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DMD in Medical News

Michael Simmons, DMD presented a poster at the American Academy of Dental Sleep Medicine Meeting

Michael Simmons, DMD of Tarzana and Palmdale in Southern California presented original research findings and poster abstract information that compared several home testing devices for evaluating severe sleep apnea at the annual meeting of the American Academy of Dental Sleep Medicine in Seattle t...

Dr. Wilhelm, DMD MSD, Makes Clients Smile with New Easy Smile Dental Appliance

Dr. Wilhelm uses latest technology to give patients the ability to improve smile in one appointment Woodbury, MN (PRWEB) March 31, 2009 -- Dr. Wilhelm, DMD MSD, announced today that he is providing patients with a new and affordable dental appliance called the Easy Smi...

Trial Of DMD Gene Therapy Initiated At Ohio

Jerry Mendell a neurologist, co-director of the Muscular Dystrophy Association (MDA) clinic at Columbus Children’s Hospital; professor of pediatrics, neurology and pathology at Ohio State University College of Medicine;// and head of the Neuromuscular Research Program and Gene Therapy Center at Col...

Cure Insight for DMD

According to the researcher Dr. Jacques P. Tremblay who is in the Human Genetics Department at Quebec City's Centre Hospitalier Universitaire de Québec (CHUQ) // and professor with Université Laval's Faculty of Medicine muscle cell transplant is one of the important alternatives to cure Duchenne mu...

Myostatin gene could hold the key to treatment for DMD

Recent studies to establish an effective treatment for Duchenne Muscular Dystrophy (DMD) have discovered that drugs or molecules used to inhibit myostatin - a protein that inhibits muscle growth - might prove to be the anticipated// answer. MDA grantee Kathryn Wagner of John Hopkins University...

Laurence I. Barsh, DMD, Founder of Snoring Isn't Sexy, to speak at Somnomed's First Annual Symposium

...nd operated affiliated offices. Visit http://www.SnoringIsntSexy.com for a directory of all participating dentists. Contact: Laurence I. Barsh, dmd 888.203.0488 315 East 70th St., #7H New York, NY 10021 ### Read the full story at http://www.prweb.com/releases/Stop_Snoring/Sleep_Apnea/prwe...

SnoringIsntSexy.com Tops 21,000 Site Visits for Second Month in a Row

...ed and operated affiliated offices. Visit www.SnoringIsntSexy.com for a directory of all participating dentists. Contact: Laurence I. Barsh, dmd 888.203.0488 315 East 70th St., #7H New York, NY 10021 ### Read the full story at http://www.prweb.com/releases/sleep_apnea/snoring/prweb2698...

BioMarin Announces Second Quarter 2009 Financial Results

...r of 2010. BMN-195 is an orally available small molecule which may upregulate utrophin, a potential replacement for the missing dystrophin protein in dmd patients. BMN-103 - alpha-glucosidase (GAA) for Pompe Disease: BMN-103 is a highly phosphorylated GAA enzyme, which the company believes could...

Snoring Isn't Sexy, LLC Announces Commendation Program to Honor Sleep Physicians Who Work with Dentists to Manage Sleep Breathing Disorders

...em. A complete list of participating dentists and physicians can be found at http://www.snoringisntsexy.com . Contact: Laurence I. Barsh, dmd 888-203-0488 315 East 70th St., #7H New York, NY 10021 # # # Read the full story at http://www.prweb.com/releases/sleep_apnea/snoring/prweb26...

Dentra™ Announces Dentistry Council of Advisors

...epartment of Dentistry at Seattle Children's Hospital. Paul Feuerstein, dmd Dr. Feuerstein holds a dmd from the UNJMD (New Jersey) and has a General Practice in North Billerica, ...
DMD in Medical Technology

PTC Therapeutics Completes Enrollment of Pivotal Trial in Muscular Dystrophy

...roximately 20,000 children worldwide are born with dmd (one of every 3,500 male children). It is estimated that one in 10 dmd patients are likely to have a Becker presentation,...tation of symptoms. Further information regarding dmd and BMD is available through the Muscular Dystroph...

PTC Therapeutics Announces Data Showing Six-Minute Walk Test Consistently Measures Ambulatory Function in Patients With Duchenne Muscular Dystrophy

... this study, it had been unclear whether boys with dmd would have the stamina and mental focus to success... This study demonstrated that ambulatory boys with dmd as young as five years old can complete the 6MWT s...a correlate well with the known natural history of dmd and suggest that the test should be able to detect...

PTC Therapeutics Announces $25 Million Award From Cystic Fibrosis Foundation Therapeutics for Development of PTC124

...as achieved target plasma concentrations that have been associated with activity in preclinical models. PTC124 is currently in Phase 2b development in dmd with the goal of demonstrating that increasing functional protein levels in patients with nonsense-mutation-mediated genetic disorders may provide cli...

