Navigation Links
Cytotoxic in Medical News

Photos: Lumixyl(TM) Enters the Market to Improve the Appearance of Hyperpigmentation without Irritation and Side Effects

...ages: Non-toxic Non-irritating Water-soluble Safe for all skin types Produces no harmful by-products Has no cytotoxic effect Lumixyl products are made exclusively for dermatologists, plastic surgeons and skin oriented aesthetic physicians. The products ...

Bionovo Presents Positive Results from Phase 1B Trial of Bezielle for Metastatic Breast Cancer

...urther support that Bezielle is safe and well-tolerated, with early signs of clinical efficacy. Safety Analysis In comparison to other oral cytotoxic agents, Bezielle was extremely safe and well tolerated. No drug-related deaths or serious adverse events occurred during the study, and 94% of all dru...

Fox Chase finds all-biologic regimen efficacious and well-tolerated in elderly lung cancer patients

... a trial testing a combination of two molecularly targeted agents in patients 70 years or older. The team reasoned that a combination lacking standard cytotoxic agents may be better tolerated by these patients, potentially without comprising efficacy. "We looked for a regimen that had few side effects, would i...

Driven by Launch of Emerging Therapies, Overall Prostate Cancer Drug Market Will Increase by $2 Billion Through 2018

...emerging agents such as Avastin," said Decision Resources Analyst Andrew Merron, Ph.D. "The use of Taxotere to treat patients not previously receiving cytotoxic agents will increase over the next decade as oncologists are expected to take a more prominent role in the treatment of prostate cancer patients." ...

Centocor Ortho Biotech Statement on the FDA ODAC Opinion Regarding Trabectedin for Relapsed Ovarian Cancer

... evaluation. The final decision regarding approval of the drug will be made by the FDA. About Trabectedin Trabectedin is a novel cytotoxic antitumor agent that was originally derived from the marine tunicate, Ecteinascidia turbinata. The compound is now produced synthetically. Trabected...

New Compounding Pharmacy Videos Provide Product Information, Teach Safety

... Video informs and educates potential and existing users of barrier isolators on the following topics:   Introduction Risks Involving cytotoxic Drug Preparation USP Guidelines & Requirements Types of isolators How Isolators Work Safe Use of Pharmacy Isolators Cleaning & Disin...

4th ESU master class on medical treatment for urological cancer held in Barcelona, Spain

...on', module 2 'Immunotherapy and targeted therapies' and module 3 'Systemic cytotoxic chemotherapy and palliation'. Each module comprises short state-of-the-a... treatment, chemoprevention, immunotherapy, targeted therapies and systemic cytotoxic chemotherapy and palliation, supplemented with case discussions and present...

Access Pharmaceuticals Announces Initiation of Two New Cobalamin(TM) Oral Insulin Drug Delivery Collaborations

...echnology, as the demand for vitamin B12 increases in many disease states." The ability of the Cobalamin technology to increase the efficacy of a cytotoxic drug through enhanced delivery to tumor cells was demonstrated in a preclinical model. This work was presented by Access at a major scientific meeting...

Early treatment of systemic onset JIA with anakinra restores the IL-18 response

... function which compromises their immune systems, since NK cells (a type of cytotoxic lymphocyte, or white blood cell, that is capable of killing infected cells)...two patients flared following anakinra treatment. *NK cells are a type of cytotoxic lymphocyte that constitute a major component of the innate immune system. N...

CEL-SCI Expands Testing of Its Vaccine to Determine Efficacy Against More Virulent Strain of H1N1 Swine and Other Influenza Viruses

...rds the development of T-cell function with primarily effector T-cell functions (T Lymphocyte; helper/effector T lymphocyte, type 1 or 2 [Th1 or Th2], cytotoxic [Tc] or suppressor [Ts]). The L.E.A.P.S. vaccine constructs are chimeric peptides which combine antigen specificity with immune response modulation. ...
Cytotoxic in Medical Technology

Pharmatek's Highly-Potent and Cytotoxic (HP/C) Facility Positions It as Industry Leader in Development and Manufacturing of HP/C Compounds

Pharmatek Demonstrates Effectiveness Of New Highly-Potent And Cytotoxic (HP/C) Facility Through Airborne Particulate Testing. SAN DIEGO, May 5 /PRNewswire/ -- Pharmatek Laboratories, Inc. - a premier pharmaceutical chemistry development organization supporting the pharmaceutical industry - ha...

