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Cytokines in Medical News

Drexel Research in Cytokines Could Treat Sepsis

Researchers from Drexel University and the University of Brighton in the U.K. have achieved groundbreaking results, which may significantly improve the treatment of sepsis. // Sepsis is an uncontrolled immune response to infection or severe trauma that results in 1,500 deaths worldwide ever...

Leptin and inflammatory cytokines in women with pre-eclampsia

Recent research shows that in women with pre-eclampsia, the level of maternal serum leptin is increased and correlates positively with the level of inflammatory cytokines, TNF-á//. The research was conducted at University Hospital of Puerto Real, Cadiz, Spain to compare maternal serum leptin co...

Avipaxin Is First Entrant in Medical Arsenal for Neuro-Endocrine-Immune Connection(C) Product and Testing Protocols

...s at NeuroScience, Inc. revealed a significant decrease in pro-inflammatory cytokines and chemokines after Avipaxin use. These studies also revealed a decrease i...n-regulate elevated pro-inflammatory cytokines. Decreasing pro-inflammatory cytokines leads to an indirect normalization of neurotransmitter levels, leading to a...

Protein level may serve as predictor of severe osteoarthritis

...CAM-1 promotes leukocyte adhesion and homing to sites of inflammation. In chondrocytes (cartilage cells), VCAM-1 expression is induced by inflammatory cytokines (proteins released by immune system ells). The authors suggest that increased VCAM-1 levels may therefore mirror active cartilage damage or an inflamm...

Bcl6 gene sculpts helper T cell to boost antibody production

...rts a nave T cell to a helper T cell that secretes cytokines which help the B cells expand and produce a large ...s colleagues reported in the journal Immunity that cytokines IL-6 and IL-21 drive the differentiation of Tfh cells. However, how these cytokines work had been unclear. In the current study, the t...

CU-Boulder study shows brain's immune system may cause chronic seizures

...e to the damaged area and release chemicals called cytokines that, unfortunately, also profoundly increase the ...ime that glial cells moving in and secreting these cytokines cause the neurons in the area to become excitable ...ked the activation of glial cells or the effect of cytokines on neurons, all signs of increased brain excitabil...
Cytokines in Medical Technology

Proteolix, Inc. Drug Candidate, PR-957, Prevents Disease Progression in Rheumatoid Arthritis Models by Selective Inhibition of the Immunoproteasome

...mmunoproteasome, known as LMP7. Inhibition of this subunit results in a decrease of the immune cell signaling cascade and a halt of the production of cytokines associated with autoimmune inflammation, without affecting proteasome function in non-immune cells. As a consequence, PR-957 induces an anti-inflamma...

Data Demonstrated ACTEMRA(R) (tocilizumab) Significantly Inhibited Progression of Structural Joint Damage in Rheumatoid Arthritis Patients

...eptor-inhibiting monoclonal antibody being studied for the treatment of RA. Studies demonstrate that reducing the activity of IL-6, one of several key cytokines involved in the inflammatory process, relieves both inflammation of the joints and certain systemic effects of RA. The extensive clinical development ...

CEL SCI Collaborators Demonstrate Novel L.E.A.P.S. Vaccines Immunize Mice Against Tuberculosis Antigens and Suggest Potential to Treat Swine and Other Influenzas

...ses. The production of too many pro-inflammatory cytokines is thought to be a cause of death in the case of H...e L.E.A.P.S. conjugates known to elicit protective cytokines such as IL-12, a precursor to producing gamma inte...therapy aimed at rheumatoid arthritis, since these cytokines cause much of the damage seen in rheumatoid arthri...

New Therapy Enlists Immune System to Boost Cure Rate in a Childhood Cancer

...nal antibodies are molecules customized to target particular cancers, while cytokines are naturally occurring signaling proteins that regulate the body's immune ...astoma," said Maris. Maris added that the supply of the antibodies and cytokines used in the trial was limited, and that pediatric oncologists were seeking ...

Two-Year Data Reinforce Effect of ACTEMRA(R) (tocilizumab) in Inhibiting Progression of Joint Damage and Improving Physical Function in Rheumatoid Arthritis Patients

...eptor-inhibiting monoclonal antibody being studied for the treatment of RA. Studies demonstrate that reducing the activity of IL-6, one of several key cytokines involved in the inflammatory process, relieves both inflammation of the joints and certain systemic effects of RA. The extensive clinical development ...

