RA individuals from lower GDP countries keep working despite worse symptoms than richer countries
In the study, HAQ (0-3) was used to measure everyday disability and the das28
(0-10) to measure disease activity. Data concerning work status/disability ...sability aids is required. A higher score indicates greater disability.
(Disease Activity Score) is an index used by physicians to measure how acti...
63 percent of RA patients suffer psychiatric disorders, with depressive spectrum conditions most likely
...ting Scale and the Montgomery-Asberg Depression Rating Scale. Projective psychological methods were employed for evaluation of cognitive function.
(Disease Activity Score) is an index used by physicians to measure how active an individual's RA is. It assesses number of tender and swollen joints (...
ACTEMRA(R) (tocilizumab) Studies to be Featured at the European League Against Rheumatism (EULAR) Congress
...ct Platform Presentations/Poster Sessions
"Tocilizumab Inhibits Structural Joint Damage, Improves Physical Function, and Increases das28
Remission Rates in RA Patients Who Respond Inadequately to Methotrexate: The LITHE Study," will be highlighted in an oral presentation by lead investi...
New Long-Term HUMIRA(R) (adalimumab) Data Show Up to Seven-Year Efficacy with Combination Treatment for Rheumatoid Arthritis
...for at least three consecutive visits; sustained remission was achieved in 42 percent of all patients after a mean of 18 +/- 17 months. das28
is a composite index that includes variables such as the number of tender and swollen joints, specific laboratory values and other measu...
Adalimumab therapy effective in AS, RA and PsA patients refractory to other anti-TNF therapies
...ho have not had prior anti-TNF therapy. RA patients had a mean reduction in das28
(Disease Activity Scale 28) of -1.9 following previous treatment with eithe...eviously undergone anti-TNF therapy achieved ACR50 and had a mean change in das28
of -2.1 after 12 weeks of adalimumab therapy.
About the Trials
50 percent of recent onset RA patients become free of signs and symptoms within 36 weeks
... standard clinical care.
Of 169 early RA patients, remission (defined as das28
The researchers achieved these results through implementation of a tight...rage disease duration of 16 weeks (1-52), ESR 33.2 (20.5), CRP 23.5 (26.4), das28
5.1 (1.1), HAQ 1.3 (0.6).
Effect of tumor necrosis factor a inhibitors on heart failure risk in RA Patients
..., an increased risk of heart failure was found in patients with low functional capacity and high disease activity. Notably, a 2-point increase in the das28
score resulted in a 1.8-fold increase in heart failure risk.
When adjusting for functional capacity and disease activity at follow-up, along with...
Intensity of Rheumatoid Arthritis Significantly Reduced by Pregnancy
...ding to medication use, the Disease Activity Score das28
and the level of inflammation marker C-reactive pr...les (DAS28-CRP-3).
The change between the das28
at first and third trimester was used to categoris...oderate and non-responders. The change between the das28
at 6 weeks and 12 or 26 weeks postpartum was used ...
B-Cell Biologic Therapy Could Revolutionize Rheumatoid Arthritis Treatment
...and analyses of the proportions of patients who achieved higher ACR improvement scores--50 percent and 70 percent--showed similar patterns. Changes in das28
at week 24 reflected the ACR response findings, as did the subjects reports of relief from joint pain and stiffness. What's more, subjects in the ritu...
DAS28 in Medical Technology
CombinatoRx Product Candidate CRx-150 Shows Activity on DAS28 and
Pain, but Not CRP
CAMBRIDGE, Mass.--(BUSINESS WIRE)--Jun 28, 2007 - CombinatoRx,
Incorporated (NASDAQ: CRXX) today announced preliminary results of
its randomized, blinded, placebo-controlled clinical trial of
CRx-150 in patients with rheumatoid arthritis (RA). The trial
compared CRx-150 plus a disease-modifying ant...
