Navigation Links
Deacetylase in Medical News

Michael J. Fox Foundation Awards $3.8 Million To Drive Nine Industry Partnerships For Pre-Clinical Parkinson's Drug Development

... Gerard Griffioen, PhD, NV reMYND, Leuven, Belgium Exploring curcumin and curcumin derivatives as putative epigenetic targets of histone deacetylase (HDAC) inhibition in Parkinson's disease Lawrence Helson, MD, Sign Path Pharma, Inc., Quakertown, Pennsylvania Assessment of the therap...

New Report Just Published: World Multiple Myeloma Therapeutics Market Report

...Antimetabolites II-35 Bisphosphonates II-36 Alkylating Agents and DNA-Damaging Agents II-36 DNA-Repair Enzyme Inhibitors II-36 Histone deacetylase Inhibitor II-36 Immunomodulators II-36 Proteasome Inhibitor II-36 Tyrosine Kinase Inhibitors II-36 3. Clinical Trials and Drug Approv...

EnVivo to Share Results of its EVP-6124 Phase Ib/IIa Trial at The International Conference on Alzheimer's Disease

... trials for cognition disorders in Alzheimer's disease and Schizophrenia. The company's other programs include an epigenetics program based on Histone deacetylase inhibition (HDACi) with EVP-0334 as the lead molecule for cognition in Alzheimer's disease which is in Phase 1 studies, and several preclinical progra...

Experimental drug shows promise against head and neck cancer

...ad and neck cancer survive for five or more years after diagnosis. The Einstein study involved a new class of chemotherapy agents known as histone deacetylase (HDAC) inhibitors, which affect the availability of genes that are transcribed and translated into proteins. In many types of cancer, out-of-control c...

Mayo Clinic researchers formulate treatment combination lethal to pancreatic cancer cells

...ss than 5 percent of pancreatic cancer cells, and previous tests with RAD001 showed the same minimal effect, Dr. Gupta says. Panobinostat is a histone deacetylase (HDAC) inhibitor. In cancer, HDAC proteins "silence" tumor suppressor genes, so an HADC inhibitor restores expression of these beneficial genes. The a...

Science Makes Inroads Against Prostate, Other Cancers

...s at the Mayo Clinic in Rochester, Minn., looked at inhibiting pancreatic cancer at the cellular level with a combination of two new agents: a histone deacetylase inhibitor called LBH589 and a mTOR inhibitor called rapamycin. When used together, the two drugs appeared to provide more anti-cancer punch than th...

EnVivo and Mitsubishi Tanabe Enter License Agreement on EVP-6124 in Japan, Korea, Taiwan and Other Asian Countries

... trials for cognition disorders in Alzheimer's disease and Schizophrenia. The company's other programs include an epigenetics program based on Histone deacetylase inhibition (HDACi) for cognition in Alzheimer's disease, and several preclinical programs such as a Gamma Secretase Modulator and a PDE10 inhibitor. F...

Protein Might One Day Prevent Blindness

...ts that would prevent blindness among people genetically predisposed to develop retinal disease, the scientists said. The protein, known as histone deacetylase 4 (HDAC4), is naturally produced by both mice and humans and is typically involved in the regulation of bone and muscle development. Reducing the a...

Molecular partnership controls daily rhythms, body metabolism

...fted, when compared to mice maintained on a normal sleep-wake cycle." Companies are currently targeting enzymes like HDAC with drugs called histone deacetylase (HDAC) inhibitors. "However there are dozens of HDACs, which do not all have the same molecular target," says Lazar. "If we target all of them we will...

Tackling a hard-to-treat childhood cancer by targeting epigenetic changes

...his and potentially other cancers." Armstrong notes that there are already drugs in clinic that target enzymes that modify histones, namely histone deacetylase (HDAC) inhibitors, which are used to treat a kind of lymphoma and are being tested in other cancers. ...
Deacetylase in Medical Technology

Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor

Multi-Center International Study to Determine the Efficacy of LBH589 in Patients with Relapsed or Refractory Multiple Myeloma NORWALK, Conn., Aug. 14 /PRNewswire-USNewswire/ -- The Multiple Myeloma Research Consortium (MMRC) today announced its participation in a Phase II study to dete...

