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Cytochrome in Medical News

FDA Approves LIVALO(R) for Primary Hypercholesterolemia and Combined Dyslipidemia

...in cholesterol (LDL-C) clearance and reduction of plasma cholesterol. Importantly, pitavastatin is only minimally metabolized by the liver through the cytochrome P450 pathway, through which many other medications are metabolized. In pivotal Phase III trials, LIVALO effectively reduced LDL-C and improved...

Daiichi Sankyo and Lilly Receive U.S. FDA Approval for Effient(TM)

... several early phase pharmacokinetic studies, showed that the active form of prasugrel does not appear to be affected by genetic variations in common cytochrome P450 (CYP) enzymes, including CYP2C19. Because both Effient and Plavix are "prodrugs", they require CYP450 enzymes to convert them to their active dr...

Portola Pharmaceuticals to Host Conference Call at 11:00 a.m. Eastern Time Tomorrow to Discuss Betrixaban Partnership and Provide Corporate Update

...o become the only novel oral anticoagulant available for patients with severe renal disease. In addition, betrixaban is not extensively metabolized by cytochrome P450, which may result in reduced potential for drug-drug interactions. Portola is currently conducting EXPLORE-Xa, a Phase II dose-ranging clini...

TGen and USC researchers find genetic markers to help fight diabetes

... identified five critical markers that may predict response to TZD mono-therapy. These markers include variants in a key drug metabolizing gene called cytochrome P450 3A4 and a PPARG-coactivator known as PPARGC1B. Other markers were located in genes associated with PPARG function and include the protein kinase ...

Research points to a new way to protect kidneys threatened by insufficient blood or toxins

...p. Next, two proteins, Bak and Bax, typically found at divergent places in the cell, work together to make pores in the mitochondrial outer membrane. cytochrome c, a protein that normally helps mitchondrion breathe and produce fuel, escapes through the pores. Out of place, it becomes a deadly accomplice that a...

Data on VELCADE(R) (Bortezomib) for Injection Based Therapies to be Presented at the International Myeloma Workshop

...ications and with serious underlying medical conditions. Patients who are concomitantly receiving VELCADE and drugs that are inhibitors or inducers of cytochrome P450 3A4 should be closely monitored for either toxicities or reduced efficacy. Patients on oral antidiabetic medication while receiving VELCADE shoul...
Cytochrome in Medical Technology

ALP Life Sciences, LLC Announces Nanoveson(TM) Patent Filing and Whitepaper Availability on Proposed Therapy for Non-Alcoholic Fatty Liver Disease (NAFLD) and Comorbid Diseases

...t maintains quantitative whole body homeostasis of arachidonic acid. There is extensive research focused on blocking arachidonic acid metabolism along cytochrome P450, leukotriene, prostaglandin, and thromboxane eicosanoid pathways. Arachidonic acid metabolism is implicated in many inflammatory diseases, includ...

TriLink BioTechnologies, Inc. Announces Supply Agreement With Osmetech Molecular Diagnostics

...ic Fibrosis Carrier Detection and Warfarin Sensitivity testing, respectively. The eSensor(R) XT-8 system is designed to support a broad test menu. A cytochrome P450 2C9 genotyping test (RUO) is now available while planned menu expansion includes an extended warfarin panel with the proprietary 4F2 marker, a ve...

New Analysis Evaluated Impact of Genetic Variation on Response to Prasugrel

... Prasugrel is a "prodrug" that requires the use of cytochrome P450 (CYP) enzymes to convert the drug into the ac...he substudy, researchers examined how variation in cytochrome P450 (CYP) genes affected the response to prasugre...er J, Antman E, Macias B, Braunwald E, Sabatine M, cytochrome P450 Genetic Polymorphisms and the Response to Pra...

Sequoia Pharmaceuticals Presents Proof of Clinical Concept of SPI-452, a Novel Pharmacokinetic Enhancer

...tic enhancer (PKE) with no inherent antiviral activity. Pharmacokinetic enhancers increase drug levels of co-administered agents through inhibition of cytochrome P450 (CYP)-mediated drug metabolism. These increased drug levels can lead to improved efficacy, reduced pill burden, and reduced daily dosing. Because...

