Fruit fly protein acts as decoy to capture tumor growth factors, find Penn researchers
PHILADELPHIA -- Researchers at the University of Pennsylvania School of Medicine have shown how Argos, a fruit fly protein, acts as a decoy' receptor, binding growth factors that promote the progression of cancer. Knowing how Argos neutralizes tumor growth may lead to new drug designs for inhibiti...
Scientists identify lab-made proteins that neutralize multiple strains of seasonal and pandemic flu
...lutinin protein to which humans rarely make antibodies," says Dr. Marasco. "We believe this is because the head of the hemagglutinin protein acts as a decoy
by constantly undergoing mutation and thereby attracting the immune system to produce antibodies against it rather than against the pocket in the neck...
Manipulating Key Protein May Prevent Eczema
...ard Medical School.
Geha and his colleagues found that even mice with IL-21 receptors could be spared from developing eczema by pumping them with a decoy
receptor to fool their immune system and keep it from attacking the inflamed area. The finding offers further evidence that IL-21 is important in the...
New method to overcome multiple drug resistant diseases developed by Stanford researchers
...tuation by adding another molecule to the mix to inhibit the pump, keeping it busy so the medication can slip in while the pumps are occupied with the decoy
molecule. But if any of the molecules make their way into healthy cells, they can gum up the proper functioning of the pumps in those cells, too, add...
Myostatin inhibitors may improve recovery of wartime limb injuries
A $1.2 million grant from the Office of Naval Research to Dr. Hamrick is enabling laboratory studies of two experimental myostatin inhibitors: a decoy
receptor and a binding protein, both developed by MetaMorphix, Inc. of Beltsville, Md. Both inhibitors have been shown effective in muscle regeneratio...
Scientists discover new role for miRNA in leukemia
... microRNA called miR-328 binds with a protein that, in blast phase CML, prevents immature blood cells from maturing. We believe that miR-328 acts as a decoy
molecule that normally ties up the protein, which enables the white blood cells to mature as they should, Perrotti says.
During progression from chr...
Story ideas from molecular & cellular proteomics
...ase of the larvae, the scientists suggest that although the chemicals secreted prompt the human immune system to attack them, these chemicals act as a decoy
so that the larvae themselves are not destroyed and can spread at will. The chemicals released by the eggs also attract molecules from the immune syst...
Quack of Gurgaon Confesses of Aborting 250 Female Fetuses
Acting on a complaint by the health department, the police raided the clinic after the doctor did conduct a sex determination test on a decoy
female customer sent by the authorities.
O.P. Mittal, the head of Haryana's health services, led the raiding team, which recovered the ultraso...
Doctor Caught Red-Handed For Conducting Sex-Determination Test
... unborn child//.
Vijay Bhargawa was caught immediately after she conducted the test at Rewari town and disclosed the sex of the unborn child to a decoy
customer sent to her by state health officials.
A bribe of Rs.2,350 allegedly paid for the test was recovered from her.
Sex determination ...
Punjab Government To Clamp Down On Sex Determination Tests
... The authorities in India’s Punjab state are using decoy
customers to trap doctors who conduct sex determination tests for unborn ba...o is less than 800 females for every 1,000 males.
Officials said the decoy
customers would be paid up to Rs.5,000 to help nab diagnostic centers indul...
Decoy in Medical Technology
Decoy in Biological News
Scientists determine drug target for the most potent botulinum neurotoxin
...k the toxins action, the researchers designed four decoy
protein fragments that mimic the structure of the ...arily binds. The toxin then attaches itself to the decoy
fragments instead of to the cells protein. This re...o the protein inhibitors. They found that all four decoy
proteins are efficient at inhibiting the toxins bi...
Decoy makes sitting duck of superbugs
...n a couple of years and at a fraction of the normal cost.
The technology can give fresh patent life to existing antibiotics - when combined with a decoy
they can be patented as a new drug.
This comes at a time when the number of new antibiotics receiving approval has dramatically declined. Faced wi...
Odd protein interaction guides development of olfactory system
...th derailed and Wnt5 are known to play key roles in the growth and development of the nervous system.
In the antennal lobe, derailed is acting as a decoy
receptor, said U. of I. cell and developmental biology professor Huey Hing, who led the study.
It is nonproductively just sucking up the ligand. No...
Cancer-killing invention also harvests stem cells
...bind to TRAIL, but only two trigger cell death. The other three are called decoy
receptors. Healthy cells contain a lot of decoy
receptors, giving them a natural protection against TRAIL, whereas cancer c...
Decoy pill saves brain cells
The researchers injected laboratory mice with a decoy
peptide containing a snippet of a receptor that fa...ped the toxic enzyme calpain would latch on to the decoy
instead of the actual receptor, averting brain dam...ed a calcium-calpain feedback loop, treatment with decoy
peptides might save some cells, Baudry said.
Tool developed to silence genes in specific tissues using RNAi
...if they could produce a double-stranded RNA that mimics the RNA produced by a gene they wish to silence, RNAi would do the job for them. Producing the decoy
"small RNAs" that trigger RNAi has become a fairly simple process, Wilkinson says, but the difficulty has been to use these matches only in specific t...
Grabbing addiction by the tail
...have sidestepped this problem by crafting a peptide that mimics a portion of the tail of the glutamate receptor and, once inside a neuron, serves as a decoy
to prevent the loss of glutamate receptors.
Yu Tian Wang, an HHMI international research scholar, and colleagues at the University of British Colum...
UCLA scientists reveal how Nipah virus infects cells
...neered a harmless virus with Nipah virus proteins embedded in its coat. The decoy
virus successfully infected cells vulnerable to the Nipah virus, but could not infect Nipah-resistant cells.
In the final step, the decoy
virus entered nerve cells and cells lining blood vessels by latching onto E...
New binding target for oncogenic viral protein
...wever, unlike the other substrates recognized by Fbw7, T antigen is not destroyed by the cell.
Drs. Clurman and Welcker suspect that by acting as a decoy
and binding to Fbw7, T antigen protects cellular Fbw7 targets that facilitate viral replication and tumorigenesis.
"I think this work underlines th...
Decoy in Biological Technology
Decoy in Biological Products
TypeOne Restriction Inhibitor from EPICENTRE Biotechnologies
Description:...ge protein called "ocr", TypeOne Inhibitor is readily electroporated into cells along with transforming DNA. In vivo the protein acts as a molecular decoy
that blocks the DNA binding site of type I R-M enzymes and inhibits DNA cleavage....
Decoy in Biological Dictionary
... hepatocytes , ... Incubation of rat hepatocytes with Hcy (50–200 µ) caused a significant increase ... When hepatocytes were transfected with decoy
AP-1 oligodeoxynucleotide to ... Human hepatocytes generated in this model retained functional properties of ... To identify human hepatocytes...
...ian Olympic-training Regatta, Kingston, a ... WE Cork offers the highest level of experience and quality in natural cork . ... expansion joints, decoy
blocks, cork hand bags and wallets. ... Open source travel guide to Cork , featuring up-to-date information on ... Cork is the anglicised vers...