Chipscreen and HUYA Bioscience to Present Clinical Data on Novel HDAC Inhibitor at the 2009 ASCO Annual Meeting

... in Orlando, Florida. Chidamide/HBI-8000 is a novel benzamide class histone deacetylase (HDAC) inhibitor in development by Chipscreen and HUYA for oncology indicat...dy of chidamide (CS055/HBI-8000), a novel histone deacetylase inhibitor, in patients with advanced solid tumors...

Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types

...he pipeline portfolio encompasses a broad array of therapeutic strategies for fighting cancer, including novel targeted agents, monoclonal antibodies, deacetylase (DAC) inhibitors, multiligand somatostatin analogs and novel cytotoxics. Sandostatin LAR important safety information Sandostatin LAR is a lo...

Pharmacyclics, Inc. Announces Closing of a Private Financing With the Principals of Pacific Biopharma Group, Ltd.

...ul relationship." Pharmacyclics currently has four drugs in Phase I to Phase III clinical development for cancer. This includes a leading histone deacetylase inhibitor (PCI-24781) for multiple cancers; an inhibitor of Factor VIIa (PCI-27483) targeting pancreatic, gastric, colon and breast cancers; a first i...

S*BIO Advances JAK2 Inhibitor SB1518 into Phase 1/2 Clinical Trial in Australia for the Treatment of Chronic Idiopathic Myelofibrosis

...h CIMF possess the JAK2 mutation. In addition to SB1518, S*BIO has a robust proprietary pipeline including SB939, the company's lead histone deacetylase (HDAC) inhibitor, which is currently in Phase 1 trials in Singapore and Canada. S*BIO's target-driven approach to innovative small molecule therapies ...

Chipscreen Biosciences and HUYA Bioscience Int'l Announce Promising Preclincial and Phase I Solid Tumor/Lymphoma Data for Chidamide/HBI-8000, New HDAC Inhibitor for Cancer

...vity against T-lymphoma and other tumor types. The compound, known as Chidamide in China and HBI-8000 in the US, is a novel, benzamide class histone deacetylase (HDAC) inhibitor discovered by Chipscreen using a computer-aided rationale design approach. Chidamide/HBI-8000 shows promise for the treatment of a br...

S*BIO Initiates U.S. Phase I Clinical Trials of Oral JAK2 Inhibitor SB1518 for the Treatment of Hematological Malignancies

...nter and the Fred Hutchinson Cancer Research Center." In addition to SB1518, S*BIO has a robust pipeline including SB939, the company's lead histone deacetylase (HDAC) inhibitor, which is currently in Phase I trials in Singapore and Canada. S*BIO's target-driven approach to developing innovative small molecule...

Arno Therapeutics, Inc. Completes $18 Million Financing and Reverse Merger with Laurier International, Inc.

...studies, AR-42 has demonstrated greater potency and a competitive profile in tumors when compared with vorinostat (SAHA), the leading marketed histone deacetylase inhibitor. Arno plans to initiate Phase I studies of AR-42 and AR-12 in early 2009. Arie Belldegrun, M.D., FACS, Chairman of the Board of Directors ...

HUYA Bioscience Int'l Announces First Pre-IND Outcome for a Development Stage Compound Sourced From China - HBI-8000, Promising New Cancer Compound

...harmaceutical co-development." HBI-8000 is an orally bioavailable histone deacetylase (HDAC) inhibitor derived from the benzamide class. Histone deacetylase inhibitors are a new class of cancer drugs that induce selective regulation...

Sunesis Pharmaceuticals to Present Non-Clinical Data at the Annual Meeting of the American Association for Cancer Research

...t kinases 2, 7, and 9, blocks transcription of cyclin D1 and Mcl-1, causing cell death in mantle cell lymphoma cell lines Session: Histone deacetylase Inhibitors and Cell Cycle Inhibitors Abstract #756 8:00 a.m. - 12:00 p.m. Exhibit Hall B-F, San Diego Convention Center Preclinical data pro...
Deacetylase in Biological News

UC San Diego engineer provides insights to decades-old DNA squabble

...get the chromatin around abnormally regulated genes to correct their activity. "In fact, there are already drugs being developed called HDIs (histone deacetylase inhibitors) that can modulate structure of chromatin around oncogenic genes so as to inhibit cancer progression, though their exact mechanisms are not...