National Cancer Institute Research Identifies Unique Mechanism of Brostallicin's Anti-Tumor Effectiveness

...hetic second-generation DNA minor groove binder, has shown potent cancer killing activity, and has demonstrated synergism in combination with standard cytotoxic agents as well as with newer targeted therapies, in preclinical experimental tumor models. Brostallicin binds covalently to DNA within the DNA minor g...

CuraGen Updates CR011-vcMMAE Data at ASCO

....88 mg/kg administered intravenously once every three weeks. Eligible patients had progressive disease at trial entry and may have received one prior cytotoxic regimen and any number of prior immunotherapies. Of the patients enrolled, 94% had Stage IV disease of which two-thirds were classified as M1c, the po...

Video: Phase III Study Data With Vandetanib (Zactima(TM)) in Patients With Advanced Non-Small Cell Lung Cancer (NSCLC) Presented at American Society of Clinical Oncology

... (3) Natale, R. et al. Vandetanib versus erlotinib in patients with advanced non-small-cell lung cancer (NSCLC) after failure of at least 1 prior cytotoxic chemotherapy: a randomized, double-blind phase III trial (ZEST). ABS 31610. ASCO. 2009. (4) Ferlay, J. et al. GLOBOCAN 2002: Cancer Incidence, M...

Clinical Data on Semafore's SF1126, a Vascular Targeted Pan-PI3K/mTOR Inhibitor, to be Presented at the 2009 ASCO Meeting

... Presenter: Elena G. Chiorean, MD Location: Level 2 - West Hall C. Poster Session Track: #79 Developmental Therapeutics: cytotoxic Chemotherapy; Poster Board B19 (Abstract # 2558) About SF1126 SF1126 is the only clinical stage vascular targeted pan-PI3...

FDA Accepts Arno Therapeutics' IND for AR-12 a PDK1 Inhibitor That Blocks the PI3K/Akt Pathway

...demonstrated that AR-12 is active in a wide range of tumor types and it also shows promising activity in combination with several widely used approved cytotoxic as well as molecularly targeted anti-cancer agents," stated Dr. Roger G. Berlin, Chief Executive Officer of Arno. About AR-12 AR-12 is a pot...

Medarex Announces Preclinical Data from Multiple Research Programs Demonstrating Anti-Tumor Activity in Cancer

...l cell lung cancers (SCLC). In in vitro preclinical studies, a fully human, non-fucosylated anti-fucosyl-GM1 antibody, MDX-1110, demonstrated robust cytotoxic effector function (both antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity) for killing tumor cells. Additionally, MD...

First Candidate from Esperance's Targeted Anti-cancer Platform, EP-100, Establishes Preclinical Proof of Concept

...that EP-100 was fast-acting, destroying LHRH receptor over-expressing OVCAR-3 cells within an hour compared to the unconjugated CLIP 71 which was less cytotoxic and was slow-acting (p<0.005). LHRH receptor negative SKOV-3 cells were significantly less sensitive to EP-100 than OVCAR-3 cells and the effects o...

Genes Identified That Enhance Tumor Cell Sensitivity to CTI's Cancer Drug Brostallicin

...thetic second-generation DNA minor groove binder, has shown potent cancer killing activity and has demonstrated synergism in combination with standard cytotoxic agents as well as with newer targeted therapies in preclinical experimental tumor models. Brostallicin binds covalently to DNA within the DNA minor g...