Genomas Clinical Study Finds Increased Prevalence of Drug Metabolism Deficiencies in Patients With Serious Psychotropic Side Effects

...dy was conducted at The Institute of Living of Hartford Hospital in collaboration with Genomas. The CYP2C9, CYP2C19 and CYP2D6 genes from the cytochrome P450 family were chosen for DNA typing because their common variants result in deficient metabolic capacity for many psychotropic drugs. Combinatorial...

Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma

...ications and with serious underlying medical conditions. Patients who are concomitantly receiving VELCADE and drugs that are inhibitors or inducers of cytochrome P450 3A4 should be closely monitored for either toxicities or reduced efficacy. Patients on oral antidiabetic medication while receiving VELCADE shoul...
Cytochrome in Medical Products

Concise Guide to Drug Interaction Principles for Medical Practice

Description:...abolism, updates of existing chapters and tables, new graphics, and extensive Web site references. Brand-new chapters discuss P-glycoproteins, "minor" cytochrome P450 enzymes, pain management with narcotic and nonnarcotic analgesics, prescribing guidelines, and medicolegal issues....
Company:Skyscape, Inc.

Physician's Drug Handbook, 10th Ed

Features:...x on herbal medicines Other appendices include guidelines for use of selected antimicrobials, selected analgesic combination products, topical drugs, cytochrome P-450 enzymes and common drug interactions, therapeutic drug monitoring, dialyzable drugs, and phone numbers and Web addresses for pharmaceutical comp...
Company:Skyscape, Inc.

Nursing2006 Drug Handbook

Features:...ver 20 recently approved drugs and new indications New appendices include chemotherapy acronyms and protocols and a table of common interactions with cytochrome P-450 enzymes Color Photoguide Index help you identify drugs visually - NEW ...
Company:Skyscape, Inc.
Cytochrome in Biological News

Study finds DNA barcoding requires caution without closer examination

...in plants, there is still much debate over which gene sequence region should be used and its reliability. In animals, the 5' segment of mitochondrial cytochrome oxidase subunit I (COI) is relatively established as a barcoding marker, but Spooner highlights many groups where COI fails to distinguish species. T...

How mitochondria get their membranes bent

...ion') allows separation of the intracristal space and storage of molecules. cytochrome c, for example, an important signaling protein in programmed cell death (ap...red in this compartment. When apoptosis is triggered, the pores enlarge and cytochrome c is released into the cytosol. Thus, understanding of how the pore diamete...

Caffeic acid inhibits colitis in a mouse model -- is a drug-metabolizing gene crucial?

... at Iowa State University have found that increased expression of a form of cytochrome P-450 (CYP4B1) is a key marker of inhibition of colitis in mice by caffeic ...9 issue of Experimental Biology and Medicine , implicate CYP4B1, a form of cytochrome P450 previously found to be associated with resolution of allergic inflamma...

Caltech and UCSD researchers shed light on how proteins find their shapes

...the Journal of the American Chemical Society --with Wolynes's protein-folding models to see if they could come up with the precise folding pattern of cytochrome c, a protein that is part of the mitochondrial electron-transfer chain that turns food into cellular energy. At first the models and the experimen...

Genetic testing not cost-effective in guiding initial dosing of common blood thinner

...cogenetic-guided dosing is to help guide the initial, and possibly lower, dose of warfarin for patients found to possess certain variants of the genes cytochrome P450 CYP2C9 and vitamin K epoxide reductase, or VKORC1. The hope is that more accurate dosing will translate into decreased major bleeds during the in...

NIH grants Phylonix Phase II SBIR to develop high-throughput in vivo zebrafish assays

...lth (NIH) to develop in vivo zebrafish assays for assessing drug effects on cytochrome (CYP) P450s. CYP profiling, a critical step in drug development, is requir...ministration (FDA) for all new drug approvals. "This grant, 'Zebrafish cytochrome P450 Assays for Assessing Drug Metabolism and Drug Safety,' will support th...
Cytochrome in Biological Technology

Genomas and Institute of Living Among Organizers of Pharmacogenetics Symposium at 2009 Annual Meeting of the American Psychiatric Association

...sm Deficiencies Gualberto Ruano, M.D., Ph.D., and John W. Goethe, M.D. Genomas Inc. and Institute of Living/Hartford Hospital, Hartford, CT cytochrome P-450 2D6, 2C19, and Serotonin Transporter Genotyping for Depressed Inpatients at the Mayo Clinic Mood Disorders Unit Simon Kung, M.D. Mayo Clini...