Universitat Autonoma de Barcelona researchers first to clone mice in Spain

...inhibitor of the enzyme histone deacetylase, located at the cell nucleus where the DNA is found. Research carried out until now has shown that histone deacetylase inhibitors seem to contribute to an increase in levels of gene expression, which would favour the reprogramming of the somatic cell nucleus transferre...

The Burnham buzz

...ase was unknown. Lorenzo Puri, M.D., Ph.D. and colleagues have discovered that the dystrophin mutation causes an increase in the amount of the histone deacetylase enzyme, HDAC2. Increased HDAC2 activity alters the gene expression profile in the diseased muscle cells compared to normal muscle cells. By inhibiting...

Research uncovers new steps on pathway to enlarged heart

...hypertrophic response. "Our study supports a model where AKAP-Lbc facilitates activation of protein kinase D, which in turn phosphorylates the histone deacetylase HDAC5 to promote its export from the nucleus. The reduction in nuclear HDAC5 favored MEF2 transcription and the onset of cardiac hypertrophy." Thes...

Viral 'magic bullet' targets cancer cells with help of new compound

... Institute, along with Dr. John C. Bell and colleagues at the University of Ottawa and OHRI, have discovered that a family of compounds called histone deacetylase inhibitors (HDIs) may be the missing link that turns oncolytic viruses into a potent new weapon against cancer. Their research program is supported by...

Controlling embryonic fate by association

...arts of genomic DNA structures or chromatins, acting as spools around which the genetic material winds in the nucleus. The DNA wraps more tightly when deacetylase removes the acetyl tails from the histones. The tight wrapping makes it hard for genes to be transcribed into the message that allows them to carry ou...

NCI renewal grant to develop new cancer therapies

...ivity of a novel class of agents, known as histone deacetylase inhibitors, in the treatment of leukemia and other...t ongoing basic and clinical research. Histone deacetylase inhibitors represent a diverse group of agents tha...ng proteins, notably histones. However, histone deacetylase inhibitors acetylate other proteins and exert mult...

U-M researchers discover gene switched off in cancer can be turned on

...ions to the gene but rather that it was just silent – essentially like a switch that had been turned off. Knowing that a class of drugs called histone deacetylase inhibitors, or HDAC inhibitors, can affect gene expression, the researchers applied these drugs to the cells and found the BRM expression could be res...

Salk scientists hammer out a pathway that promotes muscle cell survival in mice

...uscle tissue was unknown. Then, the researchers noticed that mice lacking CREB activity in their muscle cells also had a genetic brake, called histone deacetylase (HDAC), stuck in place. Without loosening the brake by a chemical modification process known as phosphorylation, muscle-specific genes could not be ac...

Massey researchers induce cell death in leukemia

...cal evidence that bortezomib interacts synergistically with both agents to induce cell death in human CLL cells. Romidepsin and belinostat are histone deacetylase (HDAC) inhibitors. "To the best of our knowledge, this is the first report describing synergistic interactions between HDAC inhibitors and Borte...
Deacetylase in Biological Technology

Repligen Reports First Quarter Fiscal Year 2010 Financial Results

...e million adults worldwide have bipolar disorder. HDAC Inhibitors for Friedreich's Ataxia We are currently developing inhibitors of histone deacetylase enzymes (HDACs) for the treatment of inherited neurodegenerative diseases such as Friedreich's ataxia. Preclinical studies have shown that specific H...

EnVivo Pharmaceuticals Announces Results and Successful Completion of EVP-6124 Phase Ib/IIa Trial at the International Conference on Alzheimer's Disease

...trials for cognition disorders in Alzheimer's disease and Schizophrenia. The company's other programs include an epigenetics program based on Histone deacetylase inhibition (HDACi) with EVP-0334 as the lead molecule for cognition in Alzheimer's disease which is in Phase I studies, and several preclinical progra...

EnVivo Pharmaceuticals Announces Reversal of Cognitive Deficits in Alzheimer's Disease Transgenic Mouse Model With Gamma-Secretase Modulator

... trials for cognition disorders in Alzheimer's disease and Schizophrenia. The company's other programs include an epigenetics program based on Histone deacetylase inhibition (HDACi) with EVP-0334 as the lead molecule for cognition in Alzheimer's disease which is in Phase 1 studies, and several preclinical progra...

