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Deacetylase in Medical News

Michael J. Fox Foundation Awards $3.8 Million To Drive Nine Industry Partnerships For Pre-Clinical Parkinson's Drug Development

... Gerard Griffioen, PhD, NV reMYND, Leuven, Belgium Exploring curcumin and curcumin derivatives as putative epigenetic targets of histone deacetylase (HDAC) inhibition in Parkinson's disease Lawrence Helson, MD, Sign Path Pharma, Inc., Quakertown, Pennsylvania Assessment of the therap...

New Report Just Published: World Multiple Myeloma Therapeutics Market Report

...Antimetabolites II-35 Bisphosphonates II-36 Alkylating Agents and DNA-Damaging Agents II-36 DNA-Repair Enzyme Inhibitors II-36 Histone deacetylase Inhibitor II-36 Immunomodulators II-36 Proteasome Inhibitor II-36 Tyrosine Kinase Inhibitors II-36 3. Clinical Trials and Drug Approv...

EnVivo to Share Results of its EVP-6124 Phase Ib/IIa Trial at The International Conference on Alzheimer's Disease

... trials for cognition disorders in Alzheimer's disease and Schizophrenia. The company's other programs include an epigenetics program based on Histone deacetylase inhibition (HDACi) with EVP-0334 as the lead molecule for cognition in Alzheimer's disease which is in Phase 1 studies, and several preclinical progra...

Experimental drug shows promise against head and neck cancer

...ad and neck cancer survive for five or more years after diagnosis. The Einstein study involved a new class of chemotherapy agents known as histone deacetylase (HDAC) inhibitors, which affect the availability of genes that are transcribed and translated into proteins. In many types of cancer, out-of-control c...

Mayo Clinic researchers formulate treatment combination lethal to pancreatic cancer cells

...ss than 5 percent of pancreatic cancer cells, and previous tests with RAD001 showed the same minimal effect, Dr. Gupta says. Panobinostat is a histone deacetylase (HDAC) inhibitor. In cancer, HDAC proteins "silence" tumor suppressor genes, so an HADC inhibitor restores expression of these beneficial genes. The a...

Science Makes Inroads Against Prostate, Other Cancers

...s at the Mayo Clinic in Rochester, Minn., looked at inhibiting pancreatic cancer at the cellular level with a combination of two new agents: a histone deacetylase inhibitor called LBH589 and a mTOR inhibitor called rapamycin. When used together, the two drugs appeared to provide more anti-cancer punch than th...

EnVivo and Mitsubishi Tanabe Enter License Agreement on EVP-6124 in Japan, Korea, Taiwan and Other Asian Countries

... trials for cognition disorders in Alzheimer's disease and Schizophrenia. The company's other programs include an epigenetics program based on Histone deacetylase inhibition (HDACi) for cognition in Alzheimer's disease, and several preclinical programs such as a Gamma Secretase Modulator and a PDE10 inhibitor. F...

Protein Might One Day Prevent Blindness

...ts that would prevent blindness among people genetically predisposed to develop retinal disease, the scientists said. The protein, known as histone deacetylase 4 (HDAC4), is naturally produced by both mice and humans and is typically involved in the regulation of bone and muscle development. Reducing the a...

Molecular partnership controls daily rhythms, body metabolism

...fted, when compared to mice maintained on a normal sleep-wake cycle." Companies are currently targeting enzymes like HDAC with drugs called histone deacetylase (HDAC) inhibitors. "However there are dozens of HDACs, which do not all have the same molecular target," says Lazar. "If we target all of them we will...

Tackling a hard-to-treat childhood cancer by targeting epigenetic changes

...his and potentially other cancers." Armstrong notes that there are already drugs in clinic that target enzymes that modify histones, namely histone deacetylase (HDAC) inhibitors, which are used to treat a kind of lymphoma and are being tested in other cancers. ...
Deacetylase in Medical Technology

Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor

Multi-Center International Study to Determine the Efficacy of LBH589 in Patients with Relapsed or Refractory Multiple Myeloma NORWALK, Conn., Aug. 14 /PRNewswire-USNewswire/ -- The Multiple Myeloma Research Consortium (MMRC) today announced its participation in a Phase II study to dete...