DNA Therapeutics Closes 2.2 Million EUR Series A Financing Round

...timately, inhibit their repair during the treatment period. Thus siDNA increases the effectiveness of radiotherapy and chemotherapy without adding any cytotoxic effect. The company possesses a portfolio of exclusive worldwide licenses resulting from the pioneering work of its founding scientists at the Institu...
Cytotoxic in Medical Dictionary

Lymphocyte

... is a type of white blood cell and a type of lymphocyte . Also called cytotoxic T cell and cytotoxic T lymphocyte . kilogram. A measure of weight. ... ...

Hyposensitization

... treatments, and other medical and health issues. Variety of methods of testing for allergies ... Hyposensitization . Patch testing. RAST test. cytotoxic testing (ALCAT, Nutron etc. ... Pediatricians at Children ... Choose a Condition or Topic. Disorders, Diseases and ... It is also called desensiti...
Cytotoxic in Biological News

New drug shows promise in treating drug-resistant prostate cancer

...d to try to develop drugs that prevent that renewed resistance." For years, no treatment was available for CRPC; recently paclitaxel a strongly cytotoxic drug was approved. ...

TGen Clinical Research Services at Scottsdale Healthcare and Mayo Clinic study new cancer drug

...of the tumor occurs. After conversion to the active form of the drug, the more resistant hypoxic cells are exposed to high concentrations of released cytotoxic agent, which can also diffuse into the oxygenated regions of a tumor cell. The Phase 1/2 trials are investigating the safety and activity of TH-3...

A double-barreled immune cell approach for neuroblastoma

...sappeared from the body too quickly to have an anti-cancer effect. However, cytotoxic T cells that already have a natural receptor for the Epstein-Barr virus are..."In effect they trampoline off the virus and onto the tumor." Thus these cytotoxic T-lymphocytes remain in the body because they are constantly stimulated by ...

Viral recombination another way HIV fools the immune system

...velopment of more complex strains of HIV." Part of the immune system's response against HIV is carried out by HIV-specific CD8 T cells, also called cytotoxic T lymphocytes (CTLs), which can identify and kill virus-infected cells. Previous PARC/MGH research showed that the effectiveness of the CTL response ...

Mitochondrial cholesterol makes response to chemotherapy difficult in hepatic cancer

... the study, IIBB-CSIC-IDIBAPS researchers describe how the increase of cholesterol in the mitochondrial membrane plays a key role in the resistance to cytotoxic agents acting via mitochondrion, including doxorubicin, a common drug in chemotherapy. This research has been developed in the framework of the Centre...

American Chemical Society's Weekly PressPac -- June 25, 2008

...ects of polyphenols. The polyphenols work not only to prevent generation of cytotoxic compounds, but also as compounds which prevent the absorption of cytotoxic compounds from the gastrointestinal tract into the blood stream. MTS AR...

Research identifies first method for testing, assessing drug treatments for Chagas' disease

...ystem develops a stable, protective memory. This idea of memory is at the heart of the study, and it involves T-cells, specifically one kind called cytotoxic or killer T-cells, which are blood-borne white blood cells that destroy T. cruzi-infected cells in the case of Chagas disease and virally infected and...

Yale scientists create artificial 'cells' that boost the immune response to cancer

...s that lead to T-cell proliferation in the body. It also causes a fast and effective stimulation of the patients T-cells particularly T-cells of the cytotoxic type important for eradicating cancer. Safe and efficient T-cell stimulation and proliferation in response to specific antigens is a goal of immuno...

Cells get sprayed

...is suitable for a large variety of cell typesmammalian cell cultures and bacteria, as well as living tissue, as was demonstrated with bird embryos. No cytotoxic reagents that could damage the cells are needed; only pure water or a cell-tolerated saline solution are used. An entire plate of cell cultures can be...