Results of Two Phase 3 CAPACITY Studies of Pirfenidone in IPF Presented at American Thoracic Society (ATS)

...IPF. About Pirfenidone Preclinical and in-vitro evidence had shown that pirfenidone inhibits collagen synthesis, down-regulates profibrotic cytokines and decreases fibroblast proliferation. Prior to the current results, data were presented from one Phase 3 study and four Phase 2 clinical trials in ...
Cytokines in Medical Products

EPO EIA Human Cytokines 021-SDX021 Erythropoietin Anemia

Description: EPO EIA Human Cytokines 021-SDX021 Erythropoietin Anemia...
Company:ALPCO Diagnostics

CRP, Ultra-Sensitive ELISA Test

Description:...by the liver and is normally present at very low levels. Following acute trauma or infection, CRP is rapidly synthesized by hepatocytes in response to cytokines released into circulation by activated leukocytes. This acute inflammation-dependent response can lead to a 1000-fold or greater increase in serum CRP...
Company:Diagnostic Systems Laboratories, Inc.
Cytokines in Medical Definition

Cachexia

... Mechanism The exact mechanism in which these diseases cause cachexia is poorly understood, but there is probably a role for inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) -which is also nicknamed cachexin for this reason-, Interferon gamma (IFNɣ), and Interleukin 6 (I...

Central tolerance

...• Cellular immune system Lymphatic system • Inflammation • Complement system ( Classical , Alternative , Lectin , Anaphylatoxins ) • cytokines • White blood cells • Antibody ( Monoclonal antibodies , Autoantibody ) • Antigen • APC • MHC Immunity • Autoimmunity • Toleran...
Cytokines in Medical Dictionary

Sepsis

...es, patient stories, videos, forums, prevention, and prognosis. : What's new in the literature regarding severe sepsis ? ... The pro-inflammatory cytokines TNF and IL-6 are important mediators in sepsis . ... Mortality Due to Severe Sepsis and Septic Shock. Recombinant Activated Protein C (rhAPC) ....

Haptoglobin

...is ... Correspondence from The New England Journal of Medicine -- Haptoglobin Phenotype and Vascular Complications in Patients with Diabetes cytokines & Cells Online Pathfinder Encyclopaedia ... Haptoglobin is one of the acute phase proteins produced during the acute phase reaction. ... ...

Gastrin

...ST gene (protein-coding), gastrin ... Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the ... cytokines & Cells Online Pathfinder Encyclopaedia ... Glycine-extended nonsulfated gastrin -17 corresponds to Progastrin-(55-72) ... Texas A&M Univ...

Factor XII

... 1 Blood -- Factor XII gene alteration in Hageman trait detected by TaqI restriction enz... 5 Factor XII deficiency and pregnancy. ... cytokines & Cells Online Pathfinder Encyclopaedia ... The human factor XII gene has been cloned by Cool and MacGillivray (1987) ... The specific ...
Cytokines in Biological News

Neuropathic pain: The sea provides a new hope of relief

...lammation activates supporting cells, such as microglia and astrocytes, that surround the nerve cells. These activated cells release compounds called cytokines that can excite nerves carrying pain sensation (nociceptive pathways) and cause the person to experience mildly uncomfortable stimuli as very painful ...

Stem cell research: From molecular physiology to therapeutic applications

...y for the damaged tissues in which they reside, but also for damaged tissues at other locations in the body via migration triggered by proinflammatory cytokines and growth factors. The potential use of MSCs in tissue regeneration has been shown in several models, including skin, muscle, lung, heart and the sma...

Discovery to aid in future treatments of third-world parasites

... secreted by immune cells. Due to their fundamental importance, cytokine research is a significant focus of research at the Trudeau Institute. Because cytokines travel through the body to relay critical information, it is difficult to identify the cells that produce them and to learn about their role. Trude...

UAB study reveals bone coupling factor key to skeletal health

...o balance bone resorption with formation, and hopefully we can help change that." Discovered many years ago, TGF beta-1 is one of the most abundant cytokines in bone. It has been identified in lung, liver, kidney and other organs that undergo remodeling as a natural part of the growth and aging process. Und...