Chipscreen and HUYA Bioscience to Present Clinical Data on Novel HDAC Inhibitor at the 2009 ASCO Annual Meeting

... in Orlando, Florida. Chidamide/HBI-8000 is a novel benzamide class histone deacetylase (HDAC) inhibitor in development by Chipscreen and HUYA for oncology indicat...dy of chidamide (CS055/HBI-8000), a novel histone deacetylase inhibitor, in patients with advanced solid tumors...

Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types

...he pipeline portfolio encompasses a broad array of therapeutic strategies for fighting cancer, including novel targeted agents, monoclonal antibodies, deacetylase (DAC) inhibitors, multiligand somatostatin analogs and novel cytotoxics. Sandostatin LAR important safety information Sandostatin LAR is a lo...

Pharmacyclics, Inc. Announces Closing of a Private Financing With the Principals of Pacific Biopharma Group, Ltd.

...ul relationship." Pharmacyclics currently has four drugs in Phase I to Phase III clinical development for cancer. This includes a leading histone deacetylase inhibitor (PCI-24781) for multiple cancers; an inhibitor of Factor VIIa (PCI-27483) targeting pancreatic, gastric, colon and breast cancers; a first i...

S*BIO Advances JAK2 Inhibitor SB1518 into Phase 1/2 Clinical Trial in Australia for the Treatment of Chronic Idiopathic Myelofibrosis

...h CIMF possess the JAK2 mutation. In addition to SB1518, S*BIO has a robust proprietary pipeline including SB939, the company's lead histone deacetylase (HDAC) inhibitor, which is currently in Phase 1 trials in Singapore and Canada. S*BIO's target-driven approach to innovative small molecule therapies ...

Chipscreen Biosciences and HUYA Bioscience Int'l Announce Promising Preclincial and Phase I Solid Tumor/Lymphoma Data for Chidamide/HBI-8000, New HDAC Inhibitor for Cancer

...vity against T-lymphoma and other tumor types. The compound, known as Chidamide in China and HBI-8000 in the US, is a novel, benzamide class histone deacetylase (HDAC) inhibitor discovered by Chipscreen using a computer-aided rationale design approach. Chidamide/HBI-8000 shows promise for the treatment of a br...

S*BIO Initiates U.S. Phase I Clinical Trials of Oral JAK2 Inhibitor SB1518 for the Treatment of Hematological Malignancies

...nter and the Fred Hutchinson Cancer Research Center." In addition to SB1518, S*BIO has a robust pipeline including SB939, the company's lead histone deacetylase (HDAC) inhibitor, which is currently in Phase I trials in Singapore and Canada. S*BIO's target-driven approach to developing innovative small molecule...

Arno Therapeutics, Inc. Completes $18 Million Financing and Reverse Merger with Laurier International, Inc.

...studies, AR-42 has demonstrated greater potency and a competitive profile in tumors when compared with vorinostat (SAHA), the leading marketed histone deacetylase inhibitor. Arno plans to initiate Phase I studies of AR-42 and AR-12 in early 2009. Arie Belldegrun, M.D., FACS, Chairman of the Board of Directors ...

HUYA Bioscience Int'l Announces First Pre-IND Outcome for a Development Stage Compound Sourced From China - HBI-8000, Promising New Cancer Compound

...harmaceutical co-development." HBI-8000 is an orally bioavailable histone deacetylase (HDAC) inhibitor derived from the benzamide class. Histone deacetylase inhibitors are a new class of cancer drugs that induce selective regulation...

Sunesis Pharmaceuticals to Present Non-Clinical Data at the Annual Meeting of the American Association for Cancer Research

...t kinases 2, 7, and 9, blocks transcription of cyclin D1 and Mcl-1, causing cell death in mantle cell lymphoma cell lines Session: Histone deacetylase Inhibitors and Cell Cycle Inhibitors Abstract #756 8:00 a.m. - 12:00 p.m. Exhibit Hall B-F, San Diego Convention Center Preclinical data pro...
Deacetylase in Biological News

UC San Diego engineer provides insights to decades-old DNA squabble

...get the chromatin around abnormally regulated genes to correct their activity. "In fact, there are already drugs being developed called HDIs (histone deacetylase inhibitors) that can modulate structure of chromatin around oncogenic genes so as to inhibit cancer progression, though their exact mechanisms are not...