Soft-cell approach cuts animal tests

...pioneered by Dr Amanda Hayes and her UNSW colleagues, Shahnaz Bakand and Chris Winder, directly exposes human cells to airborne toxicants and measures cytotoxic effects. The cells are grown on a porous polyester membrane inside a small diffusion chamber and then exposed to selected toxic air pollutants. After ...
Cytotoxic in Biological Technology

Pharmatek Announces Official Opening of New Highly-Potent & Cytotoxic Development and Manufacturing Facility

New Facility Enables Pharmatek to Serve Growing Highly-Potent and Cytotoxic Compound Market SAN DIEGO, Sept. 17 /PRNewswire-FirstCall/ -- Pharmatek -- a pharmaceutical chemistry development organization supporting the pharmaceutical industry -- today announced the open...

AEterna Zentaris to Further Develop Three Follow-up Multi-targeted Cytotoxic Candidates to AEZS-112 as Potential Novel Cancer Treatment

New In Vitro Data presented at AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in San Francisco QUEBEC CITY, Oct. 25 /PRNewswire-FirstCall/ - AEterna Zentaris Inc. (TSX: AEZ; Nasdaq: AEZS), a global biopharmaceutical company focused on endocrine therap...

Pharmatek Adds Cytotoxic and High-Potent Drug Development Capabilities to San Diego Laboratory

Pharmatek Now Offers Contract Cytotoxic & High-Potent Analytical, Formulation and Manufacturing Services SAN DIEGO, Aug. 16 /PRNewswire/ -- Pharmatek Laboratories, Inc. today announced the addition of cytotoxic and high-potent drug development capabilities to its pharmaceuti...

The Breast Cancer Therapeutics Market in Australia

...e adverse effects on normal cells when compared to cytotoxic chemotherapeutic drugs. New offerings must constit... for chemotherapy. "Due to higher cost compared to cytotoxic and hormonal therapies, the use of targeted therap...s of these highly specific therapies with existing cytotoxic and hormonal therapies will soon become the standa...

Sanofi-aventis Announces Second Quarter 2009 Results

...sed on the results of the AVADO study. First-half net sales of Taxotere((R)) were up 9.5% at euro 1,118 million. Eloxatin ((R)) , the leading cytotoxic agent in the colorectal cancer market as an adjuvant and as a first-line treatment in the metastatic phase, achieved second-quarter growth of 10.0% in...

New Report Just Published: World Prostate Cancer Therapeutics Market Report

... II-47 Chemotherapy II-47 Taxotere(R) (Docetaxel) II-48 Bone Complication Treatments II-48 Bisphosphonate Drugs II-48 Doxazosin, a cytotoxic Drug for Prostate Cancer II-49 Radiation Therapy II-49 Strategies to Enhance Recurrent Prostate Cancer Treatment II-49 Chemotherapy - New ...

CEL-SCI Files Patent Application to Support Company's Treatment for More Virulent Strain of H1N1 Swine and Other Influenza Viruses

...rds the development of T-cell function with primarily effector T-cell functions (T Lymphocyte; helper/effector T lymphocyte, type 1 or 2 [Th1 or Th2], cytotoxic [Tc] or suppressor [Ts]). The L.E.A.P.S. vaccine constructs are chimeric peptides which combine antigen specificity with immune response modulation. ...

Helix BioPharma to Present L-DOS47 Analytical Method Development Findings at 2009 AAPS National Biotechnology Conference

...vival. As well, the local production of ammonia at the site of cancerous tissues is thought to readily diffuse into the cancer cells to exert a potent cytotoxic effect by interfering with their critical metabolic functions. About Helix BioPharma Corp. Helix BioPharma Corp. is a biopharmaceutical co...

Phase II Trial Demonstrates Elacytarabine May Increase Survival Threefold in Patients With Late-Stage Leukaemia

...5%, p<0.0001) - Well tolerated - short-term mortality substantially lower (13 per cent vs. 25 per cent) Elacytarabine is a novel cytotoxic agent being developed by Clavis Pharma for the treatment of hematologic cancers and solid tumors, especially those resistant to existing agents. One p...

