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Cytidine in Medical News

Pharmasset Presents R7128 14-Day Monotherapy Study Results for the Treatment of Chronic Hepatitis C

...seases, R7128 demonstrated potent antiviral activity and was generally safe and well-tolerated. R7128 is an orally administered prodrug of PSI-6130, a cytidine nucleoside analogue polymerase inhibitor of hepatitis C virus (HCV) that is being developed through Pharmasset's collaboration with Roche. "R7128 has...

Scientists Develop Method to Track Immune System Enzyme in Live Animals

...toimmunity and B cell tumor development. Their report appears in the Journal of Experimental Medicine. The enzyme, known as activation-induced cytidine deaminase or AID (which has no relation to the AIDS virus), is expressed by B cells, which are produced in the bone marrow and are responsible for mak...
Cytidine in Medical Technology

Ground-Breaking Combination of All-Oral Agents Demonstrates Potential as Hepatitis C Treatment Regimen

...days as monotherapy and when combined with PEGASYS and COPEGUS. R7227 was safe and well-tolerated in these studies. About R7128 R7128, a cytidine nucleoside analog inhibitor of HCV RNA polymerase, is being developed for the treatment of chronic HCV infection. R7128 has shown potent in vivo activ...

Roche and Pharmasset Initiate Phase IIb Clinical Trial of R7128, Most Advanced Nucleoside Polymerase Inhibitor in Development for Chronic Hepatitis C

...rms. The remaining 300 will be enrolled following a review of the 12-week data by the data safety monitoring board. More About R7128 R7128, a cytidine nucleoside analog inhibitor, is being developed for the treatment of chronic HCV infection. R7128 has shown in vitro activity against all of the mos...

Roche, InterMune and Pharmasset Announce Initiation of INFORM-1, the First Dual-Combination Clinical Trial with Oral Antivirals in Hepatitis C

... that are currently not on treatment." About R7128 R7128, being developed for the treatment of chronic HCV infection, is a pro-drug of PSI-6130, a cytidine nucleoside analog inhibitor of HCV RNA polymerase. A pro-drug is a chemically modified form of a molecule designed to enhance the absorption, distribu...

Pharmasset Reports Preliminary Results of a 4-week Combination Study of R7128 for the Treatment of Chronic Hepatitis C

...ll be reported at a later date. About R7128 R7128 is being developed for the treatment of chronic HCV infection. R7128 is a prodrug of PSI-6130, a cytidine nucleoside analog inhibitor of HCV RNA polymerase. A prodrug is a chemically modified form of a molecule designed to enhance the absorption, distribut...

Pharmasset Receives Notice of Allowance

... significant commercial value." About R7128 R7128 is being developed for the treatment of chronic HCV infection. R7128 is a prodrug of PSI-6130, a cytidine nucleoside analog inhibitor of HCV RNA polymerase. A prodrug is a chemically modified form of a molecule designed to enhance the absorption, distribut...

Pharmasset Commences Dosing R7128 Cohorts 3 and 4 for the Treatment of Chronic Hepatitis C

...asset.com for more information. About R7128 R7128 is being developed for the treatment of chronic HCV infection. R7128 is a prodrug of PSI-6130, a cytidine nucleoside analog inhibitor of HCV RNA polymerase. A prodrug is a chemically modified form of a molecule designed to enhance the absorption, distribut...

Pharmasset Presents Results of 4-Week Combination Study of R7128 for the Treatment of Chronic Hepatitis C

... following the conference call. About R7128 R7128 is being developed for the treatment of chronic HCV infection. R7128 is a prodrug of PSI-6130, a cytidine nucleoside analog inhibitor of HCV RNA polymerase. A prodrug is a chemically modified form of a molecule designed to enhance the absorption, distribut...

Romark Announces Presentation of New Data for Nitazoxanide in Chronic Hepatitis C at EASL 2008

...etabolite, tizoxanide, does not induce viral mutations conferring resistance to nitazoxanide, tizoxanide, interferon, ribavirin or 2'C- methyl cytidine (a polymerase inhibitor). The presentation, titled, "Studies of the Potential for Resistance to Nitazoxanide or Tizoxanide in HCV-Containing ...

Pharmasset Announces R7128 Achieves 85% Rapid Virologic Response in a 4-week Combination Study for the Treatment of Chronic Hepatitis C

... following the conference call. About R7128 R7128 is being developed for the treatment of chronic HCV infection. R7128 is a prodrug of PSI-6130, a cytidine nucleoside analog inhibitor of HCV RNA polymerase. A prodrug is a chemically modified form of a molecule designed to enhance the absorption, distribut...

Pharmasset Announces Clevudine and R7128 Presentations at HEP-DART

...vity of the Nucleoside HCV Inhibitor, R7128, in Prior IFN Non-Responders. JG McHutchison, et al. Abstract Summary: R7128 is a prodrug of PSI-6130, a cytidine nucleoside analog polymerase inhibitor, for treatment of HCV. A 14-day monotherapy study demonstrated that R7128, a direct antiviral, can deliver suff...
Cytidine in Biological News

USC team reveals structure of APOBEC family protein

...der hyper-IgM immunodeficiency syndrome type 2, or HIGM-2. The syndrome is characterized by mutations in the gene encoding AID, the activation-induced cytidine deaminase protein, and a weakened immune system. USC biochemist Myron Goodman and his former graduate student Ronda Bransteitter collaborated wit...
Cytidine in Biological Technology

Pharmasset and Roche Obtain FDA Consent to Start a Phase 2b Study With R7128 in Treatment Naive HCV Patients

...the progress of the trial. About R7128 R7128 is being developed for the treatment of chronic HCV infection. R7128 is a prodrug of PSI-6130, a cytidine nucleoside analog inhibitor of HCV RNA polymerase. A prodrug is a chemically modified form of a molecule designed to enhance the absorption, distribut...

