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Cytotoxicity in Medical News

Materials and Processes for Medical Devices Event Brings Clinicians, Engineers, Designers Together

...r implantable device surfaces for the improvement of functional properties. Biostability and Biocompatibility provides data on in vitro assessment of cytotoxicity of Nitinol and Nitinol alloys, the relative roles of osteolysis and hypersensitivity by particulate debris to loosening of metal-on-metal hips, and a ...

Compendia Bioscience Announces Collaboration with MDS Pharma Services to Deliver Novel Solution for Oncology Drug Development

.../20070213/NYTU093LOGO ) MDS Pharma Services OncoPanel(TM) service provides high content screening of up to 240 cancer cell lines to assess the cytotoxicity and chemotherapeutic potential of specific cancer drugs and drug combinations. Compendia's Oncomine(TM), a database of cancer genomic profiles coupled...

BD Announces FDA 510(k) Clearance of Novel Molecular Assay to Diagnose Clostridium difficile Infections

...Until now, diagnosing CDI rapidly has proven difficult. Traditional methods, including immunoassays, lack sufficient sensitivity, while tissue culture cytotoxicity methods are difficult to perform and require several days to yield results. About BD BD is a leading global medical technology company ...

What are protective effects of anti-ricin A-chain aptamer?

...city in cell-based luciferase translation and cell cytotoxicity assays were evaluated. They have shown that 31R...cin ribotoxicity in cell-based luciferase and cell cytotoxicity assays. Hence, RNA aptamer that inhibits RTA enzy...and cell-based luciferase assays and ricin-induced cytotoxicity assay. The use of a stably transfected cell-based...

Keryx Biopharmaceuticals' KRX-0401 (Perifosine) Data Selected for Oral Presentation at the 50th Annual Meeting of the American Society of Hematology

... Pre-Clinical Poster Presentations: MONDAY, DECEMBER 8th Abstract 3663 TITLE: Combination of Nab-Rapamycin and Perifosine Induces Synergistic cytotoxicity and Antitumor Activity Via Autophagy and Apoptosis in Multiple Myeloma (MM) Session Name: Myeloma - Pathophysiology / Preclinical Studies excluding...

MCG receives $100,000 Grand Challenges Explorations grant for innovative global health research

...undation. The grant will support an innovative global health research project conducted by Dr. Pandelakis A. Koni titled "Antibody-Dependent Cellular cytotoxicity Targeted Against HIV-1 Env Glycans." Dr. Koni's project is one of 104 grants recently announced by the Gates Foundation for the first funding round...

Stanford researchers find molecule that kills kidney cancer cells

...s study are some of the first using the center's equipment. The high-throughput equipment at Stanford can analyze thousands of molecules for their cytotoxicity at the same time, allowing researchers like those in Giaccia's lab to search for hidden genes and molecules that previously would have been quite labo...

TetraQ recognized for toxicology services

...tionally accredited service delivery which includes acute and chronic toxicology services, said Professor Smith. These toxicology services include cytotoxicity assays, genotoxicity assays - bacterial mutation (Ames) tests; mouse lymphoma assay; mammalian erythrocyte micronucleus testing; dose range finding; s...

EAU Technologies to Present at AeA Micro Cap Conference

...ed animal health and production. EAU uses terms like "green", "natural", "non-toxic" and "organic" based on our NAMSA studies that show no toxicity or cytotoxicity at levels as high as 70 ppm of HOCl. EAU uses only water, food grade electrolytes and electricity to create all of its solutions. The active ingredien...

Electrolyzed Water Gives Boost to Eliminating Food-Borne Bacteria Such as Salmonella, E. coli and Listeria Murray's Chicken to be First Poultry Processor to Utilize New Technology in its Food Sanitation Process

...ed animal health and production. EAU uses terms like "green", "natural", "non-toxic" and "organic" based on our NAMSA studies that show no toxicity or cytotoxicity at levels as high as 70 ppm of HOCl. EAU uses only water, food grade electrolytes and electricity to create all of its solutions. The active ingredien...
Cytotoxicity in Medical Technology

Affitech-Discovered Anti-PS Antibodies in Development by Peregrine Pharmaceuticals Show Excellent Functionality in Preclinical Studies

...anisms such as antibody-dependent cell-mediated cytotoxicity (ADCC). Their data further defined the role of anti-PS antibodies in mediating tumor cell cytotoxicity and the tumor microenvironment, showing that the anti-PS antibody induced a sequential release of cytokines and beta-chemokines and stimulated enhance...