Calvert Research Licenses Novel Technology to Treat Age Related Macular Degeneration from Tulane University

...ess. The preclinical stage compounds licensed by Calvert T1 combine the known anti-proliferative effects of a somatostatin peptide analog with a cytotoxic drug chemically linked to the peptide, resulting in a dual mechanism drug candidate designed to specifically target and kill abnormal blood vessels fo...
Cytotoxic in Biological Definition

Antigen

...o secrete cytokines . The cytokines then activate cytotoxic lymphocytes T (CTL), antibodies secreting lymphoc...ex with class I histocompatibility molecules . If cytotoxic CD8 + T cells recognize them, they begin to sec...ptosis of the infected cell. In order to keep the cytotoxic cells from killing cells just for presenting norma...

Cytotoxic T cell

... A cytotoxic (or T C ) T cell is a T cell (a type of white blood cell ) which has on its surface antigen receptors that can bind to fragments of antigens ...

Immune system

...ces that are unique to every individual. T cells, a group that encompasses cytotoxic T lymphocytes ( CTLs ), the cells that kill virally-infected cells, contain...s they develop in the thymus ). There are two major types of T cells: cytotoxic T cells (T C cells) recognize infected cells by using T-cell receptors...

Major histocompatibility complex

...found in the cytosol, it is the primary way for a virus-infected cell to signal to T cells. It interacts exclusively with CD8+ T cells (also known as cytotoxic T cell lymphocytes or CTLs). The fate of a virus-infected cell is almost always apoptosis , or programmed cell death, initiated by the CD8+ T cell. ...

Proprioception

...nd pyridoxamine). Most of the impaired function discontinues shortly after the intake of vitamins returns to normal. Impairment can also be caused by cytotoxic factors such as chemotherapy . External links The Imperial Society of Teachers of Dancing A comprehensive Alexander Technique site ...

Stem cell

...e been used to treat cancer patients with conditions such as leukemia and lymphoma . During chemotherapy , most growing cells are killed by the cytotoxic agents. These agents not only kill the leukemia or neoplastic cells, but also the stem cells needed to replace the killed cells as a patient recover...

T cell

...final stage of development occurs. There are many types of T cells: cytotoxic T cells (CD8 + ) destroy infected cells. These cells function as 'killer' or cytotoxic cells because they are able to destroy target cells which express specific ...
Cytotoxic in Biological Dictionary

T lymphocytes

... How is a tumour destroyed by T lymphocytes ? ... CD8 T cells are cytotoxic and are often called cytotoxic T lymphocytes (CTLs) ... Lymphocytes . CD40L on T helpers (CD4+) FAS...

T cell

...lities of the immune system. These cells are unusual in that they have no cytotoxic or phagocytic activity;... T cells get their name from the organ k...on about T cell in the free online English dictionary and encyclopedia. cytotoxic t ... T cell - a small lymphocyte developed in the thymus; it ... ...

Lymphocytes

...gnize specific peptide antigens through the receptors on their lymphocytes . monocytes ... consist of lymphocytes and monocytes with ... cytotoxic T lymphocytes (CTLs) that kill virus-infected and, perhaps, tumor cells ... One cannot watch cells crawling, dividing, segregating their ...

Helper T cell

...em. These cells are unusual in that they have no cytotoxic or phagocytic activity;... Their major role is ...r T cells do not directly kill infected cells, as cytotoxic T cells do. Instead they help activate cytotoxic T cells and macrophages to attack infected cells...

Effector cell

...ptides that stimulate or ... Tutorial : Assay: cytotoxic Cell Effector Function Studies Genetic Enginee...ir antigen specific receptors and ... Effector cytotoxic T Lymphocytes (CTL) bind targets (infected cells ...granulation associated ... and ability to estimate cytotoxic effector cell frequency, the GrB ELISPOT assay...

Cytotoxic T cell

... A cytotoxic T cell belongs to a sub-group of T lymphocyte...ity toward the end of an ... T cells . αβ ( cytotoxic CD8+, Helper CD4+/Regulatory) · γδ. NK cells .... and ... The best understood CD8+ T cells are cytotoxic T lymphocytes (CTLs) ... Movie showing how...