Tigris Pharmaceuticals Presents Results of Breast Cancer Research at AACR Annual Meeting

... subtype were not. However, when the latter was pre-treated with a histone deacetylase inhibitor, such as the suberoylanilide hydroxamic acid (SAHA), also known a...achieved is believed to be the de-silencing of ER expression by the histone deacetylase inhibitor, followed by CYP1A1 induction and subsequent AFP metabolism into ...

FDA Accepts IND for Arno Therapeutics' Pan-DAC / Akt Inhibitor, AR-42

...d a competitive profile in tumors when compared with vorinostat (also known as SAHA and marketed as Zolina (R) by Merck), the leading marketed histone deacetylase inhibitor. Arno in-licensed the exclusive worldwide rights to AR-42 from The Ohio State University . About Arno Therapeutics Arno Therap...

S*BIO Completes US$26 Million Equity Financing

...cal development of its promising anti-cancer agents." About SB939 SB939 belongs to a new class of targeted anti-cancer therapeutics called histone deacetylase (HDAC) inhibitors. SB939 is designed to be a "best-in-class" therapeutic amongst HDAC inhibitors being developed worldwide, and has demonstrated the p...

Repligen Announces Publication of Positive Results with Proprietary HDAC Inhibitor in Huntington's Disease Model

...6 /PRNewswire-FirstCall/ -- Repligen Corporation (Nasdaq: RGEN ) today reported publication of a preclinical study demonstrating that a novel histone deacetylase (HDAC) inhibitor improved disease symptoms in a transgenic animal model of Huntington's disease. The study, led by scientists at The Scripps Research ...

Ortho Biotech Oncology Research & Development Unites Johnson & Johnson Biopharmaceutical Oncology R&D Assets

...s an attractive target for the development of anti-cancer agents. Histone deacetylase (HDAC) DNA in chromatin is wound around proteins called histones. HDACs a...mistry & Cell Biology; 2007, 39(7-8):1476-82. (iv) Johnstone, RW. Histone deacetylase inhibitors: novel drugs for the treatment of cancer. Nature Reviews Drug Di...

MedImmune Presents Data Highlighting its Progressive Oncology Portfolio at Annual Meeting of the American Association For Cancer Research

...I-504, a Novel Hsp90 Inhibitor is Effective in EGFR T790M and non-T790M Gefitinib-Resistant Lung Cancer Cell Lines (Oral Presentation: Histone deacetylase and Heat Shock Protein Inhibitors, abstract 2450) - Joon O. Park, M.D., Monday, April 14 from 11:55 a.m. - 12:10 p.m. in Room 24A-C. -- Phar...

Pharmacyclics Announces Multiple Presentations at the American Association for Cancer Research Annual Meeting

...ws: Sunday, April 13, 2008: -- Session: Histone deacetylase Inhibitors and Cell Cycle Inhibitors Poster pr...n, Ph.D., Pharmacyclics, Inc. -- Session: Histone deacetylase Inhibitors and Cell Cycle Inhibitors Poster pr...er Monday, April 14, 2008: -- Session: Histone deacetylase and Heat Shock Protein Inhibitors Oral present...
Deacetylase in Biological Products

Anti-Histone Deacetylase (HDAC) Sampler Kit Antibody, Unconjugated from Cell Signaling Technology

Description: Histone Deacetylase (HDAC) Antibody Sampler Kit Kit Includes: Histone Deacetylase 1 (HDAC1) Antibody, Catalog #2062, 40 ul Histone Deacetylase 3 (HDAC3) Antibody, Catalog #2632, 40 ul Histone Deacetylase 4 (HDAC4) Antibody, Catalog #2072, 40 ul Histone Deacetylase 5 (HDAC5) Antibody, Catalog #208...
Company:Cell Signaling Technology

Histone Deacetylase Radiometric (3H) Assay Kit from Upstate

Description: Request Info...
Company:Upstate

Rabbit Anti-HDAC4 Polyclonal Antibody, Unconjugated from GeneTex

Description:... 1084 amino acid residues. Its C-terminal sequence is highly similar to the deacetylase domain of yeast HDA1. HDAC4, unlike other deacetylases, shuttles between th...ommercially sensitive Specificity: The antibody detects ~140 kDa histone deacetylase 4. It does not cross-react with other HDAC proteins including HDAC1, 2, 3, ...
Company:GeneTex

