Scripps Research cancer biology department awarded more than $8 million in new research grants
Cleveland received a five-year grant (approximately $2.1 million) from NIH/NCI to study the regulation and role of the enzyme ornithine decarboxylase
(Odc). This enzyme plays key roles in cancer and is directly regulated by cancer-causing Myc oncoproteins and also by mutated Ras oncogenes, which tog...
Older Drug Effective in Treating Pediatric Nerve Cancer
In the study, published in the Jan. 15 issue of Cancer Research , researchers successfully used DFMO to target ornithine decarboxylase
(Odc), a protein that aids in cancer cell growth and has been found in abundance in neuroblastoma with a poor prognosis, to prevent neuroblastoma in g...
DFMO may affect Barrett's esophagus
...ne putrescine, a target of the drug and a possible cancer risk marker. The agent works by inhibiting an enzyme in polyamine synthesis called ornithine decarboxylase
(ODC). "ODC activity in Barrett's mucosa has been shown to be significantly higher in Barrett's than in normal adjacent mucosa from the same patients,...
Schizophrenia linked to dysfunction in molecular brain pathway activated by marijuana
...umber of factors, including age and sex. The researchers evaluated levels of CB1R messenger RNA and protein, and also measured levels of glutamic acid decarboxylase
(GAD-67), an enzyme that makes GABA, and cholecystokinin (CCK), a neuropeptide released from GABA neurons that, among other actions, regulates the pro...
Hope For Stiff-Person Syndrome
... At present, there is no cure for stiff-person syndrome, a disease marked by high levels of antibodies to glutamic acid decarboxylase
(GAD65), an enzyme involved in the production of a movement-regulating neurotransmitter.// Patients are usually treated with Valium (diazepam), which ...
Decarboxylase in Medical Technology
Decarboxylase in Medical Products
Glutamic Acid Decarboxylase Antibody
Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Glutamic Acid Decarboxylase (GAD65) Autoantibody ELISA
Description: ELISA kit for the quantitative determination of autoantibodies to glutamic acid decarboxylase
(GAD65) in serum...
Glutamic Acid Decarboxylase (GAD65) Autoantibody RIA
Description: The autoimmune destruction of the insulin-producing pancreatic beta cells generally occurs over a period of time leading to the eventual onset of overt diabetes mellitus. During this extended pre-clinical phase, the characteristic circulation of autoantibodies against a variety of islet cell antige...
GAD/IA-2 Autoantibody Screen
Description:...ng this extended pre-clinical phase, the characteristic circulation of autoantibodies against a variety of islet cell antigens including glutamic acid decarboxylase
(GAD65), IA-2 (a tyrosine phosphatase-like protein), and insulin provides early markers of autoimmune disease activity.
Measurement of these immun...
Decarboxylase in Biological News
Tobacco makes medicine
... other auto-antigens associated with the disease. The team has a particular auto-antigen in its sights the 65-kDa isoform of the enzyme glutamic acid decarboxylase
(GAD65) which they have also produced in transgenic tobacco plants.
According to Pezzotti, "Transgenic plants are attractive systems for the produ...
Biomarkers allow doctors to match therapy to patient
...et for treatment of neuroblastoma, the most common solid tumor among young children.
The treatment involves inhibiting the production of ornithine decarboxylase
(ODC1), a gene driven by the MYCN oncogene that is a powerful predictor of death from this disease. Researchers report that ODC1 inhibition delayed or...
Gene therapy study shows safety and statistically significant improvement in Parkinson's disease
... activity specific to the treated hemisphere.”
The study used an adeno-associated virus (AAV) vector to deliver an inhibitory gene (glutamic acid decarboxylase
or “GAD”) to the subthalmic nucleus (STN) of the brain. In Parkinson’s disease, STN activity is abnormally increased, largely due to a deficit in GABA...
Neurologix announces positive results of gene therapy clinical trial in Parkinson's disease
...vector was injected into a specific target site in the brain in order to transfer a gene to treat Parkinson's disease. The gene encodes glutamic acid decarboxylase
(GAD), an enzyme which synthesizes the major inhibitory neurotransmitter in the brain, (gamma)-aminobutyric acid (GABA).
Under the FDA-sanctioned t...
Decarboxylase in Biological Technology
Transformation of Filamentous Fungi by Microprojectile Bombardment
...t., 23 , 42-46 (1993).
3. Ballance, D. J., Buxton F. P. and Turner, G., Transformation of Aspergillus nidulans by the ornithine-5-phosphate decarboxylase
gene of Neurospora
crassa, Biochem. Biophys. Res. Comm., 112 , 284-289 (1983).
4. Bennett, J. W. and Klich, M. A., Aspergillus: ...
Quantitation of GAD67 Gene Expression in Prefrontal Cortex of Schizophrenia Patients Using the iCycler iQ Detection System and Molecular Beacons, Rev A
The synthesis of GABA is catalyzed by the enzyme glutamic acid decarboxylase
(GAD). Molecular cloning studies have shown that in the adult br...n in the
γ-aminobutyric acid-producing enzyme glutamic acid decarboxylase
Natl Acad Sci USA 94, 1145111455 (1997)
New Kit Generates Exceptionally Pure Total RNA for RT-PCR
as medium abundance, its expression level is higher in liver than in brain 7
3 ). Similarly, ornithine decarboxylase
is expressed at overall low
levels but the levels vary in tissues throughout the body. 8
The presence of the expected PCR bands...
Decarboxylase in Biological Definition
...eral insulin application mechanisms under experimental development as of 2004. There have also been proposed vaccines for type I using glutamic acid decarboxylase
(GAD), but these are currently not being tested by the pharmaceutical companies that have sublicensed the patents to them.
For type 2 diabetics, ...
...yrase : catalyzes the negative supercoiling of prokaryotic DNA
: synthesizes the neurotransmitter GABA in the brain
Glutathione perox...rring electrons from NADH to coenzyme Q
: processes ornithine as the first step in the production of polyamines ...