Biogen Idec's baminercept alfa shows promise in patients with rheumatoid arthritis

...ns "Long-term safety assessment of Baminercept alfa (BG9924, LTR-Ig) in cynomolgus monkeys (Poster FRI0156 Friday, June 13, 11:45 13:30 CEST) "Treatment of cynomolgus monkeys with Baminercept alfa (BG9924, LTR-Ig) results in modulation of a s...

Subordinate monkeys more likely to choose cocaine over food

...San Diego. The presentation was part of the scientific program of the American Society for Pharmacology and Experimental Therapeutics (ASPET). Male cynomolgus monkeys live in a complex social structure in which the social hierarchy is established by physical aggression and maintained by clear signals. A monk...

Animal Study Links Social Standing With Drug Use Risk

... stressful situation, a new study finds. The Wake Forest University School of Medicine researchers exposed four dominant and four subordinate male cynomolgus monkeys to a socially stressful situation. Each monkey was taken out of its home cage and placed in an unfamiliar cage surrounded by four unfamiliar a...

Cynomolgus in Medical Technology

AACR Data Highlights InNexus Preclinical Antibody Candidate

..." InNexus' AACR presentations are titled, " A Novel High Avidity Anti-CD20 With Markedly Increased Cytotoxicity Shows No Systemic Toxicity In The cynomolgus Monkey At A Dose 100-Fold Above The Anticipated Therapeutic Dose ", (AACR# 1231) and " Oxidative Modification Of An Anti-CD20 Antibody Imparts Autophi...

Nostrum Announces the Successful Completion of Early Proof-of-Concept Study for its Novel Clot Busting Therapeutic Protein

...humans. In this study, an appropriate dose of SMRX11 was administered as an intravenous bolus and successfully restored femoral arterial blood flow in cynomolgus monkeys following a stable thrombus formation. The animal model utilized has been previously validated on other, FDA approved thrombolytic products su...

Lpath Demonstrates Strong Safety Profile of Lead Drug Candidate, Sphingomab(TM), in Non-Human Primates

...f both cancer and AMD. The safety tests included cardiovascular studies in cynomolgus monkeys as well as tests to evaluate the potential of the antibody to elici... The panel of tests also included a pivotal multiple-dosing 28-day study in cynomolgus monkeys. This study featured intravenous administration of humanized Sphing...

Cynomolgus in Medical Dictionary

Ebola

...bola virus is transmitted by direct contact with the blood, secretions, ... The transmission of the Ebola Reston strain through the handling of cynomolgus ... Ebola -Côte d'Ivoire. 1. 0. 0% 1995. Democratic Republic of Congo (formerly ... 1A fourth virus subtype, Ebola -Reston, was detected in Oc...

Cynomolgus in Biological News

Birth control has long-term effect on hormone exposure

...effect of post-menopausal dietary soy consumption on estrogen metabolism in cynomolgus monkeys, Latanya M. Scott, Ph.D., discovered that monkeys who had been give...the National Institutes of Health, researchers began with 181 premenopausal cynomolgus monkeys and followed them for seven years in a study designed to look at ho...

Environmental enrichment can reduce cocaine use, researchers find

...f cocaine that monkeys will self-administer. Housed in groups of four, male cynomolgus monkeys will invariably stratify by social rank from the most dominant to t... Therapeutics (ASPET). Nader and colleagues worked with a group of 24 cynomolgus macaques who were already categorized socially. For additional enrichment, ...

Cynomolgus in Biological Technology

Celsis Outlines the Top Five Advantages of Cryo-plateable Hepatocytes

...Conjugation Activity A High Throughput Screening Assay for Hepatotoxicity Using Cryopreserved Hepatocytes Comparison of Fresh and Cryo cynomolgus Monkey Hepatocyte CYP P450 Levels 1 Drug Interaction Studies - Study Design, Data Analysis, and Implications for Dosing and Labe...

AACR 100th Annual Meeting Highlights Superior Ability of InNexus' DXL-Modified Anti-CD20 Antibody to Attach and Kill NHL With Safety Comparable to Approved Antibody Therapies in Preclinical Studies

...es. InNexus' AACR presentations are titled, " A Novel High Avidity Anti-CD20 With Markedly Increased Cytotoxicity Shows No Systemic Toxicity In The cynomolgus Monkey At A Dose 100-Fold Above The Anticipated Therapeutic Dose ", (AACR# 1231) and " Oxidative Modification Of An Anti-CD20 Antibody Imparts Autophi...

PharmAthene Presents Data for SparVax(TM) and Valortim(R), a Novel Vaccine and Anti-Toxin for the Prevention and Treatment of Anthrax Infection at the 7th Annual ASM Biodefense Meeting

...tional anthrax in certain primates such as African Green Monkeys (AGMs) and cynomolgus monkeys (cynos) is believed to follow a similar disease course as in humans...models. Additional PK testing of Valortim(R) is currently ongoing. The cynomolgus PK project was funded in whole or in part with Federal funds from the Natio...

InNexus Biotechnology Announces Launch of Large Scale Primate Study of DXL625

...hnology, announced today that it has launched a large scale primate study of DXL625 (CD20), the company's lead program. "We are beginning a study in cynomolgus monkeys of DXL625, an antibody directed against the B-cell marker CD20 and enhanced in potency with our DXL(TM) technology," said Thomas Kindt, Ph.D.,...

Analysis of a Verapamil Microsomal Incubation using Metabolite ID and Mass FrontierTM

...re used in order to generate the maximum number of metabolites. The UDPGA was added to generate phase two glucuronide conjugates. Microsomes from male cynomolgus monkeys, male Wistar rats, and male Beagle dogs were used to probe interspecies variations in metabolism. The incubation mixtures were analyzed withou...

Cynomolgus in Biological Products

Cyno Serum from Innovative Research

Description:... Cyno Serum • Cyno serum is collected off the clot from fasted cynomolgus monkeys of mixed sex and 5-7 years of age. Available Anticoagulants: N-02: Citrate N-04: Heparin (Na) N-06: K2EDTA N-08: Potassium Oxalate ...
Company:Innovative Research

Dr. P Set - Monkey (Cynomolgus) Normal Tissue: Small Intestine from BioChain

Description:... Dr. P Set from different cynomolgus monkey normal tissues are available. More organs maybe available upon request. Customers can choose any two items from the whole set, and pay 70% of...
Company:BioChain

15(R)-17-phenyl trinor Prostaglandin F2alpha isopropyl ester from Cayman Chemical

Description:...ssay using the cat iris sphincter muscle. A 3 µg dose of 15(R)-17-phenyl trinor PGF2α caused a 1.9 mmHg reduction of IOP in normotensive cynomolgus monkeys....
Company:Cayman Chemical

Cynomolgus in Biological Dictionary

Spermatid

... sheds a residual body containing membrane ... A round spermatid was drawn into the injection pipette (Figure 2 b-1) ... Pronucleus formation in cynomolgus monkey oocytes post-round spermatid injection (ROSI) ... Since fertilization by round spermatid nucleus was first reported (Ogura and ......