Mouse Anti-HDAC8 Monoclonal Antibody, Unconjugated, Clone HDAC8-48 from GeneTex

Description:...tion of HDAC4, 5, and 7 with members of the MEF2 family of transcription factors represses their transcriptional activity and prevents myogenesis. The deacetylase activity of class II HDACs is regulated by subcellular localization. The HDAC8 gene encodes for a 377 amino acid protein with a molecular weight of 43...
Company:GeneTex
Deacetylase in Biological Definition

Histone

...r nuclear DNA. During the early 1990s, the regulatory functions of histones were discovered. See also Gene silencing Genetics Histone deacetylase ...
Deacetylase in Biological Dictionary

Histone

...a. histones ... high magnification these DNA- histone complexes look like a ... CoREST is an integral component of the CoREST- human histone deacetylase complex" ... RBP1 recruits both histone deacetylase-dependent and -independent repression ... The histone H2A variant of Drosophila melanogas...
Other Tags
(Date:12/24/2014)... National (PRWEB) December 25, 2014 Over ... back to their local communities. That is 700 smiling ... a single gift. Additionally over $6000 in monetary donations ... help offset some of the expenses they incur through ... years drive were A Child's Haven , Shrine's ...
(Date:12/24/2014)... Connie Casad, MD, a well-known and respected gynecologist, ... years of practice experience in Dallas, Texas, has announced ... dietary detoxification. The second study is scheduled to begin ... test patients who just completed a 21-day detoxification regimen. ... conducting the study, Dr. Casad said, "About 10 years ...
(Date:12/24/2014)... New York (PRWEB) December 24, 2014 ... mount in a mass tort litigation currently underway in ... reports. As of December 24, 2014, court documents ... proceeding on behalf of individuals who developed gynecomastia (male ... use. Data from the Court indicates that this represents ...
(Date:12/24/2014)... 24, 2014 Dr. Vu Ho, a ... of his practice and med-spa with the addition of ... list of cosmetic treatments and services. , “Silk Peel ... skin,” says Dr. Ho. “As a result it can ... wrinkles, sun spots, discolorations or blemishes.” , Similar to ...
(Date:12/24/2014)... UWDress.com, the famous women’s dress supplier, has presented its new ... wedding gown promotion. , For those who prefer ... way, the collection should be a great choice. The dresses ... they are available with custom service. , Now, all the ... to 75% off; most of them come in hot designs. ...
Breaking Medicine News(10 mins):Health News:AlignLife Donates Over 700 Toys This Year 2Health News:Connie Casad, MD, Now Accepting Test Participants for January Dietary Detoxification Study 2Health News:Connie Casad, MD, Now Accepting Test Participants for January Dietary Detoxification Study 3Health News:Risperdal Lawsuits Continue to Climb, as Claims in Pennsylvania Litigation Exceed 1,180 Filings, Bernstein Liebhard LLP Reports 2Health News:Risperdal Lawsuits Continue to Climb, as Claims in Pennsylvania Litigation Exceed 1,180 Filings, Bernstein Liebhard LLP Reports 3Health News:Risperdal Lawsuits Continue to Climb, as Claims in Pennsylvania Litigation Exceed 1,180 Filings, Bernstein Liebhard LLP Reports 4Health News:Dr. Vu Ho Expands Facial Plastic Surgery Practice to Include New Skin Care Treatment 2Health News:Buy Cheap Long Sleeve Wedding Gowns At UWDress.com 2
(Date:12/5/2014)... Dec. 4, 2014  Tute Genomics, a leader in ... in Series A1 funding led by UK-based Eurovestech. Peak ... in the investment round. "We are at ... adopts next-generation sequencing and seeks new approaches for the ... Robison , MD MBA, and CEO of Tute Genomics. ...
(Date:12/3/2014)... , Dec. 2, 2014 As part ... readers, Inception Technologies is pleased to announce the release ... for customers to collect the workforce data that they ... that have been left by existing readers. Many such ... interface, connectivity and modern technology. Older models force users ...
(Date:11/21/2014)... Strict laws against distracted driving and the ... American and European automotive sector towards gesture recognition technologies. ... that are intuitive and able to retrieve information with ... New analysis from Frost & Sullivan,s Strategic ... Europe and North America ...
Breaking Biology News(10 mins):Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3Inception Technologies to Release New Biometric Reader 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4
Other Contents