Cell-mediated immunity

...he activation of macrophages, natural killer cells (NK), antigen-specific cytotoxic T-lymphocytes, and the release of various cytokines in response to an antig...ted immunity is particularly active against virus-infected cells, ... cytotoxic T cell mediated immunity . Cyotoxic T lymphocyte. Giant cells. Inclusi...

B lymphocytes

...e in ... B cells! CD8+ T cells. The best understood CD8+ T cells are cytotoxic T lymphocytes (CTLs) ... T lymphocytes (CTLs); Th2 helper cells for ... cells) ... B cells! CD8+ T cells. The best understood CD8+ T cells are cytotoxic T lymphocytes (CTLs) ... B lymphocytes . colostrum. cytokines. gran...
Other Tags
(Date:9/17/2014)... 17, 2014 The global metrology services ... due to the key driving factors of increasing demands ... CAGR of 8.2 % puts the metrology services market ... 2018, as stated in a Transparency Market Research report ... Share, Growth, Trends, and Forecast 2012 – 2018”. , ...
(Date:9/17/2014)... This news release is available in Spanish . ... overweight affect more than half of the population in ... organism, one of which affects liver function. Fat accumulates ... circumstances, causes inflammation, fibrosis and finally, cirrhosis. To date, ... been hepatic biopsy. Imaging techniques such as abdominal ecography ...
(Date:9/17/2014)... (GSA) invites all journalists to attend its ... interdisciplinary conference in the field of aging from ... may register free of charge. , An estimated 4,000 ... the Walter E. Washington Convention Center and Marriott Marquis ... From Cells to Societies" and the program schedule contains ...
(Date:9/17/2014)... September 17, 2014 Representatives with Capitol ... sponsor of Thursday’s Anti-Defamation League Event at the Four Seasons ... we consider it an honor to be a sponsor for ... Pain Institute. , Schocket went on to explain that the ... 600 community leaders and members at the Four Seasons to ...
(Date:9/17/2014)... Neon Sport and Fitmark have an ... industry’s most anticipated event, Joe Weider's Olympia Fitness & ... each take home a Neon Sport branded Fitmark Power ... gear. Fitmark will hold entries for the special prize ... , “There’s nothing more exciting than seeing our ...
Breaking Medicine News(10 mins):Health News:Metrology Services Market to Hit USD 720.3 Million by 2018: Transparency Market Research 2Health News:Metrology Services Market to Hit USD 720.3 Million by 2018: Transparency Market Research 3Health News:Magnetic resonance helps to detect and quantify fat in liver 2Health News:Join GSA in Washington, DC, for the Nation's Premier Aging Conference 2Health News:Capitol Pain Institute Sponsoring an Anti-Defamation League Event & Awards Dinner 2Health News:Electrifying Sports Nutrition Brand, Neon Sport, Pairs with Global Fitness Bag & Luggage Brand, Fitmark Bags, for an Exclusive Giveaway at Olympia Expo, This Weekend 2
(Date:9/17/2014)... MRSA and MSSA could be curbed by coating ... scaly surface of shark skin, according to research ... Resistance and Infection Control . , The study ... of human disease bacteria through touching, sneezes or ... of ridges formulated to resemble shark skin. The ...
(Date:9/16/2014)... the "molecular brakes" that time the generation of important ... "hair cells" translate sound waves into electrical signals that ... sounds. If the arrangement of the cells is disordered, ... research will be published in The Journal of ... and Hey2 act as brakes to prevent hair cell ...
(Date:9/16/2014)... The meteorite impact that spelled doom for the dinosaurs ... flowering plants to a much greater extent than their ... researchers. The results are published in the journal ... a treasure trove of thousands of fossilized leaves of ... team was able to reconstruct the ecology of a ...
Breaking Biology News(10 mins):Sharks' skin has teeth in the fight against hospital superbugs 2Hey1 and Hey2 ensure inner ear 'hair cells' are made at the right time, in the right place 2Meteorite that doomed dinosaurs remade forests 2Meteorite that doomed dinosaurs remade forests 3Meteorite that doomed dinosaurs remade forests 4
Other Contents