Universitat Autonoma de Barcelona researchers first to clone mice in Spain

...inhibitor of the enzyme histone deacetylase, located at the cell nucleus where the DNA is found. Research carried out until now has shown that histone deacetylase inhibitors seem to contribute to an increase in levels of gene expression, which would favour the reprogramming of the somatic cell nucleus transferre...

The Burnham buzz

...ase was unknown. Lorenzo Puri, M.D., Ph.D. and colleagues have discovered that the dystrophin mutation causes an increase in the amount of the histone deacetylase enzyme, HDAC2. Increased HDAC2 activity alters the gene expression profile in the diseased muscle cells compared to normal muscle cells. By inhibiting...

Research uncovers new steps on pathway to enlarged heart

...hypertrophic response. "Our study supports a model where AKAP-Lbc facilitates activation of protein kinase D, which in turn phosphorylates the histone deacetylase HDAC5 to promote its export from the nucleus. The reduction in nuclear HDAC5 favored MEF2 transcription and the onset of cardiac hypertrophy." Thes...

Viral 'magic bullet' targets cancer cells with help of new compound

... Institute, along with Dr. John C. Bell and colleagues at the University of Ottawa and OHRI, have discovered that a family of compounds called histone deacetylase inhibitors (HDIs) may be the missing link that turns oncolytic viruses into a potent new weapon against cancer. Their research program is supported by...

Controlling embryonic fate by association

...arts of genomic DNA structures or chromatins, acting as spools around which the genetic material winds in the nucleus. The DNA wraps more tightly when deacetylase removes the acetyl tails from the histones. The tight wrapping makes it hard for genes to be transcribed into the message that allows them to carry ou...

NCI renewal grant to develop new cancer therapies

...ivity of a novel class of agents, known as histone deacetylase inhibitors, in the treatment of leukemia and other...t ongoing basic and clinical research. Histone deacetylase inhibitors represent a diverse group of agents tha...ng proteins, notably histones. However, histone deacetylase inhibitors acetylate other proteins and exert mult...

U-M researchers discover gene switched off in cancer can be turned on

...ions to the gene but rather that it was just silent – essentially like a switch that had been turned off. Knowing that a class of drugs called histone deacetylase inhibitors, or HDAC inhibitors, can affect gene expression, the researchers applied these drugs to the cells and found the BRM expression could be res...

Salk scientists hammer out a pathway that promotes muscle cell survival in mice

...uscle tissue was unknown. Then, the researchers noticed that mice lacking CREB activity in their muscle cells also had a genetic brake, called histone deacetylase (HDAC), stuck in place. Without loosening the brake by a chemical modification process known as phosphorylation, muscle-specific genes could not be ac...

Massey researchers induce cell death in leukemia

...cal evidence that bortezomib interacts synergistically with both agents to induce cell death in human CLL cells. Romidepsin and belinostat are histone deacetylase (HDAC) inhibitors. "To the best of our knowledge, this is the first report describing synergistic interactions between HDAC inhibitors and Borte...
Deacetylase in Biological Technology

Repligen Reports First Quarter Fiscal Year 2010 Financial Results

...e million adults worldwide have bipolar disorder. HDAC Inhibitors for Friedreich's Ataxia We are currently developing inhibitors of histone deacetylase enzymes (HDACs) for the treatment of inherited neurodegenerative diseases such as Friedreich's ataxia. Preclinical studies have shown that specific H...

EnVivo Pharmaceuticals Announces Results and Successful Completion of EVP-6124 Phase Ib/IIa Trial at the International Conference on Alzheimer's Disease

...trials for cognition disorders in Alzheimer's disease and Schizophrenia. The company's other programs include an epigenetics program based on Histone deacetylase inhibition (HDACi) with EVP-0334 as the lead molecule for cognition in Alzheimer's disease which is in Phase I studies, and several preclinical progra...

