intact or defective
p53-dependent post-mitotic checkpoints.
More than 80% inhibition of tumor growth was seen in an HL60 xenograft model following a once daily or...
Accera, Inc. Launches Neuera Pharmaceuticals, Inc.
...nic neurological conditions where the mechanism of defective
energy metabolism or hypometabolism is involved. ... a physiological hallmark of Alzheimer's disease. defective
metabolism of glucose has been shown to precede th...D patients. Axona addresses the hypometabolism or defective
metabolism of glucose that occurs in those areas o...
GYNECARE PROLIFT+M(TM) Pelvic Floor Repair System Launched in US for Use in Pelvic Organ Prolapse Surgery
...tissues) of the pelvic floor in vaginal wall prolapse where surgical treatment is intended, either as mechanical support or as a bridging material for defective
fascia. The mesh is implanted using the tension-free vaginal mesh (TVM) technique, a procedure involving a small incision in the vaginal wall.
ThermoGenesis Says FDA Concurs with Plan for Previously Announced AXP(TM) Bagset Recall
...ety issues; the field action was a result of the potential for particulates to be released into the sterile, non-pyrogenic fluid path as a result of a defective
component provided by one of the suppliers to the Company. The Company indicated that it was providing customers a blood filter to be used, as necessa...
Defective in Biological Products
Rabbit Anti-Human ASIP / PAR3 Monoclonal Antibody,, Clone ZMD.283 from Invitrogen
Description:...: Fusion protein derived from human ASIP/PAR-3. Specificity: Specific for ASIP/PAR-3 (atypical PKC isotype-specific interacting protein/ partitioning defective
3). This antigen is not related to the protease-activated-receptors also called PAR. Reactivity: Human Dog Xenopus (positive controls: Caco-2 MDCK A6...
Defective in Biological Definition
...tion to its importance as a biological phenomenon, defective
apoptotic processes have been implicated in a very... interferon in tumor suppression
3.2 Cancer and defective
3.3 Role of apoptotic produc...to the cell's reproductive cycle.
Cancer and defective
Liling Yang et al. reporte...
...can cause scurvy , a disease that leads to loss of teeth and easy bruising caused by a reduction in strength of connective tissue due to a lack of or defective
The white collagen that makes up the matrix of most connective tissue in mammals consists of inter-woven fibres of the protein collagen. T...
Defective interfering particle
interfering particles ( DIPs ) are virus particles that are missing part or all of their genome . Because of these deletions in their genome, DIPs...
...into an individual's cells and tissues to treat a disease , and hereditary diseases in particular.
Gene therapy typically aims to supplement a defective
mutant allele with a functional one. Although the technology is still in its infancy, it has been used with some success. Antisense therapy is n...
Defective in Biological Dictionary
...hat the zona pellucida's ability to ... Sperm– zona pellucida binding and penetration were assessed on the oocytes that ... In conclusion, defective
sperm– zona pellucida interaction was the major cause ... Definition of zona pellucida at Dictionary.com with free online dictionary, ... z...
... the enzyme steroid ... The X Chromosome . X-Linkage. X-Inactivation. Mechanism ... With only a single X chromosome , males who inherit the defective
gene (always ... The National Fragile X Foundation unites the fragile X community to enrich lives ... The X chromosome has almost nothi...
...or genes are described in more detail below. ... When both copies of a tumor suppressor gene are functioning (represented below ... A single defective
tumor suppressor will still leave the cell with one ... Loss of Tumor Suppressor Gene Triggers Colon Cancer (09.03.98) ... Molecular Stru...
...eplacement of somatic histones by ... ... those genes that optimize spermatogenesis and spermiogenesis have been selected ... reported that defective
spermiogenesis is associated with the ... ... expressed postmeiotically during spermiogenesis in elongated spermatids and in mature sperm. .....
... FAMILIES. Human (Homo sapiens) ... Pseudogene assignments for an assortment of prokaryotic genomes are available here. ... pseudogene ( ) n. A defective
segment of DNA that resembles a gene but cannot be transcribed. ... A pseudogene structure in 5S DNA of Xenopus laevis" ... The discovery of ...
...otein ... Ribosome- initiator tRNA complex as an intermediate in translation initiation in ... Mutants of Escherichia coli initiator tRNA defective
in initiation. ... Information about Initiator Transfer RNA tRNA , Watson, Crick, Methionines,tRNAfmet, Anacystis Nidulans, Pyrimidines, Purines...