PTC Therapeutics Announces Initiation of Phase 2b Registration-Directed Clinical Trial of PTC124 in Duchenne/Becker Muscular Dystrophy

...art of this groundbreaking trial." Patients with dmd and BMD are boys and young men who lack dystrophin...d cardiac function. It is estimated that one in 10 dmd patients are likely to have a Becker presentation,... with later manifestation of symptoms. In essence, dmd and BMD represent a continuum of the same disease....

PTC Therapeutics Announces Publication of Preclinical Data in PNAS

...promising new investigational drug." As with the dmd data published in Nature, the results published in...gistration-directed clinical trials in both CF and dmd this year, as well as in studies in additional gen...phan Drug designations for the treatment of CF and dmd due to nonsense mutations. PTC124 has also been gr...

PTC Therapeutics Announces Additional Results from Phase 2 Study of PTC124 in Duchenne Muscular Dystrophy

...om/cgi-bin/prnh/20010919/PTCLOGO ) Patients with dmd are boys and young men who lack dystrophin, a prot...the loss of both muscle function and independence. dmd is perhaps the most prevalent of the muscular dyst...roximately 20,000 children worldwide are born with dmd (one of every 3,500 male children). More informati...

PTC Therapeutics Announces Pharmacokinetic and Safety Results from Phase 2 Study of PTC124 in Duchenne Muscular Dystrophy

...associated with activity in a preclinical model of dmd were achieved at the mid- and high-dose levels. "...re than 150 subjects, including patients with both dmd and cystic fibrosis. The safety profile has consis...the loss of both muscle function and independence. dmd is perhaps the most prevalent of the muscular dyst...

The Sturdier Sex?: Study by Pittsburgh Scientists Finds Female Stem Cells Work Better

...in the lab while searching for a cure for Duchene muscular dystrophy (DMD). dmd is a genetic disease estimated to affect one in every 3,500 boys. Patients with dmd lack dystrophin, a protein that gives muscle cells structure. Using an anim...

Targeting Specific Mutations Reveals Promising New Approach to Treating Genetic Disorders; Preclinical Data Published in Nature

...ated that approximately 13 percent of the cases of dmd are due to nonsense mutations. PTC Therapeutics, I...on of protein levels. Genetic disorders, such as dmd and cystic fibrosis (CF) are caused by genetic alt... data obtained from PTC's work in a mouse model of dmd in which a nonsense mutation precludes the product...

PTC Therapeutics Announces Additional Positive Interim Phase 2 Results of PTC124 in Duchenne Muscular Dystrophy

...of Neurology (AAN) Annual Meeting. Patients with dmd lack dystrophin, a protein that is critical to the...resented today includes data from 26 patients with dmd who received PTC124 at the low-dose and medium-dos...rs due to a nonsense mutation. The findings in the dmd trials are consistent with the results observed in...
DMD in Biological News

'Show me the money!' MDA greenlights grants

...D) have prolonged boys' lives, physicians are seeing more heart disease develop in young men living with the disease. "The longer patients with dmd live, the greater the risk of cardiac complications. In this study, we hope to improve cardiac care by establishing the best medication regimen and to...

Muscular dystrophy diagnosis delayed almost 2.5 years in boys

... shows that boys who are eventually diagnosed with dmd show signs of the disease for more than a year bef...d medical records of 453 boys born since 1982 with dmd or Becker Muscular Dystrophy in the Muscular Dystr... of young children to recognize the early signs of dmd and to order a CK test if they see any motor delay...

Ultrasound imaging now possible with a smartphone

...s of patients with Duchene's Muscular Dystrophy. A degenerative disease that often strikes young boys and robs them of their lives by their late 20s, dmd is a degenerative disease for which there is no cure. The leading treatment to slow its progression is a daily dose of steroids. Patients often expe...

Sarcospan, a little protein for a big problem

...re, however, suggests it might help stabilize the membrane complex, so the authors decided to test the effects of increasing sarcospan expression in a dmd mouse model. The increase did not improve the dystrophinglycoprotein interaction, but instead, the team was surprised to find sarcospan coaxed a dyst...

Scientist clears hurdles for muscular dystrophy therapy

...ve some form of muscular dystrophy. Duchenne muscular dystrophy (DMD) is the most common type of the disease, predominantly affecting males. Boys with dmd will lose the ability to walk by their teens and typically die before the age of 30. For years, scientists have studied the use of gene therapy as a p...

Pittsburgh scientists identify human source of stem cells with potential to repair muscle

...tified. One of the most promising uses could be for the treatment of DMD, a genetic disease estimated to affect one in every 3,500 boys. Patients with dmd lack dystrophin, a protein that gives muscle cells structure. Dr. Huard is an internationally recognized cell biologist conducting laboratory resea...