EnVivo Pharmaceuticals Announces Reversal of Cognitive Deficits in Alzheimer's Disease Transgenic Mouse Model With Gamma-Secretase Modulator

... trials for cognition disorders in Alzheimer's disease and Schizophrenia. The company's other programs include an epigenetics program based on Histone deacetylase inhibition (HDACi) with EVP-0334 as the lead molecule for cognition in Alzheimer's disease which is in Phase 1 studies, and several preclinical progra...

Tigris Pharmaceuticals Presents Results of Breast Cancer Research at AACR Annual Meeting

... subtype were not. However, when the latter was pre-treated with a histone deacetylase inhibitor, such as the suberoylanilide hydroxamic acid (SAHA), also known a...achieved is believed to be the de-silencing of ER expression by the histone deacetylase inhibitor, followed by CYP1A1 induction and subsequent AFP metabolism into ...

FDA Accepts IND for Arno Therapeutics' Pan-DAC / Akt Inhibitor, AR-42

...d a competitive profile in tumors when compared with vorinostat (also known as SAHA and marketed as Zolina (R) by Merck), the leading marketed histone deacetylase inhibitor. Arno in-licensed the exclusive worldwide rights to AR-42 from The Ohio State University . About Arno Therapeutics Arno Therap...

S*BIO Completes US$26 Million Equity Financing

...cal development of its promising anti-cancer agents." About SB939 SB939 belongs to a new class of targeted anti-cancer therapeutics called histone deacetylase (HDAC) inhibitors. SB939 is designed to be a "best-in-class" therapeutic amongst HDAC inhibitors being developed worldwide, and has demonstrated the p...

Repligen Announces Publication of Positive Results with Proprietary HDAC Inhibitor in Huntington's Disease Model

...6 /PRNewswire-FirstCall/ -- Repligen Corporation (Nasdaq: RGEN ) today reported publication of a preclinical study demonstrating that a novel histone deacetylase (HDAC) inhibitor improved disease symptoms in a transgenic animal model of Huntington's disease. The study, led by scientists at The Scripps Research ...

Ortho Biotech Oncology Research & Development Unites Johnson & Johnson Biopharmaceutical Oncology R&D Assets

...s an attractive target for the development of anti-cancer agents. Histone deacetylase (HDAC) DNA in chromatin is wound around proteins called histones. HDACs a...mistry & Cell Biology; 2007, 39(7-8):1476-82. (iv) Johnstone, RW. Histone deacetylase inhibitors: novel drugs for the treatment of cancer. Nature Reviews Drug Di...

MedImmune Presents Data Highlighting its Progressive Oncology Portfolio at Annual Meeting of the American Association For Cancer Research

...I-504, a Novel Hsp90 Inhibitor is Effective in EGFR T790M and non-T790M Gefitinib-Resistant Lung Cancer Cell Lines (Oral Presentation: Histone deacetylase and Heat Shock Protein Inhibitors, abstract 2450) - Joon O. Park, M.D., Monday, April 14 from 11:55 a.m. - 12:10 p.m. in Room 24A-C. -- Phar...

Pharmacyclics Announces Multiple Presentations at the American Association for Cancer Research Annual Meeting

...ws: Sunday, April 13, 2008: -- Session: Histone deacetylase Inhibitors and Cell Cycle Inhibitors Poster pr...n, Ph.D., Pharmacyclics, Inc. -- Session: Histone deacetylase Inhibitors and Cell Cycle Inhibitors Poster pr...er Monday, April 14, 2008: -- Session: Histone deacetylase and Heat Shock Protein Inhibitors Oral present...
Deacetylase in Biological Products

Anti-Histone Deacetylase (HDAC) Sampler Kit Antibody, Unconjugated from Cell Signaling Technology

Description: Histone Deacetylase (HDAC) Antibody Sampler Kit Kit Includes: Histone Deacetylase 1 (HDAC1) Antibody, Catalog #2062, 40 ul Histone Deacetylase 3 (HDAC3) Antibody, Catalog #2632, 40 ul Histone Deacetylase 4 (HDAC4) Antibody, Catalog #2072, 40 ul Histone Deacetylase 5 (HDAC5) Antibody, Catalog #208...
Company:Cell Signaling Technology

