Scripps Research cancer biology department awarded more than $8 million in new research grants

... therapy. Cleveland received a five-year grant (approximately $2.1 million) from NIH/NCI to study the regulation and role of the enzyme ornithine decarboxylase (Odc). This enzyme plays key roles in cancer and is directly regulated by cancer-causing Myc oncoproteins and also by mutated Ras oncogenes, which tog...

Older Drug Effective in Treating Pediatric Nerve Cancer

...gh-risk neuroblastoma." In the study, published in the Jan. 15 issue of Cancer Research , researchers successfully used DFMO to target ornithine decarboxylase (Odc), a protein that aids in cancer cell growth and has been found in abundance in neuroblastoma with a poor prognosis, to prevent neuroblastoma in g...

DFMO may affect Barrett's esophagus

...ne putrescine, a target of the drug and a possible cancer risk marker. The agent works by inhibiting an enzyme in polyamine synthesis called ornithine decarboxylase (ODC). "ODC activity in Barrett's mucosa has been shown to be significantly higher in Barrett's than in normal adjacent mucosa from the same patients,...

Schizophrenia linked to dysfunction in molecular brain pathway activated by marijuana

...umber of factors, including age and sex. The researchers evaluated levels of CB1R messenger RNA and protein, and also measured levels of glutamic acid decarboxylase (GAD-67), an enzyme that makes GABA, and cholecystokinin (CCK), a neuropeptide released from GABA neurons that, among other actions, regulates the pro...

Hope For Stiff-Person Syndrome

... At present, there is no cure for stiff-person syndrome, a disease marked by high levels of antibodies to glutamic acid decarboxylase (GAD65), an enzyme involved in the production of a movement-regulating neurotransmitter.// Patients are usually treated with Valium (diazepam), which ...

Decarboxylase in Medical Technology

Diamyd(R) Study Published in Prestigious New England Journal of Medicine

... disease in which the body's own immune system attacks the cells in the body that produce insulin. The active ingredient in Diamyd(R) is glutamic acid decarboxylase (GAD), which is a dominant antigen in type 1 diabetes. By treating with GAD formulated as a vaccine, the patient's immune system is affected in such a...

PET Scans Show Gene Therapy Normalizes Brain Function in Parkinson's Patients

...for Medical Research collaborated with Michael Kaplitt, MD, of Weill Cornell Medical Center in Manhattan and others to deliver genes for glutamic acid decarboxylase (or GAD) into the subthalamic nucleus of the brain in Parkinson's patients. The study was designed as a phase I safety study, and the genes were deliv...

Neurologix Announces Publication of Landmark Gene Therapy Study Demonstrating Safety and Statistically Significant Improvement in Patients With Advanced Parkinson's Disease

...ain activity specific to the treated hemisphere." The study used an adeno-associated virus (AAV) vector to deliver an inhibitory gene (glutamic acid decarboxylase or "GAD") to the subthalmic nucleus (STN) of the brain. In Parkinson's disease, STN activity is abnormally increased, largely due to a deficit in GABA...

Diagnosing Diabetes: Immediate HbA1c Results Improve Glycemic Control

...ID, offers a variety of ELISA and RIA kits for the quantitative determination of autoantibodies in serum, like the recently FDA-approved glutamic acid decarboxylase (GAD) Autoantibody RIA Test Kit. Antibodies to GAD have been shown to be the most sensitive single marker for identifying people at risk of developing...