XenoTech LLC Offers Drug Industry New Metabolite Profiling Services Following Acquisition of Waters Synapt HDMS System

...Organization (CRO) serving clients with unparalleled experience and expertise in evaluating drug candidates as substrates, inhibitors and inducers of cytochrome P450 enzymes. The company offers a variety of in vitro contract studies for drug candidate evaluation, as well as an extensive selection of product...

Celsis In Vitro Technologies and Promega to Offer Fast, Reliable Solutions for ADME-Tox Testing With Primary Hepatocytes

...s of its extensive cryopreserved hepatocytes for use with Promega's bioluminescent ADME-Tox assays, including the P450-Glo(TM) CYP Assay used to study cytochrome P450 gene induction and inhibition and the GSH-Glo(TM) Glutathione Assay for investigating mechanisms of hepatotoxicity. "Researchers are looki...

Mosquito genes linked to insecticide resistance may be new target in fight against malaria

...s of a family of genes coding for enzymes known as cytochrome P450s. The P450s are common to all classes of or...nse against toxins. The researchers found two cytochrome P450 genes in An. funestus that are associated w...finding remarkable is that this particular type of cytochrome P450s were also recently implicated in pyrethroid ...

Indevus Pharmaceuticals Announces Fiscal 2008 Year End and Fourth Quarter Results

...nstrumental in the low incidence of CNS side-effects. At therapeutic concentrations in vitro, SANCTURA does not interact with drugs metabolized by the cytochrome P-450 system, a metabolic pathway commonly associated with drug-drug interactions, and the majority of the absorbed dose is excreted largely unchanged...

Portola Pharmaceuticals Initiates Phase II Trial of Betrixaban, its Novel Oral Factor Xa Inhibitor for Stroke Prevention in Atrial Fibrillation

...e the only novel oral anticoagulant available for patients with severe renal disease. And because betrixaban is neither an inhibitor nor an inducer of cytochrome P450 enzymes, it minimizes the risk of drug-drug interactions often seen with other Factor Xa inhibitors in development and with warfarin. Portola h...
Cytochrome in Biological Products

SelectFX Alexa Fluor 488 Cytochrome c Apoptosis Detection Kit - for fixed cells from Molecular Probes (Invitrogen)

Description: The SelectFX Alexa Fluor 488 Cytochrome c Apoptosis Detection Kit provides all the reagents you need to detect cytochrome c in fixed cells. The kit employs an anti-cytochrome c primary antibody and an Alexa Fluor 488 dye-labeled secondary antibody. Alexa Fluor 488 dye exhibits bright green fluores...
Company:Molecular Probes (Invitrogen)

Rabbit Anti-Human Cytochrome P450 1A1 / 1A2 Polyclonal Antibody, Unconjugated from AbD Serotec

Description: RABBIT ANTI HUMAN CYTOCHROME P450 1A1/2 Immunogen: Purified human CYP1A2 expressed in E.Coli ...
Company:AbD Serotec

ProteoMass Cytochrome c MALDI-MS Standard from Sigma-Aldrich

Description: Mol wt: average mol wt12,360.96 Da by calculation...
Company:Sigma-Aldrich

Mouse Anti-Human Complex IV, assembly factor SURF1 Monoclonal Antibody, Unconjugated, Clone 21H2BG4 from MitoScience LLC

Description:...d cells. SURF1 is an important assembly factor for cytochrome c oxidase which is thought to participate in the f...sence of the polypeptide, are the leading cause of cytochrome c oxidase deficiency. The anti-SURF1 mAb reacts sp...ng to catalyze Complex IV assembly. In cells where cytochrome c oxidase assembly is incomplete because of mutati...
Company:MitoScience LLC

Mouse Anti-Cytochrome P450 2B1 / 2B2 Monoclonal Antibody, Unconjugated, Clone b/e4 (9.20) from Abcam

Description:... Mouse monoclonal [b/e4 (9.20)] to cytochrome P450 2B1 + 2B2 ( Abpromise for all tested applications)....
Company:Abcam

