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Cytogenetics in Medical News

Donor Stem-Cell Transplant Best For Acute Myeloid Leukemia

... Lymphoma Society, thinks this study will help doctors develop treatment plans. "If I find out I have acute myeloid leukemia, I want them to do my cytogenetics and tailor the therapy to fit me and my disease," Kamen said. "This article confirms that." More information For more information on acute my...

Gene Variant Raises Risk of Uterine Fibroids

...ations, to be valuable information for women making decisions about medical management of fibroids," senior study author Cynthia Morton, a director of cytogenetics at Brigham and Women's Hospital. "A woman with symptomatic fibroids might one day undergo diagnostic testing for the TC227 allele to determine whether...

Transgenomic Obtains Exclusive License to Mitochondrial DNA Damage Detection Technology

...ets in the fields of Pharmacogenomics and personalized medicine. Specific offerings include WAVE(R) DHPLC Systems, related consumables and assay kits, cytogenetics automated systems, and Transgenomic Pharmacogenomics and Reference Laboratory Services. Transgenomic Pharmacogenomics and Laboratory Services utilize ...

New Study Data: JANUVIA™ (sitagliptin) Significantly Reduced Blood Sugar Levels and Was Not Associated with Hypoglycemia in Elderly Patients with Type 2 Diabetes

... with or without metabolic activation in the Ames bacterial mutagenicity assay, a Chinese hamster ovary (CHO) chromosome aberration assay, an in vitro cytogenetics assay in CHO, an in vitro rat hepatocyte DNA alkaline elution assay, and an in vivo micronucleus assay. rat fertility studies with oral gavage ...

Two More Human Genomes Mapped

...ientists still need to figure out how the data they're gathering from the human genome translates into medical advances, said Charles Lee, director of cytogenetics at the Harvard Cancer Center. "We are at a stage where technology is outpacing our biological understanding," he said. "We have massive amounts of ...

Fudan-Cinpathogen Study Shows Chronic Lymphoid Neoplasms are More Common in Shanghai Than Thought

... disorders in China. The Center offers specialized clinical capabilities that meet Western standards in the fields of hematology, molecular pathology, cytogenetics and flow cytometry. For more information, visit http://www.cinpathogen.com [Cinpathogen's website] or contact our Boulder, Colorado ( 303-381-2...

U of Minn researchers discover genetic cancer link between humans and dogs

...borated on this research study. Their findings are published in the current issue of the journal Chromosome Research, a special edition on comparative cytogenetics and genomics research by scientists from around the world. Genomes are divided into chromosomes, which act as natures biological filing cabinets with...

Scoring system identifies MDS patients who have low-risk disease but a poor prognosis

...ound that a combination of older age, low platelet counts, anemia, a higher percentage of cancerous cells, or blasts, in the bone marrow and poor-risk cytogenetics (aberrant chromosomes) divided the 856 patients into three clearly defined groups: The 182 patients who had few of these characteristics (Category ...

China Medical Technologies Announces Changes in Board of Directors and Appointment of Chief Technology Officer

...otion to charities," Mr. Wu continued. Dr. Chen is the Medical Director of cytogenetics program at the Associated Regional and University Pathologists (ARUP) Labor...hology at the University of Utah. Before that, he served as the Director of cytogenetics laboratories at two leading biotechnology companies in the United States, n...

Clarient Names Michele Hibbard, Ph.D. Director of Genetics

...n biological sciences from UC Irvine. She earned a certificate from the American Board of Medical Genetics in Clinical Molecular Genetics and Clinical cytogenetics after training at Harvard Medical School. She is also a licensed Clinical Genetic Molecular Biologist and Clinical Cytogeneticist by the State of Cali...
Cytogenetics in Medical Technology

Transgenomic and Power3 Medical Complete Agreement for Exclusive License of Neurodegenerative Biomarker Test

...ts in the fields of Pharmacogenomics and personalized medicine. Specific offerings include WAVE(R) DHPLC Systems, related consumables and assay kits, cytogenetics automated systems, and Transgenomic Pharmacogenomics and Reference Laboratory Services. Transgenomic Pharmacogenomics and Laboratory Services utilize...

Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma

...tion demonstrated consistent efficacy in all patient sub-groups, including those with poor prognostic characteristics, such as advanced age, poor risk cytogenetics and renal impairment. These data were presented at the 50th Annual Meeting of the American Society of Hematology (ASH), held December 5-9, 2008 in San...

