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Dasatinib in Medical News

Addition of dasatinib to standard chemo cocktail may enhance effect in certain ovarian cancers

DURHAM, N.C. The addition of a chemotherapeutic drug for leukemia to a standard regimen of two other chemotherapy drugs appears to enhance the response of certain ovarian cancers to treatment, according to a pre-clinical study led by researchers in the Duke Comprehensive Cancer Center. "We kn...

Wonder drug Dasatinib gives hopes to leukemia patients

The company Bristol-Myers Squibb Co at Boston told the press that the drug Dasatinib has led to reduction in the number of patients with Chronic myeloid leukemia (CML).// This drug is very effective in the decreasing the leukemia cells from the bone marrow than the previously used drug Gleevec...

Chemo Combo Shows Promise Against Ovarian Cancer

...NDAY, April 19 (HealthDay News) -- Adding the drug dasatinib to a standard, two-drug chemotherapy regimen for t...termined that the combination of the leukemia drug dasatinib (Sprycel) made carboplatin and paclitaxel more eff... able to direct the use of a targeted therapy like dasatinib based on gene expression pathways in select ovaria...

New Cancer Drug Tied to Heart Problems

...ors, which target key molecular pathways thought to encourage tumor growth. Other drugs in this family include imatinib, better known as Gleevec, and dasatinib (Sprycel). In the study, which is published in the Dec. 15 issue of The Lancet , Chen's team looked at 75 patients with metastatic, gastrointestin...

Early Phase II results show bosutinib safe, effective for CML

...ients who had also become resistant to second-line treatments nilotinib and dasatinib derived some benefit from taking the new drug. Out of eight such patients, ...oups to proteins or small molecules. Bosutinib, like imatinib (Gleevec(r)), dasatinib (Sprycel(r)) and nilotinib (Tasigna(r)), is a tyrosine kinase inhibitor. ...

Dasatinib, Nilotinib show strong early results as frontline therapy for chronic myelogenous leukemia

...alled blasts that crowd out red blood cells and platelets. Nilotinib and dasatinib target a greater variety of genetic variations leading to CML than does ima..., developed, designed and conducted clinical trials that led to approval of dasatinib by the FDA in June 2007 for the same group of patients. Talpaz is now at th...

Scientists discover new role for miRNA in leukemia

...ght represent a potentially new therapeutic strategy for CML patients who do not benefit from effective targeted agents such as imatinib (Gleevec) and dasatinib (Sprycel), says principal investigator Danilo Perrotti, assistant professor of molecular virology, immunology and medical genetics and a researcher wi...

SGX Pharmaceuticals BCR-ABL Program to be Presented at the American Society of Hematology 49th Annual Meeting and Exposition

...CR-ABL inhibited by SGX393 is the T315I mutation, which is also resistant to the two second-generation BCR-ABL inhibitors, nilotinib (Tasigna (R)) and dasatinib (Sprycel (R)). In addition, SGX is engaged in a strategic collaboration with Novartis that aims to discover and develop next generation BCR-ABL inhibi...

Can cancer drugs combine forces?

...inib, individuals are treated with a drug known as dasatinib (SPRYCEL), which targets BCR-ABL in a different wa...nts whose cancer had returned after treatment with dasatinib responded to retreatment with imatinib. Analysis o...tation that rendered the protein resistant to both dasatinib and imatinib or had two mutations, one rendering t...

New Strategy for the Treatment of CML

...t and colleagues examined the effects of combining dasatinib with PD184352, another clinically relevant small m...und that combining extremely low concentrations of dasatinib with PD184352 resulted in a dramatic increase in a...of newer, more effective kinase inhibitors such as dasatinib for diseases such as CML is a clear priority, resi...
Dasatinib in Medical Technology

Independent Publication Confirms Growing Therapeutic Challenge of T315I Mutation in Patients with CML, Notes ChemGenex

...int mutation. • A further 13 patients (28.8%) acquired resistance to dasatinib after a median of 7 months, and seven (15.6%) of these patients were T315I ...e. • In summary the T315I mutation was associated with resistance to dasatinib in 31% of patients, and the total number of patients who were resistant to ...

Independent Publication Confirms Growing Therapeutic Challenge of T315I Mutation in Patients with CML, Notes ChemGenex

...eevec-resistant CML patients who were treated with dasatinib (Sprycel(R)). Key points of the publication are ...s who had failed Gleevec, and who were migrated to dasatinib therapy. -- Eight of the 45 patients (17.7%) ...e T315I mutation was associated with resistance to dasatinib in 31% of patients, and the total number of patien...

Dasatinib Shows High Early Response Rate as First Treatment for Chronic Myelogenous Leukemia, M. D. Anderson Researchers Report

...s M. D. Anderson Cancer Center. "Patients taking dasatinib achieve complete cytogenetic response - absence of...ly one. "Our hypothesis is that treating with dasatinib first will produce an earlier response, which may ...d December 2006. Patients receive either 100 mg of dasatinib once daily or 50 mg twice daily. Thirty four pat...
Dasatinib in Biological News

JCI table of contents: Aug. 16, 2007

...inib, individuals are treated with a drug known as dasatinib (SPRYCEL), which targets BCR-ABL in a different wa...nts whose cancer had returned after treatment with dasatinib responded to retreatment with imatinib. Analysis o...tation that rendered the protein resistant to both dasatinib and imatinib or had two mutations, one rendering t...
Dasatinib in Biological Technology

FDA Approves New SPRYCEL(R) (Dasatinib) Product Labeling for Patients with Chronic-Phase CML

...th persistent myelosuppression. Bleeding Events: dasatinib caused platelet dysfunction in vitro and thrombocy...ely. QT Prolongation: In vitro data suggest that dasatinib has the potential to prolong cardiac ventricular r...or to SPRYCEL administration. Drug Interactions: dasatinib is a CYP3A4 substrate. Drugs that may increase das...
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