Histone Deacetylase Radiometric (3H) Assay Kit from Upstate

Description: Request Info...
Company:Upstate

Rabbit Anti-HDAC4 Polyclonal Antibody, Unconjugated from GeneTex

Description:... 1084 amino acid residues. Its C-terminal sequence is highly similar to the deacetylase domain of yeast HDA1. HDAC4, unlike other deacetylases, shuttles between th...ommercially sensitive Specificity: The antibody detects ~140 kDa histone deacetylase 4. It does not cross-react with other HDAC proteins including HDAC1, 2, 3, ...
Company:GeneTex

Mouse Anti-HDAC8 Monoclonal Antibody, Unconjugated, Clone HDAC8-48 from GeneTex

Description:...tion of HDAC4, 5, and 7 with members of the MEF2 family of transcription factors represses their transcriptional activity and prevents myogenesis. The deacetylase activity of class II HDACs is regulated by subcellular localization. The HDAC8 gene encodes for a 377 amino acid protein with a molecular weight of 43...
Company:GeneTex
Deacetylase in Biological Definition

Histone

...r nuclear DNA. During the early 1990s, the regulatory functions of histones were discovered. See also Gene silencing Genetics Histone deacetylase ...
Deacetylase in Biological Dictionary

Histone

...a. histones ... high magnification these DNA- histone complexes look like a ... CoREST is an integral component of the CoREST- human histone deacetylase complex" ... RBP1 recruits both histone deacetylase-dependent and -independent repression ... The histone H2A variant of Drosophila melanogas...
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(Date:4/18/2014)... in French . ... and regenerative medicine. A team led by Ludwik Leibler ... Tech) and Didier Letourneur from the Laboratoire Recherche Vasculaire ... demonstrated that the principle of adhesion by aqueous solutions ... soft-tissue organs and tissues. This easy-to-use gluing method has ...
(Date:4/17/2014)... genetic variant specifically associated with the risk of ... per cent of all breast cancer cases. , ... sub-type, called invasive lobular carcinoma, gives researchers important ... kind of breast cancer, which can be missed ... in the journal PloS Genetics , was ...
(Date:4/17/2014)... the April issue of Experimental Biology and ... Drs. Rex Gaskins and Paul Kenis in the ... of the University of Illinois Urbana-Champaign describe their ... reactions underlie a variety of cell functions including ... these crucial roles in regulating normal cellular behavior, ...
(Date:4/17/2014)... Bonheur Children,s Hospital Pediatrician-in-Chief Jon McCullers, MD, was ... April issue of Nature Reviews Microbiology , ... Dr. McCullers, a world-renowned infectious disease specialist, and ... University of Tennessee Health Science Center, analyzed the ... 1957 and 1968 pandemics, as well as more ...
(Date:4/17/2014)... that as many as 10 million older Americans suffer ... and isolation. , However, new research a project ... Americans for six years found that Internet use ... by more than 30 percent. , "That,s a very ... professor of telecommunication, information studies and media who led ...
Breaking Medicine News(10 mins):Health News:Innovative strategy to facilitate organ repair 2Health News:Innovative strategy to facilitate organ repair 3Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 2Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 3Health News:Live cell imaging reveals distinct alterations of subcellular glutathione potentials 2Health News:Internet use can help ward off depression among elderly 2
(Date:4/20/2014)... demonstrate a bizarre property never before seen at a ... scientists at the University of Cambridge. The property ... application as wide-ranging as soundproofing, super-absorbent sponges and bulletproof ... if one pulls on an elastic band, the elastic ... squeeze a material and it will expand for ...
(Date:4/20/2014)... used to treat lung, breast and pancreatic cancers also ... the University of California, San Diego School of Medicine ... the surface of drug-resistant tumors that appears responsible for ... of cancer cells. , The findings, published in ... Cell Biology , may point to new therapeutic opportunities ...
(Date:4/20/2014)... with Down syndrome have a heightened risk of developing ... able to explain why. Now, a team of ... the two conditions. , In a study posted online ... researchers track the genetic chain of events that links ... havoc that occurs in ALL. Their findings are ...
Breaking Biology News(10 mins):Bulletproof nuclei? Stem cells exhibit unusual absorption property 2Cancer stem cells linked to drug resistance 2Dana-Farber researchers uncover link between Down syndrome and leukemia 2Dana-Farber researchers uncover link between Down syndrome and leukemia 3
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