Dacogen(R) (decitabine for injection) Data Presented on a Phase II Clinical Trial in Elderly Patients with Acute Myeloid Leukemia (AML)

...eutrophil and platelet counts of more than 1,000/uL and 100,000/uL, respectively. The majority of patients in the trial had intermediate or poor risk cytogenetics (bone marrow tests to identify abnormal chromosomes), which are associated with poor prognoses. Responses were observed across all patients including...

Vion Pharmaceuticals Enters into Agreement to Conduct a Phase I/II Clinical Trial of Cloretazine(R) in Combination with Induction Therapy in Poor Prognosis AML Patients

...ntline AML therapy. This study will provide important information on the combination of Cloretazine and induction therapy in patients with unfavorable cytogenetics that need new treatment options." Dr. Norbert Vey, Head of the Leukemia Service of the Institut Paoli-Calmettes and Chief Investigator, said, "AML w...

Eisai Provides Preliminary Efficacy Update On EORTC Phase III Trial of Dacogen(R) Versus Supportive Care in Patients With Myelodysplastic Syndromes

...low 10 percent were required to have had poor-risk cytogenetics in order to be eligible for randomization. DACO-...ogenetic analysis, patients must have had abnormal cytogenetics at baseline and adequate cytogenetics data available for at least one post-baseline visi...

Vion Pharmaceuticals Announces Presentation of Data of Cloretazine(R) (VNP40101M) in Elderly Patients with High-Risk Myelodysplastic Syndromes at the EHA Annual Meeting

...with RAEB-t. Five patients were diagnosed with either chronic myelomonocytic leukemias (CMML) (3) or as unknown (2). Fifteen patients had intermediate cytogenetics and 11 had unfavorable cytogenetics. Sixteen of the patients were classified as Intermediate-2 risk by the International Prognostic Scoring System (IP...

Preliminary Analyses from Phase 2 Genzyme Study Highlight Efficacy and Safety of Clofarabine in Older Adult AML Patients

...induction chemotherapy and provides support for the importance of assessing cytogenetics prior to induction treatment." "The positive results seen in this study p...lder AML patients often have disease features such as unfavorable (adverse) cytogenetics and pre-existing blood disorders such as MDS that result in lower response ...

Vion Pharmaceuticals Announces Presentation of Interim Data from Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Acute Myelogenous Leukemia at the ASCO(R) Annual Meeting

...r older and have at least one of the following adverse prognostic factors: age greater or equal to 70, ECOG performance status equal to 2, unfavorable cytogenetics or organ dysfunction. The primary endpoint of the trial is the overall complete response rate measured as either complete remission (CR) or CRp, a com...

Transgenomic Establishes Collaboration With the National Cancer Institute to Investigate Mitochondrial Genome and Associated Nuclear Genes in Cancer Cell Lines

...ets in the fields of Pharmacogenomics and personalized medicine. Specific offerings include WAVE(R) DHPLC Systems, related consumables and assay kits, cytogenetics automated systems, and Transgenomic Pharmacogenomics and Reference Laboratory Services. Transgenomic Pharmacogenomics and Laboratory Services utilize ...

Genzyme Genetics Announces Launch of Carrier Testing and Prenatal Diagnosis for Spinal Muscular Atrophy

...u including cystic fibrosis testing with 97 mutations, fragile X testing and 11 carrier tests for the Ashkenazi Jewish population; an industry-leading cytogenetics program; an extensive maternal serum screening program (which includes first trimester, integrated and second trimester screening); and an innovative ...
Cytogenetics in Medical Definition

Pathology

...ransfusion medicine (A board-certifiable subspecialty in the U.S.) Medical microbiology (A board-certifiable subspecialty in the U.S.) Medical cytogenetics Immunology Molecular genetic pathology (A board-certifiable subspecialty in the U.S.) Dental pathology In the United States, subs...