Tummy troubles -- gastrin key in bacterial-induced stomach cancer

...plan to study "host factors other than gastrin [that] are also important for Helicobacter -associated gastric carcinogenesis. These include specific cytokines and chemokines induced by Helicobacter infection, and modulated by gastrin, that link inflammation and cancer. In addition, they plan to study the r...

Cancer-causing protein can also help fight the tumors it causes

... acquire normal Ras, nothing happens. But when they acquire mutated Ras from a potential tumor, it starts a cascade. This results in the production of cytokines that help the immune system and act against the cancer." Transferring potential into a drug Rechavi says that understanding the nature of this...
Cytokines in Biological Technology

HemoGenix(R), Inc Announces Implementation of ORF Genetics Human Growth Factors and Cytokines in All Human HALO(R) Assay Kits and Contract Research Services

COLORADO SPRINGS, Colo. and REYKJAVIK, Iceland, Dec. 3 /PRNewswire/ -- HemoGenix(R) and ORF Genetics announce the collaboration and implementation of biorisk-free, green-source growth factors and cytokines for use in all HALO(R) Assay Kits and HALO(R) Contract Research Services where the response ...

Simultaneous Detection of 8 Cytokines in Mouse or Human Sera

Aiguo Zhang, Allora Aguilera, Chate Luu, Ivan Huang, Diana Davis, Chloe Etienne, Yong Song, Reni Thomas, Kris Simonyi, Jim Wong, Quan Nguyen Bio-Rad Laboratories, Life Science Group, 2000 Alfred Nobel Drive, Hercules, CA 94547 ...

GeneGo Donates Proprietary Cytokine Pathway Maps to ISICR

...from ligand-receptor interaction through enzymes and scaffold proteins to transcription factors. The donated maps describe the role of interferons and cytokines in the immune response, development (via a variety of growth hormones), cell cycle, apoptosis, survival, cell adhesion and chemotaxis. In addition to ...

Cynvec to Present at The 2009 New York Venture Summit

...to begin Phase I clinical trials of CYN 101 in the third quarter of 2009. The sindbis vector has demonstrated in vivo efficacy delivering a variety of cytokines directly to tumor sites. Additionally, a screening program is underway to identify small molecules that bind to the laminin receptor, which is implic...

Cynvec to Present at the 11th Annual Shanghai International Forum on Biotechnology and Pharmaceutical Industry

...to begin Phase I clinical trials of CYN 101 in the third quarter of 2009. The sindbis vector has demonstrated in vivo efficacy delivering a variety of cytokines directly to tumor sites. Additionally, a screening program is underway to identify small molecules that bind to the laminin receptor, which is implic...

CEL-SCI Developing Immune-Based Treatment Against Swine and Other H1N1 Flu Viruses Using Proprietary L.E.A.P.S. Technology

...nce of dying because their immune response was too strong (too many pro-inflammatory cytokines). This is called a cytokine storm. While normally many cytokines play a key role in preventing and treating swine flu, in some cases excessive cytokine amounts may exacerbate the disease as it appears that, unlike t...
Cytokines in Biological Products

ChemiArray Mouse Lysate Cytokine Antibody Array III, 62 cytokines per membrane from CHEMICON

Description: Request Info...
Company:CHEMICON

ChemiArray Mouse Lysate Atherosclerosis Antibody Array I, 20 cytokines per membrane from CHEMICON

Description: Request Info...
Company:CHEMICON

Human Atherosclerosis Antibody Array I Kit, ChemiArray, 20 cytokines per membrane from CHEMICON

Description: ChemiArray Human Cytokine Antibody Array VII, 60 cytokines per membrane...
Company:CHEMICON

ChemiArray Mouse Lysate Angiogenesis Antibody Array I , 25 cytokines per membrane from CHEMICON

Description: Chemicons protein array systems, known as ChemiArrayTM Mouse Cytokine Antibody Arrays, are particularly useful compared with current methodologies. Besides the ability to detect protein expression, Chemicons systems present a more accurate reflection of active cytokine levels because they only dete...
Company:CHEMICON

eBioscience IC Fixation Buffer 125 ml from eBioscience

Description:...n with eBioscience Permeabilization Buffer (Cat. No. 00-8333), can be used to fix and permeabilize cells prior to performing intracellular staining of cytokines and other cytoplasmic and/or nuclear antigens. These solutions have been specially formulated for reducing non-specific staining by fluorochrome-label...
Company:eBioscience

Human Cytokine Antibody Array 1.1 (4) Kit, RayBio from Raybiotech, Inc.

