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DHFR in Medical News

Cancer Scientists' Gene Research Offers New Treatment Hope

...or DHFR. When it is switched off, the rapidly dividing cancer cells are starved of a vital building block - a chemical called thymine. "Inhibiting the dhfr gene could help to prevent the growth of neoplastic cancer cells - ordinary cells which develop into tumour cells - such as in prostate cancer cells,"...

Role of RNA in Checking the Development of Tumors

...determining whether the gene is "on" or "off". The dhfr gene produces an enzyme that controls thymine prod... in rapidly dividing cells. "Inhibiting the dhfr gene could help prevent the growth of neoplastic c...ng how we can use the RNA to switch off or inhibit dhfr and other genes may have important therapeutic imp...
DHFR in Medical Technology

Arpida Comments on FDA's Anti-infective Drugs Advisory Committee Outcome

...and is the first antibiotic in the dihydrofolate reductase (DHFR) selective inhibitor class to demonstrate efficacy against cSSSIs caused by MRSA. The dhfr class has been proven safe and effective in more than four decades of clinical use. About Arpida Arpida (SWX: ARPN) is a biopharmaceut...

Pivotal Phase III Data Confirm the Efficacy and Safety of Arpida's Intravenous Iclaprim in Treating Patients With Complicated Skin and Skin Structure Infections

...and is the first antibiotic in the dihydrofolate reductase (DHFR) selective inhibitor class to demonstrate efficacy against cSSSIs caused by MRSA. The dhfr class has been proven safe and effective in more than four decades of clinical use. In March 2008, Arpida completed the U.S. filing of the New Drug ...

Interim Safety Analysis Supports Continuation of Allos Therapeutics' Pivotal Phase 2 PROPEL Trial of PDX in Patients with Peripheral T-cell Lymphoma

...able safety and efficacy profile relative to methotrexate and certain other dhfr inhibitors. About Allos Therapeutics, Inc. Allos Therapeutics is a biop...fety and efficacy profile of PDX relative to methotrexate and certain other dhfr inhibitors, the potential safety and efficacy of PDX for the treatment of P...

Interim Response and Safety Analyses Support Continuation of Allos Therapeutics' Pivotal Phase 2 PROPEL Trial of PDX in Patients with Peripheral T-Cell Lymphoma

...able safety and efficacy profile relative to methotrexate and certain other dhfr inhibitors. About Allos Therapeutics, Inc. Allos Therapeutics is a biopha...fety and efficacy profile of PDX relative to methotrexate and certain other dhfr inhibitors, the potential safety and efficacy of PDX for the treatment of P...

Allos Therapeutics Initiates Study of PDX in Patients with Cutaneous T-Cell Lymphoma

...and clinical data in a variety of tumors, suggest that PDX may have a favorable safety and efficacy profile relative to methotrexate and certain other dhfr inhibitors. About Allos Therapeutics, Inc. Allos Therapeutics is a biopharmaceutical company focused on the development and commercialization of sma...

Arpida Announces Promising Results of "First-In-Man" Studies With AR-709

...ould be developed with appropriate players in this field, could have the added benefit of avoiding unnecessary systemic exposure." AR-709 is a novel dhfr inhibitor with an outstanding microbiological activity against streptococci in general and, importantly, against multi-drug resistant Streptococcus pn...

Hana Biosciences Announces Data to be Presented On Talvesta (Talotrexin) for Injection at The American Association for Cancer Research Annual Meeting

... of various types of cancers. Talvesta has demonstrated enhanced antitumor activity in a broad spectrum of preclinical studies by targeting the enzyme dhfr to prevent DNA synthesis in tumor cells and inhibit tumor growth. These studies suggest that Talvesta, as compared to methotrexate, enters into cells ...

Allos Therapeutics' PDX Granted Orphan Medicinal Product Designation by the European Commission

...nd clinical data in a variety of tumors, suggest that PDX may have a favorable potency and toxicity profile relative to methotrexate and certain other dhfr inhibitors. About Peripheral T-cell Lymphoma Peripheral T-cell lymphomas, or PTCLs, are a biologically diverse group of blood cancers that account...

Allos Therapeutics Reports Results for Phase 3 Enrich Study of Efaproxyn in Women With Brain Metastases Originating From Breast Cancer

...ble potency and toxicity profile relative to methotrexate and certain other dhfr inhibitors. The Company believes PDX has the potential to be delivered as a...tial potency and toxicity profile of PDX relative to methotrexate and other dhfr inhibitors; the Company's projected timelines for conducting interim analys...
DHFR in Biological Technology

Arpida Announces Full Year 2007 Financial Results

...that is being developed for the treatment of upper and lower respiratory tract infections contracted in the community setting. The compound is a novel dhfr inhibitor with an outstanding microbiological activity against streptococci in general and, importantly, against multi-drug resistant Streptococcus pn...

Electroporation of Primary Bone Marrow Cells

...orometer. The stable integration of the dhfr gene was demonstrated by the acquired ability ... 10 days in culture. Cells receiving the dhfr plasmid were cultured with increasing a... was done to verify the presence of the dhfr gene within the cultured cells. High molecular wei...

Preparative SDS-PAGE Electrophoresis of a Recombinant Epstein-Barr Virus Encoded Protein and Its Application in Serodiagnostic Test Systems, Rev C

...proved by the use of purified recombinant EBV antigens. After cloning and high-level expression of a particular viral protein as dhfr fusion protein in Escherichia coli, we purified the recombinant antigen to near homogeneity with the help of continuous elution electrophor...

Translate High Yields of Biologically Active Proteins

... available kits were compared to that from the ActivePro Kit. Dihydrofolate reductase (DHFR): Activity was measured with a standard dhfr assay, which follows the rate of conversion of dihydrofolate and NADPH to tetrahydrofolate and NADP + through the successive de...
DHFR in Biological Dictionary

Gene amplification

...plification (in vivo) RNA amplification (in vivo) amplification , gene ... MTX-resistance in a tumor can occur by gene amplification of dhfr (but not often documented) ... Gene amplification ® overproduction of mdr1 ® drug resistance: ... ...
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(Date:8/29/2014)... release is available in German . ... players in the natural nitrogen cycle on Earth and ... bacteria were thought to depend on nitrite as their ... by Holger Daims, a microbiologist at the University of ... hydrogen as an alternative source of energy. The oxidation ...
(Date:8/29/2014)... them: modern materials that are light, flexible and highly ... or electronic paper. , Making such concepts affordable enough ... way of working with copper nanowires and a PVA ... success in the field of ultra-lightweight "aerogel monoliths" has ... silver nanowires. , By turning instead to copper, ...
(Date:8/28/2014)... of bacterial culprits that may drive inflammatory bowel diseases ... patients, own intestinal immune responses as a guide. , ... Cell . , Trillions of bacteria exist within ... in the development and progression of IBD. Yet it,s ... affect a person,s susceptibility to IBD and its potential ...
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