Medicine

...rge role in evidence-based medicine . Many modern molecular tests such as flow cytometry, polymerase chain reaction (PCR), immunohistochemistry , cytogenetics , gene rearragements studies and fluorescent in situ hybridization (FISH) fall within the territory of pathology. Radiology is concerned w...
Cytogenetics in Medical Dictionary

Soft tissue

...cle, nerve, ... types of soft tissue tumors is important. ... Soft Tissue Sarcoma Key Terms: Alveolar rhabdomyosarcoma , Brachytherapy , cytogenetics , Dermatofibrosarcoma protuberans , Embryonal rhabdomyosarcoma Many soft tissue sarcomas are quite fleshy in appearance. ... The tumor is na...
Cytogenetics in Biological News

2009 Signature Genomic Laboratories Travel Award winner announced

...tories Travel Award at the American College of Medical Genetics (ACMG) 2009 Annual Clinical Genetics Meeting in Tampa, Florida. Dr. Chun is Director, cytogenetics and Molecular Genetics at the North York General Hospital in Toronto, Canada. Dr. Chun received her PhD from the University of Toronto in Biochemistr...

Microarray analysis improves prenatal diagnosis

... testing should be offered more widely to pregnant women." Cheung is professor of molecular and human genetics at BCM and director of the College's cytogenetics Laboratory. "The array enables you to detect smaller deletions or duplications of genetic material that would not be seen on a regular karyotype (a...

David H. Ledbetter, PhD, FACMG is the 2008-2009 Luminex/ACMGF Award recipient

...mory University School of Medicine in Atlanta. Along with his colleague Dr. Christa Martin of Emory, he is currently leading a consortium of academic cytogenetics laboratories to develop a uniform, evidence-based Molecular Karyotype and shared national database to rapidly accumulate data on pathogenic vs. benign...

Grant supports study of abnormal ring-shaped chromosomes

...in building a knowledge foundation for eventually guiding the way to future treatments for the disorder. Dr. Spinner, the director of the Clinical cytogenetics Laboratory at Childrens Hospital, previously discovered genes responsible for the genetic disease Alagille syndrome, which affects multiple organs. Ch...
Cytogenetics in Biological Technology

Webcast Alert: Transgenomic Inc. Announces Second Quarter 2009 Earnings Release Conference Call Webcast

...s in the fields of pharmacogenomics and personalized medicine. Specific offerings include WAVE((R)) DHPLC Systems, related consumables and assay kits, cytogenetics automated systems, Transgenomic Molecular Clinical Reference Laboratory and Pharmacogenomics Research Services. Transgenomic's two laboratory services...

Transgenomic, Inc. Announces Appointment of New Board Members

...ets in the fields of Pharmacogenomics and personalized medicine. Specific offerings include WAVE(R) DHPLC Systems, related consumables and assay kits, cytogenetics automated systems, and Transgenomic Pharmacogenomics and Reference Laboratory Services. Transgenomic Pharmacogenomics and Laboratory Services utilize ...

Transgenomic, Inc. Reports First Quarter 2009 Results

...ets in the fields of pharmacogenomics and personalized medicine. Specific offerings include WAVE(R) DHPLC Systems, related consumables and assay kits, cytogenetics automated systems, Transgenomic Molecular Clinical Reference Laboratory and Pharmacogenomics Research Services. Transgenomic's two laboratory services...

Reminder: Transgenomic Inc. Announces First Quarter 2009 Earnings Release Conference Call Webcast

...ets in the fields of pharmacogenomics and personalized medicine. Specific offerings include WAVE(R) DHPLC Systems, related consumables and assay kits, cytogenetics automated systems, Transgenomic Molecular Clinical Reference Laboratory and Pharmacogenomics Research Services. Transgenomic's two laboratory services...

Transgenomic and Power3 Medical Introduce NuroPro(R) Tests for Alzheimer's and Parkinson's Diseases at AAN Annual Meeting

...ets in the fields of Pharmacogenomics and personalized medicine. Specific offerings include WAVE(R) DHPLC Systems, related consumables and assay kits, cytogenetics automated systems, and Transgenomic Pharmacogenomics and Reference Laboratory Services. Transgenomic Pharmacogenomics and Laboratory Services utilize ...

Webcast Alert: Transgenomic Inc. Announces First Quarter 2009 Earnings Release Conference Call Webcast

...ets in the fields of pharmacogenomics and personalized medicine. Specific offerings include WAVE(R) DHPLC Systems, related consumables and assay kits, cytogenetics automated systems, Transgenomic Molecular Clinical Reference Laboratory and Pharmacogenomics Research Services. Transgenomic's two laboratory services...