Switching genes to overdrive improves muscular dystrophy symptoms in mice

...al. The average age of death is the mid-teens, and most patients die by their 30s. In the United States, about 400 to 600 boys are born each year with dmd or Becker Muscular Dystrophy, a milder form of the disease. The cause is a mutation, either inherited or occurring spontaneously, that affects a muscl...

The sturdier sex? -- Study by Pittsburgh scientists finds female stem cells work better

...in the lab while searching for a cure for Duchene muscular dystrophy (DMD). dmd is a genetic disease estimated to affect one in every 3,500 boys. Patients with dmd lack dystrophin, a protein that gives muscle cells structure. Using an anim...

'Smart' genetic therapy helps the body to heal itself

...ty of the code can be restored and the progress of dmd delayed or even stopped. In collaboration with ...drug that induces the skipping of exon 51 from the dmd gene. Six Dutch dmd patients aged between 8 and 16 years with genetic ...

Research casts doubt on circulating stem cells

...indeed, by the simple means of transplanting healthy bone marrow. For boys, dmd is the second most common hereditary disease. Due to a genetic defect, the ...sting. They only have a life expectancy of 15 to 20 years. "In mice with dmd we have replaced the bone marrow with healthy marrow marked by a fluorescen...
DMD in Biological Technology

PTC Therapeutics Receives $2.6 Million in Government Grants

...across all clinical studies to date. The FDA and the European Commission have granted PTC124 (ataluren) orphan drug status for the treatment of dmd and cystic fibrosis due to nonsense mutations. The FDA has also granted PTC124 (ataluren) Subpart E designation for expedited development, evaluation...

BioMarin Announces First Quarter 2009 Financial Results

...ate utrophin, a potential replacement for the missing dystrophin protein in dmd patients. BMN-103 - alpha -glucosidase (GAA) for Pompe Disease:...ovascular program 1Q10: Initiation of Phase I trial for BMN-195 for dmd 1H10: Results from Phase I/II trial for GALNS for MPS IVA M...

PTC124 Shows Promising Activity in Cystic Fibrosis; Phase 2 Proof-of-Concept Data Published in the Lancet

...will safely provide clinical benefits. PTC124 has been granted orphan drug status by the FDA and the European Commission for the treatment of CF and dmd due to nonsense mutations. The FDA has also granted PTC124 Subpart E designation for expedited development, evaluation, and marketing. PTC has an ex...

Genzyme Corporation and PTC Therapeutics Announce Collaboration on Small Molecule for Genetic Diseases

...approach that holds great potential to help CF and dmd patients, and many others with a variety of devast...ased on phase 2a clinical proof of concept in both dmd and CF, further development in each of these indic... multicenter trials. A phase 2b trial of PTC124 in dmd is currently enrolling, and is expected to include...

PTC124 Featured at Third Annual Congress of Myology

... a global, registration-directed Phase 2b trial in dmd and Becker muscular dystrophy (BMD) to evaluate th... development program. Genetic disorders, such as dmd and cystic fibrosis (CF), are caused by genetic al... to continuing to advance our clinical programs in dmd and CF and evaluating PTC124 in a number of additi...

PTC Therapeutics Announces Encouraging Additional Phase 2 Results of PTC124 in Cystic Fibrosis

...ug designations for the treatment of CF and DMD due to nonsense mutations. PTC124 has also been granted orphan drug status for the treatment of CF and dmd by the European Commission. PTC124's development is supported by grants from the Muscular Dystrophy Association (MDA), Cystic Fibrosis Foundation Ther...

Rapid detection of genomic duplications and deletions using the Agilent 2100 bioanalyzer

...ere examined, of whom 13 were known to be carriers for mutations in the dmd gene and 4 were non-carriers. The MAPH protocol has been described prev...sly published work on the analysis of deletions and duplications in the dmd geneusing MAPH3. While this concentrated on the analysis of a large gro...

The use of the Mastercycler gradient for single-cell PCR and preimplantation diagnosis

...ous for the CA repeat in intron 45 of the dmd gene, and an individual heterozygous for ...s buffer (ALB; 50 mM DTT and 200 mM KOH for CF and dmd or NaOH for DM). ...es and PCR programs are summarized in Table 1. The dmd sequence was amplified in a similar way...
DMD in Biological Dictionary

Voluntary muscle

...via ... muscle cells, which comprise about 40% of the body weight, are voluntary . ... What happens to the voluntary muscles of someone with dmd or BMD? ... gradually weakens the skeletal, or voluntary , muscles , those in the arms, legs and trunk. ... In the cells of voluntary muscle...
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