Medarex Announces Preclinical Data from Multiple Research Programs Demonstrating Anti-Tumor Activity in Cancer

...d robust cytotoxic effector function (both antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity) for killing tumor cells. Additionall...ng glypican-3 with antibodies enhanced for antibody-dependent cell-mediated cytotoxicity properties, as drug-conjugates or used in combination with existing therapi...

First Candidate from Esperance's Targeted Anti-cancer Platform, EP-100, Establishes Preclinical Proof of Concept

...ls (OVCAR-3). As a negative control, the study utilized LHRH receptor negative SKOV-3 ovarian cancer cells. In in vitro studies designed to test the cytotoxicity of EP-100 in ovarian cancer cell lines, cells were cultured in the presence of various concentrations of EP-100 or unconjugated CLIP 71 for one to 24 ...

Studies Presented at AACR Annual Meeting Highlight Multiple Immunomodulatory Mechanisms of Peregrine's PS-Targeting Antibodies

...ikely via cell-mediated mechanisms such as antibody-dependent cell-mediated cytotoxicity (ADCC). Their data further define the role of anti-PS antibodies in mediating tumor cell cytotoxicity and the tumor microenvironment, showing that the anti-PS antibody induced a...

AACR Data Highlights InNexus Preclinical Antibody Candidate

... unusual investment and commercial opportunity." InNexus' AACR presentations are titled, " A Novel High Avidity Anti-CD20 With Markedly Increased cytotoxicity Shows No Systemic Toxicity In The Cynomolgus Monkey At A Dose 100-Fold Above The Anticipated Therapeutic Dose ", (AACR# 1231) and " Oxidative Modifica...

Aching Back? Cholesterol Medication Might Help

...is of collagen I, a protein that is related to fibrosis (the formation or development of excess fibrous connective tissue). Lovastatin had no cytotoxicity (the quality of being toxic) on nucleus pulposus cells. "Regeneration of the nucleus pulposus tissue in the early stage of intervertebr...

DNA Therapeutics Closes 2.2 Million EUR Series A Financing Round

...s scope to all indications currently treated by radiotherapy and chemotherapy. The ability of siDNA to improve therapeutic efficacy without additional cytotoxicity has potential to extend the market for radiotherapy and chemotherapy. It is anticipated that DNA Therapeutics will have a pipeline with products at di...

Medarex Announces Enhanced Activity Data with Second Generation Anti-CD30 Antibody for Malignant Lymphoma

... About MDX-1401 MDX-1401 is a non-fucosylated version of the MDX-060 antibody and is enhanced for greater antibody-dependent cellular cytotoxicity (ADCC) activity, an important function of the human immune system, whereby immune cells can kill target cells. ADCC activity is one important mechanis...

Micromet Presents Data at the 23rd Annual Meeting of the International Society for Biological Therapy of Cancer on the Activity of Human Antibody Adecatumumab against KRAS-mutated Colon Cancer Cells

... data indicated that human colon cancer cells are efficiently eliminated in tested cell lines by adecatumumab, mediated by antibody-dependent cellular cytotoxicity (ADCC), irrespective of their KRAS mutation status. Recent studies suggest that anti-EGFR antibodies cetuximab (Erbitux(R); ImClone, BMS, Merck KGaA) ...

Panacea Pharmaceuticals Announces Issuance of a U.S. Patent Covering Anti-HAAH Antibodies

... utilizing PAN-622. Panacea has demonstrated that anti-HAAH antibodies are internalized upon binding to the cell surface of cancer cells. In addition, cytotoxicity as measured by a cell proliferation assay has been demonstrated following internalization of a PAN-622-toxin conjugate. This fact, coupled with the ex...
Cytotoxicity in Biological News

Peregrine's PS-targeting antibodies highlighted in AACR Annual Meeting studies

...ikely via cell-mediated mechanisms such as antibody-dependent cell-mediated cytotoxicity (ADCC). Their data further define the role of anti-PS antibodies in mediating tumor cell cytotoxicity and the tumor microenvironment, showing that the anti-PS antibody induced a...

New high-throughput screening technique makes probing puzzling proteins possible

...ne would be able to block probe labeling of RBBP9 until we did the screen," says Cravatt. Now the group can explore the possibility that emetine's cytotoxicity may involve activity against RBBP9, and understanding this binding interaction better should also further our understanding of the substrates to which...