R788 in TASKi3 Clinical Trial Does Not Meet Efficacy Endpoints in RA Patients Who Had Previously Failed Biologic Therapies - Results Incongruent
...ib disodium) did not report significantly higher ACR 20, ACR 50, ACR 70 and das28
response rates than the placebo group at three months, and therefore, the t...respond to R788, but the objective and subjective components of the ACR and das28
scores are incongruent, mainly because the reported subjective placebo resp...
Rigel's R788 Significantly Improves Rheumatoid Arthritis in Phase 2b Clinical Trial
...ed for up to 6 months. The groups treated with 100 mg of R788 bid (twice a day) and 150 mg qd (once a day) reported higher ACR 20, ACR 50, ACR 70 and das28
response rates than the placebo group. The efficacy results for the two dosing groups were comparable, although the response rates for the 100 mg bid...
Data Demonstrated ACTEMRA(R) (tocilizumab) Significantly Inhibited Progression of Structural Joint Damage in Rheumatoid Arthritis Patients
...he analysis showed that long-term efficacy was maintained in all three patient populations treated with ACTEMRA, as measured by ACR response rates and das28
ACTEMRA monotherapy was proven to be statistically superior to methotrexate in ACR20, ACR50 and ACR70 responses(4) (at six months), accor...
Two-Year Data Reinforce Effect of ACTEMRA(R) (tocilizumab) in Inhibiting Progression of Joint Damage and Improving Physical Function in Rheumatoid Arthritis Patients
The two-year data from the LITHE study showed that patients treated with ACTEMRA maintained consistently high disease remission rates according to das28
criteria, which measures disease activity in RA patients(2). The study also showed that a greater proportion of patients treated with ACTEMRA (8 mg/kg...
New Study Demonstrated ACTEMRA(R) (tocilizumab) Inhibited Progression of Joint Damage in Rheumatoid Arthritis Patients
...previous studies that patients treated with ACTEMRA
experienced an improvement in the signs and symptoms of RA and achieved
remission according to the das28
criteria more often than with DMARDs,"
said Kenneth Bahrt, M.D., Global Medical Director, Autoimmunity, Roche.
"The LITHE study not only confirmed the...
ACTEMRA (R) (tocilizumab) Significantly Reduced Signs and Symptoms of Rheumatoid Arthritis in Patients Who Failed Prior Treatments
...ve dose regimen of methotrexate alone.
In both studies, nearly one-third of all ACTEMRA (8 mg/kg) patients
achieved disease remission (as defined by das28
<2.6(2)) and ACTEMRA was
generally well-tolerated compared with existing therapies.
About the RADIATE Study
RADIATE (RheumAtoiD ArthritIs Study in...
ACTEMRA(R) (tocilizumab) Significantly Reduces Rheumatoid Arthritis Signs and Symptoms Regardless of Previous Therapy in Two New Global Studies
...ACTEMRA patients from both studies reached disease remission (as
defined by das28
"We are very encouraged by the results of the AMBITION study th...low (DAS28 less than or equal to 3.2), moderate (3.2 (DAS28>5.1). das28
the criteria of the American College of Rheumatology.
(3) The EULAR ...
Data From Two Phase 3 Studies Show Anti-TNF Golimumab Significantly Improved Signs and Symptoms of Rheumatoid Arthritis
... of patients in the respective golimumab groups achieved remission
based on das28
(CRP), compared with 13 percent of patients receiving
placebo plus MTX (p<0...-six percent
of patients in the combined golimumab group were classified as das28
responders, and 38 percent achieved DAS 28 remission, compared with 6...
International ACTEMRA Rheumatoid Arthritis Study Highlighted in The Lancet
...on of patients treated with
ACTEMRA plus methotrexate, with 27.5% achieving das28
less than or equal to
2.6 by 24 weeks.
Additionally, results showed that ...of disease activity is interpreted as low (DAS28 moderate (3.2 5.1). das28
corresponds to being in remission according to the criteria of the ...
DAS28 in Biological News
DAS28 in Biological Technology