Smac/DIABLO, Human, Recombinant, E. coli from Calbiochem

Description:...uman Smac/DIABLO with a carboxy terminal His•Tag ® sequence was expressed in and purified from E. coli . Smac/DIABLO is released along with cytochrome c during apoptosis and promotes caspase activation through the neutralization of IAPs, including XIAP (Cat. No. PF137). Biological activity: IC 50 ...
Company:Calbiochem

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Cytochrome in Biological Definition

Apoptosis

...sults in the release of caspase activators, namely cytochrome c [11] , [12] ., but other molecules like SMAC or AIF are also released. Once the cytochrome c is released, it binds with Apaf-1 and ATP whic..., and suppress the activity of apoptotic activator cytochrome c (see previous section on biochemical execution)....

ATP synthase

...the protonmotive force is generated not by respiratory electron transport chain, but by primary photosynthetic proteins - photosystems I and II and cytochrome b 6 f . E. coli ATP synthase E. coli ATP synthase is the simplest known form of ATP synthase, with 8 different subunit types. Yeast ATP ...

Chemiosmotic hypothesis

...itchell was awarded the Nobel Prize in Chemistry . see also: mitochondrion , chloroplasts , chemiosmotic potential , electron transfer chain , cytochrome References: http://www.life.uiuc.edu/crofts/bioph354/mitchell.html http://www.owlnet.rice.edu/~bios301/Bios301/lecture/Lec11-Chemios-photo.p...

Electron transfer chain

...nzyme Q reductase . Complex III - Coenzyme Q - cytochrome c reductase . Complex IV - cytochrome c oxidase . Complex V - ATP synthase , also kn... by NADH and/or FADH2 ) to make water . cytochrome c ...

Enzyme

...ndance of oxygen without the action of the enzyme, cytochrome oxidase. Enzymes are also necessary for muscle con...ymotrypsin : can digest proteins Coenzyme Q - cytochrome c reductase : participates in the electron transfer chain by reducing cytochrome c and pumping protons across the membrane ...

Metabolism

...m Drug metabolism pathways, the modification or degradation of drugs and other xenobiotic compounds through specialized enzyme systems: cytochrome P450 oxidase system Flavin-containing monooxygenase system Alcohol metabolism Nitrogen metabolism Nitrogen metabolism includes ...
Cytochrome in Biological Dictionary

Pseudogene

...ene Suite provides an opportunity for ... Numt census ... and a corresponding nuclear pseudogene . Proc. R. Soc. ... A Translocated Mitochondrial cytochrome b Pseudogene in Voles (Rodentia: Microtus) ... New evidence from molecular geneticists joins with the immense body of clues from other discipline...

Polymorphisms

...morphisms to predict cyclosporine and ... The Environmental Genome Project: Functional Analysis of Polymorphisms , analysis of function in genes, cytochrome P450, Environmental Genome Project, enzymes ... Single nucleotide polymorphisms are minor alterations in the genetic code, but they can resul...

Peripheral protein

...R003936 Peripheral myelin protein PMP22 44 - 56 ... Peripheral membrane proteins ... An example of peripheral membrane protein is the cytochrome C in the electron transport chain. ... Coordinates of all examined peripheral proteins and peptides with the calculated ... Peripheral pro...

NADPH

...etic pathways, the increasing ... The pathway also produces some NADPH . ... Information on EC 1.6.2.4 - NADPH -hemoprotein reductase ... NADPH cytochrome P450 reductase. Homo sapiens. 672881, 672891, 673808 ... Information on EC 1.1.1.34 - hydroxymethylglutaryl-CoA reductase ( NADPH ) ... (R)-mevalon...

Molecular phylogeny

...ry Olsen, University of Illinois ... Molecular ... molecular clock'. cytochrome c is an essential part of cellular respiration ... Since the " molecular clock" for cytochrome oxidase II is not ... Molecular phylogeny summary with 12 pages of e...

Mitochondrial membrane

...mbrane . fusion ... Mitochondrial Membrane Permeability Transition Detection Kits for Apoptosis MitoPT ... MITOCHONDRIAL MEMBRANE POTENTIAL cytochrome C RELEASE APOPTOSIS DETECTION KITS ... Human protein-coding gene TOMM40. Represented by 552 ESTs from 178 cDNA libraries. ... Homo sapiens mitoc...
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