3-substituted indolones as novel therapeutic compounds for neurodegenerative conditions

...tive in a fly model of Alzheimer's disease. " The current study identifies several compounds that are more efficacious than GW5074 and that display no cytotoxicity even when used at high doses. These 3-substituted indolones are thus novel and promising candidate therapeutic agents for pre-clinical testing agains...

National Institutes of Health award Williams professor $217,710 research grant

...rchitectures. The molecules that will be examined are acutphycin, which inhibits the growth of malignant cells; tedanolide C, which exhibits potent cytotoxicity against cancer cell lines; and other novel natural products of marine origin. This study will build on Smith's earlier work on pyran-based products...

Galiximab in combination with rituximab in patients with previously untreated follicular lymphoma

...crophages, dendritic cells and cells from various subtypes of NHL. Galiximab's potential mechanisms of action include Antibody-Dependent Cell-Mediated cytotoxicity (ADCC) and possible immunomodulatory effects on host effector cells affecting the tumor microenvironment. ...

Going live with click chemistry

...ly shown that glycans can be metabolically labeled with azides, permitting their chemical tagging with imaging probes through click chemistry, but the cytotoxicity of the click reaction would not allow dynamic imaging of live cells. To apply click chemistry to glycans, Bertozzi and her colleagues designed a ne...

VCU Massey Cancer Center researchers identify a new class of anti-cancer drugs based on platinum

...from currently used drugs. This research was selected as the cover article for the print version of the journal, Issue 26. Researchers compared the cytotoxicity and cellular concentrations of three anti-cancer drugs including the phase II clinical drug, BBR 3464, cisplatin and the new trinuclear platinum compo...

Data published in PNAS show antibodies can be made 10 times more toxic to cancer cells

...on of immune cells for tumor lysis, called Antibody-Dependent Cell-mediated cytotoxicity (ADCC), by more than two orders of magnitude. Studies conducted in in vivo ...us studies to be responsible for mediating antibody-dependent cell-mediated cytotoxicity and has been the target of Xencor's XmAb technology. Xencor has leveraged ...

GlycoFi announces the first production of antibodies with human glycosylation in yeast

...ain of the antibody and destroy the cancer cell to which the antibody is bound. Research has shown that this process, known as antibody dependent cell cytotoxicity (ADCC), is sensitive to the composition of sugars (or "glycans") in the antibody's constant region. Moreover, in the absence of these sugars, the anti...

University of Delaware researchers develop cancer 'nanobomb'

...es might cause blockage and create problems, Panchapakesan said. Furthermore, the nanobomb route is probably the only way to use nanotubes without any cytotoxicity as the nanotubes are destroyed completely. Current surgical techniques are not precise and cancerous cells are often left behind. In addition, ca...
Cytotoxicity in Biological Technology

BioWa Announces License of POTELLIGENT(R) Technology to Merck KGaA

...ENT((R)) Technology platform for the research, development and commercialization of their antibody therapies with enhanced antibody-dependent cellular cytotoxicity (ADCC). "We are extremely pleased about our partnership with Merck KGaA, a global healthcare company with a strong worldwide presence," comm...

High-Tech 'Smart' Face Mask Helps Hong Kong Families Combat Swine Flu

...ibility following internationally recognized standards set out in ISO10933: Biological Evaluation of Medical Devices. Tests were conducted to evaluate cytotoxicity to cells, skin irritation on contact, and skin sensitization after repeated contact. No cytotoxicity, irritation or incidence of sensitization was obs...

Australia: Face Mask That Kills Swine Flu Readied for Australian Pandemic Fight

...ibility following internationally recognized standards set out in ISO10933: Biological Evaluation of Medical Devices. Tests were conducted to evaluate cytotoxicity to cells, skin irritation on contact, and skin sensitization after repeated contact. No cytotoxicity, irritation or incidence of sensitization was obs...

Cepheid Announces Symposium Speakers and Program Highlights for 19th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)

...arison of the performance of four rapid tests against the gold standards of cytotoxicity assay and culture in the diagnosis of Clostridium difficile infection (CDI)...ka Institutet , Stockholm: Comparison of a multiplex real-time PCR and the cytotoxicity neutralization assay for the diagnosis of Clostridium difficile infections ...

