Vitamin D Deficit May Trigger MS Risk Gene
...the DRB1*1501 variant, which causes the gene to switch on.
The study was published in the Feb. 6 edition of PLoS Genetics .
"In people with the drb1
variant associated with MS, it seems that vitamin D may play a critical role. If too little of the vitamin is available, the gene may not function pro...
The Past, Present and Future of HLA Typing
...T-cells, are expressed by the HLA DR, -DQ and DP loci. Each locus is highly polymorphic; for example, there appear to be 300+ alleles in the HLA-B or drb1
loci. A clear understanding of the differences between HLA polymorphisms has provided ample insight into why and how foreign tissue is rejected by th...
HLA-DRB1 - Wikipedia, the free encyclopedia
Major histocompatibility complex, class II, DR beta 1, also known as HLA-DRB1
, is a human gene. DRB1
encodes the most prevalent beta subunit of HLA-DR.
HLA-DR15 - Wikipedia, the free encyclopedia
HLA-DR15 (DR15) is a HLA-DR serotype that recognizes the DRB1
*1501 to *1505 and *1507 gene products. DR15 is found at high levels from Ireland to Central Asia. frequencies. DR15 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR16...
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HLA-DRB1*08, DRB1*03/DRB3*0101, and DRB3*0202 are susceptibility genes ...
We examined HLA genotypes of DRB1
and DQB1 plus DRB3 subtypes using PCR-based ... As expected, we found that DRB1
*03 was associated with Graves' disease, but at a ...