Description:... RayBio Human Cytokine Antibody Array 1.1 (4 array membranes) with Accessory, detects 20 cytokines (for lysate) Class: Antibody Array Products Product Group: Antibody Array...
Company:Raybiotech, Inc.
Cytokines in Biological Definition

Anabolism

... Insulin Testosterone Estrogen Classic catabolic hormones include Cortisol Glucagon Adrenalin and other catecholamines cytokines Newer hormones associated with the balance of the catabolic and anabolic states include Orexin and Hypocretin (a hormone pair) Melatoni...

Antibody

...n blot method. A similar technique is used in ELISPOT and ELISA assays, in which detection antibodies are used to detect cell secretions such as cytokines or antibodies. Antibodies are also used to separate proteins (and anything bound to them) from the other molecules in a cell lysate. These purified...

Antigen

... Those that are specific for them, get activated, so they start to secrete cytokines . The cytokines then activate cytotoxic lymphocytes T (CTL), antibodies secreting lymphocy...

Anabolism

... Insulin Testosterone Estrogen Classic catabolic hormones include Cortisol Glucagon Adrenalin and other catecholamines cytokines Newer hormones associated with the balance of the catabolic and anabolic states include Orexin and Hypocretin (a hormone pair) Melatoni...

Diabetes mellitus

...n resistance that can develop into diabetes, most likely because adipose tissue is a (recently identified) source of chemical signals (hormones and cytokines ). Other research shows that type 2 diabetes causes obesity. 12 Type 2 is initially treated by changes in diet and through weight loss . This ...

Helper T cell

...ated T H cells and memory T H cells. Activated T H cells secrete cytokines , proteins or peptides that stimulate other lymphocytes ; the most com...ls, Th1 and Th2 cells. These subtypes are defined on the basis of specific cytokines produced. Th1 cells produce interferon-gamma and interleukin 12, while Th2...
Cytokines in Biological Dictionary

Schwann cells

...Meaning of Schwann cell medical term. What does Schwann cell mean? ... Schwann cells or embryonal nevoblasts; they are clustered in ... cytokines & Cells Online Pathfinder Encyclopaedia ... Schwann cells (or discrete subpopulations thereof) have been shown to express: ... SOX10: Req...

Rod cells

...d cell in the free online English dictionary and encyclopedia. ... rod cell . Also found in: Medical, Encyclopedia, Wikipedia, Hutchinson ... cytokines & Cells Online Pathfinder Encyclopaedia ... Rod cells possess a non-motile cilium that contains the light-sensitive pigment ... Rod ...

Recombinant

...g genetic material ... InSoc Recombinant , an album by synthpop band Information Society ... For resources and information on Antibodies and cytokines ... Recombinant protein. Human parasite. Parasite cleanse. Proteins. Online plants. Molecular biology ... When you enter three or more characte...

Lysozyme

...me ? Lysozyme is a protein found in many human secretions, such as tears, ... Lysozyme protects against bacterial infection by breaking ... cytokines & Cells Online Pathfinder Encyclopaedia ... For lysozyme -like proteins see: LLP. ... Since partially unfolded Lysozyme exerts broad spectrum...

Hepatocytes

...ct on FVIIa binding and internalization in hepatocytes . ... Rat hepatocytes were harvested by a two-step collagenase perfusion as described ... cytokines & Cells Online Pathfinder Encyclopaedia ... Hepatocytes perform critical metabolic, endocrine, and secretory ... The terms small hepatocytes (...

Helix-turn-helix

...HTH stand for? Definition of Helix - turn - helix in the list of acronyms and abbreviations provided by the Free Online Dictionary and Thesaurus. cytokines & Cells Online Pathfinder Encyclopaedia ... The helix - turn - helix motif is detected in many transcription regulators (Brennan ... The ...
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