Idenix Pharmaceuticals Reports Data From Three Hepatitis C Development Programs at the 44th Annual Meeting of the European Association for the Study of the Liver

...in HCV-infected patients based on favorable bioavailability and plasma drug exposure levels in animal studies. IDX375 showed limited metabolism and no cytotoxicity when incubated with mouse, rat, monkey or human hepatocytes. IDX375 demonstrated no adverse effects in monkeys given daily oral doses of 10 or 100 mg/...

Trubion Presents Preclinical Data on Its SCORPION(TM) Multispecific Therapeutics at the 2009 American Association of Cancer Research Annual Meeting

...egies to improve efficacy of B-cell directed therapies include boosting the cytotoxicity of agents and expanding to targets beyond CD20. The objective of this... the CD79BxDR SCORPION molecule elicited strong Antibody-Dependent Cellular cytotoxicity (ADCC) as well as highly potent direct killing, confirming the ability of T...

AACR 100th Annual Meeting Highlights Superior Ability of InNexus' DXL-Modified Anti-CD20 Antibody to Attach and Kill NHL With Safety Comparable to Approved Antibody Therapies in Preclinical Studies

...ified antibody. The study determined that the increased target activity and cytotoxicity of DXL-modified anti-CD20 does not affect safety even at doses 100 times th...ations are titled, " A Novel High Avidity Anti-CD20 With Markedly Increased cytotoxicity Shows No Systemic Toxicity In The Cynomolgus Monkey At A Dose 100-Fold Abov...

BioWa Announces License of POTELLIGENT(R) Technology to sanofi-aventis

...IGENT(R) Technology platform for the research, development and commercialization of their antibody therapies with enhanced antibody-dependent cellular cytotoxicity (ADCC). "We are extremely pleased about our partnership with sanofi-aventis, a global healthcare company with a strong worldwide presence," comm...

Nereus Pharmaceuticals Initiates ADVANCE, a Randomized Phase 2 Clinical Trial of NPI-2358 in Non-Small Cell Lung Cancer

...ers without altering the dynamic function of formed microtubules. As demonstrated in preclinical testing, this results in a highly specific nanomolar cytotoxicity while producing a favorable profile relative to the cardiotoxic and neuropathic side effects seen in first-generation VDAs. Results from Phase 1 stud...

Frost & Sullivan European Drug Discovery Product Innovation Award Bestowed on Xenometrix AG

... in the production of single and multiple endpoint cytotoxicity assays. (Logo: http://www.newscom.com/cgi-...waste and consequently, the cost." The PAN I cytotoxicity kit allows the application of 4 commonly used cytotoxicity assays sequentially on a cellular sample. Such an ...
Cytotoxicity in Biological Products

Cytotoxicity Fluorometric (green / red) Assay Kit, LIVE/DEAD® from Molecular Probes (Invitrogen)

Description:... LIVE/DEAD® Cell-Mediated cytotoxicity Kit *for animal cells* *2000 assays*...
Company:Molecular Probes (Invitrogen)

Mynox Mycoplasma Elimination Reagent from Minerva Biolabs GmbH

Description:...asmas by killing them, and not just by inhibiting growth. Mynox is the only anti-mycoplasma agent that can be used to clean virus stocks directly. The cytotoxicity of Mynox is extremely low....
Company:Minerva Biolabs GmbH

MicroBeta Filtermat-96 Harvester from PerkinElmer

Description:...apid harvesting samples for applications such as cell proliferation, receptor binding, nucleic acid degradation, trichloroacetic acid preparations and cytotoxicity assays. FilterMate harvests 24 or 96 samples simultaneously, so it takes only minutes to harvest and wash samples from shallow- or deep-well micropla...
Company:PerkinElmer
Cytotoxicity in Biological Dictionary

Effector cell

...e described in Humoral Immunity. ... The T cell is triggered to release effector molecules into the close spaces ... Effector cell mediated cytotoxicity measured by intracellular Granzyme B release ... The effector cells are triggered when their antigen specific receptors and ... The number of...

Alkylating agents

...erm. What does alkylating agent mean in law? ... alkylating agent . All fours. all the estate I own. Allegata. Allegata ... Ethanol-enhanced cytotoxicity of alkylating agents . Couch DB, Baker RC. ... Alkylating Agents . Central Nervous System Depressants. Ethanol ... Polyfunctional alkylating...
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