Pharmasset Reports Preliminary Results of a 4-week Proof-of-Concept Combination Study of R7128 for the Treatment of Chronic Hepatitis C in Genotype 2 or 3 Non-Responders

... an additional 20 weeks of SOC. About R7128 R7128 is being developed for the treatment of chronic HCV infection. R7128 is a prodrug of PSI-6130, a cytidine nucleoside analog inhibitor of HCV RNA polymerase. A prodrug is a chemically modified form of a molecule designed to enhance the absorption, distribut...

Pharmasset Adds Two Cohorts to R7128 Hepatitis C Study

... following the conference call. About R7128 R7128 is being developed for the treatment of chronic HCV infection. R7128 is a prodrug of PSI-6130, a cytidine nucleoside analog inhibitor of HCV RNA polymerase. A prodrug is a chemically modified form of a molecule designed to enhance the absorption, distribut...

Pharmasset and Roche to Present R7128 Data at the 14th International Symposium on Hepatitis C Virus and Related Viruses

...Symposium on Hepatitis C Virus and Related Viruses being held from September 9-13, 2007 in Glasgow, Scotland. R7128, a prodrug of PSI-6130, is an oral cytidine nucleoside analog polymerase inhibitor of HCV that is being developed through Pharmasset's collaboration with Roche. In addition, Pharmasset will pres...

Measuring RNase Activity A Real-time Kinetic Analysis

... 2. Crook, E, Mathias, A Rabin, B (1960) Spectrophotometric assay of bovine pancreatic ribonuclease by the use of cytidine 2',3'-phosphate. Biochem. J. 74 : 234. back to top ...

Successful PCR amplification and subcloning of a GC-rich DNA fragment

... DNA fragment from the first c-myb intron, and has a GC content of about 60%. Sequences that contain a high ratio of guanosine and cytidine base pairs (GC-rich sequences) can form robust secondary structures that resist denaturation and prevent annealing of PCR primer...
Cytidine in Biological Products

Rabbit Anti-Dideoxycytidine Polyclonal Antibody, Unconjugated from GeneTex

Description:... Rabbit polyclonal to Dideoxycytidine Dideoxycytidine is a cytidine analog that has been shown to be effective in inhibiting retroviral activity. Immunogen: Chemical / Small Molecule conjugated to BSA. Specificity...
Company:GeneTex
Cytidine in Biological Definition

Nucleoside

... Uracil Uridine U Deoxyuridine dU Cytosine cytidine C Deoxycytidine dC Nucleosides are glycosylamines made by attaching a nucleobase to a ribose ring. Examples of these include cytidine , uridine , adenosine , guanosine , thymidine and inosine . Nucleos...

Nucleotide

...osphate UDP Uridine triphosphate UTP cytidine monophosphate CMP cytidine diphosphate CDP cytidine triphosphate CTP Deoxynucleotides ...

Phospholipid

...ter linkage between the hydroxyl of an alcohol ( serine or inositol ) and cytidine diphosphodiacylglycerol (CDP-diacylglycerol). In the synthesis of phospat..., the alcohol is first phosphorylated by ATP and subsequently reacts with cytidine diphosphate (CDP) to form the activated alcohol. The alcohol then reacts wi...
Cytidine in Biological Dictionary

Somatic hypermutation

...MMR ... Because this somatic hypermutation is potentially dangerous, it has been ... This somatic hypermutation requires activation-induced cytidine deaminase (AID) ... Evolution and the molecular basis of somatic hypermutation of antigen receptor genes. ... to evolution immune somati...

RNA editing

...RNA editing ... Ralph Bock's site on C to U RNA editing in plant organelles ... The types of RNA editing vary from. uridine (U) or cytidine (C) insertions and deletions ... tion in quite dramatic ways, a phenomenon known as RNA . editing . ... The RNA editing events appear to occu...

Ribonucleotides

.... ... Ribonucleotides are not permitted in foods intended specifically for ... ... to the four classical ribonucleotides , adenosine, guanosine, cytidine and ... These so called modified ribonucleotides are synthesized post-transcriptionally ... RNA (ribonucleic acid) is a polymer of ribonucleotid...

Deamination

... deamination to uracil by 7-fold. ... Enzymes mediating tRNA adenosine deamination in bacteria and yeast contain ... Higher organisms use cytidine deamination as a mutagenic tool to catalyze or ... ... is generated by reductive deamination from tryptophan via the intermediate ... Tryptopha...

Autoradiography

...ews ... BioInfoBank Library :: Autoradiography :: Functional and neuroreceptor imaging ... Mesh-terms: Animals; Autoradiography ; Base Sequence; cytidine Triphosphate : ... Encyclopedia article about Autoradiography . Information about Autoradiography in the Columbia Encyclopedia, Computer Desktop...
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