Decarboxylase in Medical Products

Glutamic Acid Decarboxylase Antibody

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Glutamic Acid Decarboxylase (GAD65) Autoantibody ELISA

Description: ELISA kit for the quantitative determination of autoantibodies to glutamic acid decarboxylase (GAD65) in serum...
Company:KRONUS

Glutamic Acid Decarboxylase (GAD65) Autoantibody RIA

Description: The autoimmune destruction of the insulin-producing pancreatic beta cells generally occurs over a period of time leading to the eventual onset of overt diabetes mellitus. During this extended pre-clinical phase, the characteristic circulation of autoantibodies against a variety of islet cell antige...
Company:KRONUS

GAD/IA-2 Autoantibody Screen

Description:...ng this extended pre-clinical phase, the characteristic circulation of autoantibodies against a variety of islet cell antigens including glutamic acid decarboxylase (GAD65), IA-2 (a tyrosine phosphatase-like protein), and insulin provides early markers of autoimmune disease activity. Measurement of these immun...
Company:KRONUS

Decarboxylase in Biological News

Tobacco makes medicine

... other auto-antigens associated with the disease. The team has a particular auto-antigen in its sights the 65-kDa isoform of the enzyme glutamic acid decarboxylase (GAD65) which they have also produced in transgenic tobacco plants. According to Pezzotti, "Transgenic plants are attractive systems for the produ...

Biomarkers allow doctors to match therapy to patient

...et for treatment of neuroblastoma, the most common solid tumor among young children. The treatment involves inhibiting the production of ornithine decarboxylase (ODC1), a gene driven by the MYCN oncogene that is a powerful predictor of death from this disease. Researchers report that ODC1 inhibition delayed or...

Gene therapy study shows safety and statistically significant improvement in Parkinson's disease

... activity specific to the treated hemisphere.” The study used an adeno-associated virus (AAV) vector to deliver an inhibitory gene (glutamic acid decarboxylase or “GAD”) to the subthalmic nucleus (STN) of the brain. In Parkinson’s disease, STN activity is abnormally increased, largely due to a deficit in GABA...

Neurologix announces positive results of gene therapy clinical trial in Parkinson's disease

...vector was injected into a specific target site in the brain in order to transfer a gene to treat Parkinson's disease. The gene encodes glutamic acid decarboxylase (GAD), an enzyme which synthesizes the major inhibitory neurotransmitter in the brain, (gamma)-aminobutyric acid (GABA). Under the FDA-sanctioned t...

Decarboxylase in Biological Technology

Transformation of Filamentous Fungi by Microprojectile Bombardment

...t., 23 , 42-46 (1993). 3. Ballance, D. J., Buxton F. P. and Turner, G., Transformation of Aspergillus nidulans by the ornithine-5-phosphate decarboxylase gene of Neurospora crassa, Biochem. Biophys. Res. Comm., 112 , 284-289 (1983). 4. Bennett, J. W. and Klich, M. A., Aspergillus: ...

Quantitation of GAD67 Gene Expression in Prefrontal Cortex of Schizophrenia Patients Using the iCycler iQ Detection System and Molecular Beacons, Rev A

.... The synthesis of GABA is catalyzed by the enzyme glutamic acid decarboxylase (GAD). Molecular cloning studies have shown that in the adult br...n in the γ-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67, Proc Natl Acad Sci USA 94, 1145111455 (1997) Kash ...

New Kit Generates Exceptionally Pure Total RNA for RT-PCR

...fied as medium abundance, its expression level is higher in liver than in brain 7 ( Figure 3 ). Similarly, ornithine decarboxylase is expressed at overall low levels but the levels vary in tissues throughout the body. 8 The presence of the expected PCR bands...

Decarboxylase in Biological Definition

Diabetes mellitus

...eral insulin application mechanisms under experimental development as of 2004. There have also been proposed vaccines for type I using glutamic acid decarboxylase (GAD), but these are currently not being tested by the pharmaceutical companies that have sublicensed the patents to them. For type 2 diabetics, ...

Enzyme

...yrase : catalyzes the negative supercoiling of prokaryotic DNA Glutamate decarboxylase : synthesizes the neurotransmitter GABA in the brain Glutathione perox...rring electrons from NADH to coenzyme Q Nitrogenase Ornithine decarboxylase : processes ornithine as the first step in the production of polyamines ...