Ambry Genetics Announces the Addition of Array CGH Services Through Partnership With Baylor College of Medicine

...nome-wide chromosomal imbalances with a single laboratory test consisting of multiple probes targeting virtually all disorders detected by traditional cytogenetics and fluorescent in situ hybridization (FISH). Array CGH is designed for patients with unexplained developmental delay, autism spectrum disorders, dysm...

Transgenomic Completes Licensing Option With Dana-Farber Cancer Institute on Cold-PCR for Enrichment of DNA Mutations

...ets in the fields of Pharmacogenomics and personalized medicine. Specific offerings include WAVE(R) DHPLC Systems, related consumables and assay kits, cytogenetics automated systems, and Transgenomic Pharmacogenomics and Reference Laboratory Services. Transgenomic Pharmacogenomics and Laboratory Services utilize ...

Polycystic Kidney Disease Assay at Cornell University Uses Transgenomic's Surveyor Nuclease & WAVE Technology

...ets in the fields of Pharmacogenomics and personalized medicine. Specific offerings include WAVE(R) DHPLC Systems, related consumables and assay kits, cytogenetics automated systems, and Transgenomic Pharmacogenomics and Reference Laboratory Services. Transgenomic Pharmacogenomics and Laboratory Services utilize ...

Transgenomic, Inc. Reports Fourth Quarter and Fiscal Year 2008 Results

...ets in the fields of pharmacogenomics and personalized medicine. Specific offerings include WAVE(R) DHPLC Systems, related consumables and assay kits, cytogenetics automated systems, Transgenomic Molecular Clinical Reference Laboratory and Pharmacogenomics Research Services. Transgenomic's two laboratory services...
Cytogenetics in Biological Products

LNA-ISH Cytogenetics - Human centromere alpha satelliteISH probes from Exiqon

Description: Exiqons LNA technology enables sensitive, fast and specific detection of chromosomal sequences directly on intact chromosomes. Short hybridisation time ( Works on fixed cells and chromosome spreads Multiplex capability Available with different tags Pre-validated probes Probes available w...
Company:Exiqon
Cytogenetics in Biological Definition

Cancer

... diagnosis indicates the type of cell that is proliferating, its severity (degree of dysplasia ), its extent and size, and - sometimes with help from cytogenetics and immunohistochemistry - prognostic and therapeutic determinants. Biopsy can be curative if the whole lesion is removed; in this case, the bord...

Molecular genetics

...DNAs imprinting bacterial and phage molecular genetics eukaryotic molecular genetics external links Atlas of Genetics and cytogenetics in Oncology and Haematology [1] ...
Cytogenetics in Biological Dictionary

Cytogenetics

Cytogenetics is a branch of genetics that is concerned with the study of the structure and function of the cell, especially the chromosomes . It includes routine analysis of G-Banded chromosomes, other cytogenetic banding... cytogenetics n. (used with a sing. verb) The branch of biology...

Karyotype

...n a sample of body cells. ... Karyotype is done to: ... Click here to view a drawing (from Bioweb) of a karyotype of Down's syndrome. ... Human cytogenetics The human karyotype and ideograms of each chromosome. ... A karyotype analysis usually involves blocking cells in mitosis and staining th...

Heterokaryon

... seem to be restricted ... IPR010730 Heterokaryon incompatibility 26 - 144 ... ... Biological Sciences > biology > cell biology > cytogenetics > heterokaryon ... Resources in heterokaryon : No resources available for this category. ... Nonself recognition and rejection of heterokar...

G-banding

...R stands for "reverse" ... G - banding is technique used in cytogenetics to produce a visible karyotype by staining condensed chromosomes. The m...e technique of demonstrating g bands. ... G-banding is technique used in cytogenetics to produce a visible karyotype by ... A simple technique for obtainin...

Chromosomes

...sponsible for heredity. Almost every cell in the human body has 46 chromosomes . ... All chromosomes can be easily sorted into 23 pairs. ... cytogenetics is the study of chromosomes and their role in heredity. ... Most of our genes are carried on nuclear chromosomes . ... Chromosome , microscopic...

Allopolyploidy

...nt ... By definition, these chromosomes are not essential for the life of a species, ... ... Sciences > biology > cell biology > cytogenetics > polyploidy > allopolyploidy ... Resources in allopolyploidy : No resources available for